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THE BEHEMOTH AND THE CYBORG
---SCIENTISTS AND CONTESTED
TECHNOLOGY
Craig K. Harris
Food Safety Policy Center
Department of Sociology
Michigan State University
Anheuser Busch Brewing Company
Anheuser-Busch was founded by immigrants searching for their American dream. In 1864, Adolphus Busch joined his father-in-law, Eberhard Anheuser, in guiding our company confidently into the future. For five generations, the Busch family and our employees have made Anheuser-Busch the premier brewer in the world.
Anheuser Busch Brewing Company
Attempting to replicate the beers of their native Bavaria, Anheuser and Busch seek out suppliers of quality grains – wheat, rice – and hops in the area around St. Louis.
To grow for Anheuser-Busch is a mark of distinction among farmers in Missouri and Arkansas.
THE AGRICULTURAL CORNUCOPIA
• Agriculture is the sector of the economy that derives the greatest benefit from ecosystem services
THE AGRICULTURAL CORNUCOPIA
• Agriculture is the sector of the economy that derives the greatest benefit from ecosystem services
• Less than 25 percent of energy used in agriculture comes from fossil fuels
THE AGRICULTURAL CORNUCOPIA
• Agriculture is the sector of the economy that derives the greatest benefit from ecosystem services
• Less than 25 percent of energy used in agriculture comes from fossil fuels
• Most of water is rainfed
THE AGRICULTURAL CORNUCOPIA
• Agriculture is the sector of the economy that derives the greatest benefit from ecosystem services
• Less than 25 percent of energy used in agriculture comes from fossil fuels
• Most of water is rainfed
• Pollination
THE AGRICULTURAL CORNUCOPIA
• Agriculture is the sector of the economy that derives the greatest benefit from ecosystem services
• Less than 25 percent of energy used in agriculture comes from fossil fuels
• Most of water is rainfed
• Pollination
• Biological nitrogen fixation
THE AGRICULTURAL CORNUCOPIA
• Agriculture is the sector of the economy that derives the greatest benefit from ecosystem services
• Less than 25 percent of energy used in agriculture comes from fossil fuels
• Most of water is rainfed
• Pollination
• Biological nitrogen fixation
• Beneficials contribute to pest management
THE CORNUCOPIA CHALLENGED
• Increasing reliance on corn and soybeans
THE CORNUCOPIA CHALLENGED• Increasing reliance on corn and soybeans
• Main marketing problems are overproduction and oligopsonistic markets lower prices
THE CORNUCOPIA CHALLENGED• Increasing reliance on corn and soybeans
• Main marketing problems are overproduction and oligopsonistic markets lower prices
• Farmers respond to lower prices by trying to increase production
THE CORNUCOPIA CHALLENGED• Increasing reliance on corn and soybeans
• Main marketing problems are overproduction and oligopsonistic markets lower prices
• Farmers respond to lower prices by trying to increase production
• Government responds to lower prices by programs of price supports and acreage set-asides for corn, soybeans, rice, cotton, sugar, and tobacco
THE CORNUCOPIA CHALLENGED• Increasing reliance on corn and soybeans
• Main marketing problems are overproduction and oligopsonistic markets lower prices
• Farmers respond to lower prices by trying to increase production
• Government responds to lower prices with price supports and acreage set-asides
• Main production problems are insect pests and weeds
THE CORNUCOPIA CHALLENGED• Increasing reliance on corn and soybeans• Main marketing problems are
overproduction and oligopsonistic markets lower prices
• Farmers respond to lower prices by trying to increase production
• Government responds to lower prices with price supports and acreage set-asides
• Main production problems are insect pests and weeds
• Both insecticides and herbicides have environmental and human health issues
CORNUCOPIA CHALLENGED - 2• 1996 Food Quality Protection Act (FQPA) –
aggregate and cumulative effects, especially to most susceptible subpopulations
CORNUCOPIA CHALLENGED - 2• 1996 Food Quality Protection Act (FQPA) –
aggregate and cumulative effects, especially to most susceptible subpopulations
• Even low residues on staple crops can be hazardous
CORNUCOPIA CHALLENGED - 2• 1996 Food Quality Protection Act (FQPA) –
aggregate and cumulative effects, especially to most susceptible subpopulations
• Even low residues on staple crops can be hazardous
• Organic corn and soybean yields approach conventional yields
CORNUCOPIA CHALLENGED - 2• 1996 Food Quality Protection Act (FQPA) –
aggregate and cumulative effects, especially to most susceptible subpopulations
• Even low residues on staple crops can be hazardous
• Organic corn and soybean yields approach conventional yields
• One of main organic insecticides is the toxin produced by a common microbe, Bacillus thuringensis (Bt)
CORNUCOPIA RECOVERED• Recombinant genetic technologies
CORNUCOPIA RECOVERED• Recombinant genetic technologies
• Identification of toxin gene in Bacillus thuringensis (Bt)
CORNUCOPIA RECOVERED• Recombinant genetic technologies
• Identification of toxin gene in Bacillus thuringensis (Bt)
• Bt corn and Bt cotton
CORNUCOPIA RECOVERED• Recombinant genetic technologies
• Identification of toxin gene in Bacillus thuringensis (Bt)
• Bt corn and Bt cotton
• Substantial equivalence
CORNUCOPIA RECOVERED - 2• Contestation over Bt plant incorporated
protectorant
CORNUCOPIA RECOVERED - 2• Contestation over Bt plant incorporated
protectorant
• Better for environment . . . Natural . . . Same as organic
CORNUCOPIA RECOVERED - 2• Contestation over Bt plant incorporated
protectorant
• Better for environment . . . Natural . . . Same as organic
• Hazardous to neutral and beneficial insects– The monarch butterfly controversy
CORNUCOPIA RECOVERED - 2• Contestation over Bt plant incorporated
protectorant
• Better for environment . . . Natural . . . Same as organic
• Hazardous to neutral and beneficial insects– The monarch butterfly controversy
• Possible tumorigenicity– Arpad Pustzai
CORNUCOPIA RECOVERED - 2• Contestation over Bt plant incorporated
protectorant
• Better for environment . . . Natural . . . Same as organic
• Hazardous to neutral and beneficial insects– The monarch butterfly controversy
• Possible tumorigenicity– Arpad Pustzai
• Resistance concerns–Mandatory refugia
CORNUCOPIA CHALLENGED AGAIN
• Decreasing consumption of tobacco in U.S.
CORNUCOPIA CHALLENGED AGAIN
• Decreasing consumption of tobacco in U.S.
• Increasing opposition to U.S. government support for tobacco
CORNUCOPIA CHALLENGED AGAIN
• Decreasing consumption of tobacco in U.S.
• Increasing opposition to U.S. government support for tobacco
• Increasing WTO scrutiny of subsidies for export crops
CORNUCOPIA CHALLENGED AGAIN
• Decreasing consumption of tobacco in U.S.
• Increasing opposition to U.S. government support for tobacco
• Increasing WTO scrutiny of subsidies for export crops
• Fiscal crisis of the state increasingly diminish ability to support subsidies
CORNUCOPIA CHALLENGED AGAIN
• Decreasing consumption of tobacco in U.S.
• Increasing opposition to U.S. government support for tobacco
• Increasing WTO scrutiny of subsidies for export crops Fiscal crisis of the state increasingly diminish ability to support subsidies
• Relative ease of transforming tobacco via recombinant DNA techniques
CORNUCOPIA CHALLENGED AGAIN• Decreasing consumption of tobacco in U.S.
• Increasing opposition to U.S. government support for tobacco
• Increasing WTO scrutiny of subsidies for export crops Fiscal crisis of the state increasingly diminish ability to support subsidies
• Relative ease of transforming tobacco via recombinant DNA techniques
• Look for new uses for land, machinery, and skills
THE REGIONAL UNIVERSITY• By 2000, Northwest
Missouri State University was experiencing the fiscal crisis of the state
THE REGIONAL UNIVERSITY• By 2000, Northwest Missouri
State University was experiencing the fiscal crisis of the state
• “In the 1980s, more than 70 percent of the University's operating budget income was derived from state appropriations. Currently, that figure hovers around 50 percent.”
THE REGIONAL UNIVERSITY• By 2000, Northwest Missouri
State University was experiencing the fiscal crisis of the state
• “In the 1980s, more than 70 percent of the University's operating budget income was derived from state appropriations. Currently, that figure hovers around 50 percent.”
• Not able to obtain funding for new science building
THE PHARMACEUTICAL CYCLE
• The pharmaceutical industry has a somewhat distinctive product cycle
THE PHARMACEUTICAL CYCLE
• The pharmaceutical industry has a somewhat distinctive product cycle
• Identify active substance that can be marketed for some health problem
THE PHARMACEUTICAL CYCLE
• The pharmaceutical industry has a somewhat distinctive product cycle
• Identify active substance that can be marketed for some health problem
• Develop process to synthesize the substance
THE PHARMACEUTICAL CYCLE
• The pharmaceutical industry has a somewhat distinctive product cycle
• Identify active substance that can be marketed for some health problem
• Develop process to synthesize the substance
• Testing and regulatory approvals
THE PHARMACEUTICAL CYCLE
• The pharmaceutical industry has a somewhat distinctive product cycle
• Identify active substance that can be marketed for some health problem
• Develop process to synthesize the substance
• Testing and regulatory approvals
• Patent protection
THE PHARMACEUTICAL CYCLE• The pharmaceutical industry has a
somewhat distinctive product cycle
• Identify active substance that can be marketed for some health problem
• Develop process to synthesize the substance
• Testing and regulatory approvals
• Patent protection
• After patent expires, open competition generics low prices
THE PHARMACEUTICAL CYCLE
• The pharmaceutical industry has a somewhat distinctive product cycle
• Identify active substance that can be marketed for some health problem
• Develop process to synthesize the substance
• Testing and regulatory approvals• Patent protection• After patent expires, open competition
generics low prices• Compete by lowering cost of production
THE BIOTECHNOLOGICAL BEHEMOTH
• Agricultural biotechnology takes off as an effort to maintain and extent proprietary control over glyphosate herbicide
THE BIOTECHNOLOGICAL BEHEMOTH
• Agricultural biotechnology takes off as an effort to maintain and extent proprietary control over glyphosate herbicide
• Main problem with glyphosate is phytotoxicity to main crops (corn, soybeans) triazine herbicides greater human health hazards
THE BIOTECHNOLOGICAL BEHEMOTH
• Agricultural biotechnology takes off as an effort to maintain and extent proprietary control over glyphosate herbicide
• Main problem with glyphosate is phytotoxicity to main crops (corn, soybeans) triazine herbicides greater human health hazards
• Discovery of tolerance gene
THE BIOTECHNOLOGICAL BEHEMOTH
• Agricultural biotechnology takes off as an effort to maintain and extent proprietary control over glyphosate herbicide
• Main problem with glyphosate is phytotoxicity to main crops (corn, soybeans) triazine herbicides greater human health hazards
• Discovery of tolerance gene
• Discovery of recombinant techniques
THE BIOTECHNOLOGICAL BEHEMOTH
• Agricultural biotechnology takes off as an effort to maintain and extent proprietary control over glyphosate herbicide
• Main problem with glyphosate is phytotoxicity to main crops (corn, soybeans) triazine herbicides greater human health hazards
• Discovery of tolerance gene
• Discovery of recombinant techniques
• Round-Up Ready corn and soybeans
THE BIOTECHNOLOGICAL BEHEMOTH
• Agricultural biotechnology takes off as an effort to maintain and extent proprietary control over glyphosate herbicide
• Main problem with glyphosate is phytotoxicity to main crops (corn, soybeans) triazine herbicides greater human health hazards
• Discovery of tolerance gene• Discovery of recombinant techniques• Round-Up Ready corn and soybeans• Substantial equivalence
THE BIOTECHNOLOGICAL BEHEMOTH - 2
• Contestation over herbicide tolerant corn and soybeans
THE BIOTECHNOLOGICAL BEHEMOTH - 2
• Contestation over herbicide tolerant corn and soybeans
• Better for environment (lower toxicity and lower persistence)
THE BIOTECHNOLOGICAL BEHEMOTH - 2
• Contestation over herbicide tolerant corn and soybeans
• Better for environment (lower toxicity and lower persistence)
• Lower human health hazard
THE BIOTECHNOLOGICAL BEHEMOTH - 2
• Contestation over herbicide tolerant corn and soybeans
• Better for environment (lower toxicity and lower persistence)
• Lower human health hazard
• Research challenges whether number of sprays reduced
THE BIOTECHNOLOGICAL BEHEMOTH - 2
• Contestation over herbicide tolerant corn and soybeans
• Better for environment (lower toxicity and lower persistence)
• Lower human health hazard
• Research challenges whether number of sprays reduced
• Some evidence that glyphosate is a carcinogen
THE BIOTECHNOLOGICAL BEHEMOTH - 2
• Contestation over herbicide tolerant corn and soybeans
• Better for environment (lower toxicity and lower persistence)
• Lower human health hazard• Research challenges whether number of
sprays reduced• Some evidence that glyphosate is a
carcinogen• Perception that only the corporation
benefits
THE BIOTECHNOLOGICAL BEHEMOTH - 3
• Contestation over herbicide tolerant corn and soybeans - continued
• Public opinion surveys – not accept risks of new technology if only corporation benefits
THE BIOTECHNOLOGICAL BEHEMOTH - 3
• Contestation over herbicide tolerant corn and soybeans - continued
• Public opinion surveys – not accept risks of new technology if only corporation benefits
• Corporations look for second and third generation technologies
THE BIOTECHNOLOGICAL BENEFACTOR
• People in Southeast Asian countries where rice is a staple food have vision illnesses because of lack of sufficient Vitamin A
THE BIOTECHNOLOGICAL BENEFACTOR
• People in Southeast Asian countries where rice is a staple food have vision illnesses because of lack of sufficient Vitamin A
• Identify Vitamin A precursor gene
THE BIOTECHNOLOGICAL BENEFACTOR
• People in Southeast Asian countries where rice is a staple food have vision illnesses because of lack of sufficient Vitamin A
• Identify Vitamin A precursor gene
• Transform rice to express Vitamin A precursor – Golden rice
THE BIOTECHNOLOGICAL BENEFACTOR
• People in Southeast Asian countries where rice is a staple food have vision illnesses because of lack of sufficient Vitamin A
• Identify Vitamin A precursor gene
• Transform rice to express Vitamin A precursor – Golden rice
• Donate genome to public health
THE BIOTECHNOLOGICAL BENEFACTOR
• People in Southeast Asian countries where rice is a staple food have vision illnesses because of lack of sufficient Vitamin A
• Identify Vitamin A precursor gene
• Transform rice to express Vitamin A precursor – Golden rice
• Donate genome to public health
• Critics claim will be more expensive than afflicted people can afford
THE BIOTECHNOLOGICAL BENEFACTOR
• People in Southeast Asian countries where rice is a staple food have vision illnesses because of lack of sufficient Vitamin A
• Identify Vitamin A precursor gene• Transform rice to express Vitamin A
precursor – Golden rice• Donate genome to public health• Critics claim will be more expensive than
afflicted people can afford• Critics argue better remedy is to make leafy
greens more available and accessible
THE BIOTECHNOLOGICAL BENEFACTOR
• People in Southeast Asian countries where rice is a staple food have vision illnesses because of lack of sufficient Vitamin A
• Identify Vitamin A precursor gene• Transform rice to express Vitamin A precursor –
Golden rice• Donate genome to public health• Critics claim will be more expensive than afflicted
people can afford• Critics argue better remedy is to make leafy
greens more available and accessible• Critics claim danger of eating too much Vitamin A
Charles Arntzen and the Magic Banana
• Malaria is single largest cause of illness worldwide
Charles Arntzen and the Magic Banana
• Malaria is single largest cause of illness worldwide
• Malaria parasite is increasingly resistant to existing drugs
Charles Arntzen and the Magic Banana
• Malaria is single largest cause of illness worldwide
• Malaria parasite is increasingly resistant to existing drugs
• Mosquito vector difficult to control without DDT (broad spectrum and persistent, but inexpensive) or less hazardous but more expensive alternatives (permethrin sleeping nets, Bt variants)
Charles Arntzen and the Magic Banana
• Malaria is single largest cause of illness worldwide
• Malaria parasite is increasingly resistant to existing drugs
• Mosquito vector difficult to control without DDT or less hazardous but more expensive alternatives
• Identification of gene construct that causes production of antibodies that block action of parasite
Charles Arntzen and the Magic Banana
• Malaria is single largest cause of illness worldwide
• Malaria parasite is increasingly resistant to existing drugs
• Mosquito vector difficult to control without DDT or less hazardous but more expensive alternatives
• Identification of gene construct that causes production of antibodies that block action of parasite
• Banana production overlaps malaria zone
Charles Arntzen and the Magic Banana - 2
• Arntzen propose to transform banana to deliver malaria vaccine
Charles Arntzen and the Magic Banana - 2
• Arntzen propose to transform banana to deliver malaria vaccine
• Look for donor to support (e.g., Gates Foundation)
Charles Arntzen and the Magic Banana - 2
• Arntzen propose to transform banana to deliver malaria vaccine
• Look for donor to support (e.g., Gates Foundation)
• Concerns about dosage and resistance
By 2002, the buzzword in the biotechnology industry was
“pharming”
By 2002, the buzzword in the biotechnology industry was
“pharming”
0
5
10
15
20
25
30
2001 2002 2003 2004
References to “biopharming” in major u.s. newspapers
The Great Corn Controversy 2002
• Iowa state government adopts corn biopharming as growth strategy
The Great Corn Controversy 2002
• Iowa state government adopts corn biopharming as growth strategy
• Grocery Manufacturers of America (GMA) and other groups express concern
The Great Corn Controversy 2002
• Iowa state government adopts corn biopharming as growth strategy
• Grocery Manufacturers of America (GMA) and other groups express concern
• USDA states lack of support for corn biopharming as a matter of policy
The Great Corn Controversy 2002
• Iowa state government adopts corn biopharming as growth strategy
• Grocery Manufacturers of America (GMA) and other groups express concern
• USDA states lack of support for corn biopharming as a matter of policy
• Iowa representatives and politicians pressure the Administration to reverse policy
The Great Corn Controversy 2002• Iowa state government adopts corn
biopharming as growth strategy• Grocery Manufacturers of America (GMA)
and other groups express concern• USDA states lack of support for corn
biopharming as a matter of policy• Iowa representatives and politicians
pressure the Administration to reverse policy
• Biotechnology Industry Organization (BIO) agrees not to grow corn pharm crops in Corn Belt
The California Rice Rebellion
• Ventria Bioscience Company proposes to grow pharmaceutical rice in California
The California Rice Rebellion
• Ventria Bioscience Company proposes to grow pharmaceutical rice in California
• Initially California Rice Commission approves proposal for ten southern counties where rice not currently grown
The California Rice Rebellion
• Ventria Bioscience Company proposes to grow pharmaceutical rice in California
• Initially California Rice Commission approves proposal for ten southern counties where rice not currently grown
• Some rice growers willing to move to new locations and grow high value crop
The California Rice Rebellion
• Ventria Bioscience Company proposes to grow pharmaceutical rice in California
• Initially California Rice Commission approves proposal for ten southern counties where rice not currently grown
• Some rice growers willing to move to new locations and grow high value crop
• Other rice growers oppose plan– Genetic escape and contamination
The California Rice Rebellion• Ventria Bioscience Company proposes to
grow pharmaceutical rice in California
• Initially California Rice Commission approves proposal for ten southern counties where rice not currently grown
• Some rice growers willing to move to new locations and grow high value crop
• Other rice growers oppose plan– Genetic escape and contamination– Only a small number of growers will benefit
The California Rice Rebellion• Ventria Bioscience Company proposes to
grow pharmaceutical rice in California
• Initially California Rice Commission approves proposal for ten southern counties where rice not currently grown
• Some rice growers willing to move to new locations and grow high value crop
• Other rice growers oppose plan– Genetic escape and contamination– Only a small number of growers will benefit
• Commissioner of Agriculture rejects plan
Bearcat Biopharming
• Ventria offers Northwest Missouri State University 22,000 square foot addition to science building in return for use of university farm fields
Bearcat Biopharming
• Ventria offers Northwest Missouri State University 22,000 square foot addition to science building in return for use of university farm fields
• Majority of rice growers in Missouri oppose plan
Bearcat Biopharming
• Ventria offers Northwest Missouri State University 22,000 square foot addition to science building in return for use of university farm fields
• Majority of rice growers in Missouri oppose plan
Bearcat Biopharming
• Ventria offers Northwest Missouri State University 22,000 square foot addition to science building in return for use of university farm fields
• Majority of rice growers in Missouri oppose plan
• Anheuser Busch announces will not buy rice grown in Missouri if biopharming rice is approved
Bearcat Biopharming• Ventria offers Northwest Missouri State
University 22,000 square foot addition to science building in return for use of university farm fields
• Majority of Missouri rice growers oppose plan
• Anheuser Busch announces will not buy rice grown in Missouri if biopharming rice is approved
• Ventria announces it will use existing approvals to grow biopharm rice in North Carolina
Farmaceuticals As Cyborgs
• More than neoclassical political economy– Competition between different interests for
profit and power– Accumulation of wealth by different capitals
Farmaceuticals As Cyborgs
• More than neoclassical political economy– Competition between different interests for
profit and power– Accumulation of wealth by different capitals
• More than regulationist theory or conventions theory–Which government agencies will regulate them–What standards will be used to evaluate them
Farmaceuticals As Cyborgs
• Lack of clear classification opens space for various sorts of activism– Growers– Agrifood NGO’s
Farmaceuticals As Cyborgs
• Lack of clear classification opens space for various sorts of activism
• Lack of clear classification produces division in biotechnology science community