Al WaterhousePresident

OIS@AAO 2016

Extending Depth of Focus with Small Aperture Optics

Small aperture technology is the only corneal-based presbyopia correcting procedure that does not rely on the use of “plus power” in the cornea to provide near vision.

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The Simple & Elegant Solution for EDOF

• Small Aperture Safety & Effectiveness:– Extended Range of Vision: Provides a

natural range of vision from near to far– Preserves Far Vision: Unlike monovision,

small aperture optics provides near vision while maintaining far vision in both eyes

– Long-Lasting: Delivers long-term performance to maintain clear near vision over time

• Strong Science: 40+ peer-reviewed papers• Inlay Experience: Over 30,000 patients

– Long-Term Data: >9 years

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KAMRA® Inlay

IC-8™ IOL

Untapped Market Opportunity

Presbyopia Cataract

Combined ~$10 Billion Market

• Global market opportunity exceeds $5 billion1

- 40% of procedures are performed in the US

• 70+ million baby boomer population is at least 50 years old2

• Presbyopia-correcting procedures are elective- Pricing determined by market forces, not

reimbursement rates; patients expect superior results

• Other surgical options exist but require significant compromise- Sacrifice intermediate and/or distance acuity- Loss of effect over time; glare and halo

complaints- Irreversible

• #1 performed surgical procedure worldwide- 3 million performed annually in the US

• Global IOL market opportunity expected to reach $4.2 billion by 20192 - Majority of growth to be driven by premium

IOLs

• By the year 2020, nearly 14% of the global population will be age 60 or over2

- 60+ population segment growing 3x faster than the total global population

- Patients seeking cataract surgery at an earlier age in developed countries

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1 Company estimate of global cumulative addressable market for 2015-20202 Market Scope

18 25 35

Condition by Age

45 55

Vision Correction Life CycleSmall aperture optics improves vision for a broad spectrum

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PRESBYOPIAAMETROPIA

KAMRA® Inlay• Glasses• Contact Lenses• Monovision• Other Inlays

75+

IC-8™ IOL• Monofocal IOL• Multifocal IOL

(Bifocal/Trifocal)• EDOF IOL• Accommodating IOL

Small Aperture Opportunity

CATARACT• Glasses• Contact Lenses• LASIK/ PRK• Phakic IOL

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PRESBYOPES

MYOPES

HYPEROPES

Positioning the KAMRA® Inlay

Market Scope 2014 Refractive Surgery Market Report

• KAMRA inlay is ideal for:– Plano presbyopes– Myopic presbyopes– Post-LASIK presbyopes– Unhappy monovision

patients

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Physician

Building & Growing the Market

Business Development

Clinical Support

Sales

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Expanding the Proven Small Aperture PlatformThe IC-8™ IOL

• Hydrophobic Acrylic Material– ABBE No. 49

• Optical Design– Single piece 360o square edge– 6.00 mm optic diameter– 12.50 mm overall diameter

• CE Mark Approved• Overcomes Other PC-IOL Limitations

– Incomplete range of vision, unreliability, glare/halo, neuroadaptation

• Commercializing in Europe, Australia and New Zealand

• Working Toward US Approval

IOL MaterialSingle-piece hydrophobic acrylic

Mask PVDF & nano-particles of carbon1.36mm aperture3.23mm total diameter3200 microperforations5 microns thick

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Well Capitalized for Growth

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THANK YOU