OIS-AAO 2016

©2016 Tear Science, Inc.

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• Cuts symptoms in HALF

• Improves secretion THREEFOLD

• Sustains for a YEAR

• … All from a SINGLE ‘dose’

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Imagine a Therapy in Dry Eye that…

3Company Confidential

• FDA cleared

• Proven safe on 150,000 eyes since 2011

Imagine LipiFlow®

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The Dry Eye / MGD Market

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MGD: Large, Untapped Market in Dry Eye

**Michael A. Lemp, MD, Leslie A. Crews, PhD,† Anthony J. Bron, FRCOphth, Gary N. Foulks, MD, and Benjamin D. Sullivan, PhD- Cornea 2012

Over 30 Million Dry Eye Sufferers in USEach eye doctor’s office sees an average 8-10 MGD patient daily.

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MGD: The Full Picture

Normal Function

Abnormal Function

Normal Structure

Abnormal Structure

Meibomian GlandStructure

Meibomian GlandFunction

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Treating MGD

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“The ocular surface health cannot be maintained or rehabilitated in the absence of healthy meibomian gland function” (Wolff, 1946)

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The Historical Gold Standard:

Warm Compresses (since ~1900)• Daily routine• Very low compliance• 1/3 as effective as a single LipiFlow

Manual Expression (since 1888)• In Office • Uncomfortable for the patient• Time consuming for the doctor and variable results

How is MGD Managed Today?

LipiFlow® is clinically more effective and more convenient.

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Vectored• Heat and pressure directed to the inner eyelid using space-age

insulation and vaulted design to protect the cornea and globe

Thermal• A maximum therapeutic temperature of 43 degrees Celsius

(109.4 Fahrenheit) is applied directly to the glands from the inner eyelid

Pulse Custom peristaltic pressure sequence and device contour

maximize safe gland clearing

LipiFlow®: A Proven MGD Treatment

VTP Technology:A Breakthrough Inner Lid Approach

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LipiFlow®: Single-Use ActivatorTherapeutic Motion

Feedback-Guided Sensors

Cornea Shield

Force Equalization

• Restores Meibomian Gland function

• Applies heat and pressure directly to the inner eyelid for 12 minutes–in office

• FDA-cleared and clinically proven

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LipiFlow®: Clinically-Proven EfficacySingle Treatment Demonstrates Sustained Improvement• In a recently published Study1 a single LipiFlow® treatment was shown to improve gland

function and symptoms with sustained duration in patients with MGD and Dry Eye

1Blackie CA, Coleman CA, Holland EJ. The sustained effect (12 months) of a single-dose vectored thermal pulsation procedure for meibomian gland dysfunction and evaporative dry eye. Clin Ophthal. 2016; 10:1385-1396.

Baseline 3 Months 12 Months0

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10

15

20

25

6.4

17.9 17.3

Thermal Pulsation Group

Mea

n M

G S

core

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LipiFlow®: Clinically-Proven Efficacy

1Blackie CA, Coleman CA, Holland EJ. The sustained effect (12 months) of a single-dose vectored thermal pulsation procedure for meibomian gland dysfunction and evaporative dry eye. Clin Ophthal. 2016; 10:1385-1396.

Baseline 3 Months 12 Months0

10

20

30

40

5044.1

19.221.6

Thermal Pulsation Group

Mea

n O

SDI S

core

Single Treatment Demonstrates Sustained Improvement• In a recently published Study1 a single LipiFlow® treatment was shown to improve gland

function and symptoms with sustained duration in patients with MGD and Dry Eye

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LipiFlow®: Impressive Results in Cataract Surgery and Contact Lens Patients

Cataract surgery patients with MGD

Contact Lens patients with MGD and reduced wearing time

Significant improvements in primary and secondary endpoints of gland secretion and ocular comfort

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LipiView® II: Dynamic Meibomian Imaging (DMI)

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LipiScan™: Rapid MGD Detection

High Definition

Rapid Capture

Broader Market Appeal

Ease of Use

NEW

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• Focused on Dry Eye due to MGD

• New management team

• Proven technology

• Shifted business model

• Validated through financial results

• Privately-held company

• Completed Series D financing

• EBITDA Positive Early 2017

Summary

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Our Technology

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LIPIFLOW®LIPIVIEW® II

Accurately Identify and Detect MGD Effectively Treat MGD

LIPISCAN™

KORB MGE ACTIVATOR

NEW

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