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©2015 Cambridge Semantics Inc. All rights reserved.
Clinical Trial Site Intelligence (CTSI)An Anzo Smart Data Lake™ Solution
©2015 Cambridge Semantics Inc. All rights reserved.
Life Sciences Use Case Clinical Trial Site Intelligence (CTSI)
©2015 Cambridge Semantics Inc. All rights reserved.
Cambridge Semantics
Cambridge Semantics is the creator of the Anzo Smart Data Lake ™ (ASDL) Based on semantic web technology, the ASDL provides an end-to-end graph-based data integration, discovery, management, and analytics technology platform. Cambridge Semantics delivers Smart Data solutions for Life Science companies including R&D Intelligence, Scientific Affairs, Clinical Data Integration, clinical site selection, and much, much more… • Founded in 2007 by senior members of IBM’s Advanced Internet Technology Group• The Anzo software suite is built on World Wide Web Consortium (W3C) open data standards and 13+
years of R&D• The award-winning Anzo software suite is our 3rd generation implementation of semantic web
technologies
©2015 Cambridge Semantics Inc. All rights reserved.
Cambridge Semantics
Cambridge Semantics is the creator of the Anzo Smart Data Lake ™ (ASDL) Based on semantic web technology, the ASDL provides an end-to-end graph-based data integration, discovery, management, and analytics technology platform. Cambridge Semantics delivers Smart Data solutions for Life Science companies including R&D Intelligence, Scientific Affairs, Clinical Data Integration, clinical site selection, and much, much more… • Founded in 2007 by senior members of IBM’s Advanced Internet Technology Group• The Anzo software suite is built on World Wide Web Consortium (W3C) open data standards and 13+
years of R&D• The award-winning Anzo software suite is our 3rd generation implementation of semantic web
technologies
©2015 Cambridge Semantics Inc. All rights reserved.
What is SMART Data?
RELATE ‘LIKE’ DATA
(contextualize)
EXPLORATO
RY ANALYTICS (graph-ware)
LINKED DATA (diverse sources)
LINKED DATA- Structured
(Relational DB, Excel, …)
- Semi-structured (XML, HTML, …)
- Unstructured (PDF, Word, email, …)
- Industry standard data structures (RDF)
EXPLORATORY ANALYTICS- Immediately query ALL the data in the graph DB- Simple self-service analytics with familiar Excel-like functions- Industry standard query structures (SPARQL)
RELATE ‘LIKE’ DATA- Associate related
concepts in a flexible & extensible graph DB
- Understand the data in a human-readable ontology
- Immediately operationalize the data in a machine-readable graph DB
- Industry standard data modeling (OWL)
©2015 Cambridge Semantics Inc. All rights reserved.
On Tuesday, Drugs123 Inc. announced phase 1 development of their newest sleep aid therapeutic, Narcoleptol.
On Tuesday, Drugs123 Inc. announced phase 1 development of their newest sleep aid therapeutic, Narcoleptol.
Smart Data - Linked & Contextualized Data with Semantics
Company Website Mkt Cap
Bio Corp biocorp.com $2.2B
Drugs123 drugs123.com $930M
… … …
Competitive Company Database
Company
Drugs123
930,000,000
name
marketcap
drugs123.com
website
Web news
Drug Development
1
developmentstage
activityDrug
developing
Insomnia
indication
Narcoleptol
brandname
Intelligence Review System
Note
about
3/7/2012
Initial safety signals are …
when
note
©2015 Cambridge Semantics Inc. All rights reserved.
Standards-based Smart Data
Semantic web technology built with World Wide Web Consortium (W3C) standards Scale & diversity of data on the web Ever-changing environments
Semantic web enables Smart Data by providing: RDF (Resource Description Framework) - A flexible and logical graph-based data model
that can consider data from any source => reduced development time and cost
OWL (Web Ontology Language) - An human understandable conceptual model of entities and relationships designed for business analysts and knowledge workers
=> improved application quality, iterative / investigative approach SPARQL – A complete, high-performance query language standard for accessing RDF data
where IT-intensive skills are not needed to access the underlying data structures => reduced development time and cost
W3C Open Standards – A backbone for industry-specific standards Benefit from industry standards e.g. CDISC, MedDRA, SNOMED, OpenPhacts …
=> improved data quality & interoperability
©2015 Cambridge Semantics Inc. All rights reserved.
Exploratory Analytics (Graph-aware)
©2015 Cambridge Semantics Inc. All rights reserved.
The Anzo Smart Data Platform™
An agile, end-to-end, platform for tackling diverse information challenges
Link and contextualize information for search, analytics, visualization and collaboration
©2015 Cambridge Semantics Inc. All rights reserved.
The Anzo Smart Data Lake™
Data SourceIngestion
Link &Contextualize
Discovery Analytics
Insight Realization
Structured Unstructured
. . .
. . .
Anzo Smart DataIntegration (ASDI)
Anzo Smart Data Lake (ASDL) Server
Anzo Graph QueryEngine (AGQE)
Anzo on theWeb (AotW)
Company’sInformation Fabric
Semi-structured
©2015 Cambridge Semantics Inc. All rights reserved.
Anzo Smart Data Lake™
Server
The Anzo Smart Data Lake™
Anzo Smart Data Integration
Server
Anzo Discovery and Analytics
Server
…..
Data Discovery and Analytics
Anzo Discovery and Analytics
Server
Anzo Smart Data Lake™
Server
Anzo Graph Query Engine….
Graph Storage and Cataloging
Integration - Ingestion and Linking
Anzo Smart Data Integration
Server
Anzo Smart Data Integration
Server
ExistingHadoop Data Lake
EnterpriseData Sources
©2015 Cambridge Semantics Inc. All rights reserved.
Engi
neer
ing
Dem
onst
ratio
n
Anzo Smart Data Lake™ is “Big Data” Analytics
Early Adopters
0
20
40
60
80
100
120
Act
ive
RD
F Tr
iple
s (B
illio
ns)
Driving Insights from
“Big Data” Analytics
©2015 Cambridge Semantics Inc. All rights reserved.
Sample Life Sciences Use Cases
• Clinical Data Standards Management - Manage the development integration of clinical metadata standards at multiple levels
• PV & Safety Data Management - Automated tagging of safety Case Report Forms (CRF) with customized curation workflow & text mining and contextual search
• R&D Competitive Intelligence – Explore the competitive landscape for Therapeutic Area, Indication, Target, Company, Compound, & Partners
• Clinical Trial Data Integration and Discovery - Create a semantic data lake for clinical trials within one or more Therapeutic Areas for analytics & decision support
• Real World Evidence (RWE) Driven Clinical Trials - Create a semantic data lake across clinical and healthcare EMR RWE for data analytics & decision support
• Clinical Trial Site Selection and Optimization - Clinical trial site selection, Key Opinion Leader (KOL) search & review, & trial site startup planning
• Scientific Affairs/Medical Science Liaisons - Track Key Opinion Leaders (KOL) in literature and clinical trials & analyze feedback from medical professionals and patients
• Information Landscape - Track and monitor data stewardship and usage through the organization to drive more efficient usage.
• Taxonomy Management - Blend taxonomies from different sources including versioning, de-duplication, & matching
©2015 Cambridge Semantics Inc. All rights reserved.
Sample Life Sciences Use Cases
• Clinical Data Standards Management - Manage the development integration of clinical metadata standards at multiple levels
• PV & Safety Data Management - Automated tagging of safety Case Report Forms (CRF) with customized curation workflow & text mining and contextual search
• R&D Competitive Intelligence – Explore the competitive landscape for Therapeutic Area, Indication, Target, Company, Compound, & Partners
• Clinical Trial Data Integration and Discovery - Create a semantic data lake for clinical trials within one or more Therapeutic Areas for analytics & decision support
• Real World Evidence (RWE) Driven Clinical Trials - Create a semantic data lake across clinical and healthcare EMR RWE for data analytics & decision support
• Clinical Trial Site Selection and Optimization - Clinical trial site selection, Key Opinion Leader (KOL) search & review, & trial site startup planning
• Scientific Affairs/Medical Science Liaisons - Track Key Opinion Leaders (KOL) in literature and clinical trials & analyze feedback from medical professionals and patients
• Information Landscape - Track and monitor data stewardship and usage through the organization to drive more efficient usage.
• Taxonomy Management - Blend taxonomies from different sources including versioning, de-duplication, & matching
©2015 Cambridge Semantics Inc. All rights reserved.
Life Sciences Use Case Clinical Trial Site Intelligence (CTSI)
ObjectiveIntegrate external curated global clinical trial subscription data, such as Citeline, Cortellis, PubMED, & CT.gov with internal operational site data to support site & Principal Investigators (PIs) selection and management. Provide a solution to capture site & PI operational experience data for wider company use. Provide high-value, reusable & controlled analytics for many users
Potential users: Power users: Site Selection (Clin Ops), Data Management, Clinical Study Teams Casual users: Clinical Operations, PV / Safety, Medical Affairs
Features BenefitsDiscover – Explore related Citeline, Cortellis, PubMED, & CT.gov content to identify PIs, Sites and Trials of interest
Access a single, unified source for global clinical trial data
Manage – Flexibly manage internal content of investigators and sites operational experience, capture Sponsor/CRO user feedback, curate (annotate) these data
Better site & PI selection & management using a single, unified source of industry & company operational clinical trial data
Analyze – Interactively analyze PIs and Site lists at all levels including Country, Site and TA.
Rapid answers to ‘what-if’ questions and data exploration: hours / days versus weeks / months
©2015 Cambridge Semantics Inc. All rights reserved.
Life Sciences Use Case Clinical Trial Site Intelligence (CTSI)
Roll-up, traverse, filter and visualize data across CTSI and Citeline
Trial
Investigator
SiteStatus
DiseaseAddressPatient
Segment
TA
Country
Organization
Phase
TrialtroveSitetroveCTSI
List Entry
Site List
Entry Site
User
SiteStatus
StatusFeedbackTierCategory…
Specialty
©2015 Cambridge Semantics Inc. All rights reserved.
Life Sciences Use Case Clinical Trial Site Intelligence (CTSI)
Demo
©2015 Cambridge Semantics Inc. All rights reserved.
Life Sciences Use CaseClinical Trial Site Intelligence (CTSI)
Anzo Unstructured (AU) Pipeline Orchestrator & Monitor
©2015 Cambridge Semantics Inc. All rights reserved.
Life Sciences Use CaseClinical Trial Site Intelligence (CTSI)
Demo