Importance of Treating Iron Deficiency Anaemia

in Pregnancy

Iron Deficiency Anaemia

Iron Deficiency Anaemia Is the Most Prevalent Micronutrient Deficiency Affecting Just Over

2 BILLION

People Of the World.

WHO Mortality Data

Around

0.8 MILLION

Deaths Are Attributed to

Iron Deficiency Each Year

WHO Mortality Data

In Terms of the Loss of Healthy Life Years (Dalys), IDA Results

in 25 MILLION

Dalys Lost Each Year.

DALYs = Disability Adjusted Life Years The sum of years of potential life lost due to premature mortality and the years of productive life lost due to disability.

Economic Cost

The Economic Cost of Iron Deficiency Is Huge Because It Decreases the

PRODUCTIVITY

And COGNITIVE

Function

Economic Loss

Annual Economic Loss Due to IDA in Four Countries of South Asia Namely Bangladesh, India, Pakistan and Sri Lanka Is

$4.2 BillionWith a loss of almost 0.6 % of

its GDP due to IDA

Prevalence

“Almost

One Out of Two

Women of Child Bearing

Age Suffer From Anemia”

National Institute Of Population StudiesNational Institute Of Population Studies

Risk

629 Pregnant Women Were Studied

• 313 Were (Hb <11 G/dl) Anaemic Group

• 316 Were (Hb >11 G/dl) Non-anaemic Group

For Anaemic Women

Preterm Delivery Was 4 Times Higher

LBW was 1.9 Times Higher

Risk of IUD Was 3.7 Times Higher

Tropical Medicine and International Health vol9(4) 486–490 apr 04 Aga Khan University, Karachi, Pakistan

Folate Deficiency

Folate Deficiency Causes

Neural Tube Defect (NTD)

to the Baby If the Pregnant Mother Has Low Folic Acid Status at the

TIME OF CONCEPTION

Developing Countries

In Many Developing Countries the Women Even Do Not Know That She Is Having a Baby.

CDC Scientists Have Estimated That Every Year

500,000 Severe Birth Defects

Are Caused by Folic Acid Deficiency.

Folic Acid In NTD

0%

23%36%

52%57%

82% 85%

0%

15%

30%

45%

60%

75%

90%

0 mg 0.2 mg 0.4 mg 0.8 mg 1 mg 4 mg 5 mg

Increase in Daily Folic Acid Intake

Perc

en

tag

e o

f N

TD

s Th

at

Wou

ld B

e P

reven

ted

Ironur-IPS

Is a compound containing 

Iron Protein Succinylate

+ Folic Acid

developed by Biocon.

Is a compound containing 

Iron Protein Succinylate

+ Folic Acid

developed by Biocon.

Ironur-IPS

Each 15 ml contains

Iron Protein Succinylate ………… 800 mg

Folic Acid ………………………………...5

mg

Iron Content

Each 1 ml contain: 2.67 mg iron *

Each 5 ml contains: 13.33 mg iron *

Each 7.5 ml contain: 20 mg iron *

Each 10 ml contains: 26.67 mg iron *

Each 15 ml contain: 40 mg iron *

*elemental iron

Description

Ironur IPS (Iron Protein Succinylate) Is an Iron Compound Specially Bonded to Chemically Modified Protein Casein (Milk Protein) in a Process Called Succinylation, Which Dramatically Stabilizes the Complex

Description

Efficacy

BJOG. 2002 Sep;109(9):1009-14.

Increase in Haemoglobin in Severe Anaemia in Pregnancy

2.3g/dl

0.5g/dl

0

0.5

1

1.5

2

2.5

1 2

Iron Protein Succinylate + Folate

Iron Protein Succinylate

Hae

mog

lobi

n C

once

ntra

tion

g/dl

P = 0.07

Efficacy

  BJOG. 2002 Sep;109(9):1009-14.

1.42g/dl

0.8g/dl

0

0.5

1

1.5

2

1 2

Iron Protein Succinylate + Folate

Iron Protein Succinylate

Hae

mog

lobi

n C

once

ntra

tion

g/dl

P < 0.001

Increase in Haemoglobin in Overall Population of Pregnant Women

Ironur IPS Vs IPC

Ironur-ips Led Not Only to a

FASTER INCREASE

of Hemoglobin, Hematocrit, MCV, Serum Iron, and Ferritin Than Iron Hydroxide Polymaltose Complex, but the Laboratory Values Remained Higher in Group A (Ironur-IPS) Than in B (Iron Hydroxide Polymaltose Complex) even After 2 Months of Treatment.

Int J Clin Pharmacol Ther. 1998 Jun;36(6):320-5.

Safety Profile

• Excellent Safety Profile in 93% Patients

Adverse Events

7%

Gastric Tolerability

93%

Additional Benefits

Ironur-IPS

• Additional Folic Acid is present for

additional benefits

• Free From

Sodium & Potassium and Sugar

Who Needs Ironur IPS

Where demands of iron is increased

– Women, especially those with the history of child bearing challenges

– People with diets that are low in both meat and ascorbic acid

– Elderly

– Who donate blood more than 3 times a year

– Growing children

Why Ironur IPS

• Unsurpassed Efficacy

• Excellent gastric tolerability

• Improved Absorption

• Additional benefits of Folic Acid

• Superior Safety Profile

Doses

Adults: 15 – 30 ml /day

Children: 1.5 ml/Kg/day in 2divided doses