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Keystone Symposia in Kampala

Leveraging Genomic Diversity to Promote Animal and Human Health

Speke Resort & Conference Centre | Kampala, Uganda | November 25–29, 2018

Discounted Registration Deadline: Oct 6, 2018; Local Registration Subsidy Award Deadline (for investigators in Kampala): Oct 12, 2018

Visit www.keystonesymposia.org/18S5 for more details.

Scientific Organizers: Michèle Ramsay, University of the Witwatersrand, South Africa Han G. Brunner, Radboud UMC, Netherlands Appolinaire Djikeng, Centre for Tropical Livestock Genetics and Health, University of Edinburgh, UK

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Fuondation

Genomic variation is a driving force of animal and human health, and susceptibility to disease. Yet our knowledge rarely spans human ethnic genomic diversity and genomic variation between animal breeds, limiting their translational impact. This symposium aims to: 1) Highlight translational genomics in humans and animals (clinical medicine and animal breeding for health and productivity); 2) Explore synergies and cross-disciplinary learning; 3) Explore opportunities to leverage genomic diversity to push the current boundaries to translation; and 4) Address translation and affordability in low- and middle-income settings. Large-scale genomics initiatives like Genomics England, the US Precision Medicine initiative, and the Human Heredity and Health in African Consortium, are providing extraordinarily large data sets to explore useful genotype-phenotype connections. Equivalent initiatives for animal data are starting. This meeting will explore the translation of genomic research in animals and humans, high and low-resourced environment, ethnic diversity, and cultural context. Identifying common strands in animal and human health opens up opportunities for repurposing of ideas and applications, and for finding innovative solutions for translational genomics through cross-boundary communities of practice.

Plenary Session Topics: • Genomic Diversity in Health• Workshop 1: Simple Genomic Solutions for a Complex World• Human Translational Genomics• Livestock Translational Genomics• Technological Innovations for Tomorrow• Solutions for Implementation of Genomic Tests• Genomics in Animal and Human Health• Enablers for Translational Genomics• Panel: Ethical Dilemmas in the Application of Genomics to Health• Toward a Perfect World – Emerging Themes

SUNDAY, NOVEMBER 25Arrival and Registration

MONDAY, NOVEMBER 26Welcome and Keynote Address *Michèle Ramsay, University of Witwatersrand, South AfricaEvan E. Eichler, HHMI/University of Washington, USARelevance of Primate Evolution to Human and Animal Diversity

Genomic Diversity in Health *Han G. Brunner, Radboud Maastricht University Medical Center,NetherlandsCharles N. Rotimi, NHGRI, National Institutes of Health, USAGlobal Genomic Diversity: History, Adaptation and HealthJordi Barretina-Ginesta, Girona Biomedical Research Institute, SpainCharacterization of Nigerian Breast Cancer Reveals PrevalentHomologous Recombination Deficiency and Aggressive MolecularFeatures

Workshop: Impact of Animal Pathogens on Human Health *Appolinaire Djikeng, Centre for Tropical Livestock Genetics andHealth, University of Edinburgh, UKJeremaih Okoro Ijomanta, National Veterinary Research Institute,NigeriaContinuous Circulation of Human-Derived Pandemic H1N1pdm09Influenza Virus in Nigerian Pigs: Implication for Public Health andPandemic PreparednessKolawole Elijah Oladipo, Adeleke University, NigeriaGenetic Characterization of H5N1 Influenza A Virus Isolated from Pigsin Ogbomoso, NigeriaPatricia Ihuaku Otuh, University of Ibadan, NigeriaMolecular Analyses Unravel Mycobactrium ulcerans TransmissionPathway from Animal Host and Environment to Human in Ogun State,NigeriaAbdul Walusansa, Islamic University in Uganda, UgandaNon-Typhoidal Salmonella and Zoonotic E. coli as Potential Drivers ofAntimicrobial Resistance in Pastoralist Communities in KaseseDistrict, UgandaOluwatoyin Modupe Aladejana, Kings University Odeomu, NigeriaOccurrence and Multiple-Antibiotics Resistance Profile ofEnterobacteriaceae Isolated from Bats Faecal Samples in OsunState, Nigeria

Human Translational Genomics *Christian T. Happi, Redeemer's University, NigeriaHan G. Brunner, Radboud Maastricht University Medical Center,NetherlandsGenetic Diagnosis of Intellectual DisabilityBrunhilde Wirth, University Hospital Cologne, GermanyTherapeutic Approaches to SMA: In the Challenges is a Solution Lea M. Starita, University of Washington, USAUsing Multiplexed Functional Assays to Understand the Effects ofGenetic Variation

Mohamed Z. Alimohamed, University Medical Center Groningen,NetherlandsShort Talk: Routine Use of Targeted NGS Panel in a DutchCardiomyopathy Cohort Jorge Da Rocha, University of the Witwatersrand, South AfricaShort Talk: Addressing Cancer Treatment in an African Setting: ABioinformatics Analysis of Pharmacogenomically Relevant Variants

Poster Session 1

TUESDAY, NOVEMBER 27Livestock Translational Genomics Michel A.J. Georges, University of Liège, BelgiumTranslation of Animal Genomics to Health: European Perspective Susan J. Lamont, Iowa State University, USAGenomics to Enhance Poultry Health Using Biodiversity *Appolinaire Djikeng, Centre for Tropical Livestock Genetics andHealth, University of Edinburgh, UKDevelopment of Genomic-Based Tools and Resources for TropicalAnimal Productivity and ResilienceVivien Jepchirchir Chebii, Nelson Mandela African Institution ofScience and Technology, TanzaniaShort Talk: Exploring Association of Copy Number Variations in WildAfrican Goats (Capra nubiana) AdaptationsOwen Powell, Roslin Institute, University of Edinburgh, ScotlandShort Talk: Can Genomics Enable Genetic Evaluations withPhenotypes Recorded on Smallholder Dairy Farms?

Technological Innovations for Tomorrow *Niklas Blomberg, ELIXIR Europe, UKChristian T. Happi, Redeemer's University, NigeriaGenomics in Stemming the Tide of Infectious EpidemicsSimon Lillico, University of Edinburgh, UKEditing Livestock Genomes: Harnessing and Expanding GenomicDiversity Luísa Pereira, Institute of Molecular Pathology and Immunology ofthe University of Porto, PortugalThe Power of Local Ancestry Inference Algorithms in MappingCandidate Genes: The Case Study of African Ancestry Protectionagainst Hemorrhagic Dengue FeverMartha Nginya, US Army Medical Research Directorate, KenyaShort Talk: Evaluation of Plasmodium falciparum Histidine-RichProtein 2 and 3 Gene Deletions in Kenya

Poster Session 2

WEDNESDAY, NOVEMBER 28Solutions for Implementation of Genomic Tests *Michèle Ramsay, University of Witwatersrand, South AfricaFarai C. Muchadeyi, Agricultural Research Council, South AfricaLandscape Genomics as a Tool to Understand Genetic Adaptation toLocal ConditionsJohn M. Hickey, University of Edinburgh, UKModern Breeding Programs for Local and Global Economies

* Session Chair † Invited but not yet accepted Program current as of November 20, 2018. Program subject to change. Meal formats are based on meeting venue.For the most up-to-date details, visit www.keystonesymposia.org/19S5.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Leveraging Genomic Diversity to Promote Animal and Human Health (S5)November 25-29, 2018 • Speke Resort & Conference Centre • Kampala, UgandaScientific Organizers: Michèle Ramsay, Han Brunner and Appolinaire Djikeng

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates FoundationGlobal Health Travel Award Deadline: June 26, 2018 / Abstract & Scholarship Deadline: August 8, 2018 / Abstract Deadline: August 23, 2018 / Discounted

Registration Deadline: October 6, 2018

David Evans, University of Queensland, AustraliaUsing Genetics to Investigate the Developmental Origins of Healthand DiseaseElizabeth Sibongile Tshabalala, Council of Scientific and IndustrialResearch, South AfricaShort Talk: Genetic Diversity of Pharmacogenes in a Bantu-SpeakingCohort and Evaluation of Variants Associated with Tenofovir-InducedNephrotoxicity Liberata Mwita, Muhimbili University of Health and Allied Sciences,TanzaniaShort Talk: Genome-Wide Associations of Liver Function in Sickle CellPatients in TanzaniaChiaka I. Anumudu, University of Ibadan, NigeriaShort Talk: Improving Schistosomiasis Control Using Genomics andProteomics Tools

Virtual Lab Tour: Makerere University Genomics in Animal and Human Health *Han G. Brunner, Radboud Maastricht University Medical Center,NetherlandsMark S. Fife, Pirbright Institute, UKGenetic Diversity of Immune Loci in Chickens across Africa andEuropeMichèle Ramsay, University of Witwatersrand, South AfricaImpact of Demographic History and Local Adaptation on PopulationDiversity and Health: Studies from AfricaSoanandrasana Rahelinirina, Institut Pasteur de Madagascar,MadagascarShort Talk: First Molecular Detection of Pathogenic Leptospira inLivestock from Slaughterhouses in MadagascarIsoken H. Igbinosa, University of Benin, NigeriaShort Talk: Characterization and Detection of Antibiotic Resistance,Virulence Gene Elements and Biofilm Formation in AeromonasSpecies Isolated from Cattle

Poster Session 3

THURSDAY, NOVEMBER 29Enablers for Translational Genomics *Appolinaire Djikeng, Centre for Tropical Livestock Genetics andHealth, University of Edinburgh, UKNiklas Blomberg, ELIXIR Europe, UKGlobal Data Infrastructure for the Scientific EnterpriseBassirou Bonfoh, CSRS/Afrique One-African Science Partnershipfor Intervention Research Excellence, Côte D'IvoireGenomics: A Half-Full Glass in One HealthNicholas Katsanis, Duke University Medical Center, USAZebrafish Models for DiseasesJim Kaufman, University of Cambridge, UKShort Talk: Typing MHC Haplotypes of African Village Chickens forStructure-Function StudiesAcho Fon Abongwa, University of Yaounde I, CameroonShort Talk: Evolution of Plasmodium Falciparum Strains andResistance Markers in Pregnant Women in Cameroon: 2008-2018

Panel Discussion: How Do We Build the Ideal Cattle Breeds forDifferent Ecological Niches?

*John M. Hickey, University of Edinburgh, UKSumaya Y. Kambal, Sudan University of Science and Technology,SudanMitogenomic Analysis of Western Baggara Cattle Breed-NyalawiPopulationEdward J. Smith, Virginia Polytechnic Institute and State University,USAGenomic Characterization of Zambian Indigenous Cattle Breeds

Panel Discussion: What Do We Need to Know About OurAncestry? *Han G. Brunner, Radboud Maastricht University Medical Center,NetherlandsGretchen Z. Johnson, Howard University, USAMolecular Genomic Diversity of Mid-19th Century Liberated EnslavedAfricans from St. Helena Island, South Atlantic

Toward a Perfect World – Emerging Themes *Charles N. Rotimi, NHGRI, National Institutes of Health, USAStephen T. McGarvey, Brown University, USAGenetics, History, Modernity and Obesity – Lessons from the SamoanArchipelagoElizabeth Marincola, African Academy of Sciences, KenyaHow African Researchers Can Lead the Way in Global ScienceCommunicationAlison L. Van Eenennaam, University of California, Davis, USAPublic Perception of Animal Biotechnology

Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

FRIDAY, NOVEMBER 30Departure

* Session Chair † Invited but not yet accepted Program current as of November 20, 2018. Program subject to change. Meal formats are based on meeting venue.For the most up-to-date details, visit www.keystonesymposia.org/19S5.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Leveraging Genomic Diversity to Promote Animal and Human Health (S5)November 25-29, 2018 • Speke Resort & Conference Centre • Kampala, UgandaScientific Organizers: Michèle Ramsay, Han Brunner and Appolinaire Djikeng

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates FoundationGlobal Health Travel Award Deadline: June 26, 2018 / Abstract & Scholarship Deadline: August 8, 2018 / Abstract Deadline: August 23, 2018 / Discounted

Registration Deadline: October 6, 2018