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S2 fibersS1 fibers
S2 MHC
S1 MHC
TnT1
TnT3
CONTINUUM OF ISOFORM EXPRESSION
= high expression = low expression
TnI3
TnI2
S1 Tm
S2 Tm
Immediate Research Focus:
Single fiber polymorphism in lobsters
• Developmental changes in fiber phenotype
• Innervation pattern and fiber phenotype
• Effects of electrical stimulation on fiber phenotype
• Mechanical measurements from single fibers
Long Term Research Interests:
• Single Fiber Polymorphism in Mammals
• Scaling Effects on Cellular/Molecular Organization of Muscles
• Physiology of Avian Flight Muscles