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Volume 7, Number 5, September 2020Neurology.org/NN
A peer-reviewed clinical and translational neurology open access journal
ARTICLE
Altered fovea in AQP4-IgG–seropositive neuromyelitis optica spectrum disorders e805
ARTICLE
Treatment and outcome of aquaporin-4 antibody–positive NMOSD: A multinational pediatric study e837
ARTICLE
Guillain-Barré syndrome: Th e fi rst documented COVID-19–triggered autoimmune neurologic disease: More to come with myositis in the offi ng e781
ARTICLE
Extending rituximab dosing intervals in patients with MS during the COVID-19 pandemic and beyond? e825
Academy OfficersJames C. Stevens, MD, FAAN, PresidentOrly Avitzur, MD, MBA, FAAN, President ElectAnn H. Tilton, MD, FAAN, Vice PresidentCarlayne E. Jackson, MD, FAAN, SecretaryJanis M. Miyasaki, MD, MEd, FRCPC, FAAN, TreasurerRalph L. Sacco, MD, MS, FAAN, Past President
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Copyright © 2020 American Academy of Neurology. Unauthorized reproduction of this article is prohibited.
A peer-reviewed clinical and translational neurology open access journal Neurology.org/NN
Neurology® Neuroimmunology & Neuroinflammation
EditorJosep O. Dalmau, MD, PhD
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Copyright © 2020 American Academy of Neurology. Unauthorized reproduction of this article is prohibited.
TABLE OF CONTENTS Volume 7, Number 5, September 2020 Neurology.org/NN
Editor’s Corner
e858 N2 in the time of COVID-19J. Dalmau
Open Access
Editorial
e843 Isotyping paranodal antibodies in inflammatoryneuropathies: One step closer to precision careC. Lleixa and L. Querol
Open Access
Articles
e781 Guillain-Barre syndrome: The first documentedCOVID-19–triggered autoimmune neurologicdisease: More to come with myositis in the offingM.C. Dalakas
Open Access
e787 Risk of COVID-19 infection in MS and neuromyelitisoptica spectrum disordersM. Fan, W. Qiu, B. Bu, Y. Xu, H. Yang, D. Huang, A.Y. Lau, J. Guo,M.-N. Zhang, X. Zhang, C.-S. Yang, J. Chen, P. Zheng, Q. Liu,C. Zhang, and F.-D. Shi
Open Access
e789 COVID-19-related acute necrotizing encephalopathywith brain stem involvement in a patient withaplastic anemiaL. Dixon, J. Varley, A. Gontsarova, D. Mallon, F. Tona, D. Muir,A. Luqmani, I.H. Jenkins, R. Nicholas, B. Jones, and A. Everitt
Open Access
e807 Ocrelizumab shorter infusion: Primary results fromthe ENSEMBLE PLUS substudy in patientswith MSH.-P. Hartung, on behalf of the ENSEMBLE Steering Committeemembers and study investigators
Open Access Class of Evidence
e805 Altered fovea in AQP4-IgG–seropositiveneuromyelitis optica spectrum disordersS. Motamedi, F.C. Oertel, S.K. Yadav, E.M. Kadas, M. Weise, J. Havla,M. Ringelstein, O. Aktas, P. Albrecht, K. Ruprecht, J. Bellmann-Strobl,H.G. Zimmermann, F. Paul, and A.U. Brandt
Open Access
e809 Recent cannabis use in HIV is associated with reducedinflammatory markers in CSF and bloodR.J. Ellis, S.N. Peterson, Y. Li, R. Schrier, J. Iudicello, S. Letendre,E. Morgan, B. Tang, I. Grant, and M. Cherner
Open Access
e817 Antiparanodal antibodies and IgG subclasses in acuteautoimmune neuropathyL. Appeltshauser, A.-M. Brunder, A. Heinius, P. Kortvelyessy,K.-P.Wandinger, R. Junker, C. Villmann, C. Sommer, F. Leypoldt, andK. Doppler
Open Access Editorial, p. e843
e815 CSF chitinase 3-like-1 association with disability ofprimary progressive MSF. Perez-Miralles, D. Prefasi, A. Garcıa-Merino, F. Gascon-Gimenez,N. Medrano, J. Castillo-Villalba, L. Cubas, C. Alcala, S. Gil-Perotın,R. Gomez-Ballesteros, J. Maurino, E. Alvarez-Garcıa, andB. Casanova
Open Access Class of Evidence
e819 Painful trigeminal neuropathy associated withanti-Plexin D1 antibodyT. Fujii, R. Yamasaki, Y. Miyachi, K. Iinuma, Y. Hashimoto, N. Isobe,T. Matsushita, and J.-i. Kira
Open Access
e825 Extending rituximab dosing intervals in patientswith MS during the COVID-19 pandemicand beyond?A. Maarouf, A. Rico, C. Boutiere, M. Perriguey, S. Demortiere,J. Pelletier, and B. Audoin, Under the aegis of OFSEP
Open Access
e827 Genetic determinants of the humoral immuneresponse in MSC. Gasperi, T.F.M. Andlauer, A. Keating, B. Knier, A. Klein,V. Pernpeintner, P. Lichtner, R. Gold, F. Zipp, F. Then Bergh,M. Stangel, H. Tumani, B. Wildemann, H. Wiendl, A. Bayas,T. Kumpfel, U.K. Zettl, R.A. Linker, U. Ziemann, M. Knop, C. Warnke,M.A. Friese, F. Paul, B. Tackenberg, A. Berthele, and B. Hemmer
Open Access
Cover Image3D foveal shape analysis method overview. The left panel shows innerlimitingmembrane surface smoothing and radial reconstruction using thecubic Bezier polynomial. The right panel shows rim disk (blue), slopedisk (red), and pit flat disk (green). The lower panel shows rim height,average pit depth, and central foveal thickness. Stylized by Kaitlyn AmanRamm, Digital Multimedia/Graphics Coordinator.See page e805
Continued
Copyright ª 2020 American Academy of Neurology. Unauthorized reproduction of this article is prohibited.
e829 Motor cortex transcriptome reveals microglial keyevents in amyotrophic lateral sclerosisO. Dols-Icardo, V. Montal, S. Sirisi, G. Lopez-Pernas,L. Cervera-Carles, M. Querol-Vilaseca, L. Muñoz, O. Belbin,D. Alcolea, L. Molina-Porcel, J. Pegueroles, J. Turon-Sans, R. Blesa,A. Lleo, J. Fortea, R. Rojas-Garcıa, and J. Clarimon
Open Access
e831 High κ free light chain is a potential biomarker fordouble seronegative and ocular myasthenia gravisA. Wilf-Yarkoni, Y. Alkalay, T. Brenner, and A. Karni
Open Access Class of Evidence
e835 COVID-19 outcomes in MS: Observational study ofearly experience from NYU Multiple SclerosisComprehensive Care CenterE. Parrotta, I. Kister, L. Charvet, C. Sammarco, V. Saha, R.E. Charlson,J. Howard, J.M. Gutman, M. Gottesman, N. Abou-Fayssal, R. Wolintz,M. Keilson, C. Fernandez-Carbonell, L.B. Krupp, and L. Zhovtis Ryerson
Open Access
e837 Treatment and outcome of aquaporin-4antibody–positive NMOSD: A multinationalpediatric studyR.B. Paolilo, Y. Hacohen, E. Yazbeck, T. Armangue, A. Bruijstens,C. Lechner, S.L. Apostolos-Pereira, Y. Martynenko, M. Breu,C. de Medeiros Rimkus, E. Wassmer, M. Baumann, L. Papetti,M. Capobianco, B. Kornek, K. Rostasy, J.A. da Paz, O. Ciccarelli,M. Lim, A. Saiz, R. Neuteboom, R. Marignier, C. Hemingway,D.K. Sato, and K. Deiva
Open Access Class of Evidence
e839 Effectof the sphingosine-1-phosphate receptormodulatorozanimod on leukocyte subtypes in relapsing MSS. Harris, J.Q. Tran, H. Southworth, C.M. Spencer, B.A.C. Cree, andS.S. Zamvil
Open Access
e845 Tailoring B cell depletion therapy in MS according tomemory B cell monitoringG. Novi, F. Bovis, S. Fabbri, F. Tazza, P. Gazzola, I. Maietta, D. Curro,N. Bruschi, L. Roccatagliata, G. Boffa, C. Lapucci, G. Pesce,M. Cellerino, C. Solaro, A. Laroni, E. Capello, G. Mancardi,M. Sormani, M. Inglese, and A. Uccelli
Open Access Class of Evidence
e847 Infliximab treatment in pathology-confirmedneurosarcoidosisD. Fritz, W.M.C. Timmermans, J.A.M. van Laar, P.M. van Hagen,T.A.M. Siepman, D. van de Beek, and M.C. Brouwer
Open Access Class of Evidence
e849 Clinically based score predicting cryptogenic NORSEat the early stage of status epilepticusA. Yanagida, N. Kanazawa, J. Kaneko, A. Kaneko, R. Iwase, H. Suga,Y. Nonoda, Y. Onozawa, E. Kitamura, K. Nishiyama, and T. Iizuka
Open Access
e852 High-throughput investigation of molecularand cellular biomarkers in NMOSDS.S. Yandamuri, R. Jiang, A. Sharma, E. Cotzomi, C. Zografou,A.K. Ma, J.S. Alvey, L.J. Cook, T.J. Smith, M.R. Yeaman, andK.C. O’Connor, on behalf of the Guthy-Jackson CharitableFoundation CIRCLES Study Group
Open Access
e854 Regional microglial activation in the substantia nigrais linked with fatigue in MST. Singhal, S. Cicero, H. Pan, K. Carter, S. Dubey, R. Chu, B. Glanz,S. Hurwitz, S. Tauhid, M.-A. Park, M. Kijewski, E. Stern, R. Bakshi,D. Silbersweig, and H.L. Weiner
Open Access
e856 Long-term prognostic value of longitudinalmeasurements of blood neurofilament levelsD.A. Haring, H. Kropshofer, L. Kappos, J.A. Cohen, A. Shah,R. Meinert, D. Leppert, D. Tomic, and J. Kuhle
Open Access Class of Evidence
e860 Validation of theNEOS score in Chinese patients withanti-NMDAR encephalitisY. Peng, F. Dai, L. Liu,W. Chen, H. Yan, A. Liu, X. Zhang, X.Wang, J. He,Y. Li, C. Li, L. Chen, Y. Zhao, L. Li, Q. Ma, and J. Wang
Open Access Class of Evidence
e862 Progressive multifocal leukoencephalopathy andsarcoidosis under interleukin 7: The price of healingA. Guffroy, M. Solis, V. Gies, Y. Dieudonne, C. Kuhnert,C. Lenormand, L. Kremer, A. Molitor, R. Carapito, Y. Hansmann,V. Poindron, T. Martin, S. Hirschi, and A.-S. Korganow
Open Access
Clinical/Scientific Notes
e783 COVID-19 in MS: Initial observations from thePacific NorthwestJ.D. Bowen, J. Brink, T.R. Brown, E.B. Lucassen, K. Smoot,A. Wundes, and P. Repovic
Open Access
e785 Guillain-Barre syndrome related to SARS-CoV-2infectionK. Bigaut, M. Mallaret, S. Baloglu, B. Nemoz, P. Morand, F. Baicry,A. Godon, P. Voulleminot, L. Kremer, J.-B. Chanson, and J. de Seze
Open Access
e791 A case of cerebral vasculitis due toneurobartonellosisM. Poursheykhi, F. Mithani, T. Garg, C. Cajavilca, S. Jaijakul, S. Fung,R. Klucznik, and R. Gadhia
Open Access
e793 The rare case of a 20-year-old male with rapidlyprogressive primary angiitis of the CNS witha good outcomeE. Graham, T. Shoemaker, D. Stefoski, M. Kontzialis,A. Naumaan, and R.K. Garg
Open Access
e797 Acute disseminated encephalomyelitis afterSARS-CoV-2 infectionG. Novi, T. Rossi, E. Pedemonte, L. Saitta, C. Rolla, L. Roccatagliata,M. Inglese, and D. Farinini
Open Access
e799 Severe paradoxical disease activation followingalemtuzumab treatment for multiple sclerosisJ. Brannigan, J.L. Jones, and S.R.L. Stacpoole
Open Access
TABLE OF CONTENTS Volume 7, Number 5, September 2020 Neurology.org/NN
Copyright ª 2020 American Academy of Neurology. Unauthorized reproduction of this article is prohibited.
e801 Acute necrotizing encephalopathy and myocarditis ina young patient with COVID-19A. Elkady and A.A. Rabinstein
Open Access
e803 COVID-19-associated acute necrotizing myelitisJ. Sotoca and Y. Rodrıguez-Alvarez
Open Access
e811 Should interferons take front stage as an essential MSdisease-modifying therapy in the era of coronavirusdisease 2019?C. Maguire, T. Frohman, S.S. Zamvil, E. Frohman, and E. Melamed
Open Access
e813 CNS inflammatory vasculopathy with antimyelinoligodendrocyte glycoprotein antibodies inCOVID-19A.A. Pinto, L.S. Carroll, V. Nar, A. Varatharaj, and I. Galea
Open Access
e821 Increased CSF levels of IL-1β, IL-6, and ACEin SARS-CoV-2–associated encephalitisM. Bodro, Y. Compta, L. Llanso, D. Esteller, A. Doncel-Moriano,A. Mesa, A. Rodrıguez, J. Sarto, E. Martınez-Hernandez, A. Vlagea,N. Egri, X. Filella, M.Morales-Ruiz, J. Yague, A. Soriano, F. Graus, andF. Garcıa, on behalf of the “Hospital Clınic Infecto-COVID-19” and“Hospital Clınic Neuro-COVID-19” groups
Open Access
e823 COVID-19-associated ophthalmoparesis andhypothalamic involvementE. Pascual-Goñi, J. Fortea, A. Martınez-Domeño, N. Rabella,M. Tecame, C. Gomez-Oliva, L. Querol, and B. Gomez-Anson
Open Access
e833 High proportion of Guillain-Barre syndromeassociated with chikungunya in Northeast BrazilA.M.B. Matos, F.M. Maia Carvalho, D.L. Malta, C.L. Rodrigues,A.C. Felix, C.S. Pannuti, A.D.R. Lima, D.L.A. Esposito,L.M.B. dos Santos, F. von Glehn, J.K.B. Colares, B.A.L. da Fonseca,A.C.P. de Oliveira, and C.M. Romano
Open Access
Views & Reviews
e841 Interleukin-6 in neuromyelitis optica spectrumdisorder pathophysiologyKazuo Fujihara, Jeffrey L. Bennett, Jerome de Seze,Masayuki Haramura, Ingo Kleiter, Brian G. Weinshenker,Delene Kang, Tabasum Mughal, and Takashi Yamamura
Open Access
Correction
e850 Guillain-Barre syndrome related to SARS-CoV-2infection
TABLE OF CONTENTS Volume 7, Number 5, September 2020 Neurology.org/NN
Copyright ª 2020 American Academy of Neurology. Unauthorized reproduction of this article is prohibited.
2020;7; Neurol Neuroimmunol Neuroinflamm 7 (5)
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