Joanna Wardlaw - Micro infarctus, a new SADB MRI marker ?

7/22/2019 Joanna Wardlaw - Micro infarctus, a new SADB MRI marker ?

http://slidepdf.com/reader/full/joanna-wardlaw-micro-infarctus-a-new-sadb-mri-marker- 1/22

Gcjraceifrjts

f ehw sgfoo frthry dcshfsh ai tbh `rfce1

MG \frdofw

Jbfcr ai Fppochd Ehuracgflcel

Bhfd ai Ehuracgflcel Zjchejhs

Xecvhrscty ai Hdceùrlb



Gcjraceifrjts= Dhicectcae

• Gcjrasjapcj ―eat vcsc oh ta tbh efkhd hyh‑

• ‟gceuth iajc wctb ehuraefo oass, locascs, pfooar, ar jysts‗

• ‟sbfrpoy dhocehfthd gcjrasjapcj csjbhgcj ohscaes

fjjagpfechd `y jhoouofr dhftb ar tcssuh ehjrascs, aithefssajcfthd wctb locascs fed jfvctftcae‗

@ruedho ht fo MJ@IG 0>60;:0=408-:9; Zgctb ht fo TOE 0>60;66=0<0-20

jfvctfthdJartcjfo eae-

jfvctfthd



Gcjraceifrjts= Oajftcae

• Foo `rfce rhlcaes

• ^rhpaedhrfejh iar jarthx (gastoy

hxfgcehd jarthx)• âsscòy garh ce àrdhrzaeh rhlcaes

• Gfey studchs dcd eat jagpfrh rhlcaes

dcrhjtoy




Gcjraceifrjts= Zczh

• Octtoh jaeshesus=

‚ ―gcjrasjapcj‑, ar 8> ¸g

‚ ta 4>> ¸g ‚ ta f ihw gg jofsshd fs gcjraceifrjts

• Jystcj aehs gfy `h ofrlhr1




Gcjraceifrjts= ^rhvfohejh

• 04% ce 6003 eae-dhghethd aodhr jaetraosu`mhjts, rfelh 0.8 ‚ 4:%6

• Twa ofrlh ehurapftbaoaly dftf`fshs, flhd ≨980

‚ Eftcaefo Fozbhcghr‑s Ja-ardceftcel Jhetrh (9623)

‚ Fduot Jbfelhs ce Tbaulbt (063)

‚ Gcjraceifrjts jaggae ‚ 63.<% fed 69%

‚ 1 Garh jaggae ce ghe tbfe waghe (06 vs 62.8%)

• Cejrhfsh ce prhvfohejh ce FD= 4:% ce 4>3pftchets ce 2 studchs,6

• Garh jaggae ce YfD= 90% ce 2< pftchets ce 9

studchs6

6@ruedho ht fo MJ@IG 0>60;:0=408-:9; 0Oaelstrhtb Foz Dcs Fssaj Dcs 0>>3;0:=036



Gcjraceifrjts= ^rhvfohejh

^hrjhet ai pftchets wctb gcjraceifrjts ce EFJJ fed FJT

ehurapftbaoaly dftf`fshs jag`cehd, tatfo e794>2Oaelstrhtb Foz Dcs Fssaj Dcsardhrs 0>>3;0:=036-4



Gcjraceifrjts= Jalectcae

Zgctb ht fo TOE 0>60;66=0<0-020

^rhvfohejh ai gcjraceifrjts ce su`mhjts wctb fed wctbaut dhghetcf ce

jagguecty-`fshd jabarts, foo-jfush gartfocty, prasphjtcvh fsshssghet ce

ocih. Gcjraceifrjts garh tbfe dauòh tbh rcsk ai dhghetcf

Gcjraceifrjts cejrhfsh rcsk ai dhghetcf= AP 0.:6 38% JC 6.4>-:.20



Gcjraceifrjts= Pcsk ifjtars

Zgctb ht fo TOE 0>60;66=0<0-020

• Flh

• Byphrthescae ‚ gcxhd rhsuots ‚ passcòy ce pftchets

?2> ùt eat 52> yhfrs

• ea johfr lhedhr `cfs ce atbhr studchs

• jhrh`rfo fgyoacd felcapftby

• frthrcaoasjohrascs• JFDFZCO

• ja-hxcst wctb dhlhehrftcvh pftbaoalchs

Gcjraceifrjts= ^ftbaoaly



Gcjraceifrjts fed Cgflcel

• Gcjrasjapcj sa bfrd ta shh ae rautceh 6.8

ar :T GP ueohss vhry `rclbt sclefo

• ―jysts‑ ar frhfs ai rfrhifjtcae

• jarthx

• 1sagh ^YZ gclbt `h gcjraceifrjts



Gcjraceifrjts fed Gfjrasjapcj Icedcels

Oaelstrhtb Foz Dcs Fssaj Dcsardhrs 0>>3;0:=036-4

Ztrael fssajcftcae wctb gfjrasjapcj ihfturhs=

Eft FD Jaard Jhetrh=

AP 38% JC

Gfjraceifrjts 4.4 (:.2-8.0)\GB 0.9 (0.6, :.:)

Bfhgarrbflh 0.> (6.9, 0.9)

Fduot Jbfelhs ce Tbaulbt=

Gfjraceifrjts 0.3 (6.4, 9.:)



Gcjraceifrjts fed Gfjrasjapcj Icedcels

Zagh sgfoo D\C +vh ohscaes ce pftchets wctbbfhgarrbflh

Zagh sgfoo D\C ohscaes ce pftchets wctb eae-

bfhgarrbflcj ZYD

Kcg`hrohy Ehuraoaly 0>>3;<0=60:>, Zgctb ht fo TOE 0>60;66=0<0-020





Mauvhet ht fo Ztrakh 0>66;40=0<-6>

Gcjraceifrjts ce JFDFZCO

Ce vcva âst garthg

Bclb rhs Oaw rhs



<T GPC

Yfe Yhouw ht fo MJ@IG 0>60;::=:00-3Daear `rfce sjfeehd ^G wctb gfjra fed gcjrasjapcj icedcels

Ce 9 `rfces ai pftchets dycel wctb FD, iaued 9 ohscaes ai wbcjb 8whrh jaeicrghd fs gcjraceifrjts ae bcstaoaly



<T GPC

âsscòh gcjraceifrjt <9 yrs

gfoh.

IOFCP (tap, >.2x>.2x>.2gg)

T0 (`hoaw >.<x>.<x>.<gg)

Yfe Yhouw ht fo MJ@IG 0>60;::=:00-3

Ce 00 aodhr cedhphedhet su`mhjts ghfe flh 92¶: yhfrs

sjfeehd ce vcva= iaued 68 pra`fòh gcjraceifrjts ce 9 su`mhjts



<T GPC


Ce 00 aodhr cedhphedhet su`mhjts ghfe flh 92¶: yhfrssjfeehd ce vcva= iaued 68 pra`fòh gcjraceifrjts ce 9

su`mhjts

99 yhfr ihgfoh.

IOFCP (ohit >.2x>.2x>.2) T0 (gcddoh >.<x>.<x>.<), T6 (rclbt 6x6x6)



gcjravfsjuofr ohscaes ae <T GPC=

sgfoo fjuth ceifrjts

IOFCP

>.2>x>.2>x>.2> gg:

Yfe @chsshos



<T GPC

• Byphrcethesh ae IOFCP fed T0,

bypacethesh ae T6

• Dhthjtfòh ci=

‚ 5>.8gg dcfg hx vcva

‚ 56gg ft jocecjfo rhsaoutcae hx fed ce vcva




36 yhfr aod su`mhjt ce Oatbcfe 6306 @crtb Jabart

6.8T GPC



Gcjraceifrjts

• Jaggae wctb fdvfejcel flh

• Fssajcftcae wctb gfjrasjapcj fed

gcjrasjapcj ZYD, JFF fed JFDFZCO

• Ohss dhicehd fssajcftcae wctb usufo

vfsjuofr rcsk ifjtars

• Ycscòh wctb joash sjrutcey hvhe ft 6.8T (ftohfst tbrhh frh..)



Gcjraceifrjts

Iuturh dcrhjtcaes• Joashr ce-vcva ‚ ^G ‚ bcstapftb jarrhoftcae

• Dcstrcùtcae

• Pcsk ifjtars

• Tclbthe up ae gfjrasjapcj cgflcel

fssajcftcaes

• Thrgceaoaly….

• Dcstcejt1 Ar must f tcey vhssho vhrscae ai

wbft wh shh forhfdy1



Gcjraceifrjts fed ZFD@1

Zcgpoy f quhstcae ai sjfoh

Documents

Joanna Wardlaw - Micro infarctus, a new SADB MRI marker ?