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Age and Fertility Handout Preg 3
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Female Age and FertilityPiedmont Reproductive Endocrinology GroupPREGJohn E. Nichols, JR., M.D.John. F. Payne, M.D.www.pregonline.comMarch 2009
Finite number of eggs in ovariesWomen are born with all their eggs in their ovaries and over their reproductive lifetime will use them up till the age of menopause
Fertility Decreases with Age
Age and Female FertilityFertility peaks in late teens to late twenties and then gradual decline after age 30 20-25% fecundity (chance for pregnancy per month) under age 30 Rapid decline in fertility after age 40 Age 35: 15% fecundity rate Age 40: 5-10% fecundity rate Age 43: 50% miscarriage rate
Prevalence of Genetically Abnormal Oocytes (Eggs) in Infertile WomenThe most common reason for declining pregnancy rates with age and increase rates of both miscarriages and genetics abnormalities (Downs Syndrome) is due to abnormalities of the eggs from aging effects
Begin to see drop in IVF pregnancy rates around 35 years of age.
PREG 2008 IVF Clinical Pregnancy Rates by Age
PREG 2007 IVF Clinical Pregnancy and Live Birth Rates by Age
Donor Egg IVF
PREG 2008 Donor Egg IVF Clinical Pregnancy Rates