7/27/2019 SPOSHROM
1/2
1 of 133TI: Mortality of 11,500 nickel workers - Extended follow
up and relationshipto environmental conditionsAU: Shannon-HS;
Walsh-C; Jadon-N; Julian-JA; Weglo-JK; Thornhill-PG; Cecutti-AGLA:
EnglishSO: Toxicology and Industrial Health; 1991, Vol.7, No.4,
p.277-294. 13 ref.PY: 1991AB: An extended follow-up from 1977-84
was achieved in a cohort of 11,567nickel workers engaged in mining,
milling and smelting originally studiedduring 1950-76. Exposure
data were incorporated into the analysis. One case ofnasal cancer
occurred. The lung cancer Standardised Mortality Ratio beyond
15years from first exposure was significantly high overall (128)
and in miners(153). However, detailed analyses by era of first
mining and duration ofmining, as well as cumulative exposure to
different nickel species, did notappear consistent with an
occupational aetiology since significant trends werenot observed.
At the levels of exposure incurred in nickel refinerieselsewhere,
no large increases in lung and nasal cancer were observed.DA:
MORTALITY-; NICKEL-; NEOPLASMS-; OCCUPATION-DISEASE-RELATIONDE:
EPIDEMIOLOGIC-STUDY; METAL-MINING; SMELTING-PLANTS;
MILLING-INDUSTRY;LUNG-CANCER; NASAL-CANCER; CANADA-; ONTARIO-CAS:
7440-02-0SC: Metal-producing-and-metal-working-industries
SP: HygieneAN: 92-1925RN: 059044
2 of 133TI: Comparative studies on the carcinogenicity of
nickel, different nickelcompounds and nickel alloysTO:
Vergleichende Untersuchungen uber die Kanzerogenitat
verschiedenerNickelverbindungen und NickellegierungenAU: Pott-F;
Rippe-RM; Roller-M; Rosenbruch-M; Huth-F; Bundesanstalt
furArbeitsschutzLA: GermanSO: Wirtschaftsverlag NW, Postfach 10 11
10, Am Alten Hafen 113-115, D-W-2850
Bremerhaven 1, Germany, 1991. 59p. Illus. 45 ref.IS:
3894291249PY: 1991AB: This study is divided into two sections. I. -
Bibliographical review (intabular form) of the carcinogenic effects
on animals of nickel (Ni), nickelcompounds and nickel alloys. II -
Assessment, through animal experiments, ofthe carcinogenicity of
nickel powder, and of six nickel compounds (chloride,sulfate,
acetate, carbonate, subsulfide, oxide) as well as 3 nickel
alloys.Highly soluble nickel compounds (Ni-chloride, -sulfate,
-acetate) were verytoxic but only weakly carcinogenic.
Ni-subsulfide showed a lower toxicity butthe strongest
carcinogenicity of all tested substances (inducement of sarcomasand
mesotheliomas in 56% of animals from 6mg Ni). Higher doses (25 to
50mg Ni)of two nickel alloys containing 50% or 66% of nickel oxide
produced a
carcinogenic but no toxic effect. 100mg Ni injected with a
nickel alloycontaining 29% Ni and 160mg of two iron oxides were not
proven to becarcinogenic. Summaries in English, French and
German.DA: CARCINOGENS-; HAZARD-EVALUATION; NICKEL-AND-COMPOUNDS;
CARCINOGENIC-EFFECTS; NICKEL-; NICKEL-ALLOYSDE: LITERATURE-SURVEY;
ANIMAL-EXPERIMENTSCAS: 7440-02-0; 7786-81-4; 373-02-4; 3333-67-3;
12035-72-2; 1313-99-1; 7718-54-9SC:
Toxic-and-dangerous-substancesSP: Hygiene
