Aim: Requirement: Reference: Formula:IngrediantsFormula for one
tabletFormula for 20 tablets
Metformin500 mg10 gm
Lactose4.7 mg0.094 gm
Starch4.5 mg0.090 gm
Isopropyl alcohol (IPA)10 ml0.2 gm
Talc0.8 mg0.016 gm
Magnesium Stearate5 mg0.1 gm
Aerosil5 mg0.1 gm
Procedure (wet granulation): All the ingredients were weighed
accurately. Metformin and lactose were taken in mortar and pestle
and grinded together to have uniform mixing and obtain fine powder.
10% of PVP solution of IPA was prepared and q.s was added to the
fine powder to obtain the lump mass. Pass this lump mass through
10# sieve and collect granules obtained. The granules were
collected on the paper and allowed to dry in oven at 45C. After
drying the mass was passed through 20# sieve and granules were
retained on 40# sieve. Talc, magnesium stearate and aerosil were
mixed with granule geometrically. Fines obtained were weighed. 15%
of fines were added to the dried granules and pack edt in zip lock
bag and punched into tablets using tablet punching machine. Tablets
were then evaluated.
Evaluation parameters:1. Weight variation2. Hardness3.
Friability4. Dissolution
1 .Observation table of weight variationSr.no.Weight of
tablets(x) x-x avgx-x avg /x avg *100
1519
2520
3520
4521
5521
6520
7522
8520
9518
10519
11520
12523
13522
14521
15520
16518
17519
18520
19520
20521
Avg.
2. Hardness of tablet:3. Observation table of Friability Initial
weight of tablet (a): Final weight of tablet (b): Weight loss: a-b
% weight loss: a-b/a*100
4. Observation table of Dissolution
Sr.no.Time(min.)absorbanceConc.per ml.Conc.in 900 ml Cumulative
conc.% drug release
10
210
320
430
540
650
760
