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Analysis of the Acute Renal Failure and Its Relationship With Creatinine and BUN Before and After the Coroner Artery Bypass Operation. Gülden Olgun. Problem Definition. Situtation of the non-renal patients after bypass surgery - PowerPoint PPT Presentation
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Gülden Olgun
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Problem DefinitionSitutation of the non-renal patients after
bypass surgeryIncrease in the serum creatinine
concentration or azotemia(blood urea nitrogen[BUN])
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OutlineProblem Definition IntroductionFeature SelectionMethodology for preop/postopAnalysis of the R-Project and Knime ResultsDemoConclusion
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Acute Renal FailureAbrupt or rapid decline in renal filtration
functionRise in serum creatinine concentration
Rise in blood urea nitrogen – BUN- concentration
Have high Potassium level
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Creatinine - BUNCreatinine
Breakdown product of creatineNormal results*: adults W : 0.66 – 1.09 mg/dL
M(<50 age): 0.84 – 1.25 mg/dL
(>50 age): 0.81 – 1.44 mg/dL
BUNBreakdown product of proteinNormal results*: adults W- M : 7.9 – 21 mg/dL > 60 age : 8 – 23 mg/dL
5* http://merkezlab.erciyes.edu.tr/biyokimya/referans.htm
Coronary Artery Bypass GraftReroute the blood flow through a new artery Requires open-chest surgeryIncrease the BUN, creatinine
Cause acute renal failure
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Feature Selection(Cardio Dataset)Renal Features
PreStatus5(70): Preop. acute renal failureRenalYetmezlik(85)Renal(751): renal failure, requirement of dialysisMortalitePrimerNeden12(842): Mortalite due to
renal failure Bypass Features
PeriferikArterHastalık(92)OperasyonGrup0(358): Coroner Bypass Surgery
Creatinine FeaturesSonPreopKreatinin(86)
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Feature Selection(Laboratuar dataset)Dosya_NoPreoperatif/PostOperatifBUNKreatininUrik_AsitSodyumPotasyum
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MethodologyPreOperation:
10 fold Decision TreeSVMNaive Bayes Learner
PostOperation:Bypass patients
SVM Decision Tree
Non-bypass patients SVM Decision Tree
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PreprocessPreprocess for preoperation
Use patients’ ids which occur in both dataset(cardio and lab) -> R project
Preprocess for post operation Get ids of patients whose operation is bypass
and non-bypass
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Knime(Preoperation)
11Decision tree for PreStatus5 (Acute Renal Failure before bypass surgery)
R-Project(Preoperation)
12Decision tree for PreStatus5 (Acute Renal Failure before bypass surgery)
R-Project 1) root 9739 476 False (0.0337817024 0.9511243454 0.0150939522) 2) SonPreopKreatinin< 2.5 9592 356 False (0.0342994162 0.9628857381
0.0028148457) 4) OperasyonGrup0= 353 158 False (0.4419263456 0.5524079320
0.0056657224) 8) SonPreopKreatinin< 1.5 348 157 False (0.4482758621 0.5488505747
0.0028735632) 16) RenalYetmezlik< -0.5 273 117 (0.5714285714 0.4285714286
0.0000000000) * 17) RenalYetmezlik>=-0.5 75 1 False (0.0000000000 0.9866666667
0.0133333333) * 9) SonPreopKreatinin>=1.5 5 1 False (0.0000000000 0.8000000000
0.2000000000) * 5) OperasyonGrup0=False,True 9239 198 False (0.0187249702
0.9785691092 0.0027059206) 10) RenalYetmezlik< 1.5 9207 178 False (0.0187900510 0.9806668839
0.0005430651) * 11) RenalYetmezlik>=1.5 32 12 True (0.0000000000 0.3750000000
0.6250000000) * 3) SonPreopKreatinin>=2.5 147 27 True (0.0000000000 0.1836734694
0.8163265306) *
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R-Project(Postoperation)
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Normal results: Sodyum Adults: 136-146 BUN Adults: 7,9 - 21
Knime(Postoperation)For Bypass Patients
Normal Results: Potassium -> Adults: 3.5 – 5.1 mmol/L
BUN Adults: 7,9 - 21
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Knime(Postoperation)For bypassPatients(without BUN)
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KnimePreoperation:
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KnimePostoperation
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KnimeFor non-bypass patients
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BUN-Creatinine-Potassium-Sodium
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Bypass patients
Non-bypas patients
ConclusionHigh correlation between OperasyonGrup0
and PreStatus5Sodium and BUN relation in bypass patients
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