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Azetidine derivativesR 0045 Stereoselective Synthesis of 3,4-Diaryl β-Lactams. — The Pd-catalyzed [2 + 2]

carbonylative cycloaddition of benzyl halides (II) with (het)arylimines (I) proceeds smoothly to afford diaryl β-lactams (IV)/(V) in moderate to high yields. The diastereo-selectivity is strongly influenced by the bulkiness of substituents at the imine nitrogen. Additionally, use of enantioenriched arylimines (VI) affords optically active β-lactams (VII)/(VIII) with high trans-diastereoselectivity. — (TROISI*, L.; PINDINELLI, E.; STRUSI, V.; TRINCHERA, P.; Tetrahedron: Asymmetry 20 (2009) 3, 368-374; Dip. Sci. Tecnol. Biol. Ambientali, Univ. Lecce, I-73100 Lecce, Italy; Eng.) — Mischke

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