PERSONAL INFORMATION Balázs Sarkadi€¦ · PERSONAL INFORMATION Balázs Sarkadi ... Methodological advances in the culture, manipulation and utilization of embryonic stem cells

Curriculum vitae

PERSONAL INFORMATION Balázs Sarkadi

WORK EXPERIENCE

October 1972–September 2014 Director of Research UnitNational Blood Service (Hungary)

Research in the area of hematology and stem cells

September 2007–Present Research ProfessorSemmelweis University (Hungary)

Conducting research in medical biophysics, mentoring PhD students

September 2011–Present Scientific adviserResearch Center of Hungarian Acad. Sci., Institute of Molecular Pharmacology (Hungary)

Research in the area of stem cells

EDUCATION AND TRAINING

September 1966–September1972

MDSemmelweis University (Hungary)

General medical doctoral degree

August 1976–August 1980 PhDHungarian Acad. Sci. (Hungary)

Ph.D. in Biochemistry

August 1980–August 1986 DScHungarian Acad. Sci.

Doctor of Sciences, Biology

ADDITIONAL INFORMATION

Expertise Cell biology, membrane biology, stem cell research

Publications Publication list of Balazs Sarkadi (https://vm.mtmt.hu/www/index.php)

Total number of publications: 248

Total number of citations: 10 550

Independent citations: 9 176

IF total: 698,085

2013+

Sarankó H, Tordai H, Telbisz A, Ozvegy-Laczka C, Erdős G, Sarkadi B, Hegedűs

T.

Effects of the gout-causing Q141K polymorphism and a CFTR ΔF508 mimicking mutation on the processing and stability of the ABCG2 protein. Biochem Biophys Res Commun. 2013, 437:140-145.

Pomozi V, Le Saux O, Brampton C, Apana A, Iliás A, Szeri F, Martin L, Monostory K, Paku S, Sarkadi B, Szakács G, Váradi A.

21/11/17 © European Union, 2002-2017 | http://europass.cedefop.europa.eu Page 1 / 36

Curriculum vitae Balázs Sarkadi

ABCC6 is a basolateral plasma membrane protein. Circ Res. 2013 112:148-151.

Várady G., Cserepes J., Németh, A, Szabó E., Sarkadi B.:

Membrane proteins as personalized biomarkers: where we stand and where we are headed. Biomarkers in Medicine, 2013 accepted for publication"

2013

1.Telbisz A, Ozvegy-Laczka C, Hegedus T, Varadi A, Sarkadi B

Effects of the lipid environment, cholesterol and bile acids on the function of purified, reconstituted human ABCG2 protein.

BIOCHEM J 450: (2)387-395 (2013)

IF: 4.897**

Journal Article/Article/Scientific

2.Grabundzija I, Wang J, Sebe A, Erdei Z, Kajdi R, Devaraj A, Steinemann D, Szuhai K, Stein U, Cantz T, Schambach A, Baum C, Izsvak Z, Sarkadi B, Ivics Z

Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells.

NUCLEIC ACIDS RES epub: 1-19 (2013)

IF: 8.026**


3.Erdei Z, Sarkadi B, Brozik A, Szebenyi K, Varady G, Mako V, Pentek A, Orban TI, Apati A

Dynamic ABCG2 expression in human embryonic stem cells provides the basis for stress response.

EUR BIOPHYS J 42: (2-3)169-179 (2013)

IF: 2.139**


4.Apáti A, Pászty K, Hegedus L, Kolacsek O, Orbán TI, Erdei Z, Szebényi K, Péntek A, Enyedi A, Sarkadi B

Characterization of calcium signals in human embryonic stem cells and in their differentiated offspring by a stably integrated calcium indicator protein

CELL SIGNAL 25: (4)752-759 (2013)

IF: 4.058**


2012

5.Telbisz A, Hegedus C, Ozvegy-Laczka C, Goda K, Varady G, Takats Z, Szabo E, Sorrentino BP, Varadi A, Sarkadi B

Antibody binding shift assay for rapid screening of drug interactions with the human ABCG2 multidrug transporter.

EUR J PHARM SCI 45: (1-2)101-109 (2012)

IF: 3.212*


Dependent (self-) citations: 2

6.Sarkadi B, Schatten G

Stem Cell Course in the Middle East: Science Diplomacy and International Collaborations During the Arab Spring

STEM CELL REV REP 8: (1)87-90 (2012)

IF: 3.739*


7.Kasza I, Varady G, Andrikovics H, Koszarska M, Tordai A, Scheffer GL, Nemeth A, Szakacs G, Sarkadi B

Expression Levels of the ABCG2 Multidrug Transporter in Human Erythrocytes Correspond to Pharmacologically Relevant Genetic Variations.

PLOS ONE 7: (11) (2012)



IF: 4.092*


8.Hegedűs C, Truta-Feles K, Antalffy G, Várady G, Német K, Özvegy-Laczka C, Kéri G, Orfi L, Szakács G, Settleman J, Váradi A, Sarkadi B

Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: Implications for the emergence and reversal of cancer drug resistance

BIOCHEM PHARMACOL 84: (3)260-267 (2012)

IF: 4.705*


Independent citations: 2

9.Hegedus C, Truta-Feles K, Antalffy G, Brozik A, Kasza I, Nemet K, Orban TI, Ozvegy-Laczka C, Varadi A, Sarkadi B

PI3-kinase and mTOR inhibitors differently modulate the function of the ABCG2 multidrug transporter.

BIOCHEM BIOPH RES CO 420: (4)869-874 (2012)

IF: 2.484*



10.Gyimesi G, Ramachandran S, Kota P, Dokholyan NV, Sarkadi B, Hegedus T

ATP hydrolysis at one of the two sites in ABC transporters initiates transport related conformational transitions (vol 1808, pg 2954, 2011)

BBA-BIOMEMBRANES 1818: (5)1435 (2012)

IF: 3.990*


11.Gyimesi G, Borsodi D, Saranko H, Tordai H, Sarkadi B, Hegedus T

ABCMdb: a database for the comparative analysis of protein mutations in ABC transporters, and a potential framework for a general application.

HUM MUTAT 33: (11)1547-1556 (2012)

IF: 5.686*


12.de Boussac H, Orban TI, Varady G, Tihanyi B, Bacquet C, Brozik A, Varadi A, Sarkadi B, Aranyi T

Stimulus-induced expression of the ABCG2 multidrug transporter in HepG2 hepatocarcinoma model cells involves the ERK1/2 cascade and alternative promoters.


IF: 2.484*


13.Apati A, Paszty K, Erdei Z, Szebenyi K, Homolya L, Sarkadi B

Calcium signaling in pluripotent stem cells.

MOL CELL ENDOCRINOL 353: (1-2)57-67 (2012)

IF: 4.192*


Independent citations: 7 Dependent (self-) citations: 1 All citations: 8

14.Anita Schamberger, Balázs Sarkadi, Orbán Tamás

Human mirtrons can express functional microRNAs simultaneously from both arms in a flanking exon-independent manner

RNA BIOL 9: (9)1177-1185 (2012)

IF: 4.933*


2011

15.Varga N, Vereb Z, Rajnavolgyi E, Nemet K, Uher F, Sarkadi B, Apati A



Mesenchymal stem cell like (MSCl) cells generated from human embryonic stem cells support pluripotent cell growth


IF: 2.484



16.Varady G, Sarkadi B, Fatyol K

TTRAP is a novel component of the non-canonical TRAF6-TAK1 TGF-beta signaling pathway.

PLOS ONE 6: (9)e25548 (2011)

IF: 4.092


17.Tamás I Orbán, Ágota Apáti, Zsuzsanna Izsvák, Zoltán Ivics, Balázs Sarkadi

Use of Transposon-Transposase Systems for Stable Genetic Modification of Embryonic Stem Cells

In: Craig Atwood(ed.)

Methodological advances in the culture, manipulation and utilization of embryonic stem cells for basic and practical applications.

Rijeka: InTech, 2011. pp. 259-274.

(ISBN:978-953-307-197-8) Chapter in Book/Study/Scientific

18.Szebenyi K, Erdei Z, Pentek A, Sebe A, Orban TI, Sarkadi B, Apati A

Human pluripotent stem cells in pharmacological and toxicological screening: new perspectives for personalized medicine

PERS MED 8: (3)347-364 (2011)

IF: 1.528

Journal Article/Survey paper/Scientific

19.Prochazkova J, Kubala L, Kotasova H, Gudernova I, Sramkova Z, Pekarova M, Sarkadi B, Pachernik J

ABC transporters affect the detection of intracellular oxidants by fluorescent probes.

FREE RADIC RES 45: (7)779-787 (2011)

IF: 2.878


20.Kolacsek O, Krízsik V, Schamberger A, Erdei A, Apáti Á, Várady G, Mátés L, Izsvák Z, Ivics Z, Sarkadi B, Orbán TI

Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers

MOB DNA 2: (2011)



21.Homolya L, Orban TI, Csanady L, Sarkadi B

Mitoxantrone is expelled by the ABCG2 multidrug transporter directly from the plasma membrane

BBA-BIOMEMBRANES 1808: (1)154-163 (2011)

IF: 3.990



22.Gyimesi G, Ramachandran S, Kota P, Dokholyan NV, Sarkadi B, Hegedus T

ATP hydrolysis at one of the two sites in ABC transporters initiates transport related conformational transitions.


IF: 3.990





23.Fulop K, Jiang Q, Wetering KV, Pomozi V, Szabo PT, Aranyi T, Sarkadi B, Borst P, Uitto J, Varadi A

ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: Relevance to pathomechanisms of pseudoxanthoma elasticum.


IF: 2.484



24.Brozik A, Hegedus C, Erdei Z, Hegedus T, Ozvegy-Laczka C, Szakacs G, Sarkadi B

Tyrosine kinase inhibitors as modulators of ATP binding cassette multidrug transporters: substrates, chemosensitizers or inducers of acquired multidrug resistance?

EXPERT OPIN DRUG MET 7: (5)623-642 (2011)

IF: 3.119



2010

25.Schneider CK, Salmikangas P, Jilma B, Flamion B, Todorova LR, Paphitou A, Haunerova I, Maimets T, Trouvin JH, Flory E, Tsiftsoglou A, Sarkadi B, Gudmundsson K, O Donovan M, Migliaccio G, Ancans J, Maciulaitis R, Robert JL, Samuel A, Ovelgonne JH, Hystad M, Fal AM, Lima BS, MoraruAS, Turcani P, Zorec R, Ruiz S, Akerblom L, Narayanan G, Kent A, Bignami F, Dickson JG, Niederwieser D, Figuerola-Santos MA, Reischl IG, Beuneu C, Georgiev R, Vassiliou M, Pychova A, Clausen M, Methuen T, Lucas S, Schussler-Lenz M, Kokkas V, Buzas Z, MacAleenan N, Galli MC, Line A, Gulbinovic J, Berchem G, Fraczek M, Menezes-Ferreira M, Vilceanu N, Hrubisko M, Marinko P, Timon M, Cheng W, Crosbie GA, Meade N, di Paola ML, VandenDriessche T, Ljungman P, D ApoteL, Oliver-Diaz O, Buttel I, Celis P

Challenges with advanced therapy medicinal products and how to meet them.

NAT REV DRUG DISCOV 9: (3)195-201 (2010)

IF: 28.712

Journal Article/Scientific

26.Sarkadi B, Szakacs G

Understanding transport through pharmacological barriers--are we there yet?

NAT REV DRUG DISCOV 9: (11)897-898 (2010)

Journal Article/Comment, Correction/Scientific


27.Sarkadi B, Orban TI, Szakacs G, Varady G, Schamberger A, Erdei Z, Szebenyi K, Homolya L, Apati A

Evaluation of ABCG2 Expression in Human Embryonic Stem Cells: Crossing the Same River Twice?

STEM CELLS 28: (1)174-176 (2010)

IF: 7.871



28.Nathwani SM, Butler S, Fayne D, McGovern NN, Sarkadi B, Meegan MJ, Lloyd DG, Campiani G, Lawler M, Williams DC, Zisterer DM

Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells.

CANCER CHEMOTH PHARM 66: (3)585-596 (2010)

IF: 2.759



29.Greene LM, Nathwani SM, Bright SA, Fayne D, Croke A, Gagliardi M, McElligott AM, O Connor L, Carr M, Keely NO, O Boyle NM, Carroll P, Sarkadi B, Conneally E, Lloyd DG, Lawler M, Meegan MJ,



Zisterer DM

The vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance.

J PHARMACOL EXP THER 335: (2)302-313 (2010)

IF: 4.017



30.BATHORI GYOERGY [HU], MEHN DORA, AKOS PAL, KRAJCSI PETER, SZENTE LAJOS, FENYVESI EVA, TELBISZ AGNES, SARKADI BALAZS, VARADI ANDRAS, GEDEY SZILVIA, GLAVINAS HRISTOS [HU], KIS EMESE, NAGY TUENDE, NEMETH ATTILA, MOLNAR EVA

CHOLESTEROL LOADED INSECT CELL MEMBRANES AS TEST SYSTEMS FOR ABC TRANSPORTER PROTEINS

Patent ID: US2010021927 (A1)

Year of submission: 2006.

Publication year: 2010

Submitted to: Magyarország

Protection forms/International patent/Scientific

2009

31.Schamberger A, Kasza I, Homolya L, Sarkadi B, Orbán TI

Sleeping Beauty transzpozon alapú génbevitel: GFP-címkézett ABCG2 multidrogtranszporter-variánsok karakterizálása stabil sejtvonalakban

BIOKÉMIA XXXIII. évf.: 38 (2009)

Journal Article/Not subtyped/Scientific

32.Polgar O, Ediriwickrema LS, Robey RW, Sharma A, Hegde RS, Li YF, Xia D, Ward Y, Dean M, Ozvegy-Laczka C, Sarkadi B, Bates SE

Arginine 383 is a crucial residue in abcg2 biogenesis


IF: 3.998



33.Orbán TI, Apáti Á, Sarkadi B

Új remény a gén- és őssejtterápiában: a transzpozon alapú génbeviteli eljárások

BIOKÉMIA 33: (1)49-58 (2009)


34.Orbán TI, Apáti Á, Izsvák ZS, Ivics Z, Sarkadi B

Egyet fizet, kettőt kap: humán embrionális őssejtek cardiomyocyta irányú differenciációja egy kettős arcú promóterrel, Sleeping Beauty transzpozon-alapú génbevitelt követően

BIOKÉMIA 33: (3)3 (2009)

Journal Article/Abstract/Scientific

35.Orbán TI, Apáti Á, Németh A, Varga N, Krízsik V, Schamberger A, Szebényi K, Erdei Z, Várady G, Karászi É, Homolya L, Német K, Gócza E, Miskey C, Mátés L, Ivics Z, Izsvák Z, Sarkadi B

Applying a "double-feature" promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery

STEM CELLS 27: (5)1077-1087 (2009)

IF: 7.747



36.Orbán TI, Apáti Á, Németh A, Varga N, Krízsik V, Schamberger A, Várady G, Német K, Izsvák Z, Sarkadi B



Application of a "double-feature" promoter to identify cardiomyocytes differentiated from human embryonic stem cells: American Society of Gene Therapy 12th Annual Meeting Abstracts

MOL THER 17: (Supplement 1)265-266 (2009)


37.Katona M, Kiss K, Angyal V, Kucsma N, Sarkadi B, Takáts Z, Szakács G

A mass spectrometry based functional assay for the quantitative assessment of ABC transporter activity

RAPID COMMUN MASS SP 23: (21)3372-3376 (2009)

IF: 2.695



38.Kasza I, Hegyi Z, Szabo K, Andrikovics H, Német K, Váradi A, Sarkadi B, Homolya L

Model system for the analysis of cell surface expression of human ABCA1.

BMC CELL BIOL 10: 93 (2009)

IF: 2.654



39.Hou Y, Li C, Palaniyandi K, Magtibay PM, Homolya L, Sarkadi B, Chang XB

Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport

BIOCHEMISTRY-US 48: (38)9122-9131 (2009)

IF: 3.226



40.Hegedüs C, Özvegy-Laczka C, Szakács G, Sarkadi B

Interaction of ABC multidrug transporters with anticancer protein kinase inhibitors: substrates and /or inhibitors?

CURR CANCER DRUG TAR 9: (3)252-272 (2009)

IF: 5.129



41.Hegedus C, Ozvegy-Laczka C, Apati A, Magocsi M, Nemet K, Orfi L, Keri G, Katona M, Takats Z, Varadi A, Szakacs G, Sarkadi B

Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties.

BR J PHARMACOL 158: (4)1153-1164 (2009)

IF: 5.204



42.Hegedus C, Szakacs G, Homolya L, Orban TI, Telbisz A, Jani M, Sarkadi B

Ins and outs of the abcg2 multidrug transporter: an update on in vitro functional assays

ADV DRUG DELIVER REV 61: (1)47-56 (2009)

IF: 11.957



43.Apáti Á, Pászty K, Hegedűs L, Orbán TI, Homolya L, Enyedi Á, Sarkadi B

Calcium signaling in beating human embryonic stem cell-derived cardiomyocytes

FASEB J 2009: (2009)





2008

44.Turk D, Apati A, Varady G, Orban T, Krizik V, Uher F, Sarkadi B, Nemet K

Comparison of various promoters driving gfp expression in hek and human embryonic stem cells, by using lentiviral transduction

HUM GENE THER 19: (10)1189 (2008)


45.Szakacs G, Varadi A, Ozvegy-Laczka C, Sarkadi B

The role of abc transporters in drug absorption, distribution, metabolism, excretion and toxicity (adme-tox)

DRUG DISCOV TODAY 13: (9-10)379-393 (2008)

IF: 6.618



46.Seres L, Cserepes J, Elkind N B, Törőcsik D, Nagy L, Sarkadi B, Homolya L

Functional ABCG1 expression induces apoptosis in macrophages and other cell types


IF: 4.180



47.Sarkadi B, Ozvegy-Laczka C, Hegedus C

The role of abc transporters in resistance to anticancer tyrosine kinase inhibitors

ANTICANCER RES 28: (5C)584 (2008)


48.Sarkadi B

Abc multidrug transporters in cancer drug resistance and drug metabolism

CYTOM PART B-CLIN CY 74B: (1)29 (2008)


49.Ozvegy-Laczka C, Laczko R, Hegedus C, Litman T, Varady G, Goda K, Hegedus T, Dokholyan NV, Nikolay V, Sorrentino BP, Varadi A, Sarkadi B

Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter

J BIOL CHEM 283: (38)26059-26070 (2008)

IF: 5.520



50.Orban TI, Apati A, Nemeth A, Varga N, Krizsik V, Schamberger A, Varady G, Karaszi E, Homolya L, Nemet K, Miskey C, Ivics Z, Izsvak Z, Sarkadi B

Identification of tissues differentiated from human embryonic stem cells using a non-typical promoter behavior

HUM GENE THER 19: (10)1186 (2008)


51.Orban TI, Seres L, Ozvegy-Laczka C, Elkind NB, Sarkadi B, Homolya L

Combined localization and real-time functional studies using a gfp-tagged abcg2 multidrug transporter


IF: 2.648



52.Cserepes J, Elkind NB, Szentpetery Zs, Sarkadi B, Varadi A, Klein I, Homolya L, Seres L, Ozvegy-



Laczka Cs

Homo and heterodimer proteins of the ABCG family, methods for detection and screening modulators thereof

Patent ID: US2008187935 (A1)


Reference number of submission: US20050571754.



53.Apáti Á, Orbán T, Varga N, Németh A, Schamberger A, Krizsik V, Erdélyi-Belle B, Homolya L, Várady G, Padányi R, Karászi É, Kemna EW, Német K, Sarkadi B

High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells.


IF: 4.180



2007

54.Vas V, Vrauko K, Regeczy N, Schwab R, Sarkadi B

Characterization of umbilical cord blood hematopoietic stem, progenitor cell subsets and mesenchymal stem cell lines: a hungarian cord blood bank report

BLOOD REV 21: S88-S89 (2007)


55.Turk D, Varga N, Varady G, Sarkadi B, Uher F, Nemet K, Apati A

A mesenchymal stem cell-like cell line obtained from human embryonic stem cells provides feeder layer for undifferentiated stem cell growth

HUM GENE THER 18: (10)1081 (2007)


56.Telbisz A, Muller M, Ozvegy-Laczka C, Homolya L, Szente L, Varadi A, Sarkadi B

Membrane cholesterol selectively modulates the activity of the human abcg2 multidrug transporter


IF: 3.640



57.Schwab R, Micsik T, Szokoloczi O, Schafer E, Tihanyi B, Tihanyi T, Kupcsulik P, Diofalvi K, Mersich T, Besznyak I, Zarand A, Mihalik R, Sarkadi B, Keri G, Pap A, Jakab F, Kopper L, Petak I

Functional evaluation of multidrug resistance transporter activity in surgical samples of solid tumors

ASSAY DRUG DEV TECHN 5: (4)541-550 (2007)

IF: 1.832



58.Orban T, Apati A, Varga N, Krizsik V, Schamberger A, Izsvak Z, Nemet K, Sarkadi B

Transposon-mediated gene transfer into human embryonic stem cells

HUM GENE THER 18: (10)1080-1081 (2007)


59.Fuller MD, Thompson CH, Zhang ZR, Freeman CS, Schay E, Szakács G, Bakos E, Sarkadi B, McMaster D, French RJ, Pohl J, Kubanek J, McCarty NA

State-dependent inhibition of cystic fibrosis transmembrane conductance regulator chloride channels by a novel peptide toxin

J BIOL CHEM 282: (52)37545-37555 (2007)



IF: 5.581



60.Feher A, Turk D, Varady G, Orban T, Szakacs G, Sarkadi B, Settleman J, Nemet K

Down-regulation of the abcg2 multidrug transporter by lentiviral shrna expression eliminates gefitinib-induced multidrug resistance in non-small lung carcinoma cells

HUM GENE THER 18: (10)1070 (2007)


2006

61.Tusnady G E, Sarkadi B, Simon I, Varadi A

Membrane topology of human ABC proteins

FEBS LETT 580: 1017-1022 (2006)

IF: 3.372



62.Szatmari I, Vámosi G, Brazda P, Balint LB, Benko S, Széles L, Jeney V, Özvegy-Laczka G, SzántóA, Barta E, Balla J, Sarkadi B, Nagy L

PPARg reguleted ABCG2 expression confers cytoprotection to human dendritic cells

J BIOL CHEM 281: (33)23812-23823 (2006)

IF: 5.808



63.Sarkadi B, Homolya L, Szakacs G, Varadi A

Human multidrug resistance ABCB and ABCG transporters: Participation in a chemoimmunity defense system

PHYSIOL REV 86: 1179-1236 (2006)

IF: 31.441



64.Sarkadi B, Muller M, Klein I, Szabo K, Homolya L, Varadi A

ABC transporters for membrane lipids

CHEM PHYS LIPIDS 143: (1-2)40-41 (2006)


65.Polgar O, Ozvegy Laczka C, Robey R W, Morisaki K, Okada M, Tamaki A, Koblos G, Elkind N B, Ward Y, Dean M, Sarkadi B, Bates S E

Mutational studies of G553 in TM5 of ABCG2: A residue potentially involved in dimerization

BIOCHEMISTRY-US 45: 5251-5260 (2006)

IF: 3.633



66.Muller M, Klein I, Kopacsi S, Remaley A T, Rajnavolgyi E, Sarkadi B, Varadi A

Co-expression of human ABCG5 and ABCG8 in insect cells generates an androstan stimulated membrane ATPase activity

FEBS LETT 580: (26)6139-6144 (2006)

IF: 3.372



67.Homolya L, Elkind NB, Seres L, Cserepes J, Sarkadi B



Apoptotic effect of ABCG1 expression and function

FEBS J 273: (Suppl. 1)322 (2006)


68.Cervenak J, Andrikovics H, Ozvegy Laczka C, Tordai A, Nemet K, Varadi A, Sarkadi B

The role of the human ABCG2 multidrug transporter and its variants in cancer therapy and toxicology

CANCER LETT 234: 62-72 (2006)

IF: 3.277



2005

69.Seres L, Cserepes J, Elkind NB, Sarkadi B, Homolya L

Subcellular localization of the ABCG1 and ABCG4 transporters in mammalian cells

FEBS J 272: (Suppl. 1)209 (2005)


70.Schwab Richard, Petak Istvan, Sarkadi Balazs, Kopper Laszlo, Keri Gyoergy, Pap Akos, Szakacs Gergely, Homolya Laszlo, Jakab Ferenc, Moldvay Judit, Feher Arnold

Method And Reagent Kit For Evaluation Of Multidrug-Resistance Activity

Patent ID: WO2005116648



71.Reményi J, Hegedus T, Kovács P, Csík G, Sarkadi B, Hudecz F

In vitro antitumor effect and localization of daunomycin-polypeptide conjugate in sensitive and resistant cell lines

FEBS J 272: 528 (2005)



72.Reményi J, Miklán Z S, Csík G, Mezo G, Gaál D, Kovács P, Sarkadi B, Hudecz F

Drug targeting by peptide conjugates

SCI PHARM 73: KL-5 (2005)


73.Ozvegy Laczka C, Cserepes J, Elkind N B, Sarkadi B

Tyrosine kinase inhibitor resistance in cancer: role of ABC multidrug transporters

DRUG RESIST UPDATE 8: 15-26 (2005)

IF: 6.172



74.Ozvegy Laczka C, Varady G, Koblos G, Ujhelly O, Cervenak J, Schuetz JD, Sorrentino BP, Koomen GJ, Varadi A, Nemet K, Sarkadi B

Function-dependent conformational changes of the ABCG2 multidrug transporter modify its interactionwith a monoclonal antibody on the cell surface

J BIOL CHEM 280: 4219-4227 (2005)

IF: 5.854



75.Ozvegy Lacka C, Koblos G, Sarkadi B, Varadi A

Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition

BBA-BIOMEMBRANES 1668: 53-63 (2005)



IF: 4.224



76.Morisaki K, Robey R, Özvegy-Laczka C, Honjo Y, Polgár O, Steadman K, Sarkadi B, Bates S

Single nucleotide polymorphisms modify the transporter activity of ABCG2

CANCER CHEMOTH PHARM 56: 161-172 (2005)

IF: 2.235



77.Morisaki K, Robey R, Ozvegy Laczka C, Honjo Y, Polgar O, Steadman K, Sarkadi B, Bates S E

Single nucleotide polymorphisms modify the transporter activity of ABCG2

CANCER CHEMOTH PHARM 56: 161-172 (2005)

IF: 2.235



78.Jakab K, Gopcsa L, Adam E, Domjan G, Sarkadi B, Paloczi K

Application of flow cytometry immunophenotyping and multidrug resistance assay in B-cell acute lymphoid leukemia and multiple myeloma

NEOPLASMA 52: 36-42 (2005)

IF: 0.731



79.Jakab K, Gopcsa L, Adam E, Domjan G, Sarkadi B, Paloczi K

Application of flow cytometry immunophenotyping and multidrug resistance assay in B-cell acute lymphoid leukemia and multiple myeloma

NEOPLASMA 52: 36-42 (2005)

IF: 0.731



80.Elkind N B, Szentpetery Z, Apati A, Ozvegy-Laczka C, Varady G, Ujhelly O, Szabo K, Homolya L, Varadi A, Buday L, Keri G, Nemet K, Sarkadi B

Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD1839, Gefitinib).

CANCER RES 65: (5)1770-1777 (2005)

IF: 7.616



2004

81.SZENTPÉTERY ZS, SARKADI B, BAKOS É, VÁRADI A

Functional studies ont he MRP1 multidrug transporter: Characterization of ABC-signature mutant variants

ANTICANCER RES 24: 449-456 (2004)

Journal Article/Conference paper in journal/Scientific


82.Szentpetery Z, Kern A, Liliom K, Sarkadi B, Varadi A

The role of the conserved glycines of ATP-binding cassette signature motifs of MRP1 in the communication between the substrate-binding site and the catalytic centers

J BIOL CHEM 279: 41670-41678 (2004)



IF: 6.355



83.Sarkadi B, Ozvegy Laczka C, Nemet K, Varadi A

ABCG2 - a transporter for all seasons

FEBS LETT 567: 116-120 (2004)

Journal Article/Conference paper in journal/Scientific


84.R Schwab, I Peták, Gy Kéri, Á Pap, B Sarkadi, I Kopper, B B Németh, T Micsik, K Diófalvy, G Szakács, J Moldvay, I Homolya

Method and Reagent Kit for Evaluation of Multidrug-Resistance Activity

Patent ID: HU098565


Protection forms/Hungarian patent/Scientific

85.Ozvegy-Laczka C, Hegedus T, Varady G, Ujhelly O, Schuetz JD, Varadi A, Keri G, Orfi L, Nemet K,Sarkadi B

High-affinity interaction of tyrosine kinase inhibitors with the ABCG2

multidrug transporter

MOL PHARMACOL 65: (6)1485-1495 (2004)

IF: 5.080



86.Krishnamurthy P, Ross D D, Nakanishi T, Bailey Dell K, Zhou S, Mercer K E, Sarkadi B, Sorrentino B P, Schuetz J D

The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme

J BIOL CHEM 279: 24218-24225 (2004)

IF: 6.355



87.KERN A, SZENTPÉTERY Z, LILIOM K, BAKOS É, SARKADI B, VÁRADI A

Nucleotide and transported substrates modulate different steps of the ATPase catalytic cycle of MRP1multidrug transporter

BIOCHEM J 380: 549-560 (2004)

IF: 4.278



88.Homolya L, Sarkadi B, Evers R

Simple quantitative fluorescent assay method for determining the activity of transport proteins of interest

Patent ID: US2004033508 (A1)





89.GLAVINAS H, KRAJCSI P, CSEREPES J, SARKADI B

The role of ABC transporters in drug resistance, metabolism and toxicity

CURR DRUG DELIV 1: 27-42 (2004)




90.CSEREPES J, SZENTPÉTERY Z, SERES L, ÖZVEGY-LACZKA C, LANGMANN T, SCHMITZ G, GLAVINAS H, KLEIN I, HOMOLYA L, VÁRADI A, SARKADI B, ELKIND NB

Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications forheterodimerization

BIOCHEM BIOPH RES CO 320: 860-867 (2004)

IF: 2.904



91.Chu X Y, Huskey S E W, Braun M P, Sarkadi B, Evans D C, Evers R

Transport of ethinylestradiol glucuronide and ethinylestradiol sulfate by the multidrug resistance proteins MRP1, MRP2, and MRP3

J PHARMACOL EXP THER 309: 156-164 (2004)

IF: 4.335



92.Chu X, Huskey SE, Braun MP, Sarkadi B, Evans DC, Evers R

Transport of ethinylestradiol glucuronide and ethinylestradiol sulfate by the multidrug resistance proteins MRP1, MRP2, and MRP3.

J PHARMACOL EXP THER 309: 156-164 (2004)

IF: 4.335



2003

93.Váradi A, Tusnády GE, Sarkadi B

Membrane topology of ABC transporters

In: Holland IB(ed.)

ABC Proteins: From Bacteria to Man.

Elsevier, 2003.

Chapter in Book/Study/Scientific


94.Ujhelly O, Özvegy C, Várady G, Cervenak J, Homolya L, Grez M, Scheffer G, Roos D, Bates SE, Váradi A, Sarkadi B, Német K

Application of a human multidrug transporter (ABCG2) variant as selectable marker in gene transfer toprogenitor cells

HUM GENE THER 14: 403-412 (2003)

IF: 4.965



95.Szakács G, Sarkadi B

Multidrug resistance in cancer and modulation of drug effects by ABC transporters

In: Keri Gy, Toth I(ed.)

Molecular pathomechanisms and new trends in drug research.

London; New York: CRC Press - Taylor and Frances Group, 2003.

(ISBN:0415277256 ; 9780415277259) Chapter in Book/Study/Scientific

96.Sinkó E, Ilias A, Ujhelly O, Homolya L, Scheffer GL, Bergen AA, Sarkadi B, Váradi A

Subcellular localization and N-glycosylation of human ABCC6, expressed in MDCKII cells


IF: 2.836





97.Hudecz F, Reményi J, Szabó R, Hegedűs T, Sarkadi B, Gaál D

Peptide targeting of daunomycin into sensitive and multidrug resistant tumors

BIOPOLYMERS 71: 299 (2003)


98.Hudecz F, Kóczán Gy, Reményi J, Hegedűs T, Sarkadi B

Modulation of bioactivity of drugs (daunomycin and methotrexate) by peptide targeting.

In: Cordopatis PA, Manessi-Zoupa E, Paira GN(ed.)

3rd Hellenic Forum on Bioactive Peptides.

Patras: Typorama, 2003. pp. 93-102.

(ISBN:960-762029-1) Chapter in Book/Conference paper/Scientific

99.Homolya L, Váradi A, Sarkadi B

Multidrug resistance-associated proteins: Export pumps for conjugates with glutathione, glucuronate or sulfate

BIOFACTORS 17: 103-114 (2003)

IF: 1.852



100.Hegedűs T, Sessler T, Scott R, Thelin W, Bakos E, Váradi A, Szabó K, Homolya L, Milgram SL, Sarkadi B

C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins


IF: 2.836



101.Bodó A, Bakos E, Szeri F, Váradi A, Sarkadi B

The role of multidrug transporters in drug availability, metabolism and toxicity

TOXICOL LETT 140-141: 133-143 (2003)

IF: 2.224



102.Bodó A, Bakos E, Szeri F, Váradi A, Sarkadi B

Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions

J BIOL CHEM 278: 23529-23537 (2003)

IF: 6.482



2002

103.Varadi A, Szakacs G, Bakos E, Sarkadi B

P glycoprotein and the mechanism of multidrug resistance

In: Bock G, Goode JA(ed.)

Mechanisms of Drug Resistance in Epilepsy: Lessons from Oncology : Symposium on Mechanisms of drug resistance in epilepsy: lessons from oncology, held at the Novartis Foundation, London, 13-15 March 2001.

Chichester: Wiley-Interscience Publication, 2002. pp. 54-68.

(Novartis Foundation Symposia; 243.)



(ISBN:9780470841464) Chapter in Book/Conference paper/Scientific


104.Váradi A, Tusnády G E, Sarkadi B

Membrane topology of the human ABC transporters

In: Cole S, Kuchlerk, Higgins C F(ed.)

ABC Proteins:From Bacteria to Man.

Amsterdam: Kluwer Academic Publishers, 2002. pp. 37-47.

(ISBN:0-12-352551-9) Chapter in Book/Study/Scientific

105.Seprodi Janos (Hu), Sarkadi Balazs (Hu), Hegedus Tamas (Hu), Keri Gyoergy (Hu), Orfi Laszlo (Hu), Idei Miklos (Hu), Hollosy Ferenc (Hu), Teplan Istvan (Hu), Okada Yoshio (Jp)

Soluble Compounds For The Inhibition Of Multidrug Resistance And Pharmaceutical Compositions Thereof

Patent ID: WO0220527



106.Seprodi Janos (Hu), Sarkadi Balazs (Hu), Hegedus Tamas (Hu), Keri Gyoergy (Hu), Orfi Laszlo (Hu), Idei Miklos (Hu), Hollosy Ferenc (Hu), Teplan Istvan (Hu), Okada Yoshio (Jp)

Soluble Compounds For The Inhibition Of Multidrug Resistance And Pharmaceutical Compositions Thereof

Patent ID: AU8613101


Protection forms/Patent in other country/Scientific

107.Özvegy C, Váradi A, Sarkadi B

Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation

J BIOL CHEM 277: 47980-47990 (2002)

IF: 6.696



108.Gy Kéri, L Orfi, Gy Bökönyi, T Hegedus, B Hegymegi-Barakonyi, A Ullrich, B Sarkadi

Development of focused tyrosine kinase inhibitory library and testing against MDR

In: Benedetti E, Pedone C(ed.)

Peptides 2002: proceedings of the twenty- seventh European Peptide symposium : August 31-September 6, 2002, Sorrento, Italy.

Napoli: Edizioni Ziino, 2002. pp. 530-531.


109.Ilias A, Urbán Z, Seidl TL, Le Saux O, Sinkó E, Boyd CD, Sarkadi B, Váradi A

Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of humanABCC6 (MRP6)

J BIOL CHEM 277: 16860-16867 (2002)

IF: 6.696



110.Homolya L, Varadi A, Sarkadi B

Multidrug Resistance-Associated Proteins: Export Pumps for Conjugates with Glutathione,Glucuronate or Sulfate

In: Pompella A, Banhegyi G, Wellman Rousseau M(ed.)

Thiol metabolism and redox regulation of cellular functions: Proceedings of the NATO Advanced Research Workshop on Thiol Metabolism and Redox Regulation of Cellular Functions, 10-13 April 2002, Pisa, Italy.



Amsterdam: IOS Press, 2002. pp. 107-118.

(NATO Science Series I: Life and Behavioural Science; 347.)

(ISBN:1 58603 282 8) Chapter in Book/Conference paper/Scientific

111.Hegedus T, Orfi L, Seprodi A, Varadi A, Sarkadi B, Keri G

Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1.

BBA-MOL BASIS DIS 1587: (2-3)318-325 (2002)

IF: 3.300



2001

112.Szakács G, Özvegy C, Bakos E, Sarkadi B, Váradi A

Role of glycine-534 and glycine-1179 of human multidrug resistance protein (MDR1) in drug-mediatedcontrol of ATP hydrolysis

BIOCHEM J 356: 71-75 (2001)

IF: 4.326



113.Szakács G, Langmann T, Özvegy C, Orsó E, Schmitz G, Váradi A, Sarkadi B

Characterization of the ATPase cycle of human ABCA1: implications for its function as a regulator rather than an active transporter


IF: 2.946



114.Seprődi J, Hollosy M, Idei M, Kéri Gy, Teplán I, Füzesi M, Hegedűs T, Sarkadi B

Peptides 2000: Synthesis, analysis and biologicak studies of highly hydrophobic but highly soluble peptidomimetics against MDR

In: Martinez J, Fehrentz JA(ed.)

Peptides 2000: Proceedings of the 26th European Peptide Symposium.

Paris: EDK, Paris, France, 2001. pp. 847-848.


115.Sarkadi B, Homolya L, Holló Zs

Assay and reagent kit for evaluation of multi-drug resistance in cells

Patent ID: US6277655 (B1), US2001019846 (A1)


Reference number of submission: US19980203553, US20010840791.



116.Reményi J, Hegedűs T, Sarkadi B, Hudecz F

Effect of a daunomycin-polypeptide conjugate in multidrug resistant tumor cell lines

In: Martinez J, Fehrentz JA(ed.)

Peptides 2000: Proceedings of the 26th European Peptide Symposium.

Paris: EDK, Paris, France, 2001. pp. 941-942.


117.Reményi J, Hegedűs T, Sarkadi B, Tóth S, Falus A, Gaál D, Hudecz F

Daunomycin-polypetide conjugates: in vitro antitumour effect in sensitive and multidrug resistant cell lines



EUR J CANCER 37: 66 (2001)


118.Özvegy C, Litman T, Szakács G, Nagy Z, Bates S, Váradi A, Sarkadi B

Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells


IF: 2.946



119.Karaszi E, Jakab K, Homolya L, Szakács G, Holló Z, Telek B, Kiss A, Rejtő L, Nahajevszky S, Sarkadi B, Kappelmayer J

Calcein assay for multidrug resistance reliably predicts therapy response and survival rate in acute myeloid leukaemia

BRIT J HAEMATOL 112: 308-314 (2001)

IF: 2.815



120.Homolya L, Sarkadi B, Boucher RC

The role of CFTR in the mechanically induced intercellular calcium waves in human airway epithelia

PEDIATR PULM 32: (S22)S239 (2001)


121.Connolly L, Moran E, Larkin A, Scheffer G, Scheper R, Sarkadi B, Kool M, Clynes M

A new monoclonal antibody, P2A8(6), that specifically recognizes a novel epitope on the multidrug resistance-associated protein 1 (MRP1), but not on MRP2 nor MRP3

HYBRIDOMA HYBRIDOM 20: 333-341 (2001)



2000

122.Szakács G, Özvegy C, Bakos E, Sarkadi B, Váradi A

Transition-state formation in ATPase-negative mutants of human MDR1 protein


IF: 3.055



123.Szakacs G, Homolya L, Sarkadi B

Selective and quantitative detection of P-glycoprotein (MDR1) and multidrug resistance protein (MRP1) function in calcein accumulation assay

CYTOMETRY 42: (2)155 (2000)


124.Smith AJ, van Helvoort A, Van Meer G, Szabó K, Welker E, Szakacs G, Varadi A, Sarkadi B, Borst P

MDR3P-glycoprotein a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping

J BIOL CHEM 275: (31)23530-23539 (2000)

IF: 7.368



125.Sarkadi B, Seprodi J, Hegedüs T, Kéri Gy, Orfi L, Idei M, Hollósy F, Teplán I, Okada Y

Multi-Drug Rezisztencia Megszüntetésére Alkalmas Oldékony Vegyületek, E Vegyületeket TartalmazóGyógyászati Készítmények És Eljárás A Vegyületek Eloállítására



Patent ID: P0003554


Protection forms/Hungarian patent/Scientific

126.Reményi J, Hegedűs T, Sarkadi B, Hudecz F

Effect of a daunomycin-polypeptide conjugate in multidrug resistant

J PEPT SCI 6: 218 (2000)


127.Nagy H, Goda K, Szakacs G, Arceci R, Varadi A, Sarkadi B, Mechetner E, Szabo G

Fluorescence resonance energy transfer studies of function-related changes in the oligomerization and conformational state of Pgp

CYTOMETRY 42: (2)151-152 (2000)


128.Kern A, Felföldi F, Sarkadi B, Váradi A

Expression and characterization of the N- and C-terminal ATP-binding domains of MRP1


IF: 3.055



129.Bakos E, Evers R, Sinkó E, Váradi A, Borst P, Sarkadi B

Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions

MOL PHARMACOL 57: 760-768 (2000)

IF: 5.678



130.Bakos E, Evers R, Calenda G, Tusnady GE, Szakács G, Varadi A, Sarkadi B

Characterization of the amino-terminal regions in the human multidrug resistance protein (MRP1)

J CELL SCI 113: (Pt 24)4451-4461 (2000)

IF: 5.996



1999

131.Vadász ZS, Szabó K, Sarkadi B, Teplán I, Mék M, Idei M, Győrffy E, Seprődi J

New hydrophobic peptide like compounds modulating MDR1-ATPase activity.

In: Bajusz S, Hudecz F(ed.)

Peptides 1998: Proceedings of the 25th European Peptide Symposium. August 30-September 4, 1998, Budapest, Hungary.

Budapest: Akadémiai Kiadó, 1999. p. 640.

(ISBN:9789630576222) Chapter in Book/Scientific


132.Szabó K, Szakács G, Hegedűs T, Sarkadi B

Nucleotide occlusion in the human cystic fibrosis transmembrane conductance regulator. Different patterns in the two nucleotide binding domains

J BIOL CHEM 274: 12209-12212 (1999)

IF: 7.666



133.Sharom FJ, Yu X, Lu P, Liu R, Chu JW, Szabó K, Müller M, Hose CD, Monks A, Váradi A, Seprődi J, Sarkadi B



Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells

BIOCHEM PHARMACOL 58: 571-586 (1999)

IF: 2.755




Assay for multi-drug resistance

Patent ID: US5872014 (A)




Submitted to: Magyarország


135.Klein I, Sarkadi B, Váradi A

An inventory of the human ABC proteins

BIOCHIM BIOPHYS ACTA 1461: 237-262 (1999)

IF: 2.590



136.Ito S, Woodland C, Sarkadi B, Hockmann G, Walker SE, Koren G

Modeling of P-glycoprotein-involved epithelial drug transport in MDCK cells

AM J PHYSIOL-RENAL 277: F84-F96 (1999)

IF: 3.590



1998

137.Váradi A, Tusnády G E, Bakos É, Sarkadi B

Membrane topology of the human multidrug resistance-associated protein (MRP) and its homologs.

In: M Clynes(ed.)

Multiple drug resistance in cancer: molecular, cellular and clinical aspects.

Dordrecht: Kluwer Academic Publishers, 1998. pp. 71-80.


138.Varadi A, Tusnady GE, Bakos E, Sarkadi B

Membrane topology of the human multidrug resistance-associated protein (MRP) and its homologs.

CYTOTECHNOLOGY 27: (1-3)71-79 (1998)

IF: 0.616



139.Tordai A, Andrikovics H, Kalmar L, Rajczy K, Pénzes M, Sarkadi B, Klein I, Varadi A

High Frequency of the Haemochromatosis C282Y Mutation in Hungary Can Argue Against the Celtic Origin of the Mutation

J MED GENET 35: (10)878-879 (1998)



140.Szakács G, Jakab K, Antal F, Sarkadi B

Diagnostics of multidrug resistance in cancer



PATHOL ONCOL RES 4: 251-257 (1998)



141.Szabo K, Welker E, Bakos E, Muller M, Roninson IB, Varadi A, Sarkadi B

Nucleotide trapping in the human multidrug transporter (MDR1) is stimulated by substrate

FASEB J 12: (4)A441 (1998)


142.Szabó K, Welker E, Bakos, Müller M, Roninson I, Váradi A, Sarkadi B

Drug-stimulated nucleotide trapping in the human multidrug transporter MDR1. Cooperation of the nucleotide binding domains

J BIOL CHEM 273: (17)10132-10138 (1998)

IF: 7.199



143.Szabo K, Muller M, Bakos E, Welker E, Roninson IB, Varadi A, Sarkadi B

Co-operation of the nucleotide binding domains in the human multidrug transporter

FASEB J 12: (8)A1456 (1998)


144.Holló Z, Homolya L, Hegedűs T, Müller M, Szakács G, Jakab K, Antal F, Sarkadi B

Parallel functional and immunological detection of human multidrug resistance proteins, P-glycoprotein and MRP1

ANTICANCER RES 18: 2981-2987 (1998)

IF: 1.236



145.Bakos E, Evers R, Szakács G, Tusnády GE, Welker E, Szabó K, de Haas M, van Deemter L, Borst P, Váradi A, Sarkadi B

Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain

J BIOL CHEM 273: (48)32167-32175 (1998)

IF: 7.199



1997

146.Tusnády GE, Bakos E, Váradi A, Sarkadi B

Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters

FEBS LETT 402: (1)1-3 (1997)

IF: 3.504



147.Tordai A, Klein I, Rajczy K, Penzes M, Sarkadi B, Varadi A

Prevalence of factor V Leiden (Arg506Gln) in Hungary.

BRIT J HAEMATOL 99: 466-467 (1997)



148.Szabó K, Bakos E, Welker E, Müller M, Goodfellow HR, Higgins CF, Váradi A, Sarkadi B

Phosphorylation site mutations in the human multidrug transporter modulate its drug-stimulated ATPase activity

J BIOL CHEM 272: 23165-23171 (1997)



IF: 6.963



149.Sarkadi B, Müller M

Search for specific inhibitors of multidrug resistance in cancer

SEMIN CANCER BIOL 8: 171-182 (1997)

IF: 4.074



150.Bakos E, Klein I, Welker E, Szabó K, Müller M, Sarkadi B, Váradi A

Characterization of the human multidrug resistance protein containing mutations in the ATP-binding cassette signature region

BIOCHEM J 323: 777-783 (1997)

IF: 3.579



1996

151.Sarkadi B, Müller M, Holló Z

The multidrug transporters--proteins of an ancient immune system

IMMUNOL LETT 54: 215-219 (1996)

IF: 1.255




Assay and reagent kit for the quantitative in vitro determination in biological specimens of the activity of proteins causing multi-drug resistance in tumors

Patent ID: CA2198731 (A1), WO9606945 (A1)


Reference number of submission: CA19952198731, WO1995HU00042.


Submitted to: Amerikai Egyesült Államok


153.Müller M, Bakos E, Welker E, Váradi A, Germann UA, Gottesman MM, Morse BS, Roninson IB, Sarkadi B

Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein

J BIOL CHEM 271: 1877-1883 (1996)

IF: 7.452



154.Homolya L, Holló Z, Hegedûs T, Sarkadi B

Quantitative Characterization of P-glycoprotein Function

CELL BIOL INT 20: (3)233 (1996)


155.Homolya L, Müller M, Holló Zs, Sarkadi B

Fluorescence assay for studying P-glycoprotein function at single cell level

In: J Slavik(ed.)

Fluorescence Microscopy and Fluorescent Probes.

New York: Plenum Press, 1996. pp. 241-245.




156.Homolya L, Holló M, Müller M, Mechetner EB, Sarkadi B

A new method for a quantitative assessment of P-glycoprotein-related multidrug resistance in tumour cells

BRIT J CANCER 73: 849-855 (1996)

IF: 3.666



157.Holló Z, Homolya L, Hegedűs T, Sarkadi B

Transport properties of the multidrug resistance-associated protein (MRP) in human tumour cells

FEBS LETT 383: 99-104 (1996)

IF: 3.750



158.Bakos E, Hegedűs T, Holló Z, Welker E, Tusnády GE, Zaman GJ, Flens MJ, Váradi A, Sarkadi B

Membrane topology and glycosylation of the human multidrug resistance-associated protein

J BIOL CHEM 271: (21)12322-12326 (1996)

IF: 7.452



1995

159.Welker E, Szabó K, Holló Z, Müller M, Sarkadi B, Váradi A

Drug-stimulated ATPase activity of a deletion mutant of the human multidrug-resistance protein (MDR1)


IF: 3.179



160.

Sarkadi B

(ed.)

ICRO International Symposium and Course on Membrane Transporters and Channels

Magyarország, Budapest1995.05.22-1995.06.04: 1995.

Conference proceedings/ /Scientific

1994

161.Stutts MJ, Gabriel SE, Price EM, Sarkadi B, Olsen JC, Boucher RC

Pyridine nucleotide redox potential modulates cystic fibrosis transmembrane conductance regulator Cl- conductance

J BIOL CHEM 269: 8667-8674 (1994)

IF: 7.716



162.Sarkadi B, Homolya L, Holló Z, Müller M

Quantitative in vitro determination of P-glycoprotein function in tumor cells.

ANTI-CANCER DRUG 5: (1)14 (1994)


163.Sarkadi B, Müller M, Homolya L, Holló Z, Seprődi J, Germann UA, Gottesman MM, Price EM, Boucher RC



Interaction of bioactive hydrophobic peptides with the human multidrug transporter

FASEB J 8: 766-770 (1994)

IF: 15.115



164.Kovács T, Corvazier E, Papp B, Magnier C, Bredoux R, Enyedi A, Sarkadi B, Enouf J

Controlled proteolysis of Ca(2+)-ATPases in human platelet and non-muscle cell membrane vesicles. Evidence for a multi-sarco/endoplasmic reticulum Ca(2+)-ATPase system

J BIOL CHEM 269: 6177-6184 (1994)

IF: 7.716



165.Holló Z, Homolya L, Davis CW, Sarkadi B

Calcein accumulation as a fluorometric functional assay of the multidrug transporter.

BRIT J HAEMATOL 87: (1)33 (1994)


166.Holló Z, Homolya L, Davis CW, Sarkadi B

Calcein accumulation as a fluorometric functional assay of the multidrug transporter


IF: 2.507



1993

167.Yankaskas Jr, Haizlip JE, Conrad M, Koval D, Lazarowski E, Paradiso AM, Rinehart CA Jr, Sarkadi B, Schlegel R, Boucher RC

Papilloma virus immortalized tracheal epithelial cells retain a well-differentiated phenotype

AM J PHYSIOL 264: C1219-C1230 (1993)

IF: 3.139



168.Yankaskas JR, Suchindran H, Sarkadi B, Nettesheim P, Randell SH

CYSTIC-FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) PROTEIN IS SELECTIVELY EXPRESSED IN CILIATED AIRWAY EPITHELIAL-CELLS

AM REV RESPIR DIS 147: A26 (1993)



169.Papp B, Pászty K, Kovács T, Sarkadi B, Gárdos G, Enouf J, Enyedi A

Characterization of the inositol trisphosphate-sensitive and insensitive calcium stores by selective inhibition of the endoplasmic reticulum-type calcium pump isoforms in isolated platelet membrane vesicles

CELL CALCIUM 14: 531-538 (1993)

IF: 4.545



170.König T, Kapus A, Sarkadi B

Effects of equisetin on rat liver mitochondria: evidence for inhibition of substrate anion carriers of the inner membrane

J BIOENERG BIOMEMBR 25: 537-545 (1993)



IF: 4.761



171.Homolya L, Holló Z, Germann UA, Pastan I, Gottesman MM, Sarkadi B

Fluorescent cellular indicators are extruded by the multidrug resistance protein

J BIOL CHEM 268: 21493-21496 (1993)

IF: 6.793



1992

172.Sarkadi B, Price EM, Boucher RC, Germann UA, Scarborough GA

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase

J BIOL CHEM 267: 4854-4858 (1992)

IF: 6.733



173.Sarkadi B, Bauzon D, Huckle WR, Earp HS, Berry A, Suchindran H, Price EM, Olson JC, Boucher RC, Scarborough GA

Biochemical characterization of the cystic fibrosis transmembrane conductance regulator in normal and cystic fibrosis epithelial cells

J BIOL CHEM 267: 2087-2095 (1992)

IF: 6.733



174.Papp B, Enyedi A, Pászty K, Kovács T, Sarkadi B, Gárdos G, Magnier C, Wuytack F, Enouf J

Simultaneous presence of two distinct endoplasmic-reticulum-type calcium-pump isoforms in human cells. Characterization by radio-immunoblotting and inhibition by 2,5-di-(t-butyl)-1,4-benzohydroquinone

BIOCHEM J 288: 297-302 (1992)

IF: 3.716



175.Olsen JC, Johnson LG, Stutts MJ, Sarkadi B, Yankaskas Jr, Swanstrom R, Boucher RC

Correction of the apical membrane chloride permeability defect in polarized cystic fibrosis airway epithelia following retroviral-mediated gene transfer

HUM GENE THER 3: 253-266 (1992)

IF: 4.950



176.Kapui Z, Hermecz I, Sarkadi B, Szentmiklósi P, Tardos L, Blaskó G

Comparative studies of drotaverine--acephyllinate (Depogen) and pentoxifylline (Trental)

THROMB RES 66: 693-706 (1992)

IF: 1.293



177.Johnson LG, Olsen JC, Sarkadi B, Moore KL, Swanstrom R, Boucher RC

Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis



NAT GENET 2: 21-25 (1992)



1991

178.Sarkadi B, Tordai A, Homolya L, Scharff O, Gárdos G

Calcium influx and intracellular calcium release in anti-CD3 antibody-stimulated and thapsigargin-treated human T lymphoblasts

J MEMBRANE BIOL 123: 9-21 (1991)

IF: 3.436



179.Sarkadi B, Parker JC

Activation of ion transport pathways by changes in cell volume


IF: 2.460



180.Papp B, Enyedi A, Kovács T, Sarkadi B, Wuytack F, Thastrup O, Gárdos G, Bredoux R, Levy Toledano S, Enouf J

Demonstration of two forms of calcium pumps by thapsigargin inhibition and radioimmunoblotting in platelet membrane vesicles

J BIOL CHEM 266: 14593-14596 (1991)

IF: 6.714



1990

181.Sarkadi B, Tordai A, Müller M, Gárdos G

Regulation of stimulus-induced calcium transport pathways in human T (Jurkat) lymphoblasts

MOL IMMUNOL 27: (12)1297-1306 (1990)

IF: 2.000



182.Sarkadi B, Tordai A, Gárdos G

Membrane depolarization selectively inhibits receptor-operated calcium channels in human T (Jurkat) lymphoblasts

BIOCHIM BIOPHYS ACTA 1027: (2)130-140 (1990)

IF: 2.411



183.Kovács T, Tordai A, Szász I, Sarkadi B, Gárdos G

Membrane depolarization inhibits thrombin-induced calcium influx and aggregation in human platelets

FEBS LETT 266: (1-2)171-174 (1990)

IF: 3.420



184.Kapui Z, Hermecz I, Sarkadi B, Szentmiklósi P, Tardos L

Drotaverin-acefillinát (Depogen) és pentoxifilln (Trental) összehasnlító vizsgálata

In: Szabó J Z, Szentmiklósi A J(ed.)



A keringésfarmakológiai kutatások újabb eredményei.

Debrecen: DOTE, 1990. pp. 247-264.

(ISBN:9637286241) Chapter in Book/Study/Scientific


1989

185.Tordai A, Sarkadi B, Görög G, Gárdos G

Inhibition of the CD3-mediated calcium signal by protein kinase C activators in human T (Jurkat) lymphoblastoid cells

IMMUNOL LETT 20: (1)47-52 (1989)

IF: 1.509



186.Sarkadi B, Gárdos G

Drug actions on potassium fluxes in red cells

In: B U Raess, G Tunnicliff(ed.)

The Red Cell Membrane: A Model For Solute Transport.

New York: Humana Press, 1989. pp. 369-396.


187.Papp B, Sarkadi B, Enyedi A, Caride AJ, Penniston JT, Gárdos G

Functional domains of the in situ red cell membrane calcium pump revealed by proteolysis and monoclonal antibodies. Possible sites for regulation by calpain and acidic lipids

J BIOL CHEM 264: 4577-4582 (1989)

IF: 6.636



188.Magocsi M, Sarkadi B, Kovács T, Gárdos G

Thrombin-induced activation of calcium transport pathways and their role in platelet functions


IF: 2.261



189.Kovács T, Szász I, Sarkadi B, Brezanoczy F, Gárdos G

Volume regulatory mechanisms of human granulocytes in hypoosmotic media

ACTA BIOCHIM BIOPHYS ACAD SCI HUNG 24: 83-99 (1989)

IF: 0.508



190.Enouf J, Bredoux R, Bourdeau N, Sarkadi B, Levy Toledano S

Further characterization of the plasma membrane- and intracellular membrane-associated platelet Ca2+ transport systems

BIOCHEM J 263: 547-552 (1989)

IF: 3.631



1988

191.Szirmai M, Sarkadi B, Szász I, Gárdos G

Volume regulatory mechanisms of human platelets

HAEMATOLOGIA (BUDAPEST) 21: 33-40 (1988)



IF: 0.127



192.Sarkadi B, Enyedi A, Penniston JT, Verma AK, Dux L, Molnár E, Gárdos G

Characterization of membrane calcium pumps by simultaneous immunoblotting and 32P radiography


IF: 2.278



193.Magocsi M, Enyedi A, Sarkadi B, Gárdos G

Effects of phosphoinositides on calcium movements in human platelet membrane vesicles


IF: 2.278



1987

194.Ujhelyi E, Onody K, Minh DQ, Sarkadi B, Fust G

Enhancing effect of alpha-interferon on the C2 synthesis by cultured human monocytes

IMMUNOL LETT 15: 41-44 (1987)

IF: 1.224



195.Sarkadi B, Enyedi A, Gárdos G

Conformational changes of the in situ red cell membrane calcium pump affect its proteolysis


IF: 2.394



196.Hunyady L, Sarkadi B, Cragoe EJ Jr, Spät A, Gárdos G

Activation of sodium-proton exchange is not a prerequisite for Ca2+ mobilization and aggregation in human platelets

FEBS LETT 225: 72-76 (1987)

IF: 3.381



197.Enyedi A, Flura M, Sarkadi B, Gárdos G, Carafoli E

The maximal velocity and the calcium affinity of the red cell calcium pump may be regulated independently

J BIOL CHEM 262: 6425-6430 (1987)

IF: 6.373



1986

198.Sarkadi B, Enyedi A, Földes Papp Z, Gárdos G

Molecular characterization of the in situ red cell membrane calcium pump by limited proteolysis

J BIOL CHEM 261: 9552-9557 (1986)

IF: 6.315





199.Enyedi A, Sarkadi B, Földes Papp Z, Monostory S, Gárdos G

Demonstration of two distinct calcium pumps in human platelet membrane vesicles

J BIOL CHEM 261: 9558-9563 (1986)

IF: 6.315



1985

200.Sarkadi B, Cheung R, MacK E, Grinstein S, Gelfand EW, Rothstein A

Cation and anion transport pathways in volume regulatory response of human lymphocytes to hyposmotic media

AM J PHYSIOL 248: C480-C487 (1985)

IF: 3.011



201.Sarkadi B, Gárdos G

Calcium-induced potassium transport in cell membranes

In: Martonosi M(ed.)

Enzymes of Biological Membranes.

New York: Plenum Press, 1985. pp. 193-234.

Vol. 3., Membrane transport

(ISBN:0306414538) Chapter in Book/Study/Scientific

202.Sarkadi B, Grinstein S, Rothstein A, Gárdos G

Analysis of Ca2+-induced K+-transport of human erythrocytes in propionate media


IF: 0.517



1984

203.Sarkadi B, Attisano L, Grinstein S, Buchwald M, Rothstein A

Volume regulation of Chinese hamster ovary cells in anisoosmotic media


IF: 2.536



204.Sarkadi B, MacK E, Rothstein A

Ionic events during the volume response of human peripheral blood lymphocytes to hypotonic media. II. Volume- and time-dependent activation and inactivation of ion transport pathways

J GEN PHYSIOL 83: 513-527 (1984)

IF: 5.306



205.Sarkadi B, MacK E, Rothstein A

Ionic events during the volume response of human peripheral blood lymphocytes to hypotonic media. I. Distinctions between volume-activated Cl- and K+ conductance pathways

J GEN PHYSIOL 83: 497-512 (1984)

IF: 5.306





206.Grinstein S, Rothstein A, Sarkadi B, Gelfand EW

Responses of lymphocytes to anisotonic media: volume-regulating behavior

AM J PHYSIOL 246: C204-C215 (1984)

IF: 2.905



207.Farkas G, Enyedi A, Sarkadi B, Gárdos G, Nagy Z, Faragó A

Cyclic AMP-dependent protein kinase stimulates the phosphorylation of phosphatidylinositol to phosphatidylinositol-4-monophosphate in a plasma membrane preparation from pig granulocytes


IF: 3.020



208.Enyedi A, Faragó A, Sarkadi B, Gárdos G

Cyclic AMP-dependent protein kinase and Ca2+-calmodulin stimulate the formation of polyphosphoinositides in a sarcoplasmic reticulum preparation of rabbit heart

FEBS LETT 176: 235-238 (1984)

IF: 2.965



1983

209.Sarkadi B, Enyedi A, Faragó A, Mészáros G, Kremmer T, Gárdos G

Cyclic AMP-dependent protein kinase stimulates the formation of polyphosphoinositides in lymphocyte plasma membrane

FEBS LETT 152: 195-198 (1983)

IF: 2.879



210.Grinstein S, Cohen S, Sarkadi B, Rothstein A

Induction of 86Rb fluxes by Ca2+ and volume changes in thymocytes and their isolated membranes

J CELL PHYSIOL 116: 352-362 (1983)

IF: 2.852



211.Enyedi A, Sarkadi B, Faragó A, Szász I, Gárdos G

The effect of cyclic AMP-dependent protein kinase on the formation of polyphosphoinositides in erythrocyte membranes

BIOMED BIOCHIM ACTA 42: S130-S131 (1983)


212.Enyedi A, Faragó A, Sarkadi B, Szász I, Gárdos G

Cyclic AMP-dependent protein kinase stimulates the formation of polyphosphoinositides in the plasmamembranes of different blood cells

FEBS LETT 161: 158-162 (1983)

IF: 2.879





1982

213.Szász I, Sarkadi B, Gárdos G

Operation of the Ca-dependent K(Rb)-transport in human lymphocytes



214.Sarkadi B, Enyedi A, Nyers A, Gárdos G

The function and regulation of the calcium pump in the erythrocyte membrane

ANN NY ACAD SCI 402: 329-348 (1982)

IF: 1.653



215.Sarkadi B, Enyedi A, Szász I, Gárdos G

Active calcium transport and calcium-dependent membrane phosphorylation in human peripheral blood lymphocytes

CELL CALCIUM 3: 163-182 (1982)

IF: 2.935



216.Enyedi A, Sarkadi B, Gárdos G

On the substrate specificity of the red cell calcium pump


IF: 2.652



217.Enyedi A, Sarkadi B, Nyers A, Gárdos G

Effects of divalent metal ions on the calcium pump and membrane phosphorylation in human red cells


IF: 2.652



1981

218.Szasz I, Sarkadi B, Enyedi A, Gardos G

Ca-transport and CaMg-ATPase activity in human red cell preparations

ACTA BIOL MED GER 40: 429-436 (1981)

IF: 0.569



219.Sarkadi B, Enyedi A, Gardos G

METAL-ATP COMPLEXES AS SUBSTRATES AND FREE METAL-IONS AS ACTIVATORS OF THERED-CELL CALCIUM-PUMP

CELL CALCIUM 2: 449-458 (1981)

IF: 1.771



220.Sarkadi B, Szász I, Gárdos G

Calcium and calmodulin in the regulation of blood cell functions (a mini-review)





221.Marino D, Sarkadi B, Gardos G, Bolis L

CALCIUM-INDUCED ALKALI CATION-TRANSPORT IN NUCLEATED RED-CELLS

MOL PHYSIOL 1: 295-300 (1981)



1980

222.Sarkadi B, Enyedi A, Gárdos G

MOLECULAR-PROPERTIES OF THE RED-CELL CALCIUM-PUMP .1. EFFECTS OF CALMODULIN, PROTEOLYTIC DIGESTION AND DRUGS ON THE KINETICS OF ACTIVE CALCIUM-UPTAKE IN INSIDE-OUT RED-CELL MEMBRANE- VESICLES

CELL CALCIUM 1: 287-297 (1980)



223.Sarkadi B, Enyedi A, Szász I, Gárdos G

Effect of calmodulin on active calcium uptake and membrane phosphorylation in inside-out red cell membrane vesicles

In: S R Hollán, G Gárdos,

B Sarkadi

(ed.)

Genetics, Structure and Function of Blood Cells: proceedings of the 28th International Congress of Physiological Sciences, Budapest, 1980.

Budapest: Pergamon Press - Akadémiai Kiadó, 1980. pp. 181-188.

(ISBN:9630527324 ; 9780080268187) Chapter in Book/Conference paper/Scientific


Characteristics and regulation of active calcium transport in inside-out red cell membrane vesicles


IF: 2.864



225.Sarkadi B

Active calcium transport in human red cells


IF: 2.864



226.

S R Hollán, G Gárdos,

B Sarkadi

(ed.)

Genetics, Structure and Function of Blood Cells: proceedings of the 28th International Congress of Physiological Sciences, Budapest, 1980

Budapest: Pergamon Press - Akadémiai Kiadó, 1980. 308p.

(ISBN:9630527324 ; 9780080268187)

Book/Conference proceedings/Scientific

227.Enyedi A, Sarkadi B, Szász I, Bot G, Gárdos G

MOLECULAR-PROPERTIES OF THE RED-CELL CALCIUM-PUMP .2. EFFECTS OF CALMODULIN, PROTEOLYTIC DIGESTION AND DRUGS ON THE CALCIUM- INDUCED MEMBRANE PHOSPHORYLATION BY ATP IN INSIDE-OUT RED-CELL MEMBRANE-VESICLES



CELL CALCIUM 1: 299-310 (1980)



1979

228.Sarkadi B, Schubert A, Gárdos G

Effects of calcium-EGTA buffers on active calcium transport in inside-out red cell membrane vesicles

EXPERIENTIA 35: 1045-1047 (1979)

IF: 0.858



1978

229.Szász I, Hasitz M, Sarkadi B, Gárdos G

Phosphorylation of the Ca2+ pump intermediate in intact red cells, isolated membranes and inside-outvesicles

MOL CELL BIOCHEM 22: 147-152 (1978)

IF: 1.706




Mechanisms for passive calcium transport in human red cells


IF: 0.421



231.Szász I, Sarkadi B, Schubert A, Gárdos G

Effects of lanthanum on calcium-dependent phenomena in human red cells


IF: 3.215




Effect of drugs on the calcium-dependent rapid potassium transport in calcium-loaded intact red cells


IF: 0.421




Changes in the Ca2+-transport processes of red cells during cold storage in ACD

BRIT J HAEMATOL 39: 559-568 (1978)

IF: 3.196



234.Szász I, Hasitz M, Breuer JH, Sarkadi B, Gárdos G

Biconcave shape and its transformations in human red cells

ACTA BIOL ACAD SCI HUNG 29: 1-17 (1978)

IF: 0.163





235.Sarkadi B, MacIntyre JD, Gárdos G

Kinetics of active calcium transport in inside-out red cell membrane vesicles

FEBS LETT 89: 78-82 (1978)

IF: 3.004



236.Sarkadi B, Alifimoff JK, Gunn RB, Tosteson DC

Kinetics and stoichiometry of Na-dependent Li transport in human red blood cells

J GEN PHYSIOL 72: 249-265 (1978)

IF: 4.855



237.Sarkadi B, Tosteson D C

Active cation transport in human red cells

In: G Giebisch, D C Tosteson, H H Ussing(ed.)

Membrane Transport in Biology.

Berlin: Springer-Verlag, 1978. pp. 117-160.

Vol. 3., Transport across multi-membrane systems


238.Pandey GN, Sarkadi B, Haas M, Gunn RB, Davis JM, Tosteson DC

Lithium transport pathways in human red blood cells

J GEN PHYSIOL 72: 233-247 (1978)

IF: 4.855



1977


Mechanism of Ca2+-dependent selective rapid K+-transport induced by propranolol in red cells

J MEMBRANE BIOL 35: 75-93 (1977)

IF: 3.453



240.Schubert A, Sarkadi B

Kinetic studies on the calcium-dependent potassium transport in human red blood cells


IF: 0.797



241.Sarkadi B, Szász I, Gerlóczy A, Gárdos G

Transport parameters and stoichiometry of active calcium ion extrusion in intact human red cells


IF: 0.797



242.Gárdos G, Szász I, Sarkadi B

Effect of intracellular calcium on the cation transport processes in human red cells



ACTA BIOL MED GER 36: 823-829 (1977)

IF: 0.499



1976


The use of ionophores of rapid loading of human red cells with radioactive cations for cation-pump studies

J MEMBRANE BIOL 26: 357-370 (1976)

IF: 3.444



1975

244.Gárdos G, Szász I, Sarkadi B

Mechanism of Ca-dependent K transport in human red cells

In: G Gárdos, I Szász(ed.)

Biomembranes: Structure and Function.

Amsterdam: Akadémiai Kiadó - Elsevier Science Publishers, 1975. pp. 167-180.

(Proceedings of meetings of the federation of european bi ochemical societies; 35.)


1974


Erythrocyte parameters during induced CA-2+-dependent rapid K+-efflux: optimum conditions for kinetic analysis



246.Goldschmidt B, Sarkadi B, Gárdos G, Matlary A

Platelet producton and survival in cyanotic congenital heart disease

SCAND J HAEMATOL 13: 110-115 (1974)

IF: 1.367


1972

247.Sarkadi B, Schubert A

Energy consumption of active sodium transport in isolated frog skin



1971

248.Spät A, Sarkadi B, Intody Z, Korner A, Szanto J

Effect of renal papillary lipids and prostaglandin E2 on corticosteroid production in the rat

ACTA PHYSIOL ACAD SCI HUNG 40: 187-199 (1971)



Projects Ongoing Research Support

Hungarian Research Fund (OTKA) 115375, 09.01. 2015 - 08.31.2019

Regulation of the expression of ABC transporters in normal human stem cells.

Role: PI grant support approx. USD 400,000



Memberships 1982- Hungarian Society of Biochemistry (vice-president);

1982- Federation of European Biochemical Societies (FEBS - president, 2006-2007)

1988- Member, American Physiological Society

1992- Member, American Society of Biochemistry and Molecular Biology

1992- Member, American Association of Cancer Research

1996- International Cell Research Organization, Panel Convener, Vice President,

2000- Member, American Society of Cell Biology

2006- Member, Academia Europeae

2010 - Full member of the Hungarian Academy of Sciences,

2017- Vice president, International Transmembrane Transporter Society

Other Relevant Information I spent several years as a post-doc and then as a visiting scientist at major universities and research centers in the United States and Canada. I am head of the Membrane Research Group and professorat Semmelweis University, member of the Hungarian Academy of Sciences, past president of the Federation of European Biochemical Societies (FEBS), member of several international research societies and the Academia Europeae. My research has been focusing on the investigation of ABC membrane transporters, which play a major role in the multidrug resistance of cancer, in general pharmacology, and in stem cell function. With my colleagues we have devised new methods for the functional analysis of ABC transporter proteins, and developed compounds that modulate their function.

I have published more than 150 papers in international scientific journals, with a citation number over 9,500. My current work is focusing on the role of ABC multidrug transporters in the cellular effects of targeted anticancer agents, and the function of these transporters in normal and cancer stem cells. I am a Research Professor of Semmelweis University, Budapest, Hungary, actively participating in the education of graduate and postgraduate students. I served as a supervisor for 14 Ph.D. students, whoalready successfully obtained their doctoral degrees.

Awards:

1982, 1986, Research Award of the Hungarian Academy of Sciences

1995-2004 Howard Hughes International Fellowship

1995 Bela Tanko Award (Hung. Biochem. Soc.)

1997-2000 Szechenyi Research Professorship, Hungary

2000 Fulbright Senior Research Fellowship

2003 Academy Award, Hungary

2004- Membership, Hungarian Academy of Sciences

2005- Membership, Academia Europaea

2006 Denis Gabor Award

2009 Ipolyi Arnold Award, Hungary


Documents

PERSONAL INFORMATION Balázs Sarkadi€¦ · PERSONAL INFORMATION Balázs Sarkadi ... Methodological advances in the culture, manipulation and utilization of embryonic stem cells