Lymphatic

FilariasisChelsae Dumbauld

Lymphatic Filariasis 2012, World Health OrganizationGPELF

Symptoms• Some asymptomatic• Lymphoedema

Disfiguration• Elephantiasis• Hydrocele• Tropical eosinophilia

http://www.who.int/lymphatic_filariasis/en/

http://www.reiseklinikken.no/horror.asphttp://www.parasitesinhumans.org/wuchereria-bancrofti-lymphatic-filariasis-pictures-videos.html

Epidemiology• Vector-borne •Helminths

Wuchereria bancroftiBrugia malayiBrugia timori

• Circulating microfilariaehttp://www.cdc.gov/parasites/lymphaticfilariasis/biology_w_bancrofti.html

TreatmentDiethylcarbamazine IvermectinAlbendazole

http://www.who.int/lymphatic_filariasis/en/

After MDA Round Otteson et al. 2008

Mf p

reva

lenc

e (%

pre

-tre

atm

ent)

2003 WHO Annual Report

Real-time PCR and HRM •mitochondrial partial 12S

rRNA gene•determine species by melting

point of PCR productWongkamchai et al. 2014

MDA in TogoFirst sub-Saharan nation to move into WHO surveillance phase (by 2015)

Sodahlon et al. 2013http://www.nationsonline.org/map_small/togo.jpg