6

Life Table Estimate of the Survival Function

Embed Size (px)

Citation preview

Page 1: Life Table Estimate of the Survival Function
Page 2: Life Table Estimate of the Survival Function

O Life table is obtained by first dividing the period into a

series of time intervals.

O For example, [0,20),[20,40),[40,80).

O Flexible interval.

O Survival function:

𝑆 𝑡 = (𝑛′

𝑖− − 𝑑 𝑖

𝑛′𝑖−

)

𝑡(𝑖)≤𝑡

Page 3: Life Table Estimate of the Survival Function

Assumption Censorings occur:

At the beginning of interval :

𝑛′(𝑖−) = 𝑛(𝑖−) − 𝑞(𝑖)

At the end of interval:

𝑛′(𝑖−) = 𝑛(𝑖−)

Uniform/Average throughout the interval:

𝑛′(𝑖−) = 𝑛(𝑖−) −

𝑞(𝑖)

2

Page 4: Life Table Estimate of the Survival Function

Interval 𝒏(𝒊−) 𝒅(𝒊) 𝒒(𝒊) 𝒏′(𝒊−)

𝒏′(𝒊−) − 𝒅(𝒊)

𝒏′(𝒊−)

𝑺 (𝒕)

[0,10) 15 7 2 15 −2

2= 14

14 − 7

14= 0.5 0.5

[10,20) 6 3 3 6 −3

2= 4.5

4.5 − 3

4.5= 0.333 0.333

Given time: 1,1,2,3,3,5,6,7+,9+,12,14+,15+,17,19,19+

Interval 𝒏(𝒊−) 𝒅(𝒊) 𝒒(𝒊) 𝒏′(𝒊−)

𝒏′(𝒊−) − 𝒅(𝒊)

𝒏′(𝒊−)

𝑺 (𝒕)

[0,10) 15 7 2 15 − 2 = 13 13 − 7

13= 0.462 0.462

[10,20) 6 3 3 6 − 3 = 3 3 − 3

3= 0 0

Assumption: Uniform

Assumption: At the end of interval.

Page 5: Life Table Estimate of the Survival Function

Hazard Function

O Assume death rate is constant during the

interval, and the average time survived in

that interval is (𝑛′(𝑖−)

−𝑑 𝑖

2)∆(𝑖).

O The life table estimate of the hazard

function is:

ℎ 𝑡 =𝑑(𝑖)

(𝑛′(𝑖−)

−𝑑 𝑖

2)∆(𝑖)

Page 6: Life Table Estimate of the Survival Function

Comparison

Life Table

Estimating survival rate for each interval.

Survival curve changes in each interval

Correction of number at risk at the beginning of

interval

Kaplan-Meier

Estimating survival rate for each observation

outcome.

Survival curve changes in each observation outcome.

No correction of number at risk at the beginning of

inteval