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Impact from Excellence
Aligning our research with
the Medtech Industry’s
requirements for Bio-
Photonics and Photonics
Integration.
Ray Burke Program Manager ICT for Health
Tyndall National Institute
Cork, Ireland
III-V FAB
Ireland’s National Institute for ICT Research Development and Innovation
ICT for Health at Tyndall
Tyndall will deliver
new opportunities for Ireland’
economic growth creating
impact from excellent research,
systems development and graduate training, delivering
disruptive ICT solutions &
highly trained people to meet challenges
in the HEALTH, Medical Devices
and Life Sciences’ sector.
Impact from Excellence in ICT for Health
ESTHER
Emerging and Strategic Technologies for Healthcare
Deliver
Commercial
Output
Technology
Platforms &
Solutions
Industry
Collaboration
Demos
Licenses
Start-ups
Primary focus on Scientific Discovery
delivering science, publications & patents
Expertise, know-how, Background IP
Commercial
PIs (Progr.
Managers)
&
Researchers
Foreground
IP
Multidisciplinary Solutions for industry
Photonics Micro/Nano Systems
Health
Secure, Agriculture, Food & Environment
Energy
Communications
Centre and Industry Sector Matrix
ICT for Health at Tyndall
Smart Systems
Electronics & Photonics
Micro & Nano Technologies
Core Enabling Technologies
Core Enabling Technologies
ICT for Health at Tyndall
Smart Systems
Electronics & Photonics
Micro & Nano Technologies
Core Enabling Technologies
Molecular modelling
Advanced Sensors
Advanced Processing
Micro Power
Photonic devices
Photonic packages
Photonic systems
Wireless inertial sensing
Lab on chip systems
Electronic integration
Research & Technology platforms
Research &Technology platforms
ICT for Health at Tyndall
Smart Systems
Electronics & Photonics
Micro & NanoTechnology
Core Enabling Technologies
Molecular modelling
Advanced Sensors
Advanced Processing
Micro Power
Photonic devices
Photonic packages
Photonic systems
Wireless intertialsensing
Lab on chip systems
Electronic integration
Applications
Research &Technology platforms
Diagnostics
Connected Health
Therapeutic Systems
Cardio-Neuro
Interfacing
Surgical Innovation
& TEL
We Collaboratewith global
medtech companies, world
leading clinicians and
leading scientists.
Tyndall ICT4 Health
- leading an ABC Ecosystem
Clinicians & Patients
Tyndall & Academic partners
Clinical Partners
BusinessPartners
ABC Ecosystem
Academic,
Business,
Clinical)
Photonics – expertise/capabilities
Photonics
Theory
Electronic structure
and properties, III-V
materials & devices
Device
Fabrication
Optical design to device
dynamics, laser physics,
power scaling, ultrafast
pulses
Device Design &
Test
Novel photonics structures
Visible, near-IR & UV
lasers, (micro)LEDs,
modulators & detectors
MicroelectronicsDriver and receiver
integrated circuits
III-V & III-Nitride
materialsSemiconductor
optoelectronic device
structures, quantum well,
wires, dots &
nanostructured epitaxy
Photonic
Integration
High-speed integrated
optoelectronic
transceivers
Packaging
Packaging & hybrid
integration
Optoelectronic
Systems
Optical fibre
communications &
optical interconnects
Bio-photonic
SystemsPoint of care
diagnostics, smart
surgical instruments &
wearable devices
Silicon Photonics
Quantum
InformationSingle photon sources,
quantum key
distribution systems
Micro-transfer printing,
integrated electronic
and photonic circuits
Basic Phenomena
Materials Epitaxy
Devices Integration Systems
Bio-PhotonicsLight and tissue
interactions
World-Class Facilities ‘atoms to systems approach’
11
Photonics - Team
• Largest photonics research activity in Ireland
– 16 PIs + teams (150 people in total, 50 PhDs)
• Internationally competitive, connected and visible
• Significant PI industry
experience:
• Lead/host for SFI/industry-
funded Irish Photonics
Integration Centre (IPIC)
Ba
sic
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O’Reilly
Photonics TheoryElectronic structure and properties
of III-V materials & devices
Device DynamicsCAPPA group: Laser dynamics,
material studies & optical design
III-V Materials& Devices
Visible & near-IRlasers & LEDs
Huyet McInerneyCorbett
TownsendGunning
Photonic SystemsFibre communications
High speed microelectronics design
Laser PhysicsLasers & devices
Morrison
Optical DetectorsAPDs & IC integration
Peters
Pelucchi
Epitaxy & Physics of Nanostructures
III-V Epitaxy, quantum dots & quantum optics
Photonic IntegrationHigh speed integrated
optoelectronic devices
III-Nitride MaterialsUV & visible sources
Parbrook
O’Brien
Photonic PackagingPackaging
& hybrid integration
Ossieur Zhao
Hegarty
Bio photonics Medical devices and bio-imaging
Schultz
Andersson-Engels
Expanding Biophotonics and Medical Application Expertise
• International search identified Prof. Stefan Andersson-Engels, Director of Medical Laser Centre at Lund University, Sweden as leading candidate
• Main fields of interest– Laser spectroscopy and imaging for medical
diagnostics, Photodynamic therapy, Tissue Optics
• Academic leader and active entrepreneur– >400 publications, H-Index of 52, 3 biomedical start-
up companies
– Extensive experience of working with clinicians
• Current status– SFI Professorship application (value €5M) funded
– Started full-time at Tyndall 1st September
13
Tissue Imaging
• Various techniques are today used
in medical imaging and
interactions.
• Optics provides unique molecular
contrast opportunities in tissues.
• There is a great need for improved
tools for interacting with deep
tissue regions.
• Photo-acoustics is a technique
starting to enter the preclinical
and clinical use.
Ultrasound Optical Tomography
1
5
Grand challenge: can we see through the body using light?
• Academic institutions
• Together with 20 industry partners
• €30 Million funding (30% industry, 70% SFI) for initial 6 years
• Focus areas: integrated systems for ICT and Medtech
Hybrid Integration
Monolithic Integration
Irish Photonic Integration Centre
Principal Investigators
• Full photonics and electronics ‘value chain’• 60 people directly funded, 150 people in wider teams
17
Prof. Stefan Andersson-Engels
(formerly Lund University)
€5M programme in
biophotonics
International Recognition
• Brian Corbett receiving 2013 Intel
Outstanding Researcher Award for
his work on light sources for
computer interconnects
• Eoin O’Reilly receiving the 2014 Rank Prize award for his pioneering work on strained-layer semiconductor laser structures
Industry Partner Expansion
• Pipeline of further target
companies being
developed with support
from IDA and Tyndall
Business Development
Team
2012 2013 2015 20162014
IPIC Start
Research Snapshots
Devices including Transfer Printed Lasers
III-V Materials & Theory
III-V PICs
New Lasers for OCTSuper Channel Systems and PONs
O2 Sensing in tissue
82.10 nm
0.00 nm
200nm
Nanostructure enhanced fluorescence
for biosensors
Optical Interconnects and Microelectronics
Photonics Packaging
Chip on tip Challange
URSUser Requirements Specification
SRSSystem Requirement Specification
DOSDesign Output Specification
DFEMADesign Failure Mode and Effects
Analysis
DVTDesign Verification Testing
FTFunctional Testing
TRSTest Requirement Specification
Implementation
Documentation DHF & Compliance
Implementation Example Flow Diagram
• Define User Case & URS• Market Analysis data• Commercial Strategy• Detailed Business Plan• Technology Licences• Clinical Requirements
Clinician Lead , Industry Lead, commercial input from team and EMR suppliers on technology, market etc.
• Design the product• Sensor Integration• Hardware• Software• Communications• Alpha Prototypes • Design for manufacture
Tyndall, Technion, Marturion Industry , EMR suppliers & Advisory Board
• Mechanical Design• Functional Prototype Build• Design verification testing• Verify Usability• Device testing• System level interface
Industry CMO, Technical TeamPartner HospitalsPartner CliniciansEMR suppliers & Advisory Board
Tyndall, Technion, Marturion Industry , EMR suppliers & Advisory Board
Industry , Partner Hospitals , distribution and manufacturing Network EMR suppliers & Advisory Board
AC
TIO
NS
STA
RT
Team
Market Analysis & Technology Phase Month 1-14
Regulatory and Commercialisation Phase Month 14-30
• Ethical Approval• Clinical Testing• Regulatory
Submissions• Approvals testing• Design Validation
Industry , Technical team, Partner Hospitals ,Distribution and manufacturing Network EMR suppliers & Advisory Board
• Commercialisation• Marketing• Distributor Development• Market Development• Product Roadmap
• Production Process• Process validation• Supply Chain Process• Sample volumes• Marketing
AC
TIO
NS
Team
Commercialisation Month 30-36
Some Suggestions
• Working with medtech companies or interested in translating
research to medtech sector, then we need to be strategic.
• They will want a system level approach or understanding.
• Device classification.
• Propose and build technology platforms. Third parties &
Supply Chain.
• Starting point remember the ABC Model.
• Understand the clinical procedures ask for a target or typical
procedure. Try and understand commercial application early.
• Regulatory Path , in-vivo testing , first in man & Clinical .
• Contract Research Agreement , NDA , get pro-forma versions
to the Industry partner early these can take a year to
conclude, insurance and liabilities.
• Researcher in Residence program.
