Zonular Capture Haptic

Accommodating-Disaccommodating IOL with Zonular Capture HapticsOIS, Chicago, October 13th 2016

Eppur si muovePaul Beer MDZ Lens LLC Founder & CEO

1

ManagementDr. Paul Beer (inventor)28 years as retinal surgeonProfessor of Ophthalmology at Albany Medical Center Founder, former President of the Retina Research FoundationMerit and Senior Honor Awards from the American Society of Retinal Specialists & AAOPI in >25 multicenter clinical trials in vitroretinal therapiesPI in multiple ISTs

Edward EvelethMultiple start-upsFounded Cyclics CorporationPurchased patents to unique plastic from GERaised over $40M in equityBuilt plant in GermanyMBA, Cornell University

The Teams:Rob Stupplebeen9+ years experience IOL and contact lens engineering 6 yrs at Bausch + LombConsulted for 5 IOL CosMEng, Cornell University

Wisconsin Primate CenterDept. of Ophthalmol, UW-Madison

Paul Kaufman MD Mary Ann Croft MAGreg Heatley MDJarred McDonald

Learner Research Institute-Biomedical Engineering

Animal ExperimentsDesignPrototypingAdvisors

Tom DunlapTom McNicholas

Overview

Validation:Rhesus monkey animal studies (9 eyes, > 1 yr.) show results beating competitionProduct:Accommodating Intraocular LensProtection:2 foundational patentsSize:$500MM+ current market - $1B anticipatedFinancing:NSF Phase I, Phase IB and Phase II SBIR; NIH Phase I STTR, NEI high program relevanceApplication:Cataract patients

Our goal:To replicate the movement of the natural lens

Our achievement:We did it!We made the best single rigid optic accommodating IOL-preclinical-

AD-IOL with ZCH Concept

Manufactured primate size AD-IOL (Rhesus monkey 9mm )

Optics certified by Photon gear Inc., 245 david parkway, Ontario, NY 14514

Successfully captures & responds to zonular forces

YAG laser activation & radial capsular sectioning

Titration of radial capsular sectioning

7

Results:Eppur si mouve!

And yet it moves and moves and moves

8

Physiologic level of accommodation via stimulation of EW electrode

9

Physiologic level of accommodation via stimulation of EW electrode

10

Physiologic level of accommodation via stimulation of EW electrode1 year post implantation

11

Crystalline Lens vs. AD-IOL

Anterior Lens face shifts: 0.48mmAnterior Optic face shifts: 0.47mmPhysiologic level of accommodation via stimulation of EW electrode

Physiologic level of accommodation via stimulation of EW electrodeAxial shift Ant. Lens face: 0.59mm

Axial shift Ant. Optic face: 0.80mm

Crystalline Lens vs. AD-IOL

13

Results in briefAxial shift Optic: 0.8mm Flexion haptics: ~ 20 degrees

Biometricly Predicted Accommodation: 1D/1mm of axial shift

Observed accommodation: ~2D/0.5-8mm (1-3D EW, 4D Carb)-objective=Hartinger Refractor-meets FDA label requirements*

14

Movement amplitude and dynamics match movement of natural young lens

15

Zonular Capture Haptics =Enabling technologyMovement captured=Movement transformedShape shifting optic provides more accommodation

Driven by a haptic structure that works

Dual Mode AD-IOL= shape & axial shifting

Small, simple, easy to make optic vesicle

Small & simple fluid filled optic vesicle gets thicker during accommodationDual Mode AD-IOLpatent pending

Dual Mode AD-IOLpatent pending

Current prototype will be ready for animal testing Q1 2017

Dual Mode AD-IOLpatent pendingFEA: lens in cross section

IP Protection

Accommodation methodU.S. Patent No. 9,220,590 "ACCOMMODATIVE INTRAOCULAR LENS AND METHOD OF IMPROVING ACCOMMODATION"

Dissaccommodation MethodU.S. Patent No. 9,364,318 B2"ACCOMMODATIVE-DISACCOMODATIVE INTRAOCULAR LENS

Devices:Divisional applications covering all device concepts and device in useProvisional Application covering Dual Mode IOL

Finacial Strategy1. Finish development of prototypes

2. Round A -2 MM to take Dual Mode AD-IOL to human trial

3. Explore Industry Partnership

Axial Shift AD-IOLDual Mode AD-IOLHuman trials of best designBuild and test prototype

SummaryNovel, powerful IOL conceptsMajor Milestones achievedExpert team with proven successPatent protectionMassive opportunity 500MM marketDr. Paul M. BeerZ Lens LLCdrbeer@zlensllc.comWe captured the movement!

Eppur si muove