The Science of Soy - The Eastern Viewpoints; Part A2: Soy and Risk of Breast cancer in Japanese Population

8/12/2019 The Science of Soy - The Eastern Viewpoints; Part A2: Soy and Risk of Breast cancer in Japanese Population

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The Science of Soy - The Eastern Viewpoints; Part A2: Soy

and Risk of Breast cancer in Japanese Popuation

By Kyle J. NortonHealth Researcher and Article Writer. Master in Mathematics and BA in World Literature and

Literary criticism. All articles written by Kyle J. Norton are for information & education only!lease consult your "octor & Related field s!ecialist before a!!lyin#.

$oy foods includin# tofu ha%e been in traditional hinese diet o%er

thousands of year accordin# to hinese literature. 'he reduced ris( of

chronic disease in Asian !o!ulation includin# metabolic syndrome such as

cardio%ascular diseases obesity and diabetes and lesser meno!ause

sym!toms in ad%anced a#e may be aided by eatin# a lot of soy food

accom!anied with lar#e !ortion of %e#etables and fruits. )ndeed accordin#

to the study only *+, of women in the -ast are e!erience sym!toms of

meno!ause in ad%anced a#e com!ared to o%er /+, of their Western

counter!arts.

Accordin# to "r. Mar( Messina 0h.". $oy foods contributed from 1.2,3

to *4.3,/ of total !rotein inta(e in older adult in Ja!an.5b6

'he a!!ro%al of cardio%ascular benefit of soy by 7"A in *888 accom!anied

with the disco%ery of health benefits in clinical studies o%er !ast

decade !rom!ted the !romotion and ad%ertisement of soy9s health benefits

in e%ery as!ect in Western society. -%idences could be seen by wal(in#throu#h the su!ermar(ets and dru# stores. $oy su!!lements and !roducts

such as tofu soy mil( soy:based infant formula and meatless ;teturinited

$oybean Board?s 4++@4++2 42, of Americans consumed soy foods or

be%era#es at least once !er wee( and /@, %iewed soy !roducts as healthy.

'oday the !romotion of soy is no lon#er eisted it may be results of

disco%ery of ad%erse effects in sin#le in#redient and animal studies as

inta(e of soy is associated to induce ris( of certain mammary cancers and

infertility. 'he !ublication of the result ha%e drawn many criticisms.

Accordin# to 'homas Bad#er director and senior in%esti#ator at the

Ar(ansas hildren?s Nutrition enter in Little Roc( these effects are seen

only under certain e!erimental conditions that are not li(ely to occur in

humansand therein lies the cru of the debate5a6. E!uo5@9/:

isofla%andiol6 an isofla%andiol metaboli


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causes as 8+, of -astern !o!ulation are eCuol !roducers but only D+, in

the West.

'he e!lanation of the !ositi%e effect of soy isofla%ones in reduced ris( of

mammary cancers by >ni%ersity of Eoettin#en may be interestin# as

researchers saidF Most im!ortantly there is dis!ute as to whether

isofla%ones deri%ed from soy or red clo%er ha%e ne#ati%e !ositi%e or any

effect at all on the mammary #land or endometrium. )t is beyond any doubt

that soy !roducts may ha%e cancer !re%entin# !ro!erties in a %ariety of

or#ans includin# the mammary #land. Howe%er these !ro!erties may only

be eerted if the de%elo!in# or#an was under the influence of isofla%ones

durin# childhood and !ubertyF.

$oybean is #enus Elycine the family 7abaceae one of the le#umes that

contains twice as much !rotein !er acre as any other maGor %e#etable or

#rain cro! nati%e to $outheast Asia. Now it is #rown worldwide withsuitable climate for commercial !rofits.

"utrients

*. arbohydrates

4. "ietary fiber

D. 7at

@. 0rotein

2. -ssential amino acid

1. itamin A

/. itamin B1

3. itamin B*4

8. itamin

*+. itamin K

**. alcium

*4. )ron

*D. Ma#nesium

*@. 0hos!horus

*2. 0otassium

*1. $odium

*/. Iinc*3. -tc.

Phytoche#icas

*. )sofla%ones

4. Eenistein

D. $a!onins

@. Beta:sitosterol


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2. "aid.$. alone and the ris( of #ettin# in%asi%e breast cancer durin#

life time of a women is *3.

'he searchin# of (eyword in 0ubMed with (eywords soy and breast cancer

in Ja!anese women found *2 related studies.

-!idemiolo#ic e%idence su##estin# hi#h inta(e of soy in

Ja!anese !o!ulation is associated to reduce ris( of breast cancer5*6 and

re#ular consum!tion of !robiotic be%era#e and isofla%ones since

adolescence was in%ersely associated with the incidence of breast cancer in

Ja!anese women54654a6.

'he study in the testin# of oral administration of )7:rich tablet 54+ and @+

m#day6 on climacteric women showed the !roduct not only reduced ris(

of breast cancer but also im!ro%ed of bone density hy!ertension and

climacteric sym!toms cardio%ascular diseases #ynecolo#ical !roblems and

!ossible immune !otentiation5D6

Ja!anese women ha%e lower incidence of and mortality from breast cancer

com!ared to aucasians it may be result of lar#e amount inta(e soy !rotein

and isofla%ones as hi#h dietary inta(e of !hytoestro#ens mainly in the form

of soy !roducts can !roduce circulatin# le%els of !hytoestro#ens that are

(nown e!erimentally to ha%e oestro#enic effects5@6.


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Accordin# to the Loma Linda >ni%ersity Asian !o!ulation consumes as

much as 42 # of soy !rotein or *++ m# of isofla%ones !er day526.

-!idemiolo#ical Western studies ha%e lin(ed le%els of Eenistein and

daid


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res!ecti%ely in the soymil(:su!!lemented #rou! but insisted that lar#er

studies will be reCuired to confirm the ability of soy !roducts to reduce

serum estro#en le%els5*4a6. ther study in 2+ healthy !remeno!ausal

Ja!anese women also showed a similar result as blood sam!les drawn from

each subGect on "ays ** and 44 of her menstrual cycle su##ested that the

consum!tion of soy !roducts lowers the ris( of de%elo!in# breast cancer ris(

in modifyin# estro#en metabolism5*4b6.

)n !ostmeno!ausal Ja!anese women accordin# to the study from the

'a(ayama with !artici!ants members a#ed D2 years or older in *884 with

follow:u! was conducted from the time of the baseline study 5$e!tember *

*8846 to the end of March 4++3 concluded that soy and isofla%one inta(es

may ha%e a !rotecti%e effect on !ostmeno!ausal breast cancer. Ris(s of

breast cancer were decreased amon# women with a moderate inta(e of soy

and isofla%one5*D6.

)n a total of 1/3 breast cancer cases and DD8+ a#e: and meno!ausal status:

matched noncancer controls soy showed a !rotecti%e effect a#ainst breast

cancer ris( differs by rece!tor status includin# with -R:!ositi%e 5-R6 and

H-R4:ne#ati%e 5H-R4:65*@6. Eenistein a maGor com!onent of soybean

isofla%one has been found to induce breast cancer in some Western study

also eerted its anti breast cancer !re%enti%e effect in a breast cancer cell

o%ere!ressin# H-R:4 as #enistein enhances necrotic:li(e cell death of the

breast cancer cells throu#h the inacti%ation of H-R:4 rece!tor and

A(t which !lays a (ey role in multi!le cellular !rocesses in combined with

chemothera!eutic a#ent 5*26.

>nfortunately re!ort on a Ja!an ollaborati%e ohort 5JA6 $tudy. 7rom

*833 to *88+ D+@2@ women a#ed @+:/8 years com!leted a Cuestionnaire

on diet and other lifestyle features su##ested that consum!tion of soy food

has no !rotecti%e effects a#ainst breast cancer but insisted that further lar#e:

scale in%esti#ations elicitin# #enetic factors may clarify different roles of

%arious soybean:in#redient foods on the ris( of breast cancer5*16.

Accordin# to "R. Na#ata . the !rotecti%e ris( a#ainst breast cancer only

found in in Asian but not Western !o!ulations with inta(e of soy may be

due to consume le%els of soy ty!ical in Asian diets. Researchers should also

ta(e account of amount of soy isofla%ones consumed the form and food

source of isofla%ones timin# of isofla%one e!osure estro#en rece!tor

status of tumors and eCuol:!roducer status and hormonal !rofile of


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indi%iduals. 'hese factors mi#ht e!lain the hetero#eneity of results from

studies5*/6.

&oncusion

"r Rice $. "r. Whitehead $A. in the differentiation of !hytoestro#ens and

breast cancer::!romoters or !rotectors said Fa !arado concernin# thee!idemiolo#y of breast cancer and the dietary inta(e of !hytoestro#ens that

bind wea(ly to oestro#en rece!tors and initiate oestro#en:de!endent

transcri!tion. )n -astern countries such as Ja!an the incidence of breast

cancer is a!!roimately one:third that of Western countries whilst their hi#h

dietary inta(e of !hytoestro#ens mainly in the form of soy !roducts can

!roduce circulatin# le%els of !hytoestro#ens that are (nown e!erimentally

to ha%e oestro#enic effects. 'he actions of !hytoestro#ens on oestro#en

rece!tors and (ey en


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5$oy !rotein and cardio%ascular disease6

5e6 %an der $chouw Q' KreiG(am!:Kas!ers $ 0eeters 0H Keinan:Bo(er L

Rimm -B Erobbee "-. 0ros!ecti%e study on usual dietary !hytoestro#en

inta(e and cardio%ascular disease ris( in Western women. irculation. 4++2P

***O @12@/*5ardio%ascular diseases in women6

5*6 $oy inta(e and breast cancer ris(O an e%aluation based on a systematic

re%iew of e!idemiolo#ic e%idence amon# the Ja!anese !o!ulation50ubMed6

546 0robiotic Be%era#e with $oy )sofla%one onsum!tion for Breast ancer

0re%entionO A ase:control $tudy by 'oi M* Hirota $ 'omota(i A $ato N

Ho


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healthy !ostmeno!ausal women by 'eas J* Hurley 'E Hebert JR 7ran(e

AA $e!(o%ic "W Kur

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The Science of Soy - The Eastern Viewpoints; Part A2: Soy and Risk of Breast cancer in Japanese Population