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Where Life and Science Mean Business
Israel – Hungary Innovation Day
Israel Medical Technology3 October 2013
Jeff Dykan
SCP Vitalife Managing Director
Where Life and Science Mean Business
Life Science Industry 2 Main Categories
Biotechnology Medical Devices
Where Life and Science Mean Business
Life Science Industry 2 Main Categories
Biotechnology Medical Devices
Where Life and Science Mean Business$100M to $150 invested by Venture Capital
annually in Life Sciences
approximately 80% to Medical Devices
ILSI Database 2013 PWC Kesselman & Kesselman
Where Life and Science Mean Business
Focus on MedTech Israel’s Life Sciences Industry - Sectors
Source: ILSI Database – 2013
Where Life and Science Mean BusinessFocus on Largest Markets
Medical Devices - Main Medical Fields
Source: ILSI Database – 2013
Where Life and Science Mean Business
Focus on Disposables, Implantables, Diagnostics and Imaging
Israel’s Medical Device Companies - Subsectors
Source: ILSI Database – 2013
Where Life and Science Mean BusinessYoung Industry
65% of active companies founded in last decadeThe Israeli Life Science Industry
Number of Companies Founded
2010 –Incomplete dataILSI Database 2013
Where Life and Science Mean Business
While the industry is young, 45% have revenues
Companies Developmental Stage
Source: ILSI Database – 2013
Where Life and Science Mean Business
Trivia
Which country has the largest number of medical device patents in the world per
capita ?
Where Life and Science Mean Business
Trivia
Which country has the largest number of medical device patents in the world per capita ?
ISRAEL
Where Life and Science Mean Business
Israel is #1Medical Devices Patents per Million Capita
Source: www.uspto.gov, Analysis: ILSI ©
Where Life and Science Mean Business
Medtech StartupsCriteria for Success
• Large market• Strong IP• Clinical evidence > superiority and value• Platform technology
• Path to Widespread Commercial Use
Where Life and Science Mean BusinessHistory of Israeli Medical Device Exits
ILSI database 2013
Where Life and Science Mean Business
Overview of SCP Vitalife
SCP Vitalife II, L.P. 1
SCP Vitalife
• Medical Technology VC
• Total $ Under Management: $230M- Vitalife I & SCP Vitalife II
• Offices: Tel Aviv and Philadelphia
• Primary focus on investments sourced in Israel (65%) and U.S. (35%)
• Partners: Dr. Avi Ludomirski, Jeff Dykan, Wayne Weisman, Win Churchill
Fund’s Investment Focus & Portfolio
• Medical Devices for Therapeutic Uses Avedro, NovoGI,, Endospan, Sightline,
BetaO2, Fluidnet, Spine21
• Novel Diagnostic Methods, especially Imaging
Sensible, Deep Breeze, Denx, Trig, D.I.R., Pocared, MediGuide
• Biomaterials and Cell Therapies Regentis, GeneGrafts, Garnet, ColBar
• Specialty Pharmaceuticals and Drug Delivery Recro, TransPharma, CanFite
• Other Argo, Procognia
Major Exits
• ColBar: Acquired by a division of J&J
• Sightline: Acquired by Stryker
• MediGuide: Acquired by St. Jude
•CanFite: IPO on TASE
Where Life and Science Mean Business
Active Portfolio Companies
Where Life and Science Mean BusinessDIR Technologies
Description• DIR Technologies was formed by SCP
Vitalife II via a spin-out from SCD, a leading Israeli developer and manufacturer of infrared detectors and laser diodes for defense and military purposes
• DIR applies infrared technology in a variety of non-contact pharmacological tests, such as identification of counterfeit drugs through the original package, and rigorous in-line quality assurance for the manufacture and packaging of drugs by the leading pharma companies
• Company is working with leading global pharma companies on both QA and anti-counterfeiting application
Where Life and Science Mean Business
Beta-O2 Technologies
• Beta-O2 has developed a bio-artificialsubstitute pancreas for diabetic patients
• The ß-Air is an implantable device thatcontains islets of Langerhans (insulin andglucagon producing cells). The cells areprotected from the host’s immune systemand supplied with oxygen
• Following extensive pre-clinical testing, Beta-O2 performed its first-in-human implantation in a leading diabetes center in Germany during 2012
• Following seven months of implantation: “For the first time it has been shown that allogeneic islets integrated into an oxygenated macrochamber can survive and function after transplantation in man without any immunosuppressive therapy ….... This finding is outstanding and a case sui generis.”
Report by the German physicians
-400 -300 -200 -100 05
6
7
8
9
10
0 30 60 90
Normal Range
Days relative to Tx
Hb
A1c
(%
)
Initial Results of First-in-Human Implantation
Hemoglobin A1c After the First 90 Days
Where Life and Science Mean Business
Sensible Medical Innovations
Description• Founded in May 2007, Sensible is developing the
SafePatchCHF, a non-invasive system for continuous monitoring of Congestive Heart Failure patients
• SafePatch is based on Remote Dielectric Sensing (ReDS) technology, which employs electromagnetic reflectometry using ultra-wide-band frequencies transmitted at very low intensities
• Technology was adapted from military application utilized by Sensible’s founders during their service in special technology units of the Israeli Defense Forces
• The SafePatch measures lung fluid content, respiratory rate and heart rate which, combined, provide an early indicator of heart failure de-compensation
• The market potential for CHF monitoring is estimated at hundreds of millions of dollars per year
Where Life and Science Mean BusinessPocared Diagnostics
Description
• Pocared Diagnostics has developed an innovative diagnostic system that provides physicians with real-time detection and identification of pathogens
• The standard (culture-based) testing process typically requires 30 hours to identify the infectious agent; Pocared’s solution will be able to provide bacterial identification within 1-2 hours
• Pathogen identification is made possible using the proprietary Pocared Optical Signature™ and Pocared Optical Fingerprint™
• The high-throughput system is compact, user-friendly and does not require the use of reagents
• Has become well-known to potential acquirers, who are awaiting results of clinical trials in first half of 2013
Where Life and Science Mean Business
Argo Medical
• Argo Medical aims to fundamentally change the health and life experiences of individuals with spinal cord injury.
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