2005

Microwave chemistryO 0170 Synthesis of Diaryl Ethers, Diaryl Sulfides, Heteroaryl Ethers and Heteroaryl Sul-

fides under Microwave Dielectric Heating. — Microwave-assisted coupling of phe-nols or thiophenols with electron-deficient aryl halides through a SN-reaction provides the rapid preparation of diaryl ethers and sulfides. The presence of a range of substitu-ents and functional groups suggests an excellent opportunity to acquire further deriva-tives from these initial compounds. Moreover, not only electron-deficient, but also elec-tronically neutral and electron-rich phenols and thiophenols can successfully be coupled with activated aryl halides in the absence of a metal catalyst. The simplicity and generality of this short and clean procedure together with the satisfactory yields render this method particularly attractive. — (LI, F.; MENG, Q.; CHEN, H.; LI, Z.; WANG*, Q.; TAO, F.; Synthesis 2005, 8, 1305-1313; Dep. Chem., Fudan Univ., Shanghai 200433, Peop. Rep. China; Eng.) — H. Hoennerscheid

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