Did sex with Neanderthals and
Denisovans shape our immune system?
A12Erin McCaskey
Mackenzie WilliamsPeyton AiringtonArturo Salmeron
Dongeun Kim
Our Immune Systems Resulted from Multiregional Admixture
Pinna 2011
Abi-Rached et al. 2011
Abi-Rached et al. 2011
Abi-Rached et al. 2011
Abi-Rached et al. 2011
Discussion & Conclusion
• Take-Home Message: Modern Human immune systems are possibly a result of breeding with Neanderthals many years ago.
Pinna 2011
Work CitedAbi-Rached, L.; Jobin, M.J.; Kulkami, S.; McWhinnie, A.; Dalva, K.; Gragert, L; Babrzadeh, F.; Gharizadeh, B.; Luo, M.;
Plummer, F.A.; Kimani, J.; Carrington, M.; Middleton, D.; Rajalingam, R.; Beksac, M.; Marsh, S.G.E.; Maiers, M.; Guethlein, L.A.; Tavoularis, S.; Little, A.; Green, R.E.; Norman, P.J.; and P. Parham. 2011. The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans. Science 334: 89-94.
Currat, M.; Ruedi, M.; Petit, R.J. and L. Excoffier. 2008. The Hidden Side of Invasions: Massive Introgression by Local Genes. Evolution 62(8): 1908-20.
Khan, M.A. 2011.Estimation of Linkage Disequilibrium (LD) Decay. PGBworks, USDA and NIFA.
National Center for Biotechnology Information. database. 2007. SNPs: A Variation on a Theme. <http://www.ncbi.nlm.nih.gov/About/primer/snps.html>
The International HapMap Consortium. 2003. The International HapMap Project. Nature 426: 789-96.
Pinna, S., 2011. Neanderthals Boost Our Immune System. <http://drpinna.com/neanderthal-genes-boosts-our-immune-system-23305>
Yong, E., 2011. Did sex with Neandethals and Denisovans shape our immune systems? The jury's still out. Discover Magazine.