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Specialist Containment Solutions
ONFAB Limited. 1 Verity Court, Middlewich, Cheshire, CW10 0GW. UK
T: +44 (0)1606 832 080
F: +44 (0)1606 835 435
www.onfab.co.uk
A message from our CEO’sWhen we set up ONFAB Limited our aim was to create a design and supply company that match the values we expect and appreciate as a customer. These values are honesty, reliability, quality and value for money. These values have been the foundation that ONFAB can attribute to ten years of success and business growth. We are proud to be able to say that we have the same customers that we started with, and that the majority of our business comes from customer referral within a highly regulated and demanding industry.
Global Leader in Containment TechnologiesSince the company was founded in 2004, ONFAB has developed an unrivalled expertise in the design and manufacture of flexible containment systems and technologyThe development and use of the equipment selection process model combined with unique product innovations has taken the capability of containment technology to new levels of performance, securing ONFAB as a global presence in the field of containment.
ONFAB Limited PartnersONFAB have partnered with a team of experts who work to ensure that all technical, material and site specifications are carefully considered and accounted for.
Quality & ExcellenceONFAB maintains a level of high quality design and manufacturing excellence, meeting the requirements of ISO 9001, the internationally recognised standard for an organisation’s internal quality management.
Industry Recognised ExpertsWith a wealth of experience in the containment industry we understand all of the critical factors that must be taken into account when evaluating a containment requirement and providing the best possible solution.
We will advise on protecting your work force, streamlining the manufacturing process, maximising floor space within a new or existing facility and generating flow strategies for personnel and materials.
Use our expertise to validate a new facility, generate detailed equipment / facility specifications and designs, project manage an installation or validate and test completed facilities.
Cost EffectiveOur priority is to provide you with the right solution, not the most expensive. This is why many of our customers make considerable cost savings when commissioning ONFAB to address their containment requirements.
Outstanding ServiceSetting up a new facility or modifying an existing one must be executed within the shortest possible time frames to minimise costs and loss of productivity. We work with you to meet the most challenging of schedules through every stage of the process from design to installation, ensuring a fast and efficient service.
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Holistic solution allowing autonomy of control
Proven engineering practices
Excellent customer service
Short lead times
Competitive prices
Why Use Onfab?
ONFAB Limited manufactures a wide range of products from flexible plastics such as Polyethylene, PVC and polyurethane film.
We have in-house technical and design skills to support product development, and can manufacture to customer specifications. We are able to provide short lead times, competitive prices with quality guaranteed to ISO 9001 standards.
ONFAB Limited’s flexible containment systems are world class and operate in various countries worldwide. We work daily with Key flagship pharmaceutical companies removing the requirements for expensive and space consuming hard walled isolators.
For many years the company has been at the forefront of technology, designing and manufacturing Flexible containment systems for the safe handling of potent Pharmaceutical ingredients and developing techniques to achieve levels of containment below 1μ/m³ in compliance with SMEPAC guidelines.
Containment Systems
Our products are made to the highest specifications by heat and high frequency electronic welding and computerized cutting systems, designing and developing intricate tooling when required.
We are ISO 9001 ISOQAR approved. This is the internationally recognised standard for the quality management of businesses, meaning we have been acknowledged as being capable of providing all of our customers with a high level of service and quality.
Quality
IsolationThe separation of a material or substance so that it does not come into contact with operators or the environment.
ContainmentThe enclosure of a material or substance so that operations/activities can take place without it coming into contact with operators or the environment.
Containment equipment / Barrier IsolationAn engineered unit that provides separation between a material or substance so that operations/activities can take place with out it coming in to contact with operators or the environment.
Containment Fundamentals
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Dust release levels. μg/m3
Open pouring 10,000
Valve on IBC 1,000
IBC and inflatable seal 500
Down flow booth (DFB) 50-100
DFB + screen 1 – 25
Split Butterfly Valve (SBV) 5 – 10
Flexible glove bags Ambient Pressure 1 – 10
Flexible glove bags Negative pressure 0.1 – 1
DFB and Flexible glove curtain 0.1 – 5
High Containment SBV 0.5 – 1
Alpha-beta port 0.1 – 1
Isolator and Rapid Transfer Port (RTP) 0.001
Monitoring campaigns vary from study to study.
The ONFAB Containment Philosophy Model Typical Equipment
Containment Performance The ONFAB Containment Philosophy Model
Scope and Standards
General Principalsand Guidelines
Activity Analysis
EquipmentSelection
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1 − Site measurement 2 − Preliminary design
3 − Final design 4 − Cut file produced upon order
Design Stages Preliminary design
Site measurement Specification
discussed with customer
Drawings or pictures sent with basic
specification
Preliminary design completed
Modifications made to design according to customer comments
Design approved by customer
Cut file produced upon order of new
products
The final design allows for any modifications to be made to the design for example:
■ Additional sleeves added
■ Dimensions finalised
■ Additional views drawn if required
■ 3D model rendered when required
Final Design
■ Produced from drawing / pictures or site measurements■ Designed to meet the required specification■ Often a very basic design to allow for a preliminary quote to be calculated within a very short lead time
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ONFAB can develop a more permanent solution to your containment needs if required with Perspex and stainless steel range
Features and Benefits
■ Increased containment performance■Elegant bespoke designs
■ Cost effective
■Simple ease of use
Rigid Isolators
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Vaporized Hydrogen Peroxide System (VHPS)
ONFAB now also offer Vaporized Hydrogen Peroxide Systems (VHPS®) and are operating exclusively in the UK as official agents to Tailin. This bio-decontamination technology offers the highest level of sterilisation across a broad spectrum including bacteria, viruses and fungi and is compatible with almost all materials, such as apparatus, computers, ceilings and floors.
It is safe and clean, leaving no residue, and is a highly effective and efficient sterilization method.
The VHPS® technology works by using a hydrogen peroxide generator to vaporise a 35% hydrogen peroxide solution and then transport it, either through pipelines or spraying directly in the enclosed spaces for bio-decontamination.
In the process of evaporation, the H2O2 will generate free hydroxyl, which could damage the cell composition (such as lipid, protein and DNA) by oxidation.
Vaporised hydrogen peroxide, under room temperature, has the ability to kill bacteria, fungi, viruses and other kinds of micro-organisms.
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ClaSP Liner Tie System
ONFAB Limited have developed a Liner Tie System, that combines ease of operation and high containment for the safe separation of glove bag feed sleeves and continuous liner material charge, discharge and storage.
Features and Benefits
■ Simple to apply■ High containment capability■ Great strength and durability■ Long term sealing■ Double lock security preventing accidental release■ Anti tamper and locking capability■ Can be used across all the linear and sleeve ranges
The ClaSP system demonstrates performance of less than10μg\m operator exposure levels when tested using the ISPE Guidelines for the Testing of Containment Equipment
Patents Pending: 0813067.6 and 0718403.9
Vaporized Hydrogen Peroxide System (VHPS)
The feature of VHPS® technology is that vapour hydrogen peroxide in the enclosed spaced isolator is always below drip point in the decontamination process.
When reaching the designed concentration, it will always control the relative humidity of the space. This will avoid the moisture saturation so as to reduce the affection of condensation.
The main advantage of dry VHPS® technology is that it minimises the impact on materials while achieving the highest level of decontamination. What’s more, it optimizes the time of H2O2 residue removal.
Key benefits: VHPS provides unique technology in hydrogen peroxide decontamination and isolator system.
Broad spectrum sterilisation including bacteria, viruses, fungi and other types of micro-organisms.
Provides complete sterile, detect and verification solutions for customers.
Minimum impact on materials, no H2O2 condensation and adherence.
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API and Development Facilities (Pilot Plant)
Pressure filter discharging (Site pressure test)
Reactor charging Containment suites
Product Range
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Reactors
Charging
Sampling
Remote charging suite
Drum Transfer
Pressure filters
Discharge liner systems
Discharge glove bags
Sampling
Discharge valve cleaning
Heel recovery glove bags
Vacuum drying de-duster containment suites
Containment suites
Filters
Safe Change
Gaff filter safe change systems
Core change out systems
CentrifugesCharge systems
Discharge systems
Flow booths Flow booth curtains
API and Development Facilities (Pilot Plant)
Small and Medium Scale Manufacture. (Phase One and Two)
Fluid bed dryer
Tablet press Blister packing room
Capsule filler
Product Range
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Dispensing Dispensing glove bags
Granulators (All manufactures 1ltr to 40ltr scale)
Charging
Sampling
Discharging
Material transfer Equipment contained connect and disconnect systems
Fluid bed dryers(All manufactures 1ltr to 40ltr scale)
Charging
Sampling
Discharging
Blenders(All manufactures 1ltr to 40ltr scale)
Charging
Sampling
Discharging
Tablet presses Bespoke designs
Tablet coaters Bespoke designs
Capsule fillers Bespoke designs
De-dusters Bespoke designs
Small to Medium Scale Manufacture. (Phase 1 & 2)
Product range
Kilo Laboratories
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Reactors
Charging
Sampling
Discharging
Flow booths Flow booths curtains
Dispensing Dispensing glove bags
Flow booth curtains Flow booth curtains
Product range
Packing Lines & Dispensing
Tablet and blister packing linesSpecifically designed
enclosures
Liner dispenserFully disposable and stainless
steel options
Discharge
Fully disposable liner dispenser Stainless steel inline liner carrier/dispenser
Support Products
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Gloves Fan Set
Support System CHEM Tape
Filters Bungee Cord
Installation Kit ClaSP System
U Grip Stretch Tape
HEPA Filter High Bond Tape
O Rings Filter Connections
Cuffs Drum
Flexible Canister Safety Scissors
Many more product available.
Support Products
ONFAB Limited. 1 Verity Court, Middlewich, Cheshire, CW10 0GW. UKT: +44 (0)1606 832 080F: +44 (0)1606 835 435
www.onfab.co.uk
Global containment supplier:
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