AB EP 459387 A UPAB: 930928 Phencyclidene derivs. of formula
(I)or (II) are new. W = CH or N. R = a linking gp. including up to
4heteroatoms selected from O, N, S, P or F and contg. a total of
0-8C and heteroatoms, and contg. 0 or 1 aliphatic or aromatic
ringstructures. Z = NH, CO or CNH; n = 0 or 1, when W = N; or n =
1, \when W = CH. Q = poly(aminoacid) or a poly(amino acid) deriv.
such asthyroglobulin. Also claimed is an antibody to (I) or (II). A
processfor detecting phencyclidine and/or its metabolites in a
sample is claimed,comprising:- (a) contacting the sample with
antibodies and (I) or(II); (b) passing plane polarised light
through the soln. to obtaina fluorescence polarisation response;
and (c) detecting thefluorescence polarisation response. A kit for
this process isprovided.USE/ADVANTAGE - (I) or (II) are tracers for
use with the antibodiesin fluorescence polarisation immunoassays.
The cpds. havedetectable fluorescence polarisation and are used to
assaycompetition between phencyclidine and phencyclidine
metabolites andas tracers for the recognition sites of the
antibodies.Phencyclidine has potent analgesic and anaesthetic
properties, and
produces serious and prolonged post-anaesthetic confusion
anddelirium.0/0
