Topic: Biomedical Engineering - MedUni Wien "Biomedical Engineering " 1. ... Biomedical Engineering and Physics at the Medical University has a very ... impulse, work, energy, power;

Dr. Sci. Med. N790 Biomedical Engineering April 14, 2008

Application for the Doctoral Study of Applied Medical Science

(Dr. Sci Med “neu” N790, Rev. 1)

Topic: "Biomedical Engineering " 1. General: Coordination: Assoc. Univ.Prof. H. Schima PhD Center for Biomedical Engineering and Physics, Medical University Vienna, Austria AKH 4L Währinger Guertel 18, A-1090 Wien Tel: +43 1 40400 3982 Fax +43 1 40400 3988 e-mail: [email protected] Homepage of the Center: http://www.bmtp.akh-wien.ac.at Program Committee: W. Birkfellner, H. Gilly, H. Lanmüller, W. Mayr, D. Rafolt, H. Schima, H.G. Stöhr 2. Short Description: In recent years Biomedical Engineering has become a key discipline for many fields of Medicine. Some specialties would even not be imaginable without the diagnostic and therapeutic tools, which they developed together with Biomedical Engineers. Due to the huge variety of questions and tasks, Biomedical Engineering has become a broad spectrum of topics, which are addressed by the interdisciplinary approach of bioengineers together with physicians and technical specialists of multiple disciplines, to use the newest and best fitting scientific and manufacturing approaches. In Vienna, Biomedical Engineering has already achieved a long tradition, and the Center for Biomedical Engineering and Physics at the Medical University has a very special position, because technical specialists can work here in very close contact directly with the clinical users. At the same time our laboratories and workshops can rapidly produce hand-on models and prototypes for research and development. Further the members of the program committee are in close contact with various technical and physical institutes to apply additional special methods if necessary. Focus of the research activities are placed in the stimulation of nerves and muscles, in applications for heart and the circulatory systems, internal artificial organs and hybrid organs, as well as questions of biocompatibility, biomechanics and rehabilitation. These projects address both basic and applied research, in close cooperation with national and international companies, educational institutions and health agencies. The basic course of this program topic shall introduce into this broad spectrum of biomedical engineering and particularly its clinical applications. Depending on the topic of the thesis appropriate special courses shall be selected in discussion with the thesis tutor. Journal clubs to the various research focuses shall discuss approaches by other groups and partners.

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The study of Biomedical Engineering shall make the participants particularly familiar with the interfaces between engineering and medicine. Depending on their scientific background the different approach and scientific style of the other disciplines shall be integrated into the personal work-style. Based on their personal scientific background, the graduates of this study shall be able to define, implement and coordinate interdisciplinary biomedical projects. 3. Courses: 3.1 Basic Course (2*2Sem-h = 64 hours) Topic Detailed contents h Presented by Basics of Physics Mass, force, impulse, work, energy, power;

Movement, oscillation, waves; Pressure, flow hydraulic resistance, flow-fields; material properties, states of aggregation; Gas equations, diffusion and filtration, partial pressures; Basics of electromagnetism, direct and alternating current;

15 Gilly, Lanmüller, Birkfellner

Biosignals Signal acquisition (from biosignal to computer data); Characterization of signals, time and frequency response; Types of biological signals, sources of disturbances, definition of error, calibration; Sensor principles (active and passive transducers, Wheatstone bridge); Parameters of signal amplifiers, digitization, Shannon theorem, aliasing; Digital signal transformation;

8 Lanmüller

Sensors Sensors for position, velocity, acceleration, force, pressure, acoustics, flow, magnetism, temperature, humidity, and radiation. Chemical and biochemical sensors, DNA-chips, Chemosensory, Biosensor, DNA- Biochips, Automatic sensor sampling and calibration Electrodes for ECG, EEG, EMG

8 Stöhr, Rafolt

Electro-stimulation

Physiological principles (nerves and muscles); Stimulation parameters; Technical solutions for electrodes and stimulators; Electrochemical, mechanical and biological boundary conditions; Diagnostic, therapeutic and functional applications; Limitations and future perspectives;

8 Mayr

Biocompatibility and Biomaterials

Definitions of Biocompatibility; Physiological Background; Biocompatibility – Bioresistivity; System-Tissue-Interface; Chemical and mechanical stress; Selection of Materials, machining and surface treatment; Plastic materials; Coating and surface modification Micro- and nanostructure materials

6 Mayr, Schima

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Biocompatibility testing in vitro and in vivo; Haemocompatibility; Scaffolds for tissue engineering and hybrid organs

Circulatory systems and artificial internal organs

Biomedical engineering for circulatory diagnostics; Cardiac Valves, vascular prostheses, stents; Blood Pumps and Oxygenators, extracorp. Circulation; Dialysis and apheresis

8 Schima

Lung diagnostics and respirators

Diagnostics with inert gas, spirometry, Spontaneous respiration and respirators (conventional and high frequency ventilators)

4 Gilly

Safety in design and application

Guidelines and laws for medical products, CE-certification, Electrical safety and measures for installation and devices; aspects of radiation; Risk and Failure analysis

4 Stöhr

System modeling Basics of models, limitations and boundary conditions; Lumped parameter models, finite element models for structures and fluids

3 Schima

3.2 Journal-Clubs (2Sem-h.): Journal-Club Biomedical Measurement; n.Ü.SE 2st. Hermann Lanmüller, Hans-Georg, Stöhr, Winfried Mayr Journal-Club Functional stimulation of nerves and muscles; n.Ü.SE 2st

Winfried Mayr, Hermann Lanmüller, Dietmar Rafolt

Journal-Club Biomedical Engineering for the circulatory system and artificial internal organs; n.Ü.SE 2st

Heinrich Schima, Hermann Gilly

3.3 Courses for Special topics (Seminars): Seminar: Actual Topics in Biomedical Engineering and clinical physics" nÜ SE 2st with Ass. Helmar Bergmann Seminar for thesis students: " Biomedical Engineering in spiro-diagnostics and respiration" nÜ SE 2st Hermann Gilly Seminar for thesis students: " Acquisition and Analysis of Biosignals " nÜ SE 2st Hermann Lanmüller Seminar for thesis students: " Electrostimulation" nÜ SE 2st

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Winfried Mayr Seminar for thesis students: "Biomedical Engineering for Circulation and artificial internal organs " nÜ SE 2st Heinrich Schima Seminar for thesis students: “Measurement and Microcomputer applications in Biomedical Engineering” nÜ SE 2st Hans-Georg Stöhr Seminar for thesis students: “Senso-Actuatorsystems and Haptic Devices”, nÜ SE 2st Dietmar Rafolt 3.4 Practical Seminars: “Practical Seminar in Biomedical Engineering I” nÜ SE 2st Hermann Gilly “Practical Seminar in Medical Electronics” nÜ SE 2st Hans-Georg Stöhr 4. Methods and Working Groups a) at the Center of Biomedical Engineering and Physics (for e-mail contact use adress [email protected]) Methoden Ansprechpartner Biomaterials Prof. DI Dr. Winfried Mayr,

Prof. DI Dr. Heinrich Schima Cardiovascular prostheses and assisted circulation

Prof. DI Dr. Heinrich Schima

Device Safety and Patient Protection Prof. DI Dr. Winfried Mayr, Prof. DI Dr. Heinrich Schima, Prof. DI Dr. Hans-Georg Stöhr

Electrical Implants Prof. DI Dr. Winfried Mayr, Prof. DI Dr. Hermann Lanmüller

Electrodiagnostics Prof. DI Dr. Hermann Lanmüller, Prof. DI Dr. Winfried. Mayr

Electrostimulation Prof. DI Dr. Winfried Mayr, Prof. DI Dr. Hermann Lanmüller, DI Dr. Manfred Bijak

Hemodynamic Monitoring Prof. DI Dr. Hans-Georg Stöhr, Prof. DI Dr. Heinrich Schima

Image Processing and Image guided Therapy Prof. Dr. Wolfgang Birkfellner Models Prof. DI Dr. Heinrich Schima,

DI Dr. Martin Reichel, DI Johannes Martinek

Plastics Engineering Prof. DI Dr. Heinrich Schima

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Rehabilitation engineering Prof. DI Dr. Winfried Mayr Sensors Prof. DI Dr. Dietmar Rafolt,

Prof. DI Dr. Hans-Georg Stöhr Signal processing Prof. DI Dr. Hans-Georg Stöhr,

DI Dr. Manfred Bijak Spiro-Monitoring and Respiration Prof. Dr. Hermann Gilly b) Clinical cooperations: Topics and Partners Methods: Contact: Image processing and visualization in Radiology

Prof. Dr. Franz Kainberger, Klinik für Radiologie [email protected]

Biological Replacement of cardiac valves and prostheses

Prof. Dr. Paul Simon, Prof. Dr. Günther Weigel, DDr. Helga Bergmeister, Abt. für Herz-Thorax-Chirurgie; Chir. Laboratorien; Zentrum für Biomedizinische Forschung [email protected] [email protected] [email protected]

Electro-stimulation of the central nervous system

Prof. Dr. Francois Alesch, Klinik für Neurochirurgie francois@[email protected]

Development of respirators and respiration therapies

Prof. Dr. Alexander Aloy, Klinik für Anästhesie [email protected]

Evidence Based Technology Assessment Prof. Dr. Michael Hiesmayr, Klinik für Anästhesie und Allg. Intensiv-medizin, Abteilung HTG [email protected]

Experimental in vivo models Univ.Prof. Dr. U. Losert, Zentrum für Biomedizinische Forschung [email protected]

Extracorporeal oxygenation Univ.Prof. Dr.Walter Klepetko, Prof. Dr. Michael Grimm, Abt. f. Herz-Thorax-Chir. [email protected] [email protected]

Extracorporeal long term oxygenation and CO2-elimination

Prof. Dr. Peter Germann, Klinik für Anästhesie und Allg. Intensivmedizin [email protected]

Functional electro stimulation Univ.Doz. Dr. Werner Girsch, Orthop. Spital Speising

Interventional robotics and therapy OA Dr. Joachim Kettenbach, Klinik für Radiologie [email protected]

Cardiologic ultrasound diagnostics clinical and in-vitro

Prof. Dr. Thomas Binder, Abt. für Kardiologie [email protected]

Clinical electrophysiology of the peripheral neural system

Prof. Dr. Tatjana Paternostro-Sluga, Prof. Dr. Richard Crevenna,

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Klinik f. Phys.Med. & Rehabilitation [email protected] [email protected] Doz. Dr. Helmut Kern, Wilhelminenspital [email protected]

Assisted Circulation, Cardiac Assist Devices Prof. Dr. Georg Wieselthaler, Abt. für Herz-Thorax-Chirurgie [email protected]

Ophthalmologic electrophysiology Prof. Dr. Manfred Lessel, Prof. Dr. Clemens Vass, Univ.klinik f. Augenheilkunde und Optometrie [email protected] [email protected]

Orthopedics Dr. Gobert Skrbensky, Dept. for Orthopedics [email protected]

Telemedicine in neuro-rehabilitation Prof. Dr. Eduard Auff, Klinik für Neurologie eduard.auff@,meduniwien.ac.at

Therapies of aortic aneurysms Prof. Dr. Marek Ehrlich, Prof. Dr. Martin Czerny, Abt. für Herz-Thorax-Chirurgie [email protected] [email protected]

Visualization and intraoperative navigation

Prof. Dr. Franz Watzinger, Prof. Dr. Arne Wagner, Prof. Dr. Felix Wanschitz, Klinik für Mund-, Kiefer- und Gesichtschirurgie [email protected] [email protected] [email protected]

Cell therapy and tissue engineering in traumatology

Prof. Dr. Stefan Marlovits, Klinik für Unfallchirurgie [email protected]

Diagnostics of cystic fibrosis Prof. Dr. Thomas Frischer , Kinderklinik [email protected]

5. Working group leaders and thesis positions: Contact Institute e-mail Positions as

April 08 overall/funded

Prof. Dr. Wolfgang Birkfellner

Z.BMT&Ph wolfgang.birkfellner@ meduniwien.ac.at

2 / 0

Prof. Dr. Hermann Gilly

Klinik für Anaesthesie

hermann.gilly@ meduniwien.ac.at 2 /0

Prof. DI. Dr. Hermann Lanmüller

Z.BMT&Ph hermann.lanmueller@ meduniwien.ac.at

2 / 0

Prof. DI. Dr. Winfried Mayr

Z.BMT&Ph winfried.mayr@ meduniwien.acat 4 / 2

Prof. DI. Dr. Dietmar Rafolt

Z.BMT&Ph [email protected] 2 / 1

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Prof. DI. Dr. Heinrich Schima

Z.BMT&Ph heinrich.schima@ meduniwien.ac.at

3 / 1

Prof. DI. Dr. Hans-Georg Stöhr

ZBF hans-georg.stoehr@ meduniwien.ac.at

2 / 0

6. Literature: General introductory works into the main fields of Biomedical Engineering: I Bankman: Handbook of Medical Imaging, Academic Press 2000 A Bolz, W Urbaszek: Technik in der Kardiologie. Springer Berlin 2002; JS Bronzino (ed): The Biomedical Engineering Handbook. CRC Press, BocaRaton 2nd

Edition, 2005; J Enderle, S Blanchard, JS Bronzino (ed): Introduction to Biomedical Engineering, Elsevier

2005; L Geddes, L Baker: Principles of Applied Biomedical Instrumentation; Wiley 1989 R Gonzalez, R Woods "Digital Image Processing", Addsion Wesley 2007 Handbook of Medical Imaging, SPIE Press 2000; Volume 2: Medical Image Processing and

Analysis; Volume 3: Display and PACS; H Hutten (ed): Biomedizinische Technik. 4 Bände, Springer Berlin, 1993; R Merletti, P Parker: Electromyography: Physiology, Engineering and Noninvasive

Applications; IEEE Press 2004 G Wnek, GL Bowlin: Encyclopedia of Biomaterials and Biomedical Engineering. Marcel

Dekker, NY 2004.

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Dr. Sci. Med. Biomedical Engineering CV Prof. W. Birkfellner

ao. Univ. – Prof. Mag. Dr. Wolfgang Birkfellner Curriculum vitae Academic title Dr. rer. nat., Mag. rer. nat., ao. Univ. – Prof.

Year of Birth 1970

Place of Birth Steyr, Upper Austria

Marital status married with Katharina, three children Joseph, Carl, and Anton

Nationality Austria

Address Center of Biomedical Engineering and Physics,

Medical University of Vienna, AKH Vienna 4L

Waehringer Guertel 18-20

A-1090 Vienna, Austria

Phone +43.1.40 400 - 5471

Fax +43.1.40 400 - 3988

e-mail [email protected]

Education 1983 - 1990 High School, Münster, Germany

1981 - 1983 High School, Vienna, Austria

1977 - 1981 Primary School, Vienna, Austria

University Nov. 2000: Final PhD Exams in Medical Physics; Title of the PhD-thesis:

“Tracking Systems in Surgical Navigation“

Nov. 1996 - Dec. 1997PhD Student at the Department of Biomedical Engineering and

Physics, General Hospital, University of Vienna

Oct. 1990 - June 1996 Studies of Physics at the University of Vienna. Diploma thesis: "The

Decay K01 -> �*�* -> l+l-l+l- in Chiral Perturbation Theory",

Department of Theoretical Physics, University of Vienna.

Several Vacation jobs in information technology

July - Aug. 1995 Summer student at the "Deutsches Elektronen Synchrotron DESY", in

Hamburg, Germany

Professional Career

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Oct. 2004 - present: Appointment as Associate Professor, Medical University Vienna (ao.

Univ. – Prof.)

Jun. 2004: Postdoctoral lecture qualification (“Habilitation”), Medical University

of Vienna

Dec. 2001 – Jul. 2003: Senior researcher at the Interdisciplinary Image Processing Laboratory,

Kantonsspital Basle, Switzerland

Dec. 1997 – Oct. 2004:Assistant Professor at the Department of Biomedical Engineering and

Physics, General Hospital, University of Vienna

Area of expertise: Medical physics, medical image processing, image – guided therapy, tracking hardware for medical applications, medical augmented reality, registration, radiology, development and assessment of image-guided surgery software and control software for medical robotics. Teaching in the curriculum of the Medical University Vienna and lecturer in medical image processing at the University of Applied Sciences Technikum Wien. Reviewer for international journals (IEEE TMI, Med Phys) and conferences (MICCAI, SPIE Medical Imaging). Organizer of several workshops on augmented reality in medicine and medical physics. Principal investigator and co-researcher for several third party funded research projects. Author or co-author of 34 peer-reviewed journal articles and 33 proceedings articles since 1998. According to the ISI database, papers authored or co-authored were cited over 370 times in the literature.

Research projects • „Intraoperative Imaging and Image-Guided Interventions“, OeNB

Jubiläumsfondsprojekt #8450; Univ. - Ass. Dr. Mag. Wolfgang Birkfellner and o. Univ. - Prof. Dr. Helmar Bergmann. Project volume: 35.336 €, Juni 2000 - Juni 2002. Cooperation: Dept. of Diagnostic Radiology, Dept. of Orthopaedics, Dept. of Internal Medicine IV (all at AKH Vienna), Dept. of Computer Science, Hebrew University Jerusalem.

• “Innovative Approaches to 2D/3D Registration for Image-Guided Therapy”, FWF Project P19931; ao. Univ. – Prof. Mag. Dr. Wolfgang Birkfellner. Project Volume: 280.297 €, January 2008 – December 2010. Cooperation: Depts. of Interventional Radiology, Trauma Surgery, and Radiation Oncology, and Excellence Center for High-Field Magnetic Resonance Tomography (Medical University Vienna), Dept. of Electrical Engineering, Univ. of Ljubljana, Slovenia, and Biomedical Imaging Resource, Mayo Clinic, Rochester/ MN.

• “Realtime 2D/3D registration in radiation therapy”, FWF Project TRP 503; ao. Univ. - Prof. Mag. Dr. W. Birkfellner, Project Volume: 272.067 €, September 2008 – August 2011. Cooperation: Dept. of Radiation Oncology, Medical University Vienna, University of Applied Sciences Technikum Wien.

Recent publications (peer-reviewed journals) Wagner, K. Schicho, W. Birkfellner, M. Figl, R. Seemann, F. Konig, F. Kainberger, R.

Ewers: “Quantitative analysis of factors affecting intraoperative precision and stability of optoelectronic and electromagnetic tracking systems”, Med Phys 29(5):905-912 (2002)

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F. Wanschitz, W. Birkfellner, F. Watzinger, C. Schopper, S. Patruta, F. Kainberger, M. Figl, J. Kettenbach, H. Bergmann, R. Ewers:“ Evaluation of accuracy of computer-aided intraoperative positioning of endosseous oral implants in the edentulous mandible“, Clin Oral Implan Res 13(1), 59-64, (2002)

P. Homolka, A. Beer, W. Birkfellner, R. Nowotny, A. Gahleitner, M. Tschabitscher, H. Bergmann: “Bone mineral density measurement with dental quantitative CT prior to dental implant placement in cadaver mandibles: pilot study”, Radiology 224(1):247-252, (2002).

W. Birkfellner, M. Figl, K. Huber, F. Watzinger, F. Wanschitz, J. Hummel, R. Hanel, W. Greimel, P. Homolka, R. Ewers, H. Bergmann: „A Head-Mounted Operating Microscope for Augmented Reality Visualization in Medicine - Design and Calibration“, IEEE Trans Med Imaging 21(8), 991-997, (2002).

F. Wanschitz, W. Birkfellner, M. Figl, S. Patruta, A. Wagner, F. Watzinger, K. Yerit, K. Schicho, R. Hanel, F. Kainberger, H. Imhof, H. Bergmann, R. Ewers: “Computer-enhanced stereoscopic vision in a head-mounted display for oral implant surgery”, Clinical Oral Implan Res 13(6), 610-616, (2002)

J. Hummel, M. Figl, C. Kollmann, H. Bergmann, W. Birkfellner: „Evaluation of a miniature electromagnetic position tracker“, Med Phys 29(10), 2205-2212, (2002).

W. Birkfellner, M. Figl, C. Matula, J. Hummel, R. Hanel, H. Imhof, F. Wanschitz, A. Wagner, F. Watzinger, H. Bergmann: “Computer - enhanced stereoscopic vision in a head-mounted operating binocular - a study in skull base surgery”, Phys Med Biol 48(3), N49-57 (2003)

Wagner, F. Wanschitz, W. Birkfellner, K. Zauza, F. Watzinger, K. Schicho, F. Kainberger, C. Czerny, H. Bergmann, R. Ewers: “Computer-Aided Placement of Endosseous Oral Implants in Patients after Ablative Tumor Surgery: Assessment of Accuracy”, Clin Oral Implant Res 14(3), 340-348, (2003)

W. Birkfellner, J. Wirth, W. Burgstaller, B. Baumann, B. Hammer, N. Gellrich, A. Jacob, P. Regazzoni, P. Messmer: „A Faster Method for 2D/3D Registration“, Phys Med Biol 48(16), 2665-2679, (2003)

Wagner, K. Schicho, F. Kainberger, W. Birkfellner, S. Grampp, R. Ewers: „Quantification and Clinical Relevance of Head Motion During Computed Tomography“, Invest Radiol 38(11), 733-741, (2003)

J. Kettenbach, G. Kronreif, M. Figl, M. Fürst, W. Birkfellner, R. Hanel, H. Bergmann.: “Robot – assisted biopsy using ultrasound: initial results from in-vitro tests”, European Radiol 15(4), 165 – 771, (2005)

J. Kettenbach, G. Kronreif, M. Figl, M. Fürst, W. Birkfellner, R. Hanel, T. Schmook, H. Bergmann: „Robot –assisted biopsy using CT-Guidance“, Invest Radiol 40(4), 219-228 (2005)

W. Korb, M. Kornfeld, W. Birkfellner, R. Boesecke, M. Figl, M. Fuerst, J. Kettenbach, A. Vogler, S. Hassfeld, G. Kronreif: “Risk analysis and safety assessment in surgical robotics: A case study on a biopsy robot”, Minim Invasiv Ther 14(1), 23 – 31, (2005)

W. Birkfellner, R. Seemann, M. Figl, J. Hummel, C. Ede, P. Homolka, X. Yang, P. Niederer, H. Bergmann: „Wobbled Splatting – a fast perspective volume rendering method for simulation of X-ray images from CT“, Phys Med Biol 50(9), N73-N84, (2005)

K. Schicho, M. Figl, M. Donat, W. Birkfellner, R. Seemann, A. Wagner, H. Bergmann, R. Ewers: “Stability of electromagnetic tracking systems in the presence of sources of distortions”, Phys Med Biol 50(9), 2089-2098, (2005)

J. Hummel, M. Bax, M. Figl, Y. Kang, R. Shahidi, C. Maurer Jr., W. Birkfellner, H. Bergmann: “Design and Evaluation of a Standardized Assessment Protocol for Electromagnetic Tracking Systems”, Med Phys 32(7), 2371-2379, (2005)

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M. Figl, C. Ede, J. Hummel, F. Wanschitz, R. Ewers, H. Bergmann, W. Birkfellner, : “Fully automated calibration of an optical see-through head-mounted display with variable zoom and focus”, IEEE Trans Med Imaging 24(11), 1492-1499, (2005)

J. Hummel, M. Figl, W. Birkfellner, MR Bax, R. Shahidi, CR Maurer Jr., H. Bergmann: “Evaluation of a new electromagnetic tracking system using a standardized assessment protocol”, Phys Med Biol 51(10), N205-10, (2006)

Beer, A. Gahleitner, A. Holm, W. Birkfellner, P. Homolka: “Adapted preparation technique for screw-type implants: In vitro pilot study in a porcine bone model”, Clinical Oral Implants Research 18(1), 103-107, (2007)

W. Birkfellner, M. Figl, J. Kettenbach, J. Hummel, P. Homolka, R. Schernthaner, T. Nau, H. Bergmann: “2D/3D Slice-to-Volume Registration and its Application on Fluoroscopic CT Images”, Med Phys 34(1), 246-255, (2007)

K. Schicho, M. Figl, R. Seemann, M. Donat, M. L. Pretterklieber, W. Birkfellner, A. Reichwein, F. Wanschitz, F. Kainberger, H. Bergmann, A. Wagner, Rolf Ewers: “Laser surface scanning versus fiducial-based patient registration in frameless stereotaxy“, J. Neurosurg. 106(4), 704-709, (2007)

T. Kuenzler, J. Grezdo, J. Bogner, W. Birkfellner, D. Georg: „2D/3D registration of lung tumours for verification of stereotactic body radiotherapy: a feasibility study“, Phys Med Biol, 52(8), 2157 – 2170 (2007)

J. Spoerk, H: Bergmann, F. Wanschitz, S. Dong, W. Birkfellner: „Fast DRR Rendering using Common Consumer Graphics Hardware“, Med Phys, accepted, (2007)

D. Brandenberger, W. Birkfellner, B. Baumann, P. Messmer, R. W. Huegli, P. Regazzoni, A. L. Jacob: “Positioning accuracy in a registration-free CT-based navigation system”, Phys Med Biol, accepted, (2007)

PhD-theses 1. Mag. Michael Figl: „Calibration and Registration of a Head-mounted Operating

Microscope for Augmented Reality Visualization in Computer-Aided Surgery”.

Vienna, 2002. Supervisor: o. Univ. - Prof. Dr. Helmar Bergmann.

2. Mag. Johann Hummel: „Image Guided Endosonography – Requirements and

Development”. Vienna, 2002. Supervisor: o. Univ. - Prof. Dr. Helmar Bergmann.

3. Xinhui Yang, Federal Institute of Technology, Zurich, Switzerland (Supervisor:

Prof. Dr. P. Niederer)

4. DI Isabella Hinterleitner, Medical University Vienna International Co-operations

• Biomedical Imaging Ressource, Mayo Clinic, Rochester/MN

• Department of Electrical Engineering, Univ. of Ljubljana, Slovenia

• Department of Computer Science, Imperial College London

• Department of Neurosurgery, Stanford University, Stanford/CA Program Committee Memberships, Reviews

• Program committee member ISAR (International Symposium on Augmented

Reality)

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• Program committee member CAS-H (Computer Aided Surgery around the Head)

• Program committee member for SPIE Medical Imaging Conference Series

• Program committee Member Workshop AMI-ARCS, Rennes, 2004

• Program committee Member 25th Meeting of the Austrian Society of Medical

Physics (OeGMP)

• Program comittee Member MICCAI 2008

• Reviewer for SIGGRAPH Conference Series

• Reviewer for MICCAI Conference Series

• Reviewer for IEEE Transactions on Medical Imaging

• Reviewer for IEEE Transactions on Information Technology in Biomedicine

• Reviewer for European Journal of Radiology

• Guest Associate Editor and Reviewer for Medical Physics

• Reviewer for Physics in Medicine and Biology

• Reviewer for Zeitschrift für Medizinische Physik

• Reviewer for various research funding agencies (OeNB research funds, Israel

National Science Foundation, Cancer Research UK, NSERC Canada).

• Chairman, SPIE Medical Imaging – Visualization, Image – Guided Procedures and

Display

• Chairman, 3Ländertreffen Biomedizinische Technik Salzburg, Sept. 2003

• Chairman CURAC General Assembly Meeting Munich 2004

• Chairman 25th Meeting of the Austrian Society of Medical Physics (OeGMP)

• General Chair ISMAR 2005 (International Symposium on Augmented and Mixed

Reality), Vienna 2005

• General Chair AMI-ARCS 06, Kopenhagen, Denmark

• Chairman CAS-H 2007, Innsbruck, Austria

• Chairman MEDICON 2007, Ljubliana, Slovenia

Awards • Golden Mile „Magna cum laude“ Award (together with J. Kettenbach), ECR 1999

1. Golden Mile „Magna cum laude“ Award, ECR 2001

2. Certificate of Merit Poster Award (together with P. Homolka), ECR 2001

3. Schering Award of the ÖRG for the ECR 2002 Matrix Exhibition (together with R.

Bale)

4. Matrix “Magna cum laude” Award (together with E. Sorantin), ECR 2003

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5. Matrix “Magna cum Laude” Award (together with J. Kettenbach and G. Kronreif),

ECR 2004

Project Description: 2D/3D-Image Fusion in Image Guided Therapy

Based on earlier research from our groups in the determination of 3D patient position from

projection images, we propose to develop a real-time 2D/3D registration method for online

tumour motion detection in image-guided radiation therapy (IGRT) at an update rate of 5 Hz.

The result of our research effort will be a software suite that tracks the tumour target volume

on a real-time x-ray during irradiation in 3D and intercepts the treatment beam if motion

beyond a given safety margin is detected.

IGRT using on-line x-ray imaging is the latest development in radiation oncology and

currently among the hottest topics in the field of medical physics. On-board imaging units

allow for acquisition of planar images as well as cone-beam CT volumetric data. Patient

position relative to the treatment plan can be determined on a daily basis, and tumour

displacement due to weight loss, movement of internal organs, or inaccurate patient

positioning can be taken into account. However, short – term movement like breathing leads

to considerable problems in precision irradiation of the targets in the lung or the abdomen and

cannot be compensated by this method. Several researchers have therefore suggested the use

of implanted gold markers or position tracking electronics in the tissue surrounding the

tumour. In our proposed project, we plan to achieve the same goal by speeding up 2D/3D

registration to real time extent. Then, any implantation of markers or sensors is unnecessary.

This will be accomplished by optimizing some of our already proven algorithmic methods for

ultra-fast generation of digitally reconstructed radiographs and optimized merit functions such

as stochastic rank correlation for standard high-performance computing hardware. State-of the

art IGRT equipment as well as clinical expertise in radiation oncology is available for the

project. Extensive pre-clinical and clinical studies as well as dosimetric examinations in close

collaboration between our departments form an integral part of the research effort.

Furthermore, we plan to integrate the University of Applied Sciences Technikum Wien into

the project by providing several master theses in the field of biomedical informatics.

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The project is intended for a three year duration. Within that period, we will deliver a well-

tested implementation of our algorithms. A registration update rate of 5 Hz is intended for

efficient tumour motion control. Dissemination of results is planned by means of publications

in peer-reviewed journals, patents, and collaborations with major vendors of IGRT

equipment.

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Dr. Sci. Med. Biomedical Engineering CV Prof. H. Gilly

Hermann Gilly Curriculum Vitae Klinische Abteilung für Spezielle Anästhesie und Schmerztherapie

Clinical Department for Special Anaesthesiology and Pain Therapy

Medical University of Vienna, AKH Vienna 9i

Waehringer Guertel 18-20, A-1090 Vienna, Austria;

Phone +43-1-40 400 - 4516

Fax +43-1-40 400 - 4519

Email [email protected]

Date of Birth: 1944

Place of Birth: Bad Gleichenberg, Styria

Nationality: Austria

Education 1993- present: "Außerordentlicher Universitätsprofessor" (Appointment as Extraordinary

University Professor)

1990 to 1992: Interim administrative manager of the Experimental Department of the Clinic

for General Anaesthesia and Intensive Care, Department B.

1990 - present: Scientific Board member (“Director) of the L. Boltzmann Institute of

Experimental Anaesthesiology and Research in Intensive Care, Vienna.

1989: Habilitation (Univ. Doz.) “Biomedical Engineering”

Career History 1989 – present: tenureship

1981: Staff member

1975: Assistant professor at the then Clinic for Anaesthesia and General Intensive Care,

Experimental Department

1973-1975: Full-time and part-time research fellow at the Karl-Franzens-University in Graz

(Experimental Physics), and freelance engagement with a private company dealing with

1972 Graduation (Doctor of Philosophy (Dr. phil.))

Educational Stays Abroad 1993 Educational Stay at the Institute for Experimental Medicine (Hungarian Academy of

Science, Prof. Dr. E.S. Vizi, 2 times 2 weeks each)

1991 Educational Stay at the Institute for Experimental Medicine (Hungarian Academy of

Science, Prof. Dr. E.S. Vizi, 3 weeks)

15

mailto:[email protected]


1991 Montefiore Hospital, Research Department of Anaesthesia

(Prof. Dr. F. F. Foldes, 1 week)

1988 Groningen (postgraduate course of the European Academy for Anaesthesiology)

1986 Bonn (postgraduate course of the European Academy for Anaesthesiology)

1986 University of Salt Lake City, Department of Anesthesia, (Prof. Dr. D. R. Westenskow)

1985 Yale University, New Haven, Dept. of Anesthesia, Prof. Dr. L.M. Kitahata (1 week)

1984 Universität Groningen, Prof. Dr. S. Agoston, Research Group of Anaesthesia and

Clinical Pharmacology (2 weeks)

1983 USA, University of Los Angeles; Neuromuscular physiology lab (1 week)

1982 Paris, L´Hopital des Enfants malades (Prof. St.Maurice)

1981 II. Physiologisches Institut der Universität Heidelberg (3 months)

1979 Braun-Scholarship for the USA (1 month)

Scientific Activities

Editorial Board Biomedizinische Technik (since 2000)

Co-Editor Biomedizinische Technik (since 2005)

Reviewer for "Der Anaesthesist"

IOPJournal (Physiological Measurement)

IEEE Transactions on Biomedical Engineering

Occasional Reviewer for "Medizinische Physik"

for "Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie"

Convenor of the Working Group "Technology Assessment" within the Austrian Society of Biomedical Engineering (since 1997) Expert assessor for the Austrian Federal Ministry for Traffic, Innovation and Technology, for the Federal Ministry for Social Security and Generations as well as for foreign universities and for the Jubilee Fund of the Austrian National Bank. Lecturer at the University of Vienna in the special postgraduate education program in medical physics. Lecturer and Member of the Examination Commission for the "Special Training for the Education of Nurses at Intensive Care and Dialysis Wards for Children and Adults at the General Hospital of the City of Vienna” (Decision of March 26, 1987) Lecturer and Examinator for „Biomedical Engineering/Technology and Physics“ in context with the Curriculum of the University for Applied Sciences Fachhochschule Technikum-Wien

Scientific Publications (2000 - 2006) E. Knolle, H. Gilly: Absorption of Carbon Dioxide by Dry Soda Lime Decreases Carbon Monoxide Formation from Isoflurane Degradation. Anesth Analg 91:446-51 (2000)

16


A. Michalek-Sauberer, H. Gilly, K. Steinbereithner, E.S: Vizi: Effects of vecuronium and rocuronium in antagonistic laryngeal muscles in the cat. Acta Anaesth Scand 44, 503-510 (2000) E. Knolle, G. Heinze, H. Gilly: Carbon monoxide formation in dry soda lime is prolonged at low gas flow: Anesth. Analg.2001;93: 488-93 M. Weindlmayr-Goettel, H. Gilly, H.G. Kress: Does Ester Hydrolysis change the in-vitro degradation rate of cisatracurium and atracurium? Brit J Anaesth 88:552-62 (2002) E. Knolle, W. Linert, H. Gilly: Using Amsorb to detect loss of humidity in customary CO2 absorbents: Anesthesiology 97:454-9 (2002) E. Knolle, G. Heinze, H. Gilly: Small carbon monoxide formation in absorbents does not correlate with small carbon dioxide absorption: Anesth Analg 2002,95: 650-5 R. Fricker, T. Raffelsberger, S. Rauch-Shorny, J. Finsterer, C. Müller-Reible, H.Gilly, R. Bittner: Positive malignant hyperthermia susceptibility in vitro test in a patient with mitochondrial myopathy and myodenylate deaminase deficiency: Anesthesiology 2002;97(6):1635-1637 Robinson R, Hopkins P., Carsana A., Gilly H., Halsall J., Heytens L., Islander G., Jurkat-Rott K., Mueller C., Shaw M.: Several interacting genes influence the malignant hyperthermia phenotype: Human Genetics (2003) 112:217-218 Knolle E., Linert W., Gilly H: The color change in CO2 absorbents on drying: an in vitro study using moisture analysis: Anesth Analg 2003;97:151-5 Michalek-Sauberer A, Nicolakis EM, Vizi ES, Gilly H. Effects of SZ1677, a new non-depolarizing steroidal neuromuscular blocking drug, and rocuronium on two laryngeal muscles and the anterior tibial muscle in guinea pigs. Acta Anaesthesiol Scand. 2006 Apr;50(4):481-7.

Scientific Awards 1999 Höchst-Award 1998 of the University of Vienna for joint publication with M. Hiesmayr et al ("Performance of proportional and continuous nitric oxide delivery system during pressure- and volume-controlled ventilation") 1989 Central European Anaesthesia Award (2nd Prize: "Closed loop-controlled muscle relaxation - results in experimental investigations”) 1984 Award of the Austrian Society for Biomedical Technology ("Vascular reactions correlated with pain due to cold") 1979 Professor-Dr.-Alfred-Pischinger-Award ("Computer-aided data evaluation of experiments for the quantification of analgesia effects after model acupuncture ")

Membership in the Following Scientific Associations Austrian Physical Society

Austrian Society for Biomedical Engineering (Member of the executive board since 1988,

general secretary 1990-2000; President from 2000-2003)

Austrian Society for Medical Physics

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http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16548861&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum


German Society for Biomedical Engineering

International Anesthesia Research Society

Supervision of doctoral students (since 2000) Name Title of thesis Year Acad.Title Univ/Faculty R. Kramer

Wirkung von Opiaten am peripheren Nervensystem – Tonische und frequenzabhängige Effekte von Morphin und Naloxon auf C-Fasern des N.saphenus der Ratte und der Katze

1986 Dr.med. Univ Vienna, Medical Faculty

A. Sauberer

Entwicklung und Prüfung eines Modells zur simultanen Bewertung der Muskelrelaxation an drei intrinsischen Larynxmuskeln und dem M. tibialis anterior


E. Stanek Untersuchungen zur Pharmakodynamik eines neuen steroidalen Muskelrelaxans an intrinsischen Larynxmuskeln


M. Leschnik

Einfluss der Körperhaltung auf die motorische Antwort auf noxische Reize bei der Ratte

1998 Dr.med.vet. University of Veterinary Medicine Vienna

P. Thöne Pharmakokinetische Modellidentifikation und Parameterschätzung mittels Spektralanalyse

1999 Dr.techn TU Graz, Faculty of Science and Technology

S. Milovic

Electrochemical Sensors for nitric oxide, nitrogen dioxide and carbon monoxide trace gas monitoring in clinical use


Sources of funding (since 2000) Period Organization Short Title k€

2005 - 2008

FWF Projekt L288-N13

CPR-Filtering Algorithms for ECG-Analysis,

220 co-researcher

2005 - 2007

Fonds des Bürgermeisters der Bundeshauptstadt Wien Nr. 2273

Entwicklung eines Baby-Reanimationsmodells

20 co-researcher

Present Research Priorities Gas measurement technologies in anaesthesia (CO, NO etc.) Online signal recording and processing of electrically evoked potentials

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Experimental and clinical investigations in pharmacodynamics and pharmacokinetics of neuromuscular blockades, Experimental investigation of the effect of relaxants on intrinsic larynx muscles Cardiopulmonary resuscitation techniques Safety aspects of the anaesthesia and intensive care workplace Carbon monoxide and anesthetic agents Blood pressure simulation

Other

Coeditor of five volumes of the periodical "Beiträge zur Anästhesiologie, Intensiv- und Notfallmedizin", Verlag Maudrich Wien Co-author of the "Forschungs- und Technologiekonzepts 1992 - Biomedizinische Technik" (on behalf of the Austrian Federal Ministry of Science and Research) Co-author of the "Innovations- und Entwicklungspotential Biomedizinische Technik: BMT Austria 2000“ (on behalf of the Austrian Federal Ministry of Science and Research)

Teaching Activities (in addition to the regular lectures) Lecturer in the theoretical education program of the Department. Organization of Scientific Events Congress President and organization of the combined congress of the Austrian, the German and the Swiss Societies for Medical and Biomedical Engineering in Salzburg (2003) Involved in the organization of annual meetings of ÖGBMT in Wien 1998, 2001 in cooperation with other societies Involved in the organization of The F.F. Foldes Memorial Symposium, 1999 Involved in the organization of the Annual Meeting of the Austrian Society for Biomedical for Biomedical Engineering in Vienna, 1994, in Graz (1992, 1993, 1995) and Vienna (1997, 1998) Enquete "Strategien zum medizinischen Einsatz von NO“ in Vienna, 20.Juni 1995 International Symposium "Gefahren der Narkosegasbelastung am Arbeitsplatz" in Vienna, 1992 International Workshop "Experimentelles Arbeiten" in Vienna, 1989 International Symposium "Monitoring" in Linz, 1984 Cooperation in Public Institutions etc. Austrian Institute for Standards (ÖNORM) - Special Committee Medical Technology (FNA 179) Convenor of the Workgroup Respiratory Technology and Anaesthesia Equipment within ÖNORM Member of the Project Team “Medical Technology in Austria” of the Federal Ministry for Science and Research International Federation of Medical and Biological Engineering (Member of Transnational Working Groups: Clinical Engineering, Health Technology Assessment)

19


Project Description:

Restoring CPR corrupted ECG signals (Entfernung von CPR-bedingten Artefakten aus EKGs) Background In the case of cardiac arrest two competing aspects come into play. While it is important on the one hand to have a sufficiently long hands-off period (in order to do a careful electrocardiogram (ECG) analysis) it is on the other hand necessary to apply cardiopulmonary resuscitation (CPR) in order to maintain an adequate blood circulation. However, interruption of CPR leads to an impairment of the fibrillating heart and therefore worsens the chance for a successful defibrillation with stable return of spontaneous circulation. The present CPR guidelines specifically focus on the problem of reducing hands-off intervals. Interestingly “no-flow times” (NFT) comprise about 50% of time during resuscitation [J. Eilevstjonn, J. Kramer-Johansen, T. Eftestøl, M. Stavland, and H. Myklebust P. A. Steen. Reducing no flow times during automated external defibrillation. Resuscitation, 67(1):95–101, 2005]. These authors gave suggestions on how to reduce no flow times. On the other hand, analysis of the ECG signal necessarily requires interruption of CPR with the ECG analysis algorithms currently implemented in defibrillators. Therefore ECG analysis during ongoing chest compression can provide a considerable progress in comparison with standard analysis techniques working only during hands-off intervals. Those intervals have recently been found to be unexpectedly long and harmful. In addition to avoidance of hands-off times, new analysis techniques could become the pre-requisite for prediction of defibrillation success probability and would allow to avoid unpromising and therefore ultimately damaging defibrillator shocks. With respect to removal of CPR artifacts from the ECG two different approaches seem promising • a single-channel approach, where only the actual ECG in one lead is used: this is particularly adapted to automated external defibrillators (AEDs), where, so far, no such additional information is available, • a multi-channel approach, with additional information being obtained, for example, from compression force applied to the sternum of the patient, compression depth, thoracic impedance, (provided by a prototype for a new generation of defibrillators and/or arterial blood pressure. For measurement of the reference signal a self built device for continuous force measurement during cardiopulmonary resuscitation is available. Thesis Subject: Generation of artificial ECG signals in the pig model An animal model is to be established and has to be verified as as a proper “ECG generator” which allows us to record the electrical potential changes in the defibrillator pad electrodes as induced during the CPR manoeuvre. It has to be proven that the ECG recorded from the animal when inducing artificial signals into the thorax via needle electrodes with a blank tip is nearly identical with the pigs live ECG. By performing CPR at the same time true CPR artifacts are generated. Recording of the corrupted ECG signal as well as the corresponding reference signal (pressure or force or equivalent) has to be established as a basis for extensive testing (off line) of artifact removal algorithms (either available from literature or our own). The performance of the CPR artifact removal algorithms has to be tested e.g. by quantifying the number of correct rhythm identifications of the Heartstart MRx defibrillator (determination of sensitivity and specificity of the underlying algorithms)

20


Techniques and infrastructure: Animal experiments, measurement of physiological variables, modelling

21

Dr. Sci. Med. Biomedical Engineering CV Prof. H. Lanmüller

Hermann Lanmüller Curriculum Vitae Center of Biomedical Engineering and Physics, Medical University of Vienna, AKH Vienna

4L, Waehringer Guertel 18-20, A-1090 Vienna, Austria

Phone +43.1.40 400 - 3985

Fax +43.1.40 400 - 3988


Date of Birth: 1961

Place of Birth: Vienna, Austria


Education 1987 Diploma, “Electronics and Control Engineering” Vienna University of

Technology 1993 Ph.D. Thesis: “Development and examination of an implantable,

multifunctional, neuromuscular pulse generator for functional electrical stimulation. ”

2000 Habilitation at the Medical University of Vienna, Professional Career 1989 – 1991 University Assistant, Department of Surgery, Vienna University

1991 – 1997 University Assistant, Department of Biomedical Engineering and Physics,

Vienna University

1997 – present Head of the Research Group “FES Implants” at the Dept. of Biomedical

Engineering and Physics

2000 - present Associate Professor, Center of Biomedical Engineering and Physics, Vienna

University, Medical University of Vienna

Scientific Activities Reviewer: Artificial Organs, Biomed Tech (Berl), IEEE Trans Biomed Eng,

Austrian Society for Biomedical Engineering (ÖGBMT), head of the working group

Functional Electrical Stimulation,

Publications (2000 -present) Lanmüller H, Buchroithner J, Wernisch J, Alesch F.Sudden failure of implantable pulse generators: cause of failure and examination. Biomed Tech (Berl). 2007;52(5):356-9.

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Ashley Z, Salmons S, Boncompagni S, Protasi F, Russold M, Lanmüller H, Mayr W, Sutherland H, Jarvis JC.Effects of chronic electrical stimulation on long-term denervated muscles of the rabbit hind limb. J Muscle Res Cell Motil. 2007;28(4-5):203-17. Epub 2007 Sep 29. Ashley Z, Sutherland H, Lanmüller H, Russold MF, Unger E, Bijak M, Mayr W, Boncompagni S, Protasi F, Salmons S, Jarvis JC.Atrophy, but not necrosis, in rabbit skeletal muscle denervated for periods up to one year. Am J Physiol Cell Physiol. 2007 Jan;292(1):C440-51. Lanmüller H, Ashley Z, Unger E, Sutherland H, Reichel M, Russold M, Jarvis J, Mayr W, Salmons S.Implantable device for long-term electrical stimulation of denervated muscles in rabbits. Med Biol Eng Comput. 2005 Jul;43(4):535-40. Sauermann S, Standhardt H, Gerschlager W, Lanmüller H, Alesch F.Kinematic evaluation in Parkinson's disease using a hand-held position transducer and computerized signal analysis. Acta Neurochir (Wien). 2005 Sep;147(9):939-45; discussion 945. Epub 2005 Jul 7. Ashley Z, Sutherland H, Lanmüller H, Unger E, Li F, Mayr W, Kern H, Jarvis JC, Salmons S.Determination of the chronaxie and rheobase of denervated limb muscles in conscious rabbits. Artif Organs. 2005 Mar;29(3):212-5. Rafolt D, Gallasch E, Fend M, Bijak M, Lanmüller H, Mayr W.Functional electrical stimulation-induced surface muscle stiffness captured by computer-controlled tonometry. Artif Organs. 2002 Mar;26(3):244-7. Bijak M, Mayr W, Rakos M, Hofer C, Lanmüller H, Rafolt D, Reichel M, Sauermann S, Schmutterer C, Unger E, Russold M, Kern H.The Vienna functional electrical stimulation system for restoration of walking functions in spastic paraplegia. Artif Organs. 2002 Mar;26(3):224-7. Bijak M, Mayr W, Girsch W, Lanmüller H, Unger E, Stöhr H, Thoma H, Plenk H Jr.Functional and biological test of a 20 channel implantable stimulator in sheep in view of functional electrical stimulation walking for spinal cord injured persons. Artif Organs. 2001 Jun;25(6):467-74. Mayr W, Bijak M, Rafolt D, Sauermann S, Unger E, Lanmüller H.Basic design and construction of the Vienna FES implants: existing solutions and prospects for new generations of implants. Med Eng Phys. 2001 Jan;23(1):53-60. Bijak M, Girsch W, Rafolt D, Mayr W, Lanmüller H.EMG monitoring in functional electrostimulation] Biomed Tech (Berl). 2000 Apr;45(4):93-7. German. Lanmüller H, Girsch W, Rab M, Sauermann S, Kamolz L, Seitelberger R, Wolner E.

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Preparation of a skeletal muscle ventricle in sheep: severe damage to the Latissimus dorsi muscle due to mobilization before preconditioning. Eur Surg Res. 2000;32(2):129-34. Memberships: Austrian Society for Biomedical Engineering (ÖGBMT)

Foundation member of the International Functional Electrical Stimulation Society (IFESS),

Foundation member of the Cardiac Bioassist Association

Sources of funding 2003-2007 WWF, Telemetrische – Adaptive Elektrode, 120k€

24

Dr. Sci. Med. Biomedical Engineering CV Prof. W. Mayr

ao. Univ. Prof. Dipl. Ing. Dr. Winfried MAYR Curriculum vitae

Date of birth: 08.04.1955


Education and Training 1983 Diploma in “Electronics and Control Engineering”

1992 Ph.D. “Reactivation of Paralyzed Muscles by Electrical Stimulation via Implants

– Basics of Clinical Application”

Positions and Employment 1996-present Head of Research Group “Clinic-Cooperations” at the Center of Biomedical

Engineering and Physics, Vienna Medical University, Vienna, Austria

2001 Associate Professor, Department of Biomedical Engineering and Physics,

University of Vienna, Medical School, Vienna, Austria

1997 Assistant Professor, Department of Biomedical Engineering and Physics,

Vienna University, Medical School

1991-1997 University Assistant, Department of Biomedical Engineering and Physics,

University of Vienna, Medical School, Vienna, Austria

1983-1991 University Assistant, Department of Surgery, University of Vienna, Vienna,

Austria

List of publications:

1. Boncompagni S, Kern H, Rossini K, Hofer C, Mayr W, Carraro U, Protasi F. Structural differentiation of skeletal muscle fibers in the absence of innervation in humans. Proc Natl Acad Sci U S A. 2007 Nov 27; [Epub ahead of print]

2. Kern H, Hofer C, Mödlin M, Mayr W, Vindigni V, Zampieri S, Boncompagni S, Protasi F, Carraro U. Stable muscle atrophy in long-term paraplegics with complete upper motor neuron lesion from 3- to 20-year SCI. Spinal Cord. 2007 Oct 23; [Epub ahead of print]

3. Ashley Z, Sutherland H, Lanmüller H, Russold MF, Unger E, Bijak M, Mayr W, Boncompagni S, Protasi F, Salmons S, Jarvis JC. Atrophy, but not necrosis, in rabbit skeletal muscle denervated for periods up to one year. Am J Physiol Cell Physiol. 2007 Jan;292(1):C440-51.

4. Ashley Z, Salmons S, Boncompagni S, Protasi F, Russold M, Lanmüller H, Mayr W, Sutherland H, Jarvis JC. Effects of chronic electrical stimulation on long-term denervated muscles of the rabbit hind limb. J Muscle Res Cell Motil. 2007;28(4-5):203-17. Epub 2007 Sep 29.

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5. Lanmüller H, Ashley Z, Unger E, Sutherland H, Reichel M, Russold M, Jarvis J, Mayr W, Salmons S. Implantable device for long-term electrical stimulation of denervated muscles in rabbits. Med Biol Eng Comput. 2005 Jul;43(4):535-40.

6. Sauermann S, Rafolt D, Bijak M, Unger E, Lanmüller H, Weigel G, Girsch W, Mayr W. Objective assessment of the fusion frequency in functional electrical stimulationusing the fast Fourier transform. Biomed Tech (Berl). 2007;52(4):267-73

7. Hausmann JT, Mayr W, Unger E, Benesch T, Vecsei V, Gabler C. Interfragmentary compression forces of scaphoid screws in a sawbone cylinder model. Injury. 2007 Jul;38(7):763-8. Epub 2007 Jan 30

8. Martinek J, Reichel M, Rattay F, Mayr W. Analysis of calculated electrical activation of denervated muscle fibers in the human thigh. Artif Organs. 2005 Jun;29(6):444-7.

9. Hofer C, Forstner C, Modlin M, Jager H, Mayr W, Kern H. In vivo assessment of conduction velocity and refractory period of denervated muscle fibers. Artif Organs. 2005;29:436-439.

10. Kern H, Rossini K, Carraro U, Mayr W, Vogelauer M, Hoellwarth U, Hofer C. Muscle biopsies show that FES of denervated muscles reverses human muscle degeneration from permanent spinal motoneuron lesion. J Rehabil Res Dev. 2005 May-Jun;42(3 Suppl 1):43-53.

11. Bijak M, Rakos M, Hofer C, Mayr W, Strohhofer M, Raschka D, Kern H. Stimulation parameter optimization for FES supported standing up and walking in SCI patients. Artif Organs. 2005 Mar;29(3):220-3.

12. Modlin M, Forstner C, Hofer C, Mayr W, Richter W, Carraro U, Protasi F, Kern H. Electrical stimulation of denervated muscles: first results of a clinical study. Artif Organs. 2005 Mar;29(3):203-6.

13. Carraro U, Rossini K, Mayr W, Kern H. Muscle fiber regeneration in human permanent lower motoneuron denervation: relevance to safety and effectiveness of FES-training, which induces muscle recovery in SCI subjects. Artif Organs. 2005 Mar;29(3):187-91.

14. Ashley Z, Sutherland H, Lanmuller H, Unger E, Li F, Mayr W, Kern H, Jarvis JC, Salmons S. Determination of the chronaxie and rheobase of denervated limb muscles in conscious rabbits. Artif Organs. 2005;29:212-215.

15. Gallasch E, Rafolt D, Kinz G, Fend M, Kern H, Mayr W. Evaluation of FES-induced knee joint moments in paraplegics with denervated muscles. Artif Organs. 2005;29:207-211.

16. Kern H, Salmons S, Mayr W, Rossini K, Carraro U. Recovery of long-term denervated human muscles induced by electrical stimulation. Muscle Nerve. 2005;31:98-101.

17. Kern H, Boncompagni S, Rossini K, Mayr W, Fano G, Zanin ME, Podhorska-Okolow M, Protasi F, Carraro U. Long-term denervation in humans causes degeneration of both contractile and excitation-contraction coupling apparatus, which is reversible by functional electrical stimulation (FES): a role for myofiber regeneration? J Neuropathol Exp Neurol. 2004 Sep;63(9):919-31.

18. Schubert HM, Hohlrieder M, Jeske HC, Obrist P, Moser PL, Mayr W, Klima G, Kolbitsch C, Margreiter R. Bipolar anastomosis technique with removable instruments: an easy, fast, and reliable technique for vascular anastomosis. Plast Reconstr Surg. 2004 Mar;113(3):961-6.

19. Crevenna R, Wolzt M, Fialka-Moser V, Keilani M, Nuhr M, Paternostro-Sluga T, Pacher R, Mayr W, Quittan M. Long-term transcutaneous neuromuscular electrical stimulation in

26


patients with bipolar sensing implantable cardioverter defibrillators: a pilot safety study. Artif Organs. 2004 Jan;28(1):99-102.

20. Crevenna R, Mayr W, Keilani M, Pleiner J, Nuhr M, Quittan M, Pacher R, Fialka-Moser V, Wolzt M. Safety of a combined strength and endurance training using neuromuscular electrical stimulation of thigh muscles in patients with heart failure and bipolar sensing cardiac pacemakers. Wien Klin Wochenschr. 2003 Oct 31;115(19-20):710-4.

21. Huckabee ML, Deecke L, Cannito MP, Gould HJ, Mayr W. Cortical control mechanisms in volitional swallowing: the Bereitschaftspotential. Brain Topogr. 2003 Fall;16(1):3-17.

22. Freilinger G, Mayr W. Electrical stimulation as a countermeasure to muscle alteration in space. J Gravit Physiol. 2002 Jul;9(1):P319-22.

23. Mayr W, Hofer C, Bijak M, Rafolt D, Unger E, Sauermann S, Lanmüller H, Kern H. Functional Electrical Stimulation (FES) of denervated muscles: existing and prospective technological solutions Basic Appl Myology. 2002;12(6):287-290

24. Ploder O, Kanz F, Randl U, Mayr W, Voracek M, Plenk H Jr. Three-dimensional histomorphometric analysis of distraction osteogenesis using an implanted device for mandibular lengthening in sheep. Plast Reconstr Surg. 2002 Jul;110(1):130-7; discussion 138.

25. Hofer C, Mayr W, Stohr H, Unger E, Kern H. A stimulator for functional activation of denervated muscles. Artif Organs. 2002 Mar;26(3):276-9.

26. Reichel M, Breyer T, Mayr W, Rattay F. Simulation of the three-dimensional electrical field in the course of functional electrical stimulation. Artif Organs. 2002 Mar;26(3):252-5.

27. Rafolt D, Gallasch E, Fend M, Bijak M, Lanmuller H, Mayr W. Functional electrical stimulation-induced surface muscle stiffness captured by computer-controlled tonometry. Artif Organs. 2002 Mar;26(3):244-7.

28. Bijak M, Mayr W, Rakos M, Hofer C, Lanmuller H, Rafolt D, Reichel M, Sauermann S, Schmutterer C, Unger E, Russold M, Kern H. The Vienna functional electrical stimulation system for restoration of walking functions in spastic paraplegia. Artif Organs. 2002 Mar;26(3):224-7.

29. Kern H, Hofer C, Modlin M, Forstner C, Raschka-Hogler D, Mayr W, Stohr H. Denervated muscles in humans: limitations and problems of currently used functional electrical stimulation training protocols. Artif Organs. 2002 Mar;26(3):216-8.

30. Machold W, Kwasny O, Eisenhardt P, Kolonja A, Bauer E, Lehr S, Mayr W, Fuchs M. Reduction of severe wrist injuries in snowboarding by an optimized wrist protection device: a prospective randomized trial. J Trauma. 2002 Mar;52(3):517-20.

31. Mayr W, Bijak M, Rafolt D, Sauermann S, Unger E, Lanmuller H. Basic design and construction of the Vienna FES implants: existing solutions and prospects for new generations of implants. Med Eng Phys. 2001 Jan;23(1):53-60.

32. Bijak M, Mayr W, Girsch W, Lanmuller H, Unger E, Stohr H, Thoma H, Plenk H Jr. Functional and biological test of a 20 channel implantable stimulator in sheep in view of functional electrical stimulation walking for spinal cord injured persons. Artif Organs. 2001 Jun;25(6):467-74.

33. Gfohler M, Angeli T, Eberharter T, Lugner P, Mayr W, Hofer C. Test bed with force-measuring crank for static and dynamic investigations on cycling by means of functional electrical stimulation. IEEE Trans Neural Syst Rehabil Eng. 2001 Jun;9(2):169-80.

27


34. Bijak M, Mayr W, Rafolt D, Tanew A, Unger E. Pruritometer 2: portable recording system for the quantification of scratching as objective criterion for the pruritus. Biomed Tech (Berl). 2001 May;46(5):137-41.

35. Quittan M, Wiesinger GF, Sturm B, Puig S, Mayr W, Sochor A, Paternostro T, Resch KL, Pacher R, Fialka-Moser V. Improvement of thigh muscles by neuromuscular electrical stimulation in patients with refractory heart failure: a single-blind, randomized, controlled trial. Am J Phys Med Rehabil. 2001 Mar;80(3):206-14; quiz 215-6, 224.

36. Mayr W, Bijak M, Rafolt D, Sauermann S, Unger E, Lanmuller H. Basic design and construction of the Vienna FES implants: existing solutions and prospects for new generations of implants. Med Eng Phys. 2001 Jan;23(1):53-60.

37. Bijak M, Girsch W, Rafolt D, Mayr W, Lanmuller H. [EMG monitoring in functional electrostimulation] Biomed Tech (Berl). 2000 Apr;45(4):93-7. German.

38. Lanmuller H, Girsch W, Sauermann S, Schwendenwein I, Unger E, Bijak M, Rafolt D, Mayr W. Long-term electromyogram recording from the posterior cricoarytenoid muscle as a potential biological trigger for phrenic pacing: results of an animal study. Artif Organs. 1999 Sep;23(9):860-8.

39. Ploder O, Mayr W, Schnetz G, Unger E, Ewers R, Plenk H Jr. Mandibular lengthening with an implanted motor-driven device: preliminary study in sheep.Br J Oral Maxillofac Surg. 1999 Aug;37(4):273-6.

40. Ploder O, Mayr W, Schnetz G, Unger E, Plenk H Jr, Losert U, Ewers R. [Distraction osteogenesis with a fully implantable system. Experimental study] Mund Kiefer Gesichtschir. 1999 May;3 Suppl 1:S140-3. German.

41. Lanmuller H, Sauermann S, Unger E, Mayr W, Zrunek M. Battery-powered miniature implant for electrical nerve stimulation. Biomed Tech (Berl). 1999 May;44(5):114-9.

42. Rakos M, Freudenschuss B, Girsch W, Hofer C, Kaus J, Meiners T, Paternostro T, Mayr W. Electromyogram-controlled functional electrical stimulation for treatment of the paralyzed upper extremity.Artif Organs. 1999 May;23(5):466-9.

43. Reichel M, Mayr W, Rattay F. Computer simulation of field distribution and excitation of denervated muscle fibers caused by surface electrodes.Artif Organs. 1999 May;23(5):453-6.

44. Kern H, Hofer C, Strohhofer M, Mayr W, Richter W, Stohr H. Standing up with denervated muscles in humans using functional electrical stimulation. Artif Organs. 1999 May;23(5):447-52.

45. Rafolt D, Gallasch E, Mayr W, Lanmuller H. Dynamic force responses in electrically stimulated triceps surae muscles:effects of fatigue and temperature.Artif Organs. 1999 May;23(5):436-9.

46. Quittan M, Sochor A, Wiesinger GF, Kollmitzer J, Sturm B, Pacher R, Mayr W. Strength improvement of knee extensor muscles in patients with chronic heart failure by neuromuscular electrical stimulation. Artif Organs. 1999 May;23(5):432-5.

47. Mayr W, Bijak M, Girsch W, Hofer C, Lanmuller H, Rafolt D, Rakos M, Sauermann S, Schmutterer C, Schnetz G, Unger E, Freilinger G. MYOSTIM-FES to prevent muscle atrophy in microgravity and bed rest: preliminary report.Artif Organs. 1999 May;23(5):428-31.

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48. Bijak M, Hofer C, Lanmuller H, Mayr W, Sauermann S, Unger E, Kern H. Personal computer supported eight channel surface stimulator for paraplegic walking: first results.Artif Organs. 1999 May;23(5):424-7.

49. Lanmuller H, Sauermann S, Unger E, Schnetz G, Mayr W, Bijak M, Rafolt D, Girsch W. Battery-powered implantable nerve stimulator for chronic activation of two skeletal muscles using multichannel techniques. Artif Organs. 1999 May;23(5):399-402.

50. Lanmuller H, Sauermann S, Unger E, Schnetz G, Mayr W, Bijak M, Girsch W. Multifunctional implantable nerve stimulator for cardiac assistance by skeletal muscle.Artif Organs. 1999 Apr;23(4):352-9.

51. Sauermann S, Bijak M, Schmutterer C, Unger E, Lanmüller H, Mayr W, Thoma H. Computer aided adjustment of the phrenic pacemaker: automatic functions, documentation, and quality control. Artif Organs 1997; (21): 216-218.

52. Lanmüller H, Bijak M, Mayr W, Rafolt D, Sauermann S, Thoma H. Useful applications and limits of battery powered implants in functional electrical stimulations. Artif Organs 1997; (21): 210-212.

53. Helbich T H, Mayr W, Schick S, Youssefzadeh S, Rudas M, Taucher S, Wagner T, Kelkar P, Wolf G, Thurnher M, Mostbeck G H. Coaxial technique: approach to breast core biopsies. Radiology 1997; (203): 684-690.

54. Trautinger F, Knobler R M, Honigsmann H, Mayr W, Kindas-Mugge I. Increased expression of the 72-kDa heat shock protein and reduced sunburn cell formation in human skin after local hyperthermia. J Invest Dermatol 1996; (107): 442-443.

55. Stein H, Bijak M, Heerd E, Mayr W, Muller C, Rafolt D, Schnetz G, Unger E. [Pruritometer 1: Portable measuring system for quantifying scratching as an objective measure of cholestatic pruritus]. Biomed Tech (Berl) 1996; (41): 248-252.

56. Mayr W. Funktionelle Elektrostimulation. Austria Innovativ, Schwerpunkt: Biomedizinische Technik 1996;30-31.

57. Girsch W, Mayr W, Bijak M, Lanmüller H, Unger E, Thoma H, Holle J. "Vienna phrenic pacemaker"- experience with diaphragm pacing in infants and children. Eur J Pediatr Surg 1996;140-143.

58. Girsch W, Koller R, Holle J, Bijak M, Lanmüller H, Mayr W, Thoma H. Vienna phrenic pacemaker--experience with diaphragm pacing in children. Eur J Pediatr Surg 1996; (6): 140-143.

59. Girsch W, Bijak M, Heger G, Koller R, Lanmüller H, Mayr W, Thoma H, Losert U. Monitoring of FES-induced muscle activity by continuous EMG-recording. Int J Artif Organs 1995; (18): 340-344.

60. Lanmüller H, Mayr W, Sauermann S, Schnetz G, Thoma H, Unger E. A fully implantable ECG triggered multichannel nerve stimulator. Int Journal of Artificial Organs 1994; (6): 141-145.

61. Mayr W, Bijak M, Girsch W, Holle J, Lanmüller H, Thoma H, Zrunek M. Multichannel stimulation of phrenic nerves by epineural electrodes. Clinical experience and future developments. ASAIO J 1993; (39): M729-M735.

62. Koller R, Girsch W, Liegl C, Gruber H, Holle J, Losert U, Mayr W, Thoma H. Long-term results of nervous tissue alterations caused by epineurial electrode application: an experimental study in rat sciatic nerve. Pacing Clin Electrophysiol 1992; (15): 108-115.

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63. Zrunek M, Bigenzahn W, Mayr W, Unger E, Feldner-Busztin H. A laryngeal pacemaker for inspiration-controlled, direct electrical stimulation of the denervated posterior cricoarytenoid muscle in sheep. Eur Arch Otorhinolaryngol 1991; (248): 445-448.

64. Thoma H, Frey M, Girsch W, Gruber H, Happak W, Lanmüller H, Losert U, Mayr W. First experimental application of multichannel stimulation devices for cardiomyoplasty. J Card Surg 1991; (6): 252-258.

65. Girsch W, Koller R, Gruber H, Holle J, Liegl C, Losert U, Mayr W, Thoma H. Histological assessment of nerve lesions caused by epineurial electrode application in rat sciatic nerve. J Neurosurg 1991; (74): 636-642.

66. Thoma H, Holle J, Mayr W. Funktionelle Elektrostimulation, der "Beinschrittmacher" implantierbare Vielkanalstimulatoren (the leg-pacemaker). Medizinisch-Orthopädische Technik 1990; (110.Jahrgang): 68-74.

67. Mayr W, Girsch W, Holle J, Stöhr H, Thoma H. Developement and application of implantable multichannel stimulation devices in high tetraplegia (Diaphragm Pacemaker). Journal of Microcomputer Applications 1990;133-144.

68. Girsch W, Holle J, Mayr W. Der Wiener Atemschrittmacher- prinzipielles zur FES. Acta Chir Austriaca 1990; (22).

69. Dengg K, Bart G, Girsch W, Mayr W, Guggenbichler J P. [Respiratory aid using a diaphragmatic pacemaker in high paraplegia]. Padiatr Padol 1990; (25): 11-17.

70. Zrunek M, Mayr W, Streinzer W, Thoma H, Losert U, Schneider B, Unger E. Laryngeal pacemaker: activity of the posterior cricoarytenoid muscle (PCM) and the diaphragm during respiration in sheep. Acta Otolaryngol 1989; (108): 311-316.

71. Thoma H, Girsch W, Holle H, Mayr W. Technology and long term application of the epineural electrode. ASAI Transactions 1989; (35): 490-494.

72. Holle J, Thoma J, Frey M, Kern H, Mayr W, Schwanda G, Stöhr H. Locomation of paraplegic patients by functional Neuro-Stimulation. Automedica (Gordon and Breach Science Publishers Inc ,U K ) 1989; (11): 263-275.

73. Carraro U, Catani C, Saggin L, Zrunek M, Szabolcs M, Gruber H, Streinzer W, Mayr W, Thoma H. Isomyosin changes after functional electrostimulation of denervated sheep muscle. Muscle Nerve 1988; (11): 1016-1028.

74. Thoma H, Gerner H, Holle J, Kluger P, Mayr W, Meister B, Schwanda G, Stohr H. The phrenic pacemaker. Substitution of paralyzed functions in tetraplegia. ASAIO Trans 1987; (33): 472-479.

75. Thoma H, Gerner H, Holle J, Frey M, Kern H, Mayr W, Schwanda G, Stöhr H. Gehen mit Händen - Implantation einer Stimulationseinheit im Tierversuch. Zeitschrift der wissenschaftlichen Kinematographie 1987;36-37.

76. Thoma H, Frey M, Holle J, Kern H, Mayr W, Schwanda G, Stohr H. State of the art of implanted multichannel devices to mobilize paraplegics. Int J Rehabil Res 1987; (10): 86-90.

77. Thoma H, Holle J, Frey M, Kern H, Mayr W, Schwanda G, Stöhr H. Gehen mit Händen - Praktische Anwendung der Elektrostimulation am Beispiel einer Patientin. Zeitschrift der wissenschaftlichen Kinematographie 1987;36-37.

78. Rattay F, Mayr W. [Quantitative assessment of electrically activated fiber populations exemplified by rotating stimulation]. Biomed Tech (Berl) 1987; (32): 184-190.

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79. Zrunek M, Steinzer W, Mayr W, Scabolcs M. [Histochemical studies of the denervated posterior cricoarytenoid muscle following direct long-term stimulation in an animal experiment]. Laryngol Rhinol Otol (Stuttg) 1986; (65): 292-296.

80. Zrunek M, Carraro U, Catani C, Scabolcs M, Gruber H, Streinzer W, Mayr W, Thoma H. [Functional electrostimulation of the denervated posticus muscle in an animal experiment: histo- and biochemical results]. Laryngol Rhinol Otol (Stuttg) 1986; (65): 621-627.

81. Zrunek M, Carraro U, Streinzer W, Mayr W, Thoma H. Isomysosinveränderungen nach direkter elektrischer Stimulation des M. Cricoarytaenoideus posterior im Tierversuch. Arch Otorhinolaryngol 1986;160-161.

82. Streinzer W, Zrunek M, Mayr W, Huber L, Burian K, Thoma H, Kern H, Gruber H, Losert U. Elektrostimulation von Kehlkopfmuskeln bei Recurrensparalysen: eine tierexperimentelle Studie. Acta Chir Austriaca 1986; (Heft 3): 346-347.

83. Stöhr H, Holle J, Kern H, Mayr W, Schwanda G, Thoma H. Application of gate arrays in implants for nerve stimulation ( remobilization of paraplegic patients). IEEE Transactions on Industrial Electronics 1986; (IE-33): 361-365.

84. Kern H, Kainz A, Lechner J, Tausch F, Mayr W, Franke H, Schmutterer C, Schwanda H, Stöhr H, Kumpan W, Schurawitzky J, Mostbeck A, Gruber H. Auswirkungen elektrisch induzierter Bewegungstherapie. Z Phys Med Baln Med Klim , 1986;317-318.

85. Lechner J, Kainz A, Mayr W, Schwanda G, Kern H. Einfluss der Elektrodengröße auf die Kraftentwicklung des M. quadr. femoirs. Z Phys Med Baln Med Klim 1985

86. Kern H, Frey M, Holle J, Mayr W, Schwanda G, Stohr H, Thoma H. [Functional electrostimulation of paraplegic patients--1 year's practical application. Results in patients and experiences]. Z Orthop Ihre Grenzgeb 1985; (123): 1-12.

87. Kern H, Aslan A, Frey M, Holle J, Mayr W, Schwande G, Stöhr H, Stranzky G, Thoma H. Funktionelle Elektrostimulation querschnittgelähmter Menschen. Z Phys Med Baln Med Klim 1985.

Honors and Awards 1992 Alfred Kressner Award

1986 Höchst Award

1985 Eugen Grabscheid Award Fields of research Functional electrical stimulation (Mobilization of paraplegics, phrenic pacing, EMG-controlled stimulation, pelvic floor applications, denervated muscles, application of FES in microgravity and bed-rest) Implant technology (Microelectronical and electromechanical implants) Dr. Mayr is specialist in Functional Electrical Stimulation (FES), with focus on the engineering aspects of stimulation, both with implanted electrodes as well as with surface electrodes. He is active in this field of research since 1983. He is experienced in clinical cooperations and translations of FES-systems to applied research and clinical systems (e.g. Industrietransfer „FES-System zur Mobilisation paraplegischer Patienten“ Fa. Otto Bock, Förderung Impulsprogramm BMVIT). His recent main scientific actvity was the co-ordination of the European FP5 R&D-Project RISE

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“Use of electrical stimulation to restore standing in paraplegics with long-term denervated degenerated muscles” – 19 partners / 4 years, 7 months / 2 million € additional cost budget. Patents: WO2007131248 – Winfried Mayr: “Surface electrode” (avoiding skin burns in transcutaneous electrostimulation, electrotherapy or electrosurgery), published Nov. 22, 2007-12-07 Priority date Mai 16, 2006 R 49626 – Winfried Mayr “Implant for functional electrical stimulation of denervated muscles” Filed March 21, 2007, pending AT-504039 – Winfried Mayr, Gobert Skrbensky, Ewald Unger, Roland Huber “In vivo adjustable ligament fixation” Filed July 27, 2006, published Feb 15, 2008 WO 04/064694 – Winfried Mayr, Clemens Vass, Ewald Unger „Implant for draining chamber water from the front eye chamber into the episcleral veins“ Priority date Jan 23, 2003 WO 02/087479 – Clemens Vass, Winfried Mayr „Drainage implant for draining aqueous humor from the anterior aqueos chamber of the eye into the schlemm’s chanal“ Priority date April 26, 2001 Recent grants: QLG5-CT-2001-02191 Mayr (PI) July 23, 2003 – May 31, 2006 European Commission, 5th Framework Programme Use of electrical stimulation to restore standing in paraplegics with long-term denervated degenerated muscles (DDM) Acronym: RISE A novel clinical rehabilitation method for patients suffering from long-term flaccid paraplegia (denervated degenerated muscles - DDM) with no chance of recovery of the nervous system, will be developed. It will restore their muscle fibers (and mass), muscle function (tetanic contractions, weight bearing) and thus their ability to rise (’standing up’) and maintain a standing posture (’standing’). Based on the results of animal experiments on rabbit and pig and initial clinical trials the associated technology will be developed and an application for modification of EU-standards is planned. It will provide European industry with a novel product. The method addresses the needs of about 100 patients per million EU inhabitants. Role: Coordinator. Budget: 1.750.000,- GZ 8.130/6-VI/1/2003 Mayr (PI) Nov. 1, 2001 – December 31, 2006 Austrian Ministry for Education, Science and Arts Use of electrical stimulation to restore standing in paraplegics with long-term denervated degenerated muscles (DDM) Acronym: RISE Co-financing of the European project to extend the experimental work. Role: Coordinator. Budget: 400.000 €

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Z060412.....Mayr (PI) Sept. 1, 2007 – Aug. 1, 2008 uni:invent – Wettbewerb PRIZ zur Unterstützung bei der Entwicklung von Prototypen Telemetrisch justierbare Sehnen- und Bandfixation für Endoprothesen und Gelenksrekonstruktionen Role: Projektleiter Budget: 90.000,- Actual Dissertations: Biomedical instrumentation for assessment of atrophy and degeneration and FES induced

retraining of denervated human muscles

fMRI based analysis of muscle fiber recruitment of the electrically stimulated denervated

human thigh.

3D-modeling of the denervated human thigh under electrical stimulation

Electrochemical degradation of metallic implants

Design and biocompatibility studies for drainage implants for glaucoma therapy

Instrumentation and methodology for vigilance recording

Biomechanical changes after knee surgery and optimization of retraining

Activation and control of the LLPG after upper motor neuron lesion

Actual Diploma Works Nichtinvasive Diagnostik der Cystischen Fibrose

Sensortechnik und biomechanische Schlaganalyse im Kyokvshinkai-Karate

Meßsystem zur Untersuchung der Kontraktionsdynamik FES-aktivierter

Oberschenkelmuskulatur

Project Descriptions (Examples): Design and biocompatibility studies for drainage implants for glaucoma therapy

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Both drug and surgical treatment of chronically increased intraocular pressure (glaucoma) occur insufficient in the long-term application. The aim of the doctoral study is the development of substantially improved implants capable of draining aqueous humour from the anterior eye chamber in Schlemms Channel or directly into the Episcleral Veins. Aiming in stable long-term results basic design and material issues are addressed to achieve constant flow resistance for years and ovoid obstructive tissue reactions. The work is based on novel ex vivo and in vitro techniques for biocompatibility testing and assessment of interaction between cells and proteins with implant surfaces. The laboratory studies prepare a clinical study, an animal model is not available due to substantial anatomical differences (no Schlemms Channel in most species, not comparable episcleral veins). The work is based on to patents and a recent medical dissertation on viscosity of human aqueous humour. The underlying project is a cooperation between the Center of Biomedical Engineering and Physics, the Clinic of Ophthalmology and the Center of Biomedical Research, all at the Vienna Medical University. Mathematical aspects of locomotor lumbar pattern generator activity in human Delivery of sustained input through electrical stimulation of lumbar posterior roots in human can elicit a variety of complex motor outputs, e.g. bilateral extension of lower limbs, and rhythmical flexion and extension pattern movements.

Even though there is extensive knowledge of the properties of interneurons and their synaptic interaction in experimental animals, it is difficult to comprehend the complex and interactive processes within interneuron networks. Therefore, the use of mathematical modelling based on studies of motor outputs is a possibility to advance knowledge of human lumbar network processing mechanisms.

Realistic computer simulation of the human lumbar locomotor pattern generator will be developed on the basis of recorded outputs elicited by epidural spinal cord stimulation. The induced complex motor output results from a specific configuration of lumbar interneuron networks as well as conduction mechanisms. How these conducting and processing mechanisms are participating in the rhythmical and non-rhythmical motor outputs is not yet known.

Within the thesis we shall study the behaviour of different units of the interneuron population involved in configuration and generation of stimulation-induced motor outputs of the lumbar cord. We shall analyze the input-output relation of a sustained train of stimuli and compound motor unit potentials. Moreover, we shall explore the lumbar network output by selective central and peripheral sensory input.

The overall goal of the thesis will be to study features of the human lumbar locomotor pattern generator and to develop mathematical models describing the conduction and processing capabilities of this network.

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Dr. Sci. Med. Biomedical Engineering CV Prof. D. Rafolt

Dietmar RAFOLT Curriculum Vitae

Center for Biomedical Engineering and Physics, Medical University of Vienna,

Waehringer Guertel 18-20, A-1090 Vienna, Austria; Phone +43 1 40400 1991;

Email: [email protected]

Personal Data

Date of Birth: 1959

Place of Birth Lustenau, Austria

Nationality Austria

Education 2005 Associate Professor (a.o. Univ.-Prof.), Med. Univ. Vienna

2005 Habilitation (Univ. Doz.), Med. Univ. Vienna

1996 Ph.D. Thesis and Examination, TU Graz

1989 Master thesis and examination (Dipl. Ing.), Technical University

of Graz, (Communication engineering & Electronics)

1978 Secondary school qualification (Matura): Höhere Techn.

Bundeslehr- und Versuchsanstalt Bregenz, Field of study:

Electrical engineering

Career History 2005 – present Associate Professor (a. o. Univ.-Prof.), tenured position,

Center for Biomedical Engineering and Physics, Medical

University of Vienna

22. Dez. 2005 Venia Docendi (Habilitation) for the entire Field of Biomedical

Engineering

2003-2005 Assistant Professor, Center for Biomedical Engineering and

Physics, Medical University of Vienna (definitives

Dienstverhältnis)

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mailto:[email protected]


1997 Parental leave during the age of 2 of my son Lorenz

(Vaterkarenz).

1996 PhD Exam (with excellent result); Title of the PhD-Thesis:

”Multichannel Sensorsystem for the Measurement of

Cardiovascular and Neuromuscular Variables during

Experiments at the Space Station MIR“

1992-2003: Appointment as Univ. Assistant at the Department of

Biomedical Engineering and Physics, General Hospital,

University of Vienna,

Responsible for Sensors and Microelectronics

1991 – 1992: Assistant at the Physiological Institute, University of Graz,

appointment as ½ VA

1991 – 1992: Teaching as an Assistant at the Institute of Electrical

Measurement, TU Graz appointment as ½ VA),

1990 - 1992: Work for the Space Project AUSTROMIR/ Experiment

MIKROVIB and PULSTRANS, Physiological Institute of the

University of Graz; Head: Prof. T. Kenner. Development of

space qualified pulse measurement systems.

1984-1989 R&D-work at WILD/ LEITZ-AG, Inc. Heerbrugg/Swizzerland,

Division of Geodesy (Laser Eng..), and Photogrammetry (Proj.

Aircraft Camera)

1988 Work at Stylux Inc. Graz, Austria, submitted for a diploma.

Title „Switching converter with variable output voltage and

sinusoidal input current for an active harmonic filter”

Career-related Activities

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Patents AT404797B/ AT206496 Vorrichtung zur Anwendung und Aufbewahrung von Hautelektroden bei Elektrostimulation und Messung bioelektrischer Signale am menschlichen Körper. Device for use and storage of skin electrodes in electrostimulation and measurement of bioelectrical signals on the human body. erteilt am 25.Feb. 1999

AT407951 / AT56699 Messbecher zur Registrierung von Kraft- und Bewegungsmustern zur Quantifizierung von neurologischen Veränderungen. Measurement beaker for recording strength and movement patterns in order to quantify neurological changes.

AT413326B Hybridelektroden zur Kompensation von Bewegungsartefakten bei der Messung von Biopotentialen

AT413327B Hybridsensoren zur Unterdrückung von Bewegungsartefakten bei der Messung von biomedizinischen Signalen

EU 0701309.3 Europäische Patentanmeldung, D.Rafolt/MUW, E.Gallasch/MUG, 2007 Device for and method of analyzing a muscle activity of a physiological object Reviewer: Artificial Intelligence in Medicine (AIM) Medical Biological Engineering and Computing Artif. Org. Memberships: Secretary: 2001– present: International Society on Biotelemetry ISOB Founding Member: International Functional Electrostimulation Society IFESS, International Neuromodulation Society INS

Member: Austrian Society for Biomedical Engineering (OEGMBT) German Society of Telemetry (ETM) Austrian Society for Space Medicine (ASM) Cooperation at International Projects

Space-Experiments on spacestation MIR:

-Project AUSTROMIR (Basic investigations of cardiovascular and neuromuscular

functions in zero gravity)

-Project RLF (Russion Long Term Flight)

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-Project MYOSTIM (Electrical Stimulation for Training of Cosmonauts)

EU-Project RISE (Mobilisation of patients with denervated musculature, 5th FP)

Supervision of student theses: Ph.D. theses (ongoing)

2007- Jörg Holzapfel, MD: Beeinflussende Faktoren auf das Ergebnis der Oszillations-Tonometriemessung am Kniegelenk

2008 - Matthias Krenn, DI, Stiffness of muscles in transversal direction Master theses 2007 Matthias Krenn: FES-Wave: Messsystem zur Untersuchung der

Kontraktionseigendynamik FES-aktivierter Oberschenkelmuskulatur bei höheren Stimulationsfrequenzen, TU Wien

2007 C. Scheibböck: Telemedizin mittels Mobiltelephonie in der Dermatologie Bachelor works: 2005 H.Reiter: Auswertung von biomechanischen Muskelparametern mit MATLAB

2006 S. Waid: Adaptive Filters I 2006 W. Buchegger: Adaptive Filters II 2006 C. Scheibböck: VB-Tools for Excel 2006 H. Bointner : Analysistools in Matlab 2007 A.Withurm: USB Interface in C# 2007 M. Dorn: Audiotest Manager in C# 2007 H. Bointner : Analysis tools II in Matlab Teaching:

LV-Nr. 738.009 / 738.063 (parallel) Elektr. Messtechnik 1; Institute of Electrical Measurement, TU Graz LV-Nr. 438.012 / 438.073 (parallel) Elektr. Messtechnik 2 Institute of Electrical Measurement, TU Graz LV-Nr. 543.007 SE, VO Aktuelle Themen aus Biomedizinischer Technik und Klinischer Physik LV-Nr. 560.029 Wissenschaft und Medizin (SSM1) Medizinische Informationssuche LV-Nr. 406.001 medizinische Physiologie II, Gastvorlesung, Physiologie Hauptvorlesung, MedUniv. Graz (SS2002) Thema „Grundlagen und Anwendung der funkt. Elektrostimulation“ LV-Nr.561276 WS Funktionelle Elektrostimulation in Theorie und Praxis I LV-Nr.561276 sS Funktionelle Elektrostimulation in Theorie und Praxis II LV-Nr :562201 Grundlagen bioelektrischer Systeme LV-Nr:562204 Physikalisches Praktikum "Biomedizin. Meßtechnik LV-Nr: 561662 BL 11 - Herz und Kreislauf, Blut und Gefäße, Physik Praktikum

LV-Nr: 560027 BL 6 Der Mensch in Umwelt Familie und Gesellschaft, Praktika Ionisierende Strahlung. Original Papers (since 2000) EMG monitoring during Functional Electrical Stimulation

M. Bijak, W. Girsch, D. Rafolt, W. Mayr, H. Lanmüller

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Biomed Tech (Berl). 45(4): 93-7, Apr. 2000

Polygraphic Belt with Force-Sensing Expander for Physiological Tests on Cosmonauts. Rafolt D, Gallasch E. Biomedizische Technik 46: 230- 235, Sept. 2001

Basic design and construction of the Vienna FES implants: Existing solutions and prospects for new generations of implants W. Mayr, M. Bijak, D. Rafolt, S. Sauermann, E. Unger, H. Lanmüller Medical Engineering and Physics 23 p. 53-60, Jan. 2001

Pruritometer 2: Portable Recording System for the Quantification of Scratching as Objective Criterion for the Pruritus. Bijak, M., Mayr, W., Rafolt, D., Tanew A., Unger E.: Biomedizische Technik (Berl) 46(5), 137-141, May 2001

Functional Electrical Stimulation - Induced Surface Muscle Stiffness Captured by Computer Controlled Tonometry D Rafolt, E Gallasch, M Fend, M Bijak, H Lanmüller, W Mayr Artificial Organs 26(3): 244-247, 2002

The Vienna Functional Electrical Stimulation System for Restoration of Walking Functions in Spastic Paraplegia Bijak M., Mayr W. Rakos M. Hofer Ch., Lanmüller H., Rafolt D., Reichel M., Sauermann St., Schmutterer Ch., Unger W. Russold M., Kern H. Artificial Organs 26(3): 224-227, May 2002

Surface myomechanical responses recorded on a scanner galvanometer.

Rafolt D, Gallasch E.

Medical & Biological Engineering & Computing Vol 40: 594-599, Okt. 2002

Functional electrical stimulation (FES) of denervated muscles: existing and prospective

technological solution.

Mayr W., Hofer Ch., Bijak M., Rafolt D., Unger E., Sauermann St., Lanmüller H., Kern

H. BAM 12[6], 287-290, 2002

Influence of contact forces on wrist photoplethysmography--prestudy for a wearable

patient monitor.

Rafolt D, Gallasch E.

Biomed Tech (Berl). 2004 Jan-Feb;49(1-2):22-6.

Evaluation of FES-induced knee joint moments in paraplegics with denervated muscles.

Gallasch E, Rafolt D, Kinz G, Fend M, Kern H, Mayr W.

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Artif Organs. 2005 Mar;29(3):207-11.

Objective assessment of the fusion frequency in functional electrical stimulation using the

fast Fourier transform / Objektive Bestimmung der Fusionsfrequenz in der funktionellen

Elektrostimulation mittels Fast Fourier Transformation

Sauermann S, Rafolt D, Bijak M, Unger E, Lanmueller H, Weigel G, Girsch W, Mayr W.

Biomed Tech (Berl). 2007;52(4):267-73.

Project Description: Haptic devices In the field of (neuro)muscular research /rehabilitation biomechanical sensor-actuator-systems provide tools for special experimental /training tasks as well as objective measurement methods to evaluate (neuro)muscular performance. So called “haptic devices” found the way into the field of biomedical engineering introducing virtual force reality in a man-machine interface. In the recent years various kinesthetic devices had been probed in medicine, most of them in man-machine applications, for example to provide some force feedback in computer assisted minimal invasive surgery. Another application is a man to man interface system, specially developed for remote sensing of limb muscle tone and for tests on bi-directional haptic transmission. Designing such an interface one challenge is, to provide it with a small enough internal compliance. For example if a subject moves the interface lever at one end, he should ‘feel’ the produced limb resistance of the subject at the other end without losses from the interface compliance. Further the sensed limb resistance is an input function of both lever deflections. Such a shared control scheme is sensitive to the delays produced in the control loops and by the data transmission lines. Special attention has to be taken to study the effects of these delays during remote sensing and haptic transmission tasks. Thesis Subjects To use haptic devices in a remote operation, fast bi-directional data-link will be needed. An optimized shared PID controller design should be developed in order to achieve or to turn out a maximal tolerable transmission delay. Longer delays will cause oscillations. In that case in a superior software level a safety algorithm will adjust control parameters in order to avoid or to damp respectively high amplitude oscillations. To study the bi-directional interface performance a remote palpation should be performed on different hard- and soft-elastic specimens. Torque-angle curves in the local and remote sensor-actuator should be compared. In former test it was found that standard data lines based on ISDN and INTERNET protocols, are applicable for a haptic transmission. Tests with simulated bandwidth, time delays and delay jitter should turn out the advantage and disadvantages of both protocols. Techniques and infrastructure This subject area requires knowledge and infrastructure in the entire field of hardware engineering (mechanics, actuators, power amplifiers, sensor and analog technique) as well as

40


software engineering especially related to communication engineering and control systems. In our center we are able the give support in all of this subjects. The thesis will be performed in a co-operation between the Center for Biomedical Engineering and Physics, Medical University Vienna and the Dep. of Physiology, Medical University Graz.

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Dr. Sci. Med. Biomedical Engineering CV Prof. H. Schima

a.o. Univ. Prof. DI Dr. Heinrich Schima Curriculum vitae Position Associate Professor of Biomedical Engineering, Med. Univ. of Vienna

Head of the Working Group on Cardiovasc Hemodynamics and the

Coordinator of the Plastics Laboratory of the Center of Biomed Engineering and

Physics (jointly used by the Ludwig Boltzmann Cluster for Cardiovascular

Research)

Address Center for Biomedical Engineering and Physics, Medical University Vienna;

AKH 4L Waehringer Guertel 18, A-1090 Vienna, Austria

Tel:

e-mail: [email protected]

Homepage: http://www.meduniwien.ac.at/cvd

Telephone +43 1 40400 5620

Telefax 01-40400-3988


Home-Page www.meduniwien.ac.at/cvd

born 1957 in Vienna, Austria

Family Status Married to Silvia Schima, four children School 1963 - 1967 Volksschule Czerninplatz, Vienna 1967 - 1975 Humanistisches Gymnasium BGII, Zirkusgasse, Vienna University

1975 - 1981: Study on electronics and control engineering at the Tech.Univ. Vienna, Master Thesis on "letter recognition for blind people with a microcontroller"

1979 - 1981: Partial Studies of Medicine at the Univ. of Vienna

1981 - 1985 Thesis Study at the Tech.Univ. of Vienna and the Boltzmann-Institute of Traumatology, topic: Functional investigations on an in-vitro-isolated heart setup. Ph.D Graduation with distinction.

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2004 Postgraduate Course for Medical Mangement, Med. Univ. Vienna, Austria Professional Career

1985 - 1993 : University assistant at the 2nd Department of Surgery

1993: Habilitation (i.e. Tenure) for Biomedical Engineering at the University of Vienna, Topic of Habilitation "Monitoring and Control of Blood Pumps"; Head of a Working Group on Cardiovascular Dynamics with up to 6 engaged and 4 free coworkers

1997 - : Assoc. Professor at the Inst. of Biomed Engineering and Physics, Univ. of Vienna

2001 - : Head of the plastics lab at the Institute of Biomed Engineering and Physics, Univ. Vienna

2004: Call for Full Professorship (C4) to the Univ. of Lübeck, Germany, declined.

Scientific Activities:

Mechanical Cardiac Assist: Development of driving and monitoring systems for pneumatic blood pumps, research on automatic control, including development of microcontroller based apparatus. Development of centrifugal blood pumps, focussing first on fluid dynamics and hemocompatibility, including development of in-vitro circuits, indices and protocols for studies to minimize blood traumatization and simulate accelerated thrombus growth (awarded with a government award and international awards in the early 1990ies) Development of pumps with mixed mechanical-magnetical and with touch-free magnetical-hydrodynamical bearings. Simulation of control of cardiac assist systems and perfusion equipment in computerized models, including comparative studies in-vivo, with development of fuzzy logic algorithms and neuronal networks in the 90ies, leading to a joint research project with a company on development of a expert-based control system with clinical evaluation started 2002. Development of driving units for centrifugal blood pumps in a joint project with the Japanese MITI/NEDO and the Baylor College of Medicine, Houston, TX, with the world-record for rotary-pump survival in animals 1997. Accompanying research at the introduction of cardiac support systems into clinical use, beginning in 1986 with the pneumatic total artificial heart, with the Novacor outdoor system 1993, and the Micromed axial pump system 1998, with special focus on physiological hemodynamical adaptation, patient monitoring and surveilance.

Measurement and Simulation of biomechanics and flow in cardiovascular prostheses, bioreactors and diagnostic systems: Hydraulic circuits of flow simulation within for bioreactors with cell cultures; Simulation of flow relationships in biological and artificial valves and vascular stenoses for investigation of ultrasound diagnostic systems and vascular stents. Investigation on the local flow interaction between biological system and diagnostic invasive devices, joint projects with external partners on comparison with numerical studies;

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Quantification of ultrasound image evaluation for indirect stenosis detection, including modelling and index development.

System and program development for hemodynamic monitoring and modular data analysis packages;

Dialysis and blood purification system development: Development of mechanical and electronic components for a blood purification system based on microspere adsorbers, contribution to a EU-project, based on an international patent. Development of an approved system for clinical studies, modelling of filter exchange and failure indicators.

Development of a clinical system for electrical impedance diagnostics for diagnosis of transplant rejection

Analysis of body structure borne sound for diagnosis objectivation purposes

Assistance within projects to bone mechanics, EEG-analysis at anaesthesia, muscle stimulation and pattern recognition.

International Activities within several cooperations with institutions and companies in USA, Japan, Germany, Greece, Italy, Czechia, Serbia, Israel and UdSSR. Participation in two EU-projects with multiple international participants.

Clinical Activities:

Technical coordination and supervision at the introduction of the pneumatically driven total artificial heart 1986-1992, - Clinical studies on outdoor patients with Novacor 1993-95 and following routine, - Clinical trials on completely implantable rotary blood pumps since 1998, with the first worldwide patient discharge 1999. - First worldwide clinical trial on automatic control of rotary blood pumps 2002-05

490 Scientific Publications out of these 119 original papers in peer reviewed journals approx. 320 Abstracts 12 patents (of which 2 international families, 4 int. applied) Important Publications 2001 - :

1. Nonaka K, Linneweber J, Ichikawa S, Yoshikawa M, Kawahito S, Mikami M, Motomura T,

Ishitoya H, Nishimura I, Oestmann D, Glueck J, Schima H, Wolner E, Shinohara T and Nose Y. Development of the Baylor Gyro Permanently Implantable Centrifugal Blood Pump as a Biventricular Assist Device. Artif Organs 25: 675-682, 2001.

2. Plöchl W, Krenn CG, Cook DJ, Gollob E, Pezawas T, Schima H, Ipsiroglu O, Wollenek G and Grubhofer G. Can Hypocapnia reduce cerebral Embolization during Cardiopulmonary Bypass? Ann Thorac Surg 72: 845-849, 2001.

3. Wieselthaler GM, Schima H, Dworschak M, Quittan M, Nuhr M, Czerny M, Seebacher G, Huber L, Grimm M and Wolner E. First Experiences with Outpatient Care of Patients with implanted Axial Flow Pumps. Artif Organs 25: 331-335, 2001.

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4. Wieselthaler GM, Schima H, Lassnigg AM, Dworschak M, Pacher R, Grimm M and Wolner W. Lessons learned from the first clinical Implants of the DeBakey Ventricular Assist Device Axial Pump: A Single Center Report. Ann Thorac Surg 71: S139-S143, 2001.

5. Leuprecht A, Perktold K, Prosi M, Berk T, Trubel W and Schima H. Numerical study of hemodynamics and wall mechanics in distal end-to-side anastomoses of bymass grafts. Journal of Biomechanics 35: 225-236, 2002.

6. Perktold K, Leuprecht A, Prosi M, Berk T, Czerny M, Trubel W and Schima H. Fluid Dynamics, Wall Mechanics and Oxygen Transfer in Peripheral Bypass Anastomoses. Annals of Biomedical Engineering 30: 1-14, 2002.

7. Simon-Kupilik N, Schima H, Huber L, Moidl R, Wipplinger G, Losert U, Wolner E and Simon P. Prosthetic Replacement of the Aorta is a Risk Factor for Aortic Root Aneurysm Development. Ann Thorac Surg 73: 455-459, 2002.

8. Vollkron M, Schima H, Huber L and Wieselthaler G. Interaction of the cardiovascular system with an implanted rotary assist device: simulation study with a refined computer model. Artif Organs 26: 349-359, 2002.

9. Wieselthaler G, Schima H, Röthy W, Grimm M and Wolner E. Alternativtherapie bei terminalem Linksherzversagen. Jatros 5: 32-33, 2002.

10. Groensfelder T, Schima H, Reindl C and Nordmann R. Building a Computer Model of the Hemobear Blood Pump. Artif Organs 27/10: 931-934, 2003.

11. Schima H, Lackner B, Prosi M and Perktold K. Numerical simulation of cartoid hemodynamics in patients with rotary blood pump cardiac assist. Int J Artif Org 26: 152-160, 2003.

12. Wieselthaler G, Schima H and Wolner E. Specific Considerations on the Implantation Technique for the MicroMed-DeBakey Ventricular Assist Device Axial Pump. Ann Thorac Surg 76: 2109-2111, 2003.

13. Bonaros N, Mueller MR, Salat A, Schima H, Roethy W, Rocher A, Wolner E and Wieselthaler G. Extensive Coagulation Monitoring in Patients After Implantation of the MicroMed DeBakey Continous Flow Axial Pump. ASAIO Journal 50/5: 424-431, 2004.

14. Mascherbauer J, Schima H, Maurer G and Baumgartner H. Doppler assessment of mechanical aortic valve prostheses: effect of valve design and size of the aorta. J Heart Valve Dis 13/5: 823-830, 2004.

15. Mascherbauer J, Schima H, Rosenhek R, Czerny M, Maurer G and Baumgartner H. Value and limitations of aortic valve resistance with particular consideration of low flow - low gradient aortic stenosis: an in-vitro study. EurHeartJ 25/9: 787-793, 2004.

16. Schima H, Vollkron M, Boehm H, Roethy W, Haisjackl M, Wieselthaler G and Wolner E. Weaning of Rotary Blood Pump Recipients after Myocardial Recovery. Journal of Thoracic and Cardiovascular Surgery 127/6: 1743-1750, 2004.

17. Schima H, Boehm H, Huber L, Schmallegger H, Vollkron M, Hiesmayr M, Noisser R and Wieselthaler G. Automatic system for non-invasive blood pressure determination in rotary pump recipients. Artif Organs 28/5: 451-457, 2004.

18. Schima H, Reindl C, Stoiber M, Roethy W and Wieselthaler G. Emergency Reinforcement of Cracked Paracoporeal Blood Pumps. ASAIO Journal 50/6: 621-623, 2004.

19. Trubel W, Schima H, Czerny M, Perktold K, Schimek MG and Polterauer P. Experimental comparison of four methods of end-to-side anastomosis with expanded polytetrafluoroethylene. British Journal of Surgery 91/2: 159-167, 2004.

20. Vollkron M, Schima H, Huber L, Benkowski B, Morello G and Wieselthaler G. Development of a suction detection system for axial blood pumps. Artif Organs 28/8: 709-716, 2004.

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21. Wieselthaler, G., Riedl, M, Schima, H., Wagner, O, Waldhäusl, W., Wolner, E., Luger, A, and Clodi, M. Endocrine function is not impaired in patients with a continous MicroMed-DeBakey axial flow pump. Journal of Thoracic and Cardiovascular Surgery . 2004. Ref Type: In Press

22. Holzer M., Behringer W., Janata A., Bayegan K., Schima H, Deckert Z, Losert U, Laggner AN. and Sterz F. Extracorporeal venovenous cooling for induction of mild hypothermia in human-sized swine. Crit Care Med 33: 1346-1350, 2005.

23. Kolodjaschna J, Berisha F., Lung S., Schima H, Polska E and Schmetterer L. Comparison of the autoregulatory mechanisms between middle cerebral artery and ophthalmic artery after thigh cuff deflation in healthy subjects. Invest Ophth Vis Sci 46: 636-640, 2005.

24. Mascherbauer J, Rosenhek R, Bittner B., Binder J., Simon P, Maurer G, Schima H and Baumgartner H. Doppler echocardiographic assessment of valvular regurgitation severity by measurement of the vena contracta: an in vitro validation study. J Am Soc Echocardiog 18: 999-1006, 2005.

25. Meinhart JG., Schense JC., Schima H, Gorlitzer M., Hubbell JA., Deutsch M. and Zilla P. Enhanced endothelial cell retentionon shear-stressed synthetic vascular grafts precoated with RGD-cross-linked fibrin. Tissue Eng 11: 887-895, 2005.

26. Thalmann M., Schima H, Wieselthaler G and Wolner E. Physiology of continous blood flow in recipients of rotary cardiac assist devices. J Heart Lung Transpl 24: 237-245, 2005.

27. Vollkron M, Schima H, Huber L, Benkowski R, Morello G and Wieselthaler G. Development of a reliable automatic speed control system for rotary blood pumps. J Heart Lung Transpl 24: 1878-1885, 2005.

28. Nishinaka T, Schima H, Roethy W, Rajek A, Nojiri C, Wolner E and Wieselthaler G. The Duraheart VAD, a magnetically levitated centrifugal pump: the University of Vienna bridge-to-transplant experience. Circ 70: 1421-1425, 2006.

29. Prosi M, Perktold K and Schima H. Effect of continous arterial blood flow in patients with rotary cardiac assist device on the washout of a stenosis wake in the carotid bifurcation: A computer simulation study. Journal of Biomechanics 2007;40(10):2236-43, 2006 epubl.

30. Schima H, Vollkron M, Jantsch U, Crevenna R, Roethy W, Benkowski R, Morello G, Quittan M, Hiesmayer M and Wieselthaler G. First clinical experience with an automatic control system for rotary blood pumps during ergometry and right-heart catheterization. Journal of Heart Lung Transplant 25: 167-173, 2006.

31. Vollkron M, Schima H, Huber L, Benkowski R, Morello G and Wieselthaler G. Advanced suction detection for an axial flow pump. Artif Organs 30: 665-670, 2006.

32. Zimpfer D, Wieselthaler G, Czerny M, Fakin R, Haider D, Zrunek P, Roethy W, Schima H, Wolner E and Grimm M. Neurocognitive function in patients with ventricular assist devices: a comparison of pulsatile and continous flow blood devices. ASAIO J 52: 24-27, 2006.

33. Vollkron M, Voitl P, Ta J, Wieselthaler G, Schima H. Suction events during left ventricular support and ventricular arrhythmias.J Heart Lung Transplant. 2007 Aug;26(8):819-25.

34. Polska E, Schima H, Wieselthaler G, Schmetterer L. Choroidal microcirculation in patients with rotary cardiac assist device. J Heart Lung Transplant. 2007 Jun;26(6):572-8. Epub 2007 May 2.

35. Stoiber M, Grasl C, Pirker S, Huber L, Gittler P, Schima H. Experimental validation of numerical simulations: a comparison of computational fluid dynamics and the oil film method.Int J Artif Organs. 2007 Apr;30(4):363-8.

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36. Moscato F, Vollkron M, Bergmeister H, Wieselthaler G, Leonard E, Schima H. Left ventricular pressure-volume loop analysis during continuous cardiac assist in acute animal trials.Artif Organs. 2007 May;31(5):369-76.

37. Zimpfer D, Zrunek P, Roethy W, Czerny M, Schima H, Huber L, Grimm M, Rajek A, Wolner E, Wieselthaler G. Left ventricular assist devices decrease fixed pulmonary hypertension in cardiac transplant candidates. J Thorac Cardiovasc Surg. 2007 Mar;133(3):689-95.

38. Zimpfer D, Zrunek P, Sandner S, Schima H, Grimm M, Zuckermann A, Wolner E, Wieselthaler G. Post-transplant survival after lowering fixed pulmonary hypertension using left ventricular assist devices. Eur J Cardiothorac Surg. 2007 Apr;31(4):698-702. Epub 2007 Feb 7.

39. Wieselthaler GM, Riedl M, Schima H, Wagner O, Waldhausl W, Wolner E, Luger A, Clodi M. Endocrine function is not impaired in patients with a continuous MicroMed-DeBakey axial flow pump. J Thorac Cardiovasc Surg. 2007 Jan;133(1):2-6.

40. Vollkron M, Voitl P, Ta J, Wieselthaler G, Schima H. Suction events during left ventricular support and ventricular arrhythmias. J Heart Lung Transplant. 2007 Aug;26(8):819-25.

41. Polska E, Schima H, Wieselthaler G, Schmetterer L. Choroidal microcirculation in patients with rotary cardiac assist device. J Heart Lung Transplant. 2007 Jun;26(6):572-8. Epub 2007 May 2.

42. Zimpfer D, Schima H, Czerny M, Kasimir MT, Sandner S, Seebacher G, Losert U, Simon P, Grimm M, Wolner E, Ehrlich M. Experimental stent-graft treatment of ascending aortic dissection. Ann Thorac Surg. 2008 Feb;85(2):470-3.

43. Seebacher G, Grasl C, Stoiber M, Rieder E, Kasimir MT, Dunkler D, Simon P, Weigel G, Schima H. Biomechanical properties of decellularized porcine pulmonary valve conduits. Artif Organs. 2008 Jan;32(1):28-35.

Major Invited Lectures: Dreiländertagung der Biomedizinischen Gesellschaften von Deutschland, Österreich und der Schweiz,

Lübeck 2000: „Mechanische Herzunterstützung: An der Schnittstelle zwischen Entwicklung und Anwendung“

Japanese Congress of Artificial Organs (JSAO), Sendai 2003: “Clinical Application and Control of a Fully Implantable Rotary Blood Pump”

Fall Meeting of the International Society for Heart and Lung Transplantation (ISHLT), Dallas 2005: “Physiology of Continuous Blood Flow”

Congress of the American Society for Artif. Int Organs (ASAIO) 2006: “The physiologic effects of continuous versus pulsatile blood flow”

Meeting on Cardiovascular Support Bad Oynhausen 2006: “Technical Reliabilities of External Blood Pump Components”

Annual Meeting of the International Society for Rotary Blood Pumps, Sydney 2007: “Monitoring and Control of Rotary Blood Pumps: Possibilities, Necessities and Limitations”

Scientific Awards:

First Author:

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Austrian state award on reduction of animal-experiments 1992;

Annual Award (Stefan-Schuy-Award) of the Austrian Society for Biomedical Engineering OEGBMT 1992;

Koyanagi Young Investigator Travel Award of the Int. Society for Rotary Blood Pumps 1992

Co-Author: 3 times Annual Award (Stefan-Schuy-Award) of the Austrian Society for

Biomedical Engineering OEGBMT 1993, 1996, 1999, 2003

Annual Award of the European Society for Artificial Organs 1994 and 2005

Award of the Austrian Society for Cardiology 1992 Koyanagi Young Investigator Travel Award of the Int. Society for Rotary Blood

Pumps 2002 and 2005

2 times Clinical Award (Don-Olsen-Award) of the Int. Society for Rotary Blood pumps

Sager-Award of the Austrian Society for Radiology 1994

Award of the European Society for Vascular Surgery 1997

Major Activities in scientific Societies and Journals

President of the International Society for Rotary Blood Pumps (ISRBP) 2006-07 (Vice

President 2002-05, Secretary General 2000-02, Board Member 1995-2000)

Secretary General of the European Society forArtificial Organs (ESAO) 2003- (Board Member 2000 – 03),

Board Member of the International Federation of Artificial Organs (IFAO) 2002-

Former board member of the International Society for Artificial Organs ISAO (1994-98)

Cashier of the Austrian Society for Biomedical Engineering (ÖGBMT) 2006 – (Board Member 1997-2006)

Member of the Editorial Board of the "International Journal of Artificial Organs" 2002-

Regular Reviewer for "Artif. Organs", Int. J. Artif Organs", occasional reviewer for the "ASAIO Journal", the "ASME Journal" and the National Czech Grant foundation.

Organization of two "International Workshops on Rotary Blood Pumps" and editor of the proceedings 1988 and 1991

Organization of the 2nd Congress of ISRBP 1994 and guest editor of the proceedings volume in Artif. Organs

Program-Chairman of the 29th Congress of the ESAO, 2002, three international meetings on rotary blood pumps 1988,1991 and 1994, the "DreiländerBMT-Tagung" 2003

Member of the Organization Board European Congress on Medical and Biomedical Engineering 1999

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Program Board Member of ISAO congresses 1995 and 1997, the cardiovascular congress in Washington 1997 and several ESAO and ISRBP meetings

Teaching:

Coordinator of the Dr.Sci.Med study “Biomedical Engineering” 2005 -

Lectures and Seminars on Cardiovascular Technology and Control Engineering at the Fachhochschule “Technikum Wien”, 2002 -

Lectures and Seminars on Biomedical Engineering in cardiovascular diagnostics and therapies at the faculty of medicine, 1992 -

Lectures and demonstrations for students of the Medico-technical Academy “MTA-Akademie AKH Wien” 1995-99.

Guidance and Seminars for Master and PhD-theses in cooperation with the faculty of natural sciences of the Univ., with the faculties electronical and of mechanical engineering of the TU Vienna, and of "Fachhochschulen" in Vienna and Germany.

Acquisition and organization of two research/lecturing stays of USA visiting professors.

Continuous physician and staff education/training for the use of cardiac assist devices, 1986 - .

Participation in company lecturing/training operations for teams of international cardiac centers.

Evening courses at a high-school for electronic engineering (“HTL-Wien1”) 1988 - 2002.

Supervised PhD-Theses:

Vogt G: Aufbau technischer Einrichtungen zur Elimination toxischer Stoffe auf der Basis der Plasmasorption, TU Wien 2000

Vollkron M: Development of an automatic speed adaptation system for continuously working left ventricular assist devices. TU Wien 2003

Moscato F: Investigating the interaction between the cardiovascular system and an axial flow ventricular assist device: Mathematical model and an acute animal study. Univ. Rende/Calabria, 2008

Voitl P: Physiological Effects of Cardiac Assist Devices with Continuous Flow, currently under review 2008.

Multiple Supervision of Diploma Theses and Bachelor Theses for the Medical University Vienna, the Technical University Vienna, the Fachhochschule Technikum-Wien.

Recently Acquired Funding:

Industrial Project: “Development of Monitoring and Control of a fully implantable Rotary Blood Pump”, 2000-2005

Industrial Project: “Development and Evaluation of Blood Pump Components”, 2005 –

Fonds des Bürgermeister der Stadt Wien: “Einsatz eines intravenösen Kühlungssystems für Notfall-Patienten” (Koautor), 2005

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Project Description:

Interactions between Cardiovascular Prostheses and Recipients in Physiological and Pathophysiological Conditions

(Supervisor: Prof. H. Schima) Cardiovascular prostheses such as blood pumps, heart valves or artificial vessels interact in multiple aspects with the recipient. These interactions include hemodynamic responses to changing hydraulic loads, to exercise and to modifications in cardiac contractility. The biomechanical interactions between prostheses and the surrounding organ structures lead to specific pathophysiological responses. Moreover, the biochemical and cellular responses to the artificial surfaces are of eminent importance for biocompatibility, depending on the individual status of the patient.

Our group accesses these questions with a variety of methods, including computerized fluid mechanics and in-vitro visualization of streamlines, hydrodynamic simulators, in-vitro test circuits for hematologic compatibility, in-vivo experiments and the analysis of patient data. For prototyping various techniques in plastic technology and microstructuring of surfaces are available.

Thesis students are currently involved or invited to participate for the following projects:

- Investigation of the interaction between heart and blood pump, including determination of heart recovery during cardiac assist;

- Investigation of physiological effects of continuously pumping cardiac support systems to end organs;

- Examination of the effects of various cardiac valves to the aortic wall;

- Optimization of pump connections to the heart and the aortic system;

- Artificial vessel grafts for small calibers with nanostructured surface;

- Control of blood cooling systems for hyperthermia treatment.

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Dr. Sci. Med. Biomedical Engineering CV Prof. H. G. Stöhr

Hans Georg Stöhr Curriculum Vitae Academic title Dipl.-Ing. Dr. techn. ao. Univ. – Prof.

Date of Birth 1951

Place of Birth Vienna, Austria

Marital status married with Zora, four children Stefan, Bettina, Frederik and

Katharina

Nationality Austria

Address Core Unit for Biomedical Research,

Medical University of Vienna, AKH Vienna 1Q

Waehringer Guertel 18-20

A-1090 Vienna, Austria

Phone +43.1.40 400 - 5219

Fax +43.1.40 400 - 5229


Home address Elsbeergasse 12, A-1140 Vienna, Austria

Education & Professional Activities Oct. 1976 - present: Appointment as Assistant / Associate Professor, University Vienna

/ Medical University Vienna (ao. Univ. – Prof.)

Sept. 1974 – present: Teacher at “HTL”, Technical College for engineering education of

adults

March 1995 – present: Assistant Director of Core Unit for Biomedical Research

March 1985: Postdoctoral lecture qualification (“Habilitation”), University

Vienna

Specialization: Bioengineering (“Bioingenierwissenschaften”)

Thesis: “Biotechnische Grundlagen und Anwendung der

funktionellen Elektrostimulation nach Querschnittslähmung“

(„Basics in bioengineering and application of electro stimulation in

paraplegia“).

June 1980: Final PhD Exams, University of Technology Vienna; Title of the

PhD-thesis: “Untersuchungen zur Optimierung einer drahtlosen

Energieübertragung mittels elektromagnetischer Felder für

medizinische Anwendungen“

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Dr. Sci. Med. Biomedical Engineering CV Prof. H. G. Stöhr

Oct. 1969 - June 1974 Studies of Electronics at the Vienna University of Technology

(Industrial Engineering, Automation and Control). Diploma thesis:

"Informationsspeicher für periodische Wiederholung einmaliger

Einlesungen", Institute of Automation and Control.

Part-time student assistant.

1961 - 1969 High School, Vienna, Austria

1957 - 1961 Primary School, Vienna, Austria

Scientific activities (past and present) Automatic control of TAH (total artificial heart) Electronic assist systems for handicapped people Electro-stimulation systems (implantable & surface applied) for para- and tetraplegic patients Computerized measurement of psychophysiologic parameter in Clinical Psychopdiagnostics Biologic data acquisition, long-time storage, monitoring and evaluation Participation in the frame of the MEDEA+ Project A109 – WITNESS (WIreless Technologies for small area Networks with Embedded Security & Safety) Publications Approx. 250 papers, proceedings and abstracts in various fields of Bioengineering.

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