Natural Vs Syntbetic Life Vs Death

Truth Vs The Lie 4)7 R;c~tlrrJ P. MurrtlJ!; Det P.A.

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OU won 't lind his name in "\Vho's \Vho" 0:: c;~ed··as an a uthority in any establishment scientific publication. Encyclopedias that hera Ld and/or memorialize pirates, terrorists, murderers and sundry other criminals or cads, never publish his name or spectacular accomplishments. \VHY???

Because he spoke the truth about matters out of hillmony with those who were Li ving off' of the propagandized public, those making fortlJn es manufacturing a nd selling counterfeit food supplements and those dumping chemjcali zed, refined and devitalized food on peopLe suffering with progressive and lethal degenera tive diseases. Those poor souls who read in dle daily newspaper and leading magazines tha t a CUBE IS JUST

AHOUND THE C:OB!\EB.

Of me man I speak, many university biochemists and honest physicians claimed he was rlPTY YEA HS allead of his tinle. I-lis writings stepped on too millly toes and the backlash was profound. Those who had the pleasure of knmving bjm persona lly, those who helped millly ill patients with his ass istance, those who were aWill·e of hois generosity and kindness, were always amazed by his energy, productivity and unlimited mental storehouse of biochemical and phy iological ,visdom. I-fis name was

nOYAL LEE.

© Copyright 1995 .. 11 rights reserved

Doctor Royal Lee was a graduate dentist, an electronic engineer and innovator, a physiological researcher ruld a mruluIactw'ing biochemist. H e developed many nutritional concentrating processes and held over 100 patents at the time of his death. Besides those things, he was a fine teacher and philanthropist but he had one very bad fault. He was silly. Silly in the sense that he thought that FACT and THlITl-I had real value in the crazy world we live in; the world that went berserk after the tw-n of the century. Since that tinle the LIE PHEVAI LS and tTUth just does not sell or bring in the big bucks. In fact, too much truth, too louclly spoken, can get a person in a great deal of c:lifficulty. But on the other hand, c:lifriculties and assaul ts will bring up the level of adrenal output which gives a person the capability of FIGI-IT rather than FLIGHT. Doctor Lee must have had very good adrenals in that he fought the establishment for over a half century and won many battles.

A large portion of the information that follows was first brought to the attention of truth-seeking physicians by the professional, ethica.l pugilisti c, tenacious pw-veyor of physiological fact: Royal Lee, DDS.

One of tJ1e most perilous deceptions of those who PLACE PESOS

ABOVE PRINCIPLES is the passing off on a gullible public, phony, syntJletic vitamins or crystalline-pure fractions of vitamin complexes and ballyhooing THAT TI-IE BODY DOES

NOT KNOW THE DIFFEHENGE. That phrase was coined on the one and on.ly Madison Avenue where truth is spelled M-O-N-E-Y. At dle very best, synthetic or pure vitamin rTactions can runction in the hUIl1ll.n body as on.ly a drug or pha rmaceutical agent; certain.ly not as a physiological supporting nutrient. At worst, as the follO\ving citations will demonstrate, that counterfeit supplements can seriously impair the most important of body fu.nctions by contributing to biochemical imbalance. (see Appendix A,B, & C)

With rega rd to VITAMINS, Dr. Lee said, "Natural Complexes differ from the synthetic crystalline vitamins in many ways. » For example:

==? They are colloidal, protein in nature, in the f orm of an enzyme or coenzyme

==? The crystalline vitamin itself, in the natural product, is in a critical combination and cannot be split off without destroying its biological activity. If separated it must recombine with the other members of [;he complex before it can function as a nutrient.

==? The natural complex carries trace mineral activators without which the vitamin fails as a biochemical catalyst.

==? If so·called "HIGH POTENTCY" crystalline vitamins are ingested, they must be put into prop er combination, as a complex, before the vitaminJunction can be appreciated . Meanwhile, most (if not all) of the crystalline component is lost through the kidneys.

In his writings, Dr. Lee says tJlat " ... synthetic vita mins seem to be dangerous. Irracliated Ergosterol (D ) the first synthetic \~tan1in to be \videly

2

ma rketed, is now known to be extremely dangerous. It has fatall y poisoned children ill doses smaller than those recommended for treatment of rickets." (TAJ.\1A, p 1209, 4/26)

Another authority, Howard H. Hilleman, MA, Ph.D., School of Science, Oregon State CoLlege, author of Mat rnal Malnutrition and Congenital De­formit): (with 80 literature references) presented March 17, 1958, gave suppon to Dr. Lee in sta ting, "Excess vitamin D in the newborn a nd young can cause death with metastatic calcification and the SYNTH ETIC FOHMS are more dangerous than the natural forms of D. "

Augmenting the story, Dr. Weston A. Price, in his book, Nutrition and Ph),sical Degeneration, reports the test effects of vitamin D in 500 huma n pregnancy cases. AU those women given the synthetic D developed calcified a nd diseased kidneys while those given natural vitamin D had no observable changes in dle kidneys. This should not be surprising in that Dr. Casimir Funk who discovered the medlOd for concentrati ng \,itanlin B, said, "dle synthetic product is less effective and MOH E TOX IC." Dr. Funk, incidentally, is the scientist who coined the word, " V1TAM1NE".

Synthetic \,itamins are reverses conformationally or MIHHOH r," IAC I::£;

of natural vitamins. H owever keep in mind that synthetic vitamins a re not vitanlins at a ll but syndlesized FRACTIONS of a \,itamin complex; a mirror image dupljcate of just a portion of the real, biologically active and physiologicaLly precise nutritional complex. T here is no possible way that a fTa ction of a \,itamin should be caLled a vitamin. The analogy here is essentially the same as an automobile salesman handing you a wheel from a car and tell ing you the wheel is an a utomobile.

Gilbert Levin Ph.D., 0) iscover, 1981) DISCUSSING OPTICAL ISOMEHS

or AS\'METH ICAL MOLECULES WIT I-I ATOMIC AHHANC I~MENTS THAT AI~E ~HHHOH IMAGES

OF EACH OTHEH, states: "Because its stTucture is reversed, a left-handed molecule carulot take part in chem ical reactions meant for a right-ha nded molecule any more than a left hand can fit in a right-ha nded glove ... its odd geometTY would prevent it from being metabolized by the body. "

In turn, the human physiology cannot properly utilize synthetic (mirror-image) fractions in the way natural complexes find dleir way into the bio­logical reactions that a re essential to tissue repair a nd the sustenance of life. As stated, a synthetic vita min fraction can on.!)' be utilized for a dl"ug or pharmacological effect. As is well known and never denied, the effect of a drug is PALLIATIITE not curative. Palliation means a making or covering-over of symptoms while the disease process rema in s uncha nged or progressively gets worse for lack of proper a ttention. Tissue and ceLl repair or replacement requ.ire the following to restore the approximately 24 bill ion ceLis that break down each day in the human body:

=> A constant, uninterrupted nerve impuLse supply => A constant, uninterrupted bLood suppLy => ALL of the VI TAMINS in the naturaL, compLex/orm

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~ All of the minerals in an organic form in most instances ~ All of the trace elements essentiaL to metaboLism ~ All of the enzymes, coenzymes, and apoenzymes ~ All of the 22 or more amino acids from protein hydrolysis ~ A discontinuance of organic and inorganic poisons either

inhaled or ingested in bad air, bad food and/ or bad water

Continuing with some of the abundant evidence against counterfeit food supplements, a report from the Koreal1 confEct is enlightenillg. A medical columrtist, wri tillg ill a Pennsylvania newspaper following the said conflict, told of his e:>q)erience as the medical officer in a North Korean prisoner-of-wm' camp. He said his fellow prisoners were becomillg totally debilitated with the classical B deficiency disease, IlEHJBEH I. From the International Red Cross he obtained synthetic B ill tlle form of Thiamine Hydrochloride. He administered the Thiamine HCI to the most ill prisoners but no change was seen a nd they contillued to worsen. Finally, he procw'ed some HICE POLISH which is a natmal source of the vitamin B complex. Rationillg this rice polish out to the very ill POWs did the trick mld their Beriberi symptoms abated. Obviously, the body does know the difference. Incidentally, another form of the synthetic Bl is called Thiamine Mononitrate.

In January of 1952, Dr. Lee ffi1llowlced: "I could write volunles on how synthetic vitaIllills like thiamine castrate the descendan ts of the victim who uses even as much as double the daily requirement. ~ In support of tills sta tement, in a taped lectm e, Dr. Lee cites a study by Dr. Barnett Sm e (Jol. NutT. , Aug., 1939). He teUs us that Dr. Sure fed a group of rats twice the daily requirement of synthetic B. A like number of pigs were given ti,e sam e a mount of natmal B. The results: ALL of the first generation offsprillg from the pigs fed the synthetic vitamin were STERILE.

NONE of the first genera tion off-spring were sterile from the pm'ents fed natural B . Obviously, synthetic B is not only NOT A NUTHI ENT, it is a genetic poison tI,at damages the chromosome packages responsible for transmitting sexual chm'acteristics from the parent to the offsprillg. In the case of Dr. Sm e's pigs, the first generation offspring reaped the toxic, genetic danwge. In me case of humans, mOre than one generation is required.

In 1981 , a report from me University of F lorida revealed some startlillg facts. It stated that in the year 1929, me average, young American male ad ult produced approximately 100 million sperm cells per milliliter of semen. In 1973, forty-fow' years later, the average sperm count had dropped to 60 m ilEon/ml. Then seven years later in the year 1980, the average count was down to 20 million/ ml. Incredible

l 229 - 100 millionL.!.!m.!.!I ____ --'"19"-7~3. - 60 rni li ion/ rntLl __ ---'128L20 mi li ion/ 1ll1

What ill the world happened to bring about such a horrible dTOp in male fertility in just 61 years? One velY possible explana tion could velY well lie in the historical use of synthetic B and other counterfeit nun·ients. Texthooks record that

4

yjtamin B was first isolated in the year 1926. About 10 years later, scientists were able to synthesize the mirror image of thiamine [rom coal tar. About the beginning of World War II (9/39) ennchment of refined, devitalized flour beca me compulsory. The enrichment, so-called, was with synthetic fractions of pseudo-yjta mins. The practice continues to th.is day. Since World Wa r II, the American people and peop le of oth.er countries as well, have had a daily ration of a genetic poison in most of the bread, flow' products, cereals a nd other food items that a re forced, by law, to enrich " rith the only cost-feas ible enricher; synthetic vitamins.

As far back as 1941, Dr. Agnes Fay Morga n (P h.D.) food resea rch scientist a t the University of CaLi.fornia, reported in SCIENCE, 93, 261-262, tlla t animals on a synthetic ,ritam in enriched diet DHOPPED DEA D LONG BEFOHE TilE

ANIMALS ON AN Ui\-Ei\HICHED DIET BECAME DISABLED. She remarked at tllat time that such phony enrichment might: " PHECIPITATE CONDIT IONS WOHSE THAN THE OHIGINA L

DEFICI ENCl'. "

Th Vitam in in Medi ·in , Bicknell and Prescott, 3 rd. Ed., wa rns about tlle toxicology of synthetic B, on page 205. It reads, "In ma n, side e!'fects have been reported a fter the pa.renteral administration of 10 to 100 mg. Doses in excess of 10 mg. daily a re unwarranted as they are nOI: metabolized and excreted unchanged in the urine. Sudden deatll has been reported foLlm'ring the intTavenous injection of' aneurine (Bl ). It may cause severe reactions and signs of meningeal irritation. "

In tlle year 1940, volume 30 of the Scandinm,ia n Veterinaria n Jomnal detailed an experiment involyjng Silver Foxes. One group was fed a U of' the known synthetic B ,' ita.m ins as part of their ra tions \Vhat happened to tlli s group? (1) they did not grow, (2) the quality of their fw' deteriorated a nd (3) they died prematurely. The second group (controls) were given natural sources of B complex willi their rations, and guess what the difference was:

(1) They grew as normally e>''j)ected, (2) they presented excellent quality fm and (3) they surnved their expected, usualliJespan.

Anollier outstanding experiment shmyjng me toxic or poisonous nature of synthetic "itamins is found in the Newsletter of llie American Academy of Applied Nutrition, March 1949. It relates a test witll aninmls fed un-enriched white bread as their food. The group fed un-enriched wllite bread lived for 54 days. Another group was fed a diet of enriched white bread (enriched willi syntlletic yjtamins). This group on the enriched bread lived for 49 days. Since the group eating un-enriched bread lived 10% longer tha n those on the synthetically fortified bread diet, tlle obyjous conclusion is tha t, again, the syn tlletic vitamin is, in reality, a poison and as tll is reported experiment shows, reduced the LIFESPA N.

As stated many limes on many occasions to many phxsicians: ASCOHBIC ACID IS NOT VITAo'"K C. ASCOHBIC ACID IS ASCOHBIC ACID W1-IICI-1 IS A

FHACT ION OF TH E BIOLOG IC/I LLY UTILIZABLE ' (ITAM IN C CO.VIPLEX.

5

Now let it be perfecdy understood, plagiarizing an expression from you know who, there is a NATURAL ascorbic acid which is derived from citrus fTuits, ascerola cherries, rose hips, green peppers and other fTuits and vegetables. H owever, most a U of the ascorbic acid (vitamin C, so-called) on the market is synthetically produced from corn sugar (glucose) and even though it is syndletically manufactu red, it is called n atural and organic because corn sugar comes from corn (unless synthetic) and corn is found in na ture and of course, anydling containing carbon is organic. In turn, the terms natW'al a nd organic have been rendered meaningless.

Again, a fraction of a vitamin whether natural or syn thetic at best is a drug and can only have a drug effect in the body--not a p hysiological or cur ative benefi t. The litera ture is a bundant with studies demonstrating d,at large or megadoses of ascorbic acid can and do create serious problems in d,e human biochem istry Some problems reported include: Collagen disease, rebound scurvy which is vitamin C deficiency disease, inlpaired mineral metabolism, inilialance of other vitamins like vitamin A and B, formation of some types of kidney stones and diabetes mellitus. In the matter of d iabetes, keep in mind that synthetic ascorbic acid is HEXOSE derived and d,at hexose is a SL." carbon sugar; a monosaccharide.

Dr. Linus Pauling was a strong advocate of ascorbic acid being used as a nu tritional supplement as wel] as a pha rmacological agent in the tTeatment of acute infectious diseases and malignant degenerative sta tes. In d,e book, New Dynamics of Preventive Medicine, 1974, Dr. Pauling is quoted as to the truth of what ascorbic acid iso-contra ry to wha t most people believe. H e wTites:

"It is worthwhile to take pW'e crystalline ascorbic acid. It is made l~'om glucose (corn sugar). What is called rose hips vitamin C is d,e same pW'e crystalline ascorbic acid with a pinch of rose hips powder added. It is almost impossible to buy ascorbic acid f~'om a natural source. The rose hip and aserolebarus ascorbic acid is out of the same bane! &'om Hoffman-LaRoche, as the oth ers, but with a pinch of rose hip powder. " There you have it from d,e horse's mouth.

T od ay, th e m a jori ty of people in ilie civilized world a re b ecoming viCtinlS of degen erative disease resulting from chrom c p oisoning and malnutr ition. E ven iliou gh well fed--they are starving to d eath for the m ost essential MICRONUTHIENTS. To administe r a counterfeit when they cry for bread is to HA1'\'1) THEM A STONE.

6

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Explanatory Notes for Appendix A, B, C '

There ex:ists in the li tera ture overwhelming empirical and clinical e,ridence, spanning more d,an seventy years, supporting Ule principle that "i tamins function as complexes and fail as nutrients when syntheticalLy manufactlll'ed or derived by refining or isolation even b'om natw'al som ces. The student of any controversial subject is well ad,rised to pmsue the truth of that subject by reviewing the literature that appe8l'ed dW'ing the period of time when U1at subject was most vigorousLy debated-usua lly at the genesis of the debate. T hat is when the most objective evidence tends to be presented becau e the matter·at-hand has not yet resolved itself politicaJJy, economically, and to tl1e benefit of special interests, Once these other non­scientific and corrupting influences a re injected into the "scientific" debate, a form of scientific censorship seCUJ'es the "winn.ing side's" position, no matter how wrong it ha ppens to be, At that poin t the flawed theory becomes ma instTeam and dominates as a guiding fa lse assumption, This has certa inly been the fate of the study of nu trition and vitamins during the 20'" Century.

To assist tl1e reader in sifting through the data, APPENDIX A, B, and C assemble significant insights into the scientific inveslLgation that has a ppeared over me course of 70 years i11 the foremost peel' reviewed scientil:ic jomnals, APPENDIX A gives the collaborating biochemical data gad1ered from me latest rese8l'ch thus fru' completed on PHYTOCIID\1JCALS and XENOBIOTICS, Appendix A, merefore, offers insight into me biochemical ra tionale for the findings presented in Band G APPEI\1J)IX C discloses d,e clearl y sta ted findings of unbiased eru'ly biomedica.l rese8l'chers who onl y had a n agenda of true discovery (including a statement by the man awarded the i'\;obel Prize roc discovering ascorbic acid-stating il did not work on human scurvy)

APPENDIX B hows me CWTent supporting evidence for the earlier Gndings presented in APPENDIX G \Vbat is not presented herein is the hundreds of rl10usands of personal docwnentation

of individual physicians who personally experienced me failure of synthetic vitamin supplements and of mose who encountered profound success using completely natural whole food complex nu tritional concentTates containing a ll natlll'a lly occurring sl'nergistic factors. The student of this matter need on ly realize mat once the concept of synthetic vitamins became the established mainstream view of nutrition, no link to cancer, no link to heart disease, and no link to most degenerative maladies were associated with nutritional therapy within conventional medicine for over seventy y ears. However, science is ultimately on the side of mose who are correct. \Vben scientists vigorously oppose d,ose who aJ'e correct, and continue to defend entrenched positions wbile scornful oJ t\1ose they oppose, they prove tbat they aJ'e not scientists at aU, but rather members of a cwt. The problem for d1el'l1 scientifically is mat tl1e truth refuses to go away,

This guiding false assumption led to an earl y death of hundreds of miUions of people who suffered and died by, as Royal Lee put it, "digging their graves wilh their teeth. "

"Explanatory Notes and Appendix A,B & C by Mark R. Anderson © Copyright 1995

ill'l'llNIHX il

Why Synthetic Vitamins Fail Pbytocbemical Complexes and Xenobiotics

I

"One of the biggest trage dies of human civ,lization is the precedents of

chemical th erapy ove r nutr ition. It's a substitution of art,/icial therapy over

natural. of poisons o ve r food, in which we are f e eding people po,'sons trying to

correct the react,'ons of starvation." Royal L e e January 12, 1951

Over two hundred s tudies since 1985 have appeared in peer-reviewed scientific journals citing significant I'eductions in cancer, head disease, chronic degenerative and autollnmWle disease a mong multiple and diverse populations consuming diets high m fresh Ii-uits and vegetables. Faced \\~th tile overwhelming evidence of these studies, coupled wi th the utter fa ilure of the pharmaceulicaUy waged "wa rs against" cancer, hec"lrt disease, elC., establishment in titutions including the Nationa l Cancer InstitlJte, American Cancer Associa tion, Ameri can Heart Association , Na tiona l Institutes of Health, and the American Medical Associa li.on have a ll done a l SD-degree about-face of their officia l positions on nLl1J'ition and disease. The dilatory response to the o'uth by these institutions, coming very many decades a fter tile evidence presented by Royal Lee, \\7 eston Price, and many of their contemporary colleagues is a m atter of great concern ; especia lly in light of the scientific censorship they executed against a ll natlJralists. However, of key-note to tills paper is m at large­scale studies show tha t WHEN SYNTHETIC VITAMLNS AHE SUIlSTITLTJ'ED FOH DlETS HICI-l IN FHESH

FR UITS AI\1]) l~cGETAIlLES, TH E PHOTEGTION AGAINST DISEASE IS LOST AN1), IN PHOOF OF FAGT,

Elf[DENGE SI-IOWS, REVERSES. Studies repor ted on in Appendix B and C further demonstra te this. These "reverse" results, tilough startling to the scientifi c communi ty, were l'ully anticipated hy the theories of Hoyal Lee, who orten reported, as is documented ea rlier in tI,is paper, ti,at synthetic vita mins can have a worse effect tI,,, n acllJa l star vation. FlU·ther augmentation of ti,e reasons previously cited as to why this is so requires a basic understanding of PHYTOGI-IE MIGALS and XENOBIOTICS. It is criticall y important to understand the meaning or these two biochemical words. na l .- d , d Di , ion 1" e d Editi 1 defines tI'em:

PHYTOCHEMISTRY--- n, the branch of biochemistry dealing with plants and plant processes. XENOBIOTIC --- n, a chemical or substance that is foreign to an organism or biological system.

Thousands of monogra phs published bl' Lee show his consta nt reference to foods containing what he cal.led "the LUlidenti.fied organic lIlatte,." 0 1' 't the un known organic factors" compounded with vita mins, minerals, o'ace elements, etc. For shorthand, Lee called tilern "vitamin synergists" 0 1' "vitamin synergisti c coractors."I'I Recognizing thai the tJ:ue potency of vitamins were delivered to tbe body's cells through the comb ined effect of the "vitamin complex," Lee inso'ucted that a vitamin was a "complex runctioning mecha nism" ra ther than a single chemical effect (as proffered by the proponents or ascorbi c acid as vitamin C). The discovery of ilwldreds or PJ-Iy roCHEMJCALS since 1990 has been complete vindication of his tileories. Goi.ng beyond mere tI,eory, Dr. Lee applied his engineering genius to biochemical manufacturi.ng processes that he designed to captw-e the complete vi ta min-phytochemical-compl.ex; active and s)'11ergisticall y intact in to nu tri tiona l supplemen ts.

Al'l'llNmx A

Phytochemicals featured on cover of Newsweek April 1994

2

THE SEARCH FOR PHYTOCHEMICALS Phytochemical discoveries evolved serendipitously from

l'esearch initially conducted by drug compa nies seeking to learn how the body breaks down and metabolizes drugs. Believing that. such resea rch would lead them to a n understanding of how mechanisms in the I.iver and organs of detoxifi ca tion broke down thei.r d rugs, they cou Id then design drugs U,at could have a more potent and long-lasting effecL. T his is u,e tudy of how the body rids itself of XENOBJOTICS, which drugs certainly a re. This im'estigation eventually led them to discover, to their grea t urpri e, that the diet of the individual held the critical key to how their body metabolized drugs. Thi research revea led the presence of compounds in foods called phytochemicals (Lee's "unidentified organ ic matter~). The "Drug l" letabolizlng Enzytnes" they ought were formed in and from non-vitamin compounds found in unrefined foods. Vitamins in foods help form phytochemicals in pla nts as well as activating them in the human body. This is. upportive of Lee's

assertion tha t vitamins were actuall y plant hormone. The April 25, 1994 edition of Newsweek dedicated the cover stOlT to phytochemical research. Some key e:xcerpts, when seen in the light of Lee' e"pla natlon of vitami.ns be'ng complexes in plants, exp la ins much of the fa ilure of l'nLhetic vitamins to l'unction as nUIJ'ientS, and why Lee's approach to t.he whole food complex was SO successftJ.

"It is whole foods--especially fruits and vegetables--that pack the disease-preventing wallop. That's because they harbor a whole ratatouille of compounds that have never seen the inside of a vitamin bottle for the simple reason that scientists have not, until very recently, even known they existed, let alone brewed them into pills." Newsweek April 25, 1994

The first sentence of the above sta tement is correct, but then fa ll apart in u,e ita licized portion. The writer is obviously uninformed that whole organic food nutritional supplements, conta ining the entire phl' tochemical-vitamin complex i exactly what Royal Lee designed and manufacturedfor almost 70 years. Add.itionally, he fought ha rd to educate resea rchers a nd spent a persona l fortune to educa te loctors a l out this precise concepL.

Hundreds of phytochemicals that a fford the body e"1.Taordinarl' xenobiotic protection have now been identified. Many of the "newly~ recognized phytochemica ls have actually been known for yea rs, as Lee often \\~'ote about their actions. Their function as trappers a nd killers of xenobiotics is now com ing into a clear focus. A number of phyto 'hemicaJs stimulate the fo rmation of Phase 2 enzymes. T h.is class of Drug Metabolizing Enzymes detoxif)' carcinogens (or a ny xenobiotics) by li nking t.h em to

molecules u,a t d.i cha rge them from the body. They work ",ithiJ, hours a rter ingestion, as xellobiotics are removed before they can cause mutations by attach.in g to DNA molecules in the cell.

"At almost every one of the steps along the pathway leading to cancer, there are one or more compounds in vegetables or fruit that will slow up or reverse the process." Epidemiologist John Potter, U. of Minn . Newsweek April 25, 1994

3

One of the leading phytochemical researchers in the country today is Elizabeth Jeffrey, Ph.D., associate Professor of Toxicology University of illinois Champagne. She began working with Drug Metabolizing Enzymes (DME) over 20 years ago at the University of Minnesota. According to Dr. Jeffrey, vitamins and phytochemicals effect the rate at which the body breaks down drugs and environmental toxins. She estimates that there are between 50 and 100 DME which do this, referred to as P450 enzymes. The DME oxidize foreign chemicals and make them more water soluble which assists the body in getting rid of them. They are protein and iron­bearing cytochromes from the plant cell mitochondria and participate in oxidative reactions.

One of the most instructive discoveries that Dr. Jeffrey reports is that when animals were fed these DME in isolated pure form, there was significantly less protective action than that which occurs from feeding the whole food, which contains all the synergists in naturally occurring forms. This lends significant support to the discoveries and statements by Royal Lee concerning whole food verses isolated extracts or crystallines. According to Dr. Jeffrey, vitamins and phytochemicals effect the rate at which the body breaks down all drugs and environmental toxins. She reports that vitamins effect the formation and action of DME in the plant and in the body.

From the understanding we have gained about the modulating influence of phyto­chemicals upon xenobiotics, and the speed at which they neutralize, trap and eliminate xenobiotics from the body, we view a critical insight into how the body perceives synthetic vitamins. By noting the speed and consistency by which synthetic vitamins (unlike naturally occurring food vitamins) are excreted by the urine, it is increasingly clear that the body treats crystalline (synthetic) vitamins as xenobiotics. Though demonstrated repeatedly with all synthetic vitamins, once again, scientists at Beloit College in Wisconsin report that the body eliminates crystalline ascorbic acid (so-called vitamin C) within 12 hours after ingestion. This was noted in Ladies Home Journal in June 1995, leading to the uninformed advice to take ascorbic acid several times during the day because it is eliminated so quickly. In other words, since you have a hole in your pocket, put money into it several times per day rather than lose it all at once! The point to be made is that vitamins, like gold to the cell, are never to be eliminated because they are not a waste substance. The fact that synthetic vitamins are recovered in urine is proof enough that they are treated as waste and xenobiotic in nature.

Because this discussion is primarily about natural vitamins, it is not the scope of this paper to cover the full range of phytochemical issues. Phytochemicals are briefly reviewed herein to demonstrate the reality that vitamins and foods are highly synergistic interactive complexes. To conclude this section, we should give the last word on the subject of the natural whole vitamin complexes vs. synthetic vitamins concocted into supplements to Royal Lee himself, since he was the first one to ever bring it up and develop the research. In describing how the whole is greater functionally than the quantitative sum of its parts, in July 1952, Royal Lee, in a speech to an Osteopathic convention, used the analogy of a functioning watch, vs. trying to assay its elemental components to understanding how it functioned as a time-piece:

·To clarify the point. assume that you wanted to have all your separate food elements like fats, carbohydrates, proteins,

vitamins. and minerals etc. purified and put up in chemically

assayable form .... What about all the unknown factors

[Phytochemicalsl that would be thrown away in the rejected 'impurities 00 that might later be found necessary to life?

'To judge a natural complex in the light of pure chemicals is

just as absurd. Natural complexes containing the various vitamins

should be considered as functional mechanisms. The oxida tion-

Al'l'llNIHX A 4

reduction enzyme system of wbicb ascorbic acid is a part. or tbe

various enzyme systems tbat form tbe complicated vitam,'n Band

G complexes in nature. must be considered as mucb of a

mecbanism as a wa tcb. and to cbemically analyze a wa tcb to

determine its ab,Jity to keep time would be as reasonable as to

remove tbe ascorbic acid from tbe vitam,'n C complex and call it

tbe 'vitamin. '

'It is as if some na,'ve indivIdual became imbued witb tbe

notion tbat tbey can bUlld a watcb by weigbing and dumpIng

togetber a prescribed quantity of brass. iron, sappbires, gold and

glass--or tba t tbey can concoct a vitamin complex tba t wlll

function as well as a natural product as found in foods by tbe

same prescription' metbod . ..

Lee's analogy of a watch and a vitamin complex: The whole is greater than the sum of its parIs.

All of the diverse components of a functioning mechanism function synergistically. Remove even one part--the function fails. Mechanically or biochemically Ihis principle holds true.

JWIJllNnIX n

1. Medium To High Dosages Of Vitamin A Supplements Synthetically Made, Provide Clear And Present Danger Of

Birth Defects. SUMMARY: New England Journa l of Medicine, (to be published) November 23,1995. Boston University School of Meclicine resea rcher found that Vitamin A supplements can cause bu·tb defects in humans, and wru-ned d,at mega vitami.n supplements can pose a danger. A lru'ge-scale study shows that women talcing vitamin A supplements ill doses of 10,000 internationa l units (iu) per day willie pregnant (even within first tlu'ee weeks of conception) risk a 240% increase ill birth defects. 20,000 iu per day increases d,e risk by 400%. This study cites no birdl defect risk from foods containing vitamin A or its precursors i.e. carotene and beta-carotene. Only synmetic forms of vitamin A a re used in supplements a t such high levels. T ills is d,e fil'st lru-ge-scale human srudy sho\\~ng that spHhetic vitam ins can be teratogens (a substance linked to birdl defects).

DIITAn.s: On October 7, 1995 The New York Times reported on a studl' to be published i.n d,e New England Journa l of Med icine on Novemher 23, 1995, linking vitamin A supplements and hirth defects. Tills was a very la rge-scale long-term study uwolving 22,748 pregnant women over a fo ur-year pef-iod. The research was cond ucted by t he Boston University School of Medicine. 'T'ho babi('~ of womell who (:o llsLlllled 10,000 iu daily ur \TitHlll in i\ from nutritiona l

supplemellts had a 2-+0% grea tcr incidence of birrh defect •. Unburn bahies exposed fO 20,000 iu of vitalllin A from supplenlcnt s Ilad a -+00% in~ rease risk of birth de fects. The defects included: cleft lip, clefl palette, heart malformations, and nervous system damage such as hydrocephalus (water on I.he brain). The researchers were careful to note that ca rotene, beta-carotene, and preformed vitamin A Ul the amounts and forms in actual foods did not result in birth defects. No amount of natlJ]'ally OCCUlTing vitanl;n A in whole foods were fowld to be mutagenic. Even liver, of which three ounces contain as much as 30,000 iu of vitamin A, showed no evidence of contributi ng to birth defects. Dr. Ken Rodunan, one of d,e studies leaders, told National Pul)l:ic Radio on October 6, 1995 that tills study provides no evidence of danlage fTom vitamill A in liver. The '~tamin A in foods, which are natm all y balanced witb synergistic cofactors, including oilier vita mu1 complexes, phytochemicals, minerals, tl'ace elements, en Z)TJl1es, and proteins, proved to be protective, growth promoting, and non-tOxic. Tins balanced effect of natul'a.Uy occurring nun'ition vS. high dose synthetic phru-l11aceut-ical nun'ition is safe and in fact essential for the development of the fetus. VitanJin A, it was noted by me BU reseru'chers, is essential for cell differentiation and organ development, especially tbe eyes in ilie fetus.

I

BU resea rchers found mat me tera togenic eHect of vitamin A supplementation fTom mrul­made forms can OCCUI' even withi 11 the mitial three weeks of conception, before the mother even knows she is pregnrul t. It is not uncommon for synthetic '~tamin A upplements and multivitamin supplement tablets to contain 10,000 iu to even 25,000 iu or more of s)~l thetic vitrunin A. It should be noted that a number of prescription drugs used by dermatologists contain over 100,000 iu of synthetic forms of vitamin A. Other tOxic eHects from hypervitaminosis A include partial or univer al loss of bod)' hair.

lUlllllNmx n 2

COMMENT: A tera togen must damage cell ular DNA or its synthesis to cause genetic mutatiDn to occur. Since the DNA, or nucleoprotein, of a cell is protected by the nucleomembrane in cells, it requires a lmost a stealth-like action of a teratogen to escape DME detection and penetrate tlus protective wrapper. It would appea r that synthetic '~tamin A is a particu la rly effective xenobiotic in this regard. Instead of being whisked out of the body, as most xenobioucs are, the synthetic \citamin apparently fools the body's enzymes into not attacking it because it is "disgu.ised" as a \~taID in , thus initially allowing it where real vitamins a re allowed. By the time it's xenobiotic identit), is recognized, it has alr'ead), reacted with cellular genetic components in the M'ong wa)' . [n this form, the teratogen is "clisguised" as a vitamin. I ronicall y, most birtll defects a re associated with vitamin defi ciencies, such as foli c acid (spina bifida) a nd other B complex vitamins. Teratogen ic effects on laboratory animals were first noted witl) synthetic B vitamins as long ago as ti,e 1930s. Dr. Royal Lee designed \~tam in A su pplemen ts from whole foods for over 50 years. They included various nutrili.onal fonnulas containing nntw"aJl y occurring carotene, beta­carotene, a nd sometimes preformed \cital1un A. The maximum amoLmt of aClUa l preformed vitamin A he concentl'ated from whole food uno a supplement was only 1,500 iu per tablet. The potency of the vitamin A supplements he designed were not predicated Llpon tbe quanrit,' of vitamiJl A, but rather the effectiveness derived from the balanced phytochemical complex containing the right forms of vitamin A \\~th synergists. The following reference from Appenclix C is reproduced here to shed light on hypervitaminosis. Even by 1936, Doctors in ti,e US and Germany had reported that hypervitaminosis on ly resulted wben vitamins were given in isolated forms, a nd not when given in ti,e nattn'ally occurring balance oj' who le f:oods.

"By simullaneous supply or water-soluble and rat-soluble vitamins together a hypervitaminosis cannot be produced, even though they may be given in very large quantities .... .. . ".

STEPP, \\7. , KUHNAU, J., and SCHROEDER, J., THE V ITAM INS AND 'DiEm CLINICAL APPLICATIONS, (Die Vitamine unci lhre lCinische Anwendung) Ferdinand Enke. Stuttgarl~ Germany, 1936

2 . Long-Term Large-Scale Study by NCI Shows Reversal Of Fortune For Smokers Who Ingest Synthetic Vitamins. Cancer,

Stroke, And Death Rate Increase. Researchers Confounded.

SUMMARY: Two importan t vitami ns in sl'ntlletic forms, beta-cru'otene ruld \cirarnin E, gave no protection against lung cancel' i.n a controlled test of 29,000 Finnish male smokers, a nd the data suggests the supplements were actually harmful. lV/ en taking synthetic beta-carotene had an 18% higher incidence of lung cancel', more heart attacks, and an 8% h.igher overall death rate. Those taking synth.etic vitamin E had more strokes from bleeding in the brain .

lUtI-llNmx II :1

D ETA""S: New Engl ~Uld JOllrna l of Medicine reported on April 14, 1994, tbe results of a ver y large-scale long-term 10 yea r stud y costing 43 miJ.i.ion dolla rs of "ra ndomized, double-blind, placebo-cono'oUed primary-prevention tria l to determine whedler daily supplementat-ion of a lpha-tocopherol, beta-carotene, or both would reduce ule incidence of lung cancer and other cancers." A tota l of 29,133 male smokers 50-69 years of age, from F inla nd were given syntbe\.ic "itami.ns. "The daily dose of beta-carotene used in the trial was 20 mg of a synthetic form, a formulation with a particularly high bioavailability which increased blood levels more than 10jold. This is about as much as it is practical 1.0 use, since elLen at this do~>--betw..e-'m one_qparter and oneJhirdQf-the_p_artic.ip_ants report~dyeliowing.Q/.1/.le .~l'in [see comments on this point below]. The daily dose of alpha-tocopherol, however, was 50 mg of a sy nthetic f orm that does not have a high bioavailability and that increased blood levels of vitamin E by only about one third. " NEJM Vol. 330 No. 13 Apri.l14, 1994 T he New York T imes reported on tlus study and quoted the researchers sta ting that they "saw a confusing pattern of mostly adverse effects, " and can ti n ued "these supplements may actually have harmful as well as beneficial effects" although they noted no beneficia l effects observed in thi study. The New York T imes n oted on April 14''': "After five to eight years, the investigators rep orted, they could find no evidence that the supplements had helped. " The Washington Post reported on the same day that "Scientists who launched a major study to prove that a form of vitamin A [beta-carotene] prevents cancer were amazed when their findings suggested just the opposite." The \Vasbington Post continued "After 10 years of study, it turns out that beta-carotene mIght actually cause cancer. "(p.A6). Hesea rchers note that a n 18% increase in lung cancer among the group taking syntbe tic beta-carotene is an extremely statisticall y signif icant number a nd tlla t the chrulces of a statisti cal fluke in this study were about one in a hWldred.

C OMMENT : Syn thetic vitamins fa il when put to the scientific test in actual huma n feeding studies, again a nd again a nd again. This is no refl ection of natural vita min complexes, anymore than counterfeit money can be used to appra ise wealth. Synt hetic '~ I:amins do not work the way food does. That is why over two hun dred studies about foods, not syntheti c supplemen ts, show the opposite resuJ ts. The first overlooked point that should have been recognized by these researchers was that when one-third to onejourth of the men taking synthetic beta-carotene complained of skin turning y ellow, they should have known that naturally occurring beta-carotene does NOT yellow the skin. Carotene does yellow the pigment of the skin, but beta-carotene does not. Beta-carotene is naturally occurring in the chlorophy ll complex of all green plants. If it did y ellow the skin, all of the grazing mammals on earth would be yellow, which, of course, they are not (it usually tends towards a light pinkish color; lift up the fur on your dog or cat). Obviously syntlleti c beta-ca rotene is metabolized as a xenobiotic a nd the oxidized waste substilllce of its breakdown is sta.ining the p igments o[ skin. T he natl.1raUy occurring family o[ ca:rotenoids in pla nt Life is vast, with literally hundreds of forms. Beta-ca rotene is just perhaps the most frunolls of d,e carotenoid phytochemical family.

3. Four Year Dartmouth College Colon Cancer Study shows synthetic vitamins no protection

SUMMARY: July 22, 1994, New E ngland Journa l of Meclicine. Researchers [owld tha t syn thetic antioxidan t vitamins were not effective against recurrence of benign growths of the colon wben consumed for a four-year period. The Dartmouth study sought to document the effects of antioxidant vitamin supplementation in preventing reCLUTence of adenomas of the colon. In the stud y, 864 patients who once had adenomas and had them excised were given daily 25 mg of beta-carotene, 1 gram (1000 mg)of crystalline ascorbic acid (so-called vitamin C), and 400 mg synthetic vitamin E, a ll three aJltioxidao ts, or a placebo. The study showed no effectS of an y of the tTeatments. A Dartmouth researcber sta ted tha t '·current data do not support the use of antioxidant vitamin supplements f or purposes of cancer prevention. »

COMMEi\'T: Cancers of the CI tract effects are diagnosed over 120,000 times per year in the US. Diets high in na tura l vitanlin-rich fruits and vegetables have repea tedl y shown in wide scale stuclies to he protective of these cancers. However, wben yn thetic vitamins a re substituted [or the natmally OCCWTing ,' itamin-phytochemical-mineral complexes of foods, no protection is conferred. More evidence is again developed demonstrating the faul ty premise tha t synthetic "itamins function like nu trien tS fowld in foods and tha t food­sourced nutrien tS fWlction synergisticaUy a nd not in isolation.

4. Nutritional Supplements And The Elderly SUMMARY: Jillle 23rd 1994 issue of the New Englruld Journal of Mecli cine, reports that multinulJ·ient symhetic vitrullin supplementation does not benefit elderly people (average 63 years age) who were pre,rious ly e>.-periencing muscle weakness and physical frailty.

COMMENT: This study failed to show any improvement of elderly Americans while on a t)'Pical multi-vita min supplement. Since the supplements were not derived !Tom raw foods, it is no surprise a nd is more confirming support that synthetic vitam.ins fail to act nutTitionally.

I

>

5

What physicians d 1 +j#!. alik h uld an aymen 1IiI1!;l1.,I. -,W"=·· 11"'/111/ e s 0

ask themselves ;:s; about pw"e crystalline vitamin supplementation

(tha t common sense might prevaIl)

=> Why do I need to purchase and take synthetic vitamin supplements if all the refined foods are already "enriched" with them? All refined flour, grain, and rice products, as well as many processed food-stuffs are spiked with synthetic vitamins by federal law (since 1939). Some breakfast cereals are spiked with particularly high doses of synthetic vitamins, as well as inorganic minerals.

=> If these artificial crystalline vitamins are actually the same, why would a person ever be deficient in them? Is it just because there is just not a high enough dosage of synthetic vitamins "enriched" into these refined ''foods'' and therefore I should take more?

=> Why should I bother eating fresh fruits and vegetables if the vitamins provided in "enriched" foods are just the same? Is fiber the only advantage to fresh produce over "enriched" foods?

=> Why should I buy something that is already artificially added to the food supply?

=> If the body does not know the difference between artificial vitamins and natural vitamin complexes, why are artificial vitamins recovered in the urine?

ANNOTATIONS Note: all italicized or bold type

added for emphasis

Artificial vitamins inferior to natural complexes and are quickly excreted through the urine (characteristic of a xenobiotic substance). Ascorbic acid cited as weaker than natural vitamin C Synthetics are dted as unable to correct dietaty deficiency.

Balanced Vllamin intake non-toxic even in high doses.

Synthetic Vllamin E loses 99% of potency

Synthetic vitamin cited as teratogenic to offspring.

lW)))INnIX (;

Documented DIfferences Between

Natural til SynthetI'c Vitaml'ns

1. GENERAL OBSERVATIONS ON SYNTHETIC VITAMINS

Clinical and Laboratory Comp arison:

I

"The Secti.on d-ahm.intati.on .of the C.om:ite C.onsultatiJ d 'hygiene at Vichy [F rancel determined t.o .organi ze d,e systema tic disu·ibuti.on of vi tam i n5 A, B, and D, P rofess.or Lesne, a sp ecialist in vitamin research, believes that the effect .of natural vitamins is superiar ta that .of the artificial .ones. Far instance, the treatment .of scurvy by giving 50 cc . .of lemanjuice cantaining 25 mg . .of ascarbic acid praduces quicker results than 25mg . .of ascarbic acid administered as a medicament. The artificial vitamins, especially vitamin C, are quickly absarbed and also quickly secreted by the kidney. These vitamlns have t.o be amninistered eve,")' da), in .order t.o be effi caci.ous. Besides, there exists an antaganism amang the different artificial vitamins. T be bady ehmina tes, far instan ce, "itamin C if "i tamin A .or D is administered simul tane.ously. Pr.ofessar Lesne sa id a t a meeting .of the Academie de Medicine that if good resul ts have been reali zed with the administration .of artificia l vitami ns ' they are not able to mend t.he deficiency due to inadequate food.'''

JOURNAL OF THE AME RICA.!" MEDICAL ASSOC., 11 8, 60475, Februar), 7,1942

Natural Vitamins Contain all Fractions:

"'By simulta neaus supply.of water-s.oluble and fat-saluble vitamin tagetber a hype rvita minosis cannot b e produce d , thaugh they may be gi,'en in very large quan tities ...... .. »

STEPP, W .. KUHNAU, J., and SCI-mOEDER, J. , PPLICA'I'IOl\$,

(Die Vil amine unci ih re IGinische An wenclung) Ferdinand Enke, Stuugart, Germany, 1936

"Natura l farms .of vitamin E [camplexl lase up ta 99% .of their patency when separa ted fram their natura l synergists."

r NNUJ\ L R EVIEW OF B1OCHE.\11STHY, ·1943 1>.381

"When female rats a re rem-ed and bred an Steenback and Black I s rachitagenic diet number 2956 supplemented with viosterol (syn thetic vitamin D) to fa restall the develapment .of ri ckers, cangenital malfarmatians appear in about one third .of their offspring.

Synthetic vitamins and congenital defects

More than a singte isolated vitamin involved in creating deficiency disease slates

Vitamin from whole food sources protecl When extracted (even though natural) they loose effecl Synergistic co-factors apparently lacking.

? -" ... Abnormal and normal offspring can be obtained alternatively from

the same f emale when the deficient diet and the diet supplemented by liver are fed alternatively. The eA-perimenta l results described have been obtained in two diHerent stra ins of rats. It seems that the normal prenatal bone development of these rats depends on a nutritional factor wruch is absent or inadequa te in the defi cient diet and present in large amou nts in uver."

JOURNAL OF THE A.lVlER ICA1'l MBDICAL AS ·OC1ATIUN., Soc.Proc., "118, 12,1002, March 2 '1" 1942

"Attention is calJed by V. P . SydenslJ'icker, M. D., of the University of Georgia, School of Medicine, Augusta, to t he fact that among human beings more than one vitamin is concerned in the production of any deficiency. The development of avitami.nosis is clue to the failure or perversion of normal biochemical reactions which can be completed only when adequate supplies of different vitamins a re available."

MODERN MEDICTNE, 9, 10-,35, October -1941

"Until all the factors lost in milling ar e known and it is known that each of the others is adequately suppli.ed by other foods, the logical solution of the problem presented is the restoration of the grain embryo itself to the diet."

2. VITAMIN A

MARKS, H. E., Vitamin Deficiencies and Restored Foods) Letters to the Ed ito r of tJw: JOUHNAL OFTHE AM ER ICAi\'

MEDICAL ASSOCIATION, 114, 6,512, rebrua ry 10, 1940

Clinical and Laboratory Comparison--

Stephenson found that a crude (a lcohol-light petroleum) extract of dried carrot when added to a fat lacking in vitamin A conferred upon it g rowth-promoting p roperties and p rotected rats from Xeropthalmia while pure carotene extracted from carrots was without effects.

SHERMAi\'. , H., and SNI]TI-l, S., II-IE V ITAMINS, Second Ed ition, Monograph Series, No.6, page 244 The Chcmjcal Catalog Company, Inc., New York, '1931

"T he OCCLI rrenee of increased arn 0 Ufl ts of carotene in the blood of patients ,vith diabetes mellitns has long been recognized both by the cJjnjcal observation o.f xanthosis and by the resu lts oj' laboratory tests. A group of 20 patients ,vith juvenile diabetes mellitus were studied, a nd a ll were found to have poor ljght adaptation by the Frober-Faybor biophotometer. Three of the group were subjectively aware of night blindness, and nine showed cutaneous changes compatible ,,~th vita min A defi ciency. The daily administration of 60,000 U. S. P. units of vitamin A in the form of crystalline carotene dissolved in vegetable oil, for as long as 14 days did not affect the light adaptation of the patients with diabetes mellitus. The daily administration of 60, 000 U.S.P. units of vitamin A to patients with diabetes mellitus in the form of

Synthetic vitamin A useless in restoring night vision in diabetics while natural vitamin A cures night­btindness

Vitamin A in buffer more potenl than cod·hver oil. Suggestive of the need for synergistic co·factors.

Vegetable vitamin A more potent than fish oil in night blindness

Arbitrary combinations of 8 vilamins ineffective compared to whole food containing naturally occurring 8 complex

whi1e Hour inferior even when 81 (thiamin He/) added

tsolated 8 vitamins fail while 8 complex whole foods effective

concentrated fish liver oils, caused their light adaptation to return to normal or nearly normal in periods ranging from 3 to 21 day s. The ca use of poor light adaptation in pa tients with juvenile diabetes mellilus a l pears to be 811 inability to convert ca rotene to vit81nin A. "

BRAZ ER J.. and CUlHIS, A., AIlCI'II"r,., OF IN"TEHNA L M EDICINE, "1940 as abstraclCd by ENDOCIlINOLOCY, 26, 5-.936. May, 1940

........ A unil of vitamill A in butter, determined chemica ll y, is ap­p81'enti), more eHicielll biologica lly than a unit of vitamin A in cod-li, -er oil determined in lhe sa me \Va y.'

3

FRAPS, C., .1I1d KEMMEHEH, A., Texas Agr. E.xPL SUI .. Bull. 560. 3·2 1 (1938) . bstr. from CHD IICAL AI~ rHACTS, 32, 8:3039, April 20, 1938

"Spinach viuunin A is ten tUlles a potent, un.it fol' unit, as vitamin A from fish Liver oi l ;', the treannent of night blindne ."

FREDEHICI-1SEN,. and EDMUND, Studies of Hypovitaminosis A: II A New Melhod for Testing the Hesorption of Vitamin A from M cclicmnenLs, AMERICAN

JOUIlNAL OF DISEASES OF CIIILDREN, 53:89-"109, Jan., 1937; e lin. E.'XP[s. in the Vit - A bal. in chi ldren afLCr various dieLS, ib id. 53,1179-1201. Murch, '1937

3. VITAMIN B COMPLEX

ClinicaL and Laboratory Comparison:

"The add ition of yeast or Peter ' eluate to tile diel regul81'ly prevented this liver damage. Rich and Hamilton observecl tile development of cirrhosis of the liver simi lar to the Laennec lype in all of fourteen rabbits which were kept on djet supplemented by variou vitamins but lacking yeasl. These investigators determined that the injury was due to lack of some factor contained in y east other than vitamin B 1, B 2, B 6, or nicotinic acid. "

I-LA S. \\"T., Annual Review Physiol.. : :259.282, 1941

"Tbe nutritive va lue of slraight-run whjte flour (73% eX lraction, tested on young growing rats) has been found inferior to tha t of wholemeal flour, even when the defects of the fonner in protein. minerals and ,' itemin 131 have been corrected."

CH ICK, 1-1 ., TilE LANCET, 2:51"1 -512, OctObet· 26, 1940

"It (stomatitis) does not respond to treannelll wiill vitamill B6, ribofJa vin, or nicotinic acid, singly or in combination. Restora tion of the mouth to normaJ was accomplished only al'ter intensive therapy " ' ith the vitamin 13 complex. The factor or factors responsible are present in the vitamin B complex and

Synthetic B vitamins fail in normal growth tests while whole vitamin rich foods correct growth

waming that synthetic vitamins can cause worse deficiency than they are used to correct

Szent-Gyorgyi, the biochemist who discovered Ascorbic Acid (for which he was awarded the Nobel Prize for Medicine in 1931) dec/ares that other subslance(s) Ihan ascorbic acid are responsible for the anti hemorrhagic (anti-scurvy) action of vitamin C. Implies thai vitamin C is a comptex, not a single chemical.

may be any of the less well-known fractions which have not as yet been isolated of synthesized and consequently have not been applied in human nutrition studies. »

ROSEj\lJ3LUM, L, anci JOLLIFFE, N JOURNALOF'n ' IE AMERIO"~ ~ I EDICALAEfjOCIA11o.'l. , 117:2245. December 27: 19~1

"I am very familiar with the d ifficuJties involved with tbe fortification of foods with synthetic vitamins or concentrates of individuaJ vitamins, and the resuJts in Chart 1 clea rl y emphasize the problem in question, In this case chicks were placed on the modified Goldberger d iet a lone a nd supplemented with vmious synthetic vitamins and concentrates of some of the new members of the B complex. In most cases some improvement in growth was noted due to the feedin g of each additional vitamin, but normal growth was not obtained until a fair amount or a natm'al food such as liver, kidney or, yeast was added. Likewise, synthetic vitamins should be used with caution in order to prevent the development of deficiencies more serious than the deficiency we set out to control. "

ELVEHJEM, C., JOURNAL OF THE AMEilICAN DIETEllCASsoc,

16,7,654, AUl,'llSlcSeplcmber, 1940

"In dogs fed a low protein diet supplemented with thiamin hydro­chloride, nicotinic acid, ribofl avin, pyridoxine hydrochloride and either pantothenic acid or purified liver extract, a defi ciency state developed characterized by loss of a ppetite, substantia l loss of weight, modera te to severe anemia and peptic a nd cuta neous ulcers. The condition was prevented by an increase of protein diet [Disease) was not cw-ed or prevented by the addition of cystine, choli ne, paraminobenzoic acid, inositol or an eluate of clay absorbate of liver extract. "

4. VITAMIN C

FOUTS, P., JOURNAL OF THE AMEHlCAl'l MEDrCAL ASSOC., Soc. Proc., 118, 12,1002, March 2 '1, 1942

Clinical and Laboratory Comparison:

"I had a letter from an Austrian colleague who was suffering from a severe hemorrhagic diathesis. He wanted to try ascorbic acid in his condition. Possessing at that time no sufficient quantities of crystalline ascorbic acid, 1 sent him a preparation of paprika that contained much ascorbic acid and the man was cured by it. Later with my friend, St. Rusznyak, we tried to produce the same the..apeutical effect in similar conditions with pm'e ascorbic acid but we obtained no I·esponse. It was evident that the action of paprika 'o/as due to some other substance present in this plant."

ALBERT SZENT-CYOHCYI, OXfDATION, pp. 73-74, Williams and Wilkins, Baltimore, 1939

Lemon juice cures intestinal bleeding (symptom of scurvy) when ascorbic acid fails

Natural vitamin C reduces polio symptoms while ascorbic aCid is significantly less effective

Lemon juice (contains natural vitamin C complex beyond ascorbic acid) cures intestinal disease but intravenous ascorbic acid fails

Confirming observations made by Szent-Gyorgy, natural vitamin C complex stops capillary fragility while crystalline ascorbic acid fails

Group receiving crystalline vitamin shows sign of avitaminosis

Cal-Tech MD & Professor of Biochemistry cautions that ascorbic aCid fails to cure latent scurvy signs (capillary fragility) but whole food source of C Complex works. Suggests other C Complex factors

5

"It was demonstrated tbat guinea pigs, fed vitamin C-I'ree diets, could be more thoroughly protected against infections with pneumococci by lemon juice or orange juice than by pure ascorbic acid. n

STEPP, W , KUHNAU, J. and SCHROEDER, j The Vitamins and Their Clinical Applica l-ions (Die Vitam incu nd ihre luinisdhe Anwendung) Ferdinand Enke, SlUuga rt, Cermany, -1936

"The use of '~ tamin C when i.ncreased capiJJary permeability is due to deEiciency of tha t vitamin is of cow'se specific. The fruit juices are more, effective than the :;ynthetic vitamin C. "

MADTSON F. ~ comments by. on Lhe paper of Fowler and Barer, JOlJHNAL OF TI-JE ANIERICAN MEDICAL ASSOC IATION

"Three cases of hemorrhagic intestinal disease did not improve after daily intravenous injections of ascorbic acid, but were cured by I . . " emon Juice ..... .

LUND. H ." a nd ELM BY, A. , ubstr. from IlHITISH ,10UIt"ALOFCHDllSllW , NDPHYS., pah",678. AUh'US1; 1938

" ...... treatment with natural vitamin C had reduced the incidence of typical paralysis by about 1/ 3 as compared with the controls (from 92.8 to 59.1 per cent) while the reduction for the two synthetic preparations combined was less than 1/ 5 (from 92.8 to 75.2 per cent)."

JUNCEBLUr, c., J. Exp. Med, 66, H59-\??10c00ber 1, 1937

In a speech before the Tc."as Pediatric Societ)' in DaUas in 1937, I-I. C. Poncher MD, stated he had observed that "frequently the hemorrhagic mani­f estations do not stop as promptly with pure ascorbic acid as with citrus fruit juices. The implication appears that possibly the citrus fruits and natural sources of vitamin C m.ay contain something in addition to pure ascorbic acid which is important in the management of scurvy. "

PIlOCEWINCS OF TI:MS PEDIA'!'IlIC SOCII:'!'Y, 1937

"The group receiving asco rbic acid seemed to decli.ne in weight much more rapiclly and to develop more marked s),mptoms of a'~taminosi s than did the controls. Trus deleteri ous effect ma), be attribu ted to the stimulating acnon of an excess of vitami.n C (ascorbic acid) on Lhe met.abol.ism as has recendy been demonstrated by Mosol)'l and Rigo. An excess of one '~tami:n may thus prove d ecidecIJy injurious. n

CHOLLMAJ'i, A., a nd FllWH, W., JOUIlNAL OF NlJrHITION, 8,572, I o\'embe,·, 1934

"One of the clinical tes tS for lateot (em-Iy) scurvy is the measurement of the resistance of the capillaries ([nicroscopic blood vessels) ill the skin to rupture when the pressure wid1.in them is arttficia lly increased by the application of externa l pressure. III hLllnrul scw'vy the capillary resistance is low. After crysta.lIine vita min C (ascorbic acid) became com_mercia Uy available, ir was found in man y cases that the capiUaJ'Y resistance could !lot be increased even by aclminisl-ration of la rge doses o j! the crystalline vitamin. On the orher hand~ lemon juice appears to be effective in i.mproving tillS conclition. One group of workers in terprets these fincli_ngs as evidence thal-there is another vitarniJl

•

J

Naturat fonn of Vitamin 0 far more potent in much tower dosage

Natural and synthehc Vitamin 0 are different and naturat is more protective

Synthetic vitamin less effective

Natural VI/amin 0 cited as 100 hines more potent than synthetic form

Fact that synthetic vitamin 0 is less potent said to be "well known" in NEJM

Vitamin 0 in a whole food fonn ciled as 50 times more effective

which is a lso i.mpon a l11 in the preven tion a nd cure of human scurvy. T hey do not dispufe the necessity of vitamin C (ascorbic auid), bul' thei.r contention is tha t tins other factor, which they caU vitamin P, is a lso essentia l. '~ Litlle is known a t present rega rd ing the properties of or djstribution of this postulated vita min P. h a ppea rs 10 be abundant in lemon juice a nd it is probably present in otber citrus juices. Until the uncertai nty regaJ"ding the actuali ty of vitamin P is removed~ it is preferable whenever possible to use the natura l a ntiscorbutic foods--thc citrus a nd tOl11 aLO juices and vegeta bles--ra ther tha n the pure crystalline vita min. "

BOI'Sook, HOllry, Ph,D" MD, Professor o r Bioch emistry, California I.nstiwt.e or Technology, 1T\~' 1 ~s Viking Press. ' 1 9~rl. Pages 109-1'10,

5. VITAMIN D

Greater P otency of N atural Vitamin:

" Ergosterol a nd yeast when activated a nti-rachjtica lly by ultra "iolet radia tions a re ineffi cien t sources of vita min]) for the chicken. \Vhereas 1% of cod li ver oil of average potency resulted in no rma l bone prod uction, it required from 40-120% cod ljver oil equi valence as irradiated ergoste rol a nd from 7.5% to 60% cod uver oil equ.iva lence as yeast 1:0 produce the same resul ts."

STEENBOCK, I-I., KLETZIEN, S., and HALPIN, J 9 J BioI. ChelTl ., 97,249. July, 1932

"Vitamin]) facLOr in vioste rol a nd cod li ver o il ar e not iden tical. Ten ti nles as many vit8111iJl D 1I1-Uts In viosterol clo nOI" give as nl uch pro tection as p lain cod li ver oil. "

De SANCTIS, A., and CRAlC. J , New York S l at"C Med ica l Journal. , 34, 16:7 12-714, 1934

"A cha rt taken from the work done by J\I[e lla nby ind icates that in ulese stud ies vita min D of viosterol was proba bl y less e ffective tha.n the vita min D of cod li ver oil , ilJ respect to the prevention of ca ries."

M.ELLAL'I BY. Mcdi"," Reseal'ch Council, Spec. Repon 'cries, No, 2 1'1, His Ma jesty's tationa r), Office, L.ondon, 1936

"A recent report sta tes tbat ule ra t unj t of natural vita min]) is about 100 times more porem in protecting chickens a nd children from rickets tha n the ra t unit of irradiated ergosterol. "

SUPPLEE, C., ANSBACHER, S., BENDER, H. , and FLll\~CAN, C., .1. BioI. Chem ... 14 1, 1,957 107, May, '1936

"It is weU kn own that ule adminislTation to children of irradia ted ergosterol meets \\~th less clinica l success tha.n the older thera py o f cod uver oil wuess the un i t dosage of ule former is greatly increased over that of ule laner. "

BU fKE R, J., and HARRIS, R. , NEW ENCLAND JOURNAL OF MEDI CIJ'!E, 211. 25, 1141 . December 20, 1934

"T he poin t was b rought out tha t the rela ti ve effecti veness o f the vi ta min D of cod live r oil a nd the '~tam in ]) of irradia ted e rgosterol va ries with experimen ta l conditions. Under the cond itions of the p resent· e"l'eriment, cod li ver o il was fif ty times as effecti ve as the mt--equiva lent amoun t of irradiated e rgosterol for promoting ca lcification i.n the femurs of chickens""

Bills, C'l ~rl asscnga lc: 0., Mcdona ld: 17" And Wi rick, AMERICAN JOUHNAL OF BtoLOC I' AND Ct·tEMtSTHI' .. -1 08, 2,323·330. Febr",,,),, 1935

Synthetic vitamin 0 exens greater toxic effect than natural

Sinh defects from synthetic vitamin o noled. Calcification in tissues cited

Natural vitamin K complex in chlorophyll is noted as ''quite complex in composition. "Not a simple chemical in nature.

Medical research council calls '~nlichmenf' of flour a ''wrong

plinciple. " Natural products clied as more beneficial than single substances (pure chemical vitamin).

7

"In ra ts, calciferol, the vitamin D of irradiated ergosterol, exerts greater toxic effects at lower levels tha n does the vita min D of fish I.iver oil. "

MORCAN, A., KIMMEL, L., and I-IAIVK1NS, 1'1., J. BioI. Chem .. 120. 1,85-'102. August, 1937

"'Among 90 women who received viosterol a nd calcium lactate, the placenta showed calcification " beyond normal expectation or experience." Ca lcifica tion extended into the normal uterine wall in one case, Defini te calcification of t:he kidneys was a lso noted. Fetal heads were less moulded, suture lines less distinct and general appearance of ossification or post­maturity was noted.' Labors were prolonged. " "Among ninet, ' women who received viosterol only, lesser but definite areas of calcifica tion "beyond normal expectation or experience were fowld. In ninet)' women who received calcium only and also ninety women who received cod liver oil and ca lcium lacta te the placenta did not show abnormal calcifica tion fetal heads were normally moulded, fontanels were open a nd sutw'es not fused. T he same was true in two groups of ninety women each who received on ly cod uver oil or who had a normal cl.iet without viosterol, calciW11 or cod li ver. "

6. VITAMIN K

Brehm. W., 01-1 10 STATE MED ICAL JOURNAL., 33,990-993\ September, 1937. as reviewed by Modern Medicine, p. 62, October., '1937

Natural Concentrates are ComDlex in Nature: •

"In our experience, concentra tes prepared from a lfa lfa and ,,~th a potency of one unit in about 39 nucros a re quite complex in composition a nd contain several chemical ind.ivid uaJs \V·jih varying vl tal,1 in K potenoi es~ a investigations by severa l clu'omatographic a na lyses on ca.lcium sulfates show. Some of these fractions a re deep red, others are yeUow, but our most potent concentra tes were nearl y colorless. It should be noted that our process of isola tion is different from that employed by other investigators and th is may be one of the reasons why we were able to obtain con 'entrates which had such a high potency but did not give the typical color reaction for '~ tamin K. "

ANSBACHEH, S., F8HNI-IOLZ, E. , and Mac­PI-IILLA.MY, 1-1., Proc. Soc. EXPll. BioI. And ~!I ed . , 42,655-658, I ovember

7. Natural Vitamins Contain Many Fractions:

"The Nutrition Committee of the Na tion a.l Health and Medical Hesearch Council 'onsidered the proposa l fully hut decided that the add ition of synthetic vita min Bl alone to wlute flow' involves a "~'ong principle. It is weU known tha t there a re many instances in which mixtures occurring i.n na tural products have a more benefi cia l effect tha.n the admi.njstra tion of the isola ted single substances, e. g., in the treatment of peUagra" in which it has been found that whereas the primary defi ciency is of nicotinic-acid, the best results are obtained by the administration of adcl.itional members of the vitamin B complex .. .. »

In tead, it is recommended stTongly that an investiga tion be made into the

Advise against use of synthetic vitamins in food "enrichment' due to the loss of Ihe complex synergistic co·fac/ors

Pellagra symptoms persist wilh synlhetic vitamin 83

Crystalline·pure synthetic vitamin, 'It is obvious" does 170/ cure pellagra.

Vitamin deficiencies cited as multiple and 170/ single chemically pure deficiencies of single substances. Only na/ural complexes can proVide viable treatment.

possible use as additions to the di et of products such as cereal by-products [refined-out impurities], d ried milk and olher sources of t he B complex rather tban the use of imported synthetic products, since such by-produots would supply od,er known essentials besides vita min B I."

JOURNAL OF THE AMERICA.!'i MEDICAL ASSOC., Foreign Letters Section, 11 6, 9:882, March 1, 1941

n

"It was by no means certain that Yeast extract or an extract of wheat germ which was very rich in vitamin B could be replaced, as far as the B comple:,; was concerned by the synthetic vitamin. Some factors had evidendy not yet been identi.fied. Hence the reluctance to depend on other ilian the natw·al foods. However, when a mixture of synthetic Vitamins was combined, there was always the fear that some essential factor as yet unidentified, might be left out." (professor J. Drummond, Scientific Advisor to the Ministry of Food, England).

JOUn~AL OFTHE ... \:O,'jERICAN .MEDICAL ASSOCIATION. 1"I S, 1 0,S33, March 7, 1942

"In d,e present observations, these changes took place during a period when d,e intake of rood containing vitanlin B was inadequate and were relieved by therapeutic agents (brewers' yeast and li ver) known to be rich in vitamin B. Furilier identification of ilie sullsl.ance liver eA1:raCI: responsible for d,e changes noticed must remain incomplete until various factors now grouped together as vitamin B are identified and separately tested. "

ELSOM, K., and SAMPLE,. Am. J. Clin. Invest, 164632 ·1937

Clinical Deficiency-Not of S ingle Factor: "Nicotin.ic acid may aid in the restoration of healdl but an)ong the

pellagrins bere described a considerable mnoum of ill health, sucb as anemia, underweight, dia rrbea, and a few subjeotive symptoms, persisted. "

KOOSER, .I. , and BLA.NDEl\'l-TORN., M., JOUHNAL OF THE A"'!ERICAN MEDICAL ASSOC., 11 2,25S1 -25S~, June 24, ·1939

"It is obvious that p ellagra, as it occurs in human cases, is a multiple deficiency. This seems only reasonable becau se of the close association of ilie various components of the B complex in d,eir natw·al occmrence. It now seems clear from the work of many investigators that complete cure of pellagra will not take place through the administration of nicotinic acid alone, particularly if the deficient diet is maintained. "

GORDON, S, and SEVRlNGHAUS, S,YimLuin lJleraP-)Cin General PmcriL'C..TI1c Year Book Publishers, In(~, Chi~"O., 1940

"OW· investigations have ShOMl d,at definite defi ciency of vitamin B1 is not uncom mon among hospital patients in England, and we wish to emphasize that vitamin deficiencies in man are almost always multiple and are therefore usual(y inadequately treated by administration of a single pure substance. "

GOODHART R , and SINCLA ffi , H .. , BioI. Chem., 132,11-21, Jal1uary, 19'iO

Nerve degeneration of betibeti not a thiamin HCI deficiency, but rather a complex of synergistic co·fac/ors including vitamin 81. En/ire 8 complex urged (known and unknown factors onty supplied by complex food forms).

Deficiencies cited as "mul/iple" requiting complexes

Science News reporls on Dr. A.F. Morgan's expetimen/s with synthetic vitamins on dogs a/ U of C 8erkley. She proved thai synthetic vitamins cause worse slates of heal/h than pure starvation.

Nerve damage from thiamin HCI

S/erility occurred in rats given pure crys/alline synthetic vitamin 81. Toxic effect noted in lac/a/ion form synthetic vi/amino

Too much synthetic vitamin 81 confer symptoms of hyperlhyroidism

9

"Clinical conditions presenting a lack of a s ingle dietary 'onslituent ar e ra re. It is more ommon to encounter multiple de fi ciency sta tes .. .... Therapy for defi ciency disea e the refore usua ll y involves the usc o f more d,an a single constituen t as dle subsequen t discussion is intended to show ..... .

"While a deficiency of thianlin proba bLy still rema ins dle most e tiological facLOr in beriberi , there is strong evidence to indicate that the nerve degeneration of poly neuritis is due to a lack of some other factor or factors, possibly riboflavin or pa ntodlenic acid. Until this ma tter is settled ; practical therapeutic Ill ea ure must invo lve tbe kn own B co mpon e nts, and specinl attentinn should be paid supplying an adequate intake of the entire B complex. »

GORDON. E .. , and SElfHING HAUS, E., VITAMIN THEIlAPY IN GENERAL PHACn CE, Ya :u"·Book Publ.ishClS:. lnc..~ ali.c.'ah~ 'J9-iO

The followi ng quotation is taken from a speech made by Bussell L. Haden MD, chief of the medica l ru"isiol1 of the Cleveland Clinic, Cleveland. Ohio, before the International Nledical A -sembi ), of the Lllersl3te Post Crad uate Nledica1 Association of North America h Id in SL Louis, October 18-22., 1937. (published in OB UC TBAOE NEWS, October 25, 1937).

"By feeding his pa tien ts yeast, Dr. H aden c;'pla ined, be was able to

give them a ll of d'e various components of the vitamin B complex. "The 1 rouble with so man)' of the defi ciency diseases, is that they are mu ltiple," he saiel, "so wha t I t r), to do is to have patients use foods which cOnlain them aU or give t.hem ex tracts that conta in several. ~'

8. Toxicity of Synthetic Vitamins:

Attention should be given, Dr. Morgan concludes from t.hese experiments, "to the possible danger of the adminislr3tion of large amoun ts o f certa in vilarnins such as nicotin ic -acid 1O persons subsisung on d iets having mult.i ple deficiencies. Foni tication o f food with those vitamins such as thianlin or nicotiJli . acid which are available in la rge quantities may precipitate conditions worse than. the subacute deficiency state produced by the usuaL diet baLanced in its inadequacieIi. »

SCIENCE NEWS LETTER, 39, '12:183, Mal'ch 22, 1941 , (Science, Mal'eh '14, 194 1)

"The llbove case hisLOries would seem to indicate thm large doses of vitamin 81 are capable of irritating the peripheral nerve plates. Apparently, this toxic symplOm occurs in only a very small pcrccntugc of case:; Irealcd with massive doses of vitamin 131. However, one should be on guard in I he usc of this ubstance." STEll'\13ERC. CAm. J. Dig. J)is.,.~1 . Deccml.x:r 1938

~(In nils) u dail y dose of 100 ug. (gamma) of thiam in results in female sterility in the sc(;Ond. gencrmion. A dail y dose of 200 ug. (gamma) of thiamin produces to,xic effect::; in lactation in the Ihird generation. A daily dose of 400 gamma of Ihjamin results in ~entire railure in laclation in the third generation." lime: This article states 1 hat the da il y requiranent of B1 for rats is 50 lIg.) SUBE, B .. JOUHNA L OF :>IIJ]-RITION, 18, 2, 187· 19 .. , Augusl 10, 1939

1l1C ::..)'mplOIl1S of thiamin overdosing arc similar to those of hyperthyroidism: (1 ) fast pulse, (2) inil.l:lbilily~ (3) tl"eIllOI: (4) weakn~ Twem)' LO forty Mg. should nOt I~ used e.XCCpl in deficicl1('), cases."

M.ILLS G, JOURNAL OF THE j\'\1 Ell ICAl\l MEDICAL ASSOC., ,"Iny 3, ·194'1, nb&r, in CliniC1lI Medicine, -tB, 9:231 ,8cptember,: 194'1

Dr. Royal Lee (circa 1949)

Royal Lee seen working here with his famous Lee Flour M,1l bu,1t by his own Lee

Engineering Co. He designed it so the average fam,1y could secure fresh. wholesome.

low-heat. stone-ground bread with the vitamin-rich germ and fiber-full bran intact.

The Lee Foundation for Nutritional Research and his nutritional company was a

lighthouse for physicians and laymen at the time when food adulteration and

commercialism swept the 20tb Century. He trained thousands of physicians in the

principles of organic whole-food nutrition and scientific therapeutic supplementation.

He originated theories and applications on nutritional complexes. endocrine and

autoimmune diseases... protomorphogens. and biOChemical manufacturing processes

that are being independently redisc,overed fifty years later. Vindicated by the truth.

he taught the causes of health wh,1e the misguided fought the causes of disease.