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Κυτταρική Ανοσία
Γιάννης Ρούτσιας, MD, PhD Επικουρος καθηγητης Ανοσολογίας Μικροβιολογίας
2014
MHC
Μείζων σύμπλεγμα ιστοσυμβατότητας (MHC)
Η ενεργοποίηση των λεμφοκυττάρων γίνεται μέσω των μορίων MHC
Class I molecules display antigens on surface of nucleated cells, resulting in destruction of cells
Class II molecules display antigens on surface of antigen-presenting cells, resulting in activation
of immune cells
MHC molecular structure:
Peptides Binding to MHC Molecules
MHC I molecules bind short peptides, usually between 8 and 10 residues.
The typical length of a class I ligand comprises 9 amino acids.
MHC II ligands consist of 12 to 25 amino acids. A core of nine amino acids is essential for
peptide/MHC binding
TCR
CD3
TCR/peptide-MHC Complex
Movies
• Antigen receptors (2nd ½)
• T-cell education • Antigen processing • Clonal proliferation • Immunoregulation • Anti-viral defences