1
422 these cases the mean auscultatory reading was’8 mm. Hg higher than the intra-arterial. Varying the width of the cuff from the standard 13 cm. to 20 cm. improved the accuracy of both the systolic and diastolic readings in some obese subjects ; but in most subjects, particularly those with thin arms, the wide cuff yielded readings which were too low. Though their numbers are rather ’few, these workers produce figures which suggest that in people with large arms (circumference 30-42-5 cm.) the auscultatory estimate of diastolic pressure becomes an additional 3 mm. Hg too high for each 1 cm. increase in the circumference of the arm above 30 cm. They say that the sudden fading of the sounds is a more reliable guide to’ the diastolic pressure than their complete dis- appearance. These findings remind us that clinical readings of blood-pressure are merely approximate, though if recorded carefully they provide a useful guide to diagnosis and prognosis. It is clear that in plump subjects a wide cuff should be used before any opinion is given about a slight degree of hypertension. RADIOTHERAPY OF CANCER WITHIN the last few years two advances in radiology have revolutionised its value as a therapeutic agent. First, we can now control with exactitude the surface doses of X ory rays; secondly, it is possible to estimate the distribution through the living tissues of radiations at various distances and in different directions from the place of their application, so that the dosage throughout the irradiated parts can be regulated with a high degree of accuracy. - The calculation required before applying deep therapy, whether by X or y rays, needs a specially trained physicist who may or may not be the radiologist himself. For the moment the facilities for using the latest knowledge in this department of medicine are not widespread, and there are formidable obstacles to their extension. Among these obstacles are the difficulties which beset the specialist in radiology. To acquire the knowledge necessary to practise this particular kind of work is a task arduous enough to discourage any but the most determined aspirant, and when he has overcome every intermediate obstruction and gained his diploma he finds that he cannot freely practise what he professes. Radiotherapy, being a relatively new form of specialism, is not allotted beds in most hospitals. Cases submitted to the radiotherapist for treatment are not as a rule of his own selection, but are filtered through the hands of the honorary staff in whose wards they are kept and under whose care they nominally remain. These disadvantages have had to be faced by every new branch of medical specialism in turn and must be attributed to human nature, but they have been and will be overcome. It would be a pity, however, if the usual road is followed in this instance. The denial of hospital beds to specialists in the past led to the establishment of a number of independent special hospitals, with detrimental effects on the medical schools. There is much to be said for making a fully equipped radiotherapeutical department an integral part of every teaching hospital, with officers in charge whose status and voting powers are equal to those of any other member of the visiting staff. To such a vision there is yet another obstacle-the expense. But the war with its necessities has taught us to revise our notions of this barrier. SULPHATHIAZOLE OINTMENT IN IMPETIGO WORK on the use of the sulphonamides and their derivatives locally in skin and wound infections has naturally suggested their use in impetigo contagiosa. This in its turn has raised the old question whether impetigo is streptococcal or staphylococcal in origin. The prevailing view is that it may be either, with the , added factor that some streptococcal cases may become secondarily infected with staphylococci, though a year ago, R. E. Hope Simpsonl put forward a strong case for a specific "inpetigococcus." A. J. Steigman2 examined 25 cases of impetigo bacteriologically and found haemolytic streptococci in 12 cases, Staphylococcus aureus in 8 cases and a combination of both in 5 cases. This prompted him to try 5% sulphathiazole in an ointment base and he found that healing took place in about 4 days compared with an average of 8 days required to obtain a cure when ammoniated mercury ointment was used. L. H. Winer and E. A. Strakosch3 treated 60 cases of impetigo with 5% sulphathiazole in cod-liver oil ointment and obtained a cure in an average of just over 4 days. They selected cod-liver oil ointment as a base because it was an easy medium to use and it did not diminish the activity of the drug. They also treated 20 patients with sulphathiazole by the mouth and no local treatment and obtained cures in an average of 92 days. Pillsbury and others4 went further and treated a variety of infectious dermatoses with sulphathiazole, and although some of their results in other conditions were good the cases of impetigo responded far and away the best. They thought that an oil-in-water emulsion was the best base but obtained good results with an ointment. All these observers urge the importance of frequent and thorough removal of crusts and scales before applying the ointment, and favour application 4-6 times a day. It appears then that a 5% sulphathiazole ointment will cure impetigo in 4 or 5 days. This is a real advance on any previous method of treatment, and in so infectious a disease a reduced period of infectivity should lessen the number of contact cases. Judging by the results so far published there is no object in giving the drug by mouth. Mr. A. SEYMOUR HARDING, F.S.S., has retired from the general secretaryship of the Royal Institute of Public Health and Hygiene on -account of ill health. He had completed 30 years of service with the present institute and with the former Institute of Hygiene, and the good wishes of the whole fellowship go with him. THE death is announced from Lucerne of Dr. EDWARD NEUMANN who was associated with Dr. Lucius Spengler in the foundation of the Schatzalp, a luxury sanatorium high up above Davos-Platz. Neumann as resident had all the burden of administration, which was very well done, but he was also an essential partner in the early work on pneumothorax, for which Brauer paid occasional visits from Hamburg. As a guide and friend Neumann is still gratefully remembered by British and American ex-patients. THE Minister of Health and the Secretary of State for Scotland have appointed a committee " to inquire into the organisation of medical schools, particularly in regard to facilities for clinical teaching and research and to make recommendations." The following have accepted invitations to serve : Mr. W. M. Goodenough (chairman), Prof. T. R. Elliott, M.D., F.R.S., Dr. A.M. H. Gray, Prof. James Hendry,CF.R.C.O.G., Prof. A. V. Hill, F.R.B., Sir Wilson Jameson, M.D., Prof. J. R. Lear- month, F.R.C.S.E., Sir Ernest Pooley, Sir John Stopford, M.D., F.R.S., and Dr. Janet Vaughan. 1. Lancet, 1941, i, 683. 2. Brit. med. J. 1942, i, 12. 3. J. Amer. med Ass. 1942, 118, 221. 4. Pillsbury, D. M., Wammock, V. S., Livingood, C. S. and Nichols, A. C. Amer. J. med. Sci. 1941, 202, 808. ROYAL COLLEGE OF OBSTETRICIANS AND GYNaeCOLOGISTS. -After July candidates for the membership of the college may not proceed to the examination till their case-records and commentaries have been accepted by the examination committee. At present the case-records are submitted as part of the examination, but after July they must be pre- sented not less than nine weeks before the examination. Candidates not attending for examination within three years of acceptance of their case-records will be required to present a new set. Further particulars may be had from the secretary of the college, 58, Queen Anne Street, London, W.1.

SULPHATHIAZOLE OINTMENT IN IMPETIGO

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422

these cases the mean auscultatory reading was’8 mm. Hghigher than the intra-arterial. Varying the width of thecuff from the standard 13 cm. to 20 cm. improved theaccuracy of both the systolic and diastolic readings insome obese subjects ; but in most subjects, particularlythose with thin arms, the wide cuff yielded readingswhich were too low. Though their numbers are rather’few, these workers produce figures which suggest thatin people with large arms (circumference 30-42-5 cm.)the auscultatory estimate of diastolic pressure becomesan additional 3 mm. Hg too high for each 1 cm. increasein the circumference of the arm above 30 cm. They saythat the sudden fading of the sounds is a more reliableguide to’ the diastolic pressure than their complete dis-appearance. These findings remind us that clinicalreadings of blood-pressure are merely approximate,though if recorded carefully they provide a useful guideto diagnosis and prognosis. It is clear that in plumpsubjects a wide cuff should be used before any opinionis given about a slight degree of hypertension.

RADIOTHERAPY OF CANCER

WITHIN the last few years two advances in radiologyhave revolutionised its value as a therapeutic agent.First, we can now control with exactitude the surfacedoses of X ory rays; secondly, it is possible to estimatethe distribution through the living tissues of radiationsat various distances and in different directions from the

place of their application, so that the dosage throughoutthe irradiated parts can be regulated with a high degreeof accuracy. - The calculation required before applyingdeep therapy, whether by X or y rays, needs a speciallytrained physicist who may or may not be the radiologisthimself. For the moment the facilities for using thelatest knowledge in this department of medicine are notwidespread, and there are formidable obstacles to theirextension. Among these obstacles are the difficultieswhich beset the specialist in radiology. To acquire theknowledge necessary to practise this particular kind ofwork is a task arduous enough to discourage any but themost determined aspirant, and when he has overcomeevery intermediate obstruction and gained his diplomahe finds that he cannot freely practise what he professes.Radiotherapy, being a relatively new form of specialism,is not allotted beds in most hospitals. Cases submitted tothe radiotherapist for treatment are not as a rule of hisown selection, but are filtered through the hands of thehonorary staff in whose wards they are kept and underwhose care they nominally remain. These disadvantageshave had to be faced by every new branch of medicalspecialism in turn and must be attributed to humannature, but they have been and will be overcome. Itwould be a pity, however, if the usual road is followedin this instance. The denial of hospital beds to specialistsin the past led to the establishment of a number ofindependent special hospitals, with detrimental effectson the medical schools. There is much to be said for

making a fully equipped radiotherapeutical departmentan integral part of every teaching hospital, with officersin charge whose status and voting powers are equal tothose of any other member of the visiting staff. To sucha vision there is yet another obstacle-the expense. Butthe war with its necessities has taught us to revise ournotions of this barrier.

SULPHATHIAZOLE OINTMENT IN IMPETIGO

WORK on the use of the sulphonamides and theirderivatives locally in skin and wound infections has

naturally suggested their use in impetigo contagiosa.This in its turn has raised the old question whetherimpetigo is streptococcal or staphylococcal in origin.The prevailing view is that it may be either, with the, added factor that some streptococcal cases may becomesecondarily infected with staphylococci, though a year

ago, R. E. Hope Simpsonl put forward a strong case for aspecific "inpetigococcus." A. J. Steigman2 examined25 cases of impetigo bacteriologically and found haemolyticstreptococci in 12 cases, Staphylococcus aureus in 8cases and a combination of both in 5 cases. Thisprompted him to try 5% sulphathiazole in an ointmentbase and he found that healing took place in about 4days compared with an average of 8 days required toobtain a cure when ammoniated mercury ointment wasused. L. H. Winer and E. A. Strakosch3 treated 60cases of impetigo with 5% sulphathiazole in cod-liver oilointment and obtained a cure in an average of just over4 days. They selected cod-liver oil ointment as a basebecause it was an easy medium to use and it did notdiminish the activity of the drug. They also treated20 patients with sulphathiazole by the mouth and nolocal treatment and obtained cures in an average of 92days. Pillsbury and others4 went further and treated avariety of infectious dermatoses with sulphathiazole, andalthough some of their results in other conditions weregood the cases of impetigo responded far and away thebest. They thought that an oil-in-water emulsion wasthe best base but obtained good results with an ointment.All these observers urge the importance of frequent andthorough removal of crusts and scales before applying theointment, and favour application 4-6 times a day. It

appears then that a 5% sulphathiazole ointment willcure impetigo in 4 or 5 days. This is a real advance on

any previous method of treatment, and in so infectious adisease a reduced period of infectivity should lessen thenumber of contact cases. Judging by the results so farpublished there is no object in giving the drug by mouth.

Mr. A. SEYMOUR HARDING, F.S.S., has retired fromthe general secretaryship of the Royal Institute ofPublic Health and Hygiene on -account of ill health.He had completed 30 years of service with the presentinstitute and with the former Institute of Hygiene, andthe good wishes of the whole fellowship go with him.THE death is announced from Lucerne of Dr. EDWARD

NEUMANN who was associated with Dr. Lucius Spenglerin the foundation of the Schatzalp, a luxury sanatoriumhigh up above Davos-Platz. Neumann as resident hadall the burden of administration, which was very welldone, but he was also an essential partner in the earlywork on pneumothorax, for which Brauer paid occasionalvisits from Hamburg. As a guide and friend Neumannis still gratefully remembered by British and Americanex-patients.THE Minister of Health and the Secretary of State for

Scotland have appointed a committee " to inquire intothe organisation of medical schools, particularly in

regard to facilities for clinical teaching and researchand to make recommendations." The following haveaccepted invitations to serve : Mr. W. M. Goodenough(chairman), Prof. T. R. Elliott, M.D., F.R.S., Dr. A.M. H.Gray, Prof. James Hendry,CF.R.C.O.G., Prof. A. V. Hill,F.R.B., Sir Wilson Jameson, M.D., Prof. J. R. Lear-month, F.R.C.S.E., Sir Ernest Pooley, Sir John Stopford,M.D., F.R.S., and Dr. Janet Vaughan.1. Lancet, 1941, i, 683. 2. Brit. med. J. 1942, i, 12.3. J. Amer. med Ass. 1942, 118, 221.4. Pillsbury, D. M., Wammock, V. S., Livingood, C. S. and Nichols,

A. C. Amer. J. med. Sci. 1941, 202, 808.

ROYAL COLLEGE OF OBSTETRICIANS AND GYNaeCOLOGISTS.-After July candidates for the membership of the collegemay not proceed to the examination till their case-recordsand commentaries have been accepted by the examinationcommittee. At present the case-records are submitted aspart of the examination, but after July they must be pre-sented not less than nine weeks before the examination.Candidates not attending for examination within three yearsof acceptance of their case-records will be required to presenta new set. Further particulars may be had from the secretaryof the college, 58, Queen Anne Street, London, W.1.