Haem15 - Anemia conclusions & Polycythemia

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JCU Shashi

1Clinical Pathology: RBC 1.3: Anemia SummaryCPC: Term2 Week1 - Haem 1/2.System: Haematology - RBC Disorders.Topic: 1: Anemia Intro 2: IDA, MBA & ACD 3: Acquired HA 4: Congenital HA. 5: Others... foundation of clinical medicine Shashidhar Venkatesh MurthyA/Prof & Head of PathologyCollege of Medicine & Dentistry2Pathogenetic Classification of Anemia:Decreased Production:Nutrient Deficiency. Iron def (IDA) / Megaloblastic (MBA)Hemopoietic cell defect:Anemia of chronic disorders (ACD)Aplastic anemia (AA).Dysplastic anemia. Myelodysplastic SyndromesIncreased loss / destruction:Blood loss anemia Acute / Chronic - bleeding. Hemolytic anemia Congenital / Acquired.Acquired / External injury.Immune AIHA (Warm/Cold) Mechanical, Drugs, ParasitesCongenital / Internal RBC defectDefective Membrane (Spherocytic an)Defective Hemoglobin (Sickle & Thal.) Deficient Enzyme (G6PD)2Cell MemHb.EnzymesTop 6 Anemias:IDA & MegaloblasticACD & Aplastic An.IHA Warm & Cold.223

Anemia: Summary4MCV90MCV110DNA: B12, FolateHb: IronMegaloblastic anemiaIron Deficiency anemiaAplastic anemia Dysplastic anemia

Hemolytic anemiaImmuneMechanicalInfectionDrugsDefective*4Haemolytic An. IntroductionAnemia due to Increased RBC destruction life span (1007

8Sideroblastic anemia:Group of disorders anemia with sideroblasts (+ve iron). Suggesting lack of Iron utilization.Microcytic Hypochromic anemia.(Macrocytic/dimorphic)Two major types: Congenital: X-Linked, mitochondial etc.Acquired : Myelodysplastic Syndrome (MDS) Copper & Vit. B6 deficiency. Lead poisoning Alcoholism, Drugs, Idiopathic.Porphyria:Excess porphyrin secretion.Acute abdominal painNeuropathy etc.


Iron stain: bluePolycythemia: (high Hb)Relative or spurious erythrocytosis Dehydration: Diarrhea, vomiting, diuretics, excess alcohol. etc.Absolute erythrocytosis (True ):Secondary: Tissue Hypoxia: Smoking (CO), High altitude, Lung disease. Cardiac shunts, High O2 affinity Hb. High Erythropoietin Paraneoplastic Syndromes, Androgen therapy.Primary - Polycythemia Rubra vera:Myeloproliferative disorder: Neoplastic proliferation of erythroid cells in bone marrow old age, hepatosplenomegaly. 10

Hb, skin flushing & Hepatosplenomegaly10Need help? contact meOffice location: DB39-136 (Townsville)Office Tel: 4781 4566Email: venkatesh.shashidhar@jcu.edu.auEmergency?: 0416933704

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Thalassemia Minor


Thalassemia MajorNormal13