Reactions 1284 - 16 Jan 2010

■ Transcatheter arterial chemoembolisation (TACE)with drug-eluting beads results in less serious livertoxicity than conventional TACE, according to datafrom the PRECISION V trial. A total of212 intermediate-stage hepatocellular carcinomapatients were randomised to receive TACE withdoxorubicin-eluting beads [DC Bead] or conventionalTACE with doxorubicin + ethiodized oil. Patients weretreated every 2 months and followed up for 6 months.Postprocedural increases in ALT and AST were 50%and 41% lower, respectively, in patients who receivedTACE with DC Beads compared with conventionalTACE recipients. Fewer DC Bead recipients reportedserious liver toxicities (3 patients) than conventionalTACE recipients (9 patients).Lencioni R, et al. REDUCED LIVER TOXICITY IN INTERMEDIATE-STAGE HEPATOCELLULAR CARCINOMA PATIENTS TREATED BYCHEMOEMBOLIZATION WITH DRUG ELUTING BEADS: RESULTSFROM THE PRECISION V RANDOMIZED TRIAL. 60th Annual Meeting ofthe American Association for the Study of Liver Diseases : abstr. 1673, 30 Oct2009. Available from: URL: http://www.aasld.org/thelivermeeting/Pages/default.aspx 803002349

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Reactions 16 Jan 2010 No. 12840114-9954/10/1284-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved