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Supplemental figure 1 Patient undergoing CAS/ CEA Operated<March 2010 CAS : N=110, CEA: N=25 Participating CAS : N=93, CEA: N=15 Insufficient data/samples CAS : N=3, CEA: N=5 Patient cohort Operated<March 2010 CAS : N=90, CEA: N=10 Excluded by criteria CAS : N=17, CEA: N=10 EHT: N=19 EHT patient Enrolled <March 2010 N=42 Patient cohort EHT: N=23

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Supplemental figure 1. Patient undergoing CAS/ CEA Operated

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Page 1: Supplemental figure 1

Supplemental figure 1

Patient undergoing CAS/ CEA

Operated<March 2010CAS : N=110, CEA: N=25

ParticipatingCAS : N=93, CEA: N=15

Insufficient data/samplesCAS : N=3, CEA: N=5

Patient cohortOperated<March 2010CAS : N=90, CEA: N=10

Excluded by criteriaCAS : N=17, CEA: N=10

EHT: N=19

EHT patientEnrolled <March 2010

N=42

Patient cohortEHT: N=23

Page 2: Supplemental figure 1

Supplemental figure 2

Grade 0 (none)

Grade 1

Grade 2

Grade 3

Less amount of debris,“Low grade “

Much amount of debris“High grade”

A

B

C

Page 3: Supplemental figure 1

Supplemental figure 3

OPN trOPN

A B

C D