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ZHENG-RONG LU
M. Frank Rudy and Margaret Domiter Rudy Professor of Biomedical Engineering
Case Western Reserve UniversityDepartment OF Biomedical EngineeringWickenden Building Room 42710900 Euclid Avenue Cleveland, Ohio 44106-7207Phone: (216) 368-0187 (Office)FAX: (216) 368-4969E-mail: [email protected]
EDUCATION
1980 -1987 Department of Chemistry, Lanzhou University, Lanzhou, China B.Sc. in 1984 and M.Sc. (Organic Chemistry) in 1987
1987-1990 Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, ChinaPh.D. (Physical Chemistry) in 1991
1990-1992 Postdoctoral Fellow, Department of Chemistry, Wuhan University, China
1996-1998 Postdoctoral Fellow, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah
APPOINTMENTS AND RESEARCH ACTIVITIES
1992-1993 Associate Professor of Chemistry, Department of Chemistry, Wuhan University, Wuhan, China
1993-1996 Professor of Chemistry, Laboratory of Biomedical Polymers of the Ministry of Education of China, Department of Chemistry, Wuhan University, China
Nov. 1994- Jun. 1995 Visiting Scientist, at School of Chemistry and Molecular Science, University of
Sussex at Brighton, UKJul. 1995- Oct. 1995 Visiting Scientist, at the Centre of Polymer Therapeutics, School of Pharmacy,
University of London, UK.
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1998 –July 1999 Research Associate, Department of Pharmaceutics and Pharmaceutical Chemistry,
University of UtahJuly 1999-2001 Research Assistant Professor, Department of Pharmaceutics and Pharmaceutical
Chemistry/CCCD, University of UtahJan. 2002-June 2006 Assistant Professor, Department of Pharmaceutics and Pharmaceutical Chemistry,
University of UtahAug. 2002-present Adjunct Assistant Professor, Department of Radiology, University of Utah
2003-present Cancer Center Member, Huntsman Cancer Institute, University of Utah
2004-present Adjunct Assistant Professor, Department of Materials Science and Engineering, University of Utah
July 2006 –April 2009 Associate Professor with tenure, Department of Pharmaceutics and Pharmaceutical
Chemistry, University of Utah
May 2009 – Professor, Department of Biomedical Engineering, Case Western Reserve University
AWARD AND HONORS
Royal Society K.C. Wong Fellowship, UK, 1995.
Session Chair, International Symposium on Tumor Targeted Delivery Systems, NCI and CRS, Bethesda, MD. September 25 –27, 2000.
Finalist of 2006 Utah Innovation Awards.
Guest Editor on the Special Issue on Molecular Imaging, Molecular Pharmaceutics
Guest Editor on the Biomedical Imaging in Drug Discovery and Development, Pharmaceutical Research
Member of Editorial Board, Pharmaceutical Research
Member of Editorial Board, Molecular Pharmaceutics
Member of Editorial Board, ISRN Biomaterials.
Member of Editorial Board, American Journal of Nuclear Medicine and Molecular Imaging.
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Member of Advisory Editorial Board, American Journal of Cancer Therapy and Pharmacology.
Moderator of the Symposium on Biomedical Imaging on Drug Discovery and Development at 2006 AAPS Annual Meeting
Co-Chair of the Workshop on Molecular Imaging and Drug Delivery at 2007 Annual Meeting of the Controlled Release Society
Organizing Committee, nanoUtah 2008
International Program Committee for the IASTED, 2012
Convenor, Symposium of Contrast Media Research, 2011-2013.
Moderator of the 2012 International Symposium of Controlled Release Society, 2012
Moderator of the NanoDDS’12, 2012
Moderator of the 2012 symposium of OCSMRM, 2012
PROFESSIONAL SOCIETIES
American Chemical SocietyControlled Release SocietyInternational Society for Magnetic Resonance in MedicineSociety for Molecular Imaging
TEACHING ACTIVITIES
1. Pharmaceutics 5125, Dosage Forms and Drug Delivery Systems; professional Pharm.D. class, 50 students, three lecture hours, 2004 -2009, University of Utah
2. Pharmaceutics 7020 or 7040, Drug Stability-Kinetics and Mechanisms of Drug Degradation and Stabilization; core course for graduate students, course designer, since Fall, 2002 – 2009, University of Utah
3. Bioengineering 7120, BIOCOMPATIBILITY, two lecture hours, 2002 – 2009, University of Utah
4. Pharmaceutics 7110, Molecular Imaging; elective course for professional students and graduate students, course designer, 2005, University of Utah
5. Journal Club, Bioconjugate Chemistry; Fall 2000
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6. Journal Club, Molecular Imaging; Spring 2004.
7. EBME426, Nanomedicine, Elective for Graduate Students, since 2010, Case Western Reserve University
8. EBME316/416, Drug Delivery, elective course for undergraduate students and graduate students, since 2010, Case Western Reserve University
9. Supervisor for the research of following undergraduate students
1. Nicole Polson (Access Research Program, Spring 2004)2. Amanda Meldrum (Access Research Program, Spring 2005)3. Thanh Nguyen (Access Research Program, Spring 2006)4. Ronny Li (CWRU, 2009)5. Hardy Han (CWRU, 2010)6. Xiu-Feng Peng (CWRU, 2011)7. Vivian Huynh (CWRU, 2011)
10. Supervisor for the research of following summer undergraduate students
1. Todd Kaneshiro (summer 2002, Pharmaceutics)2. Todd Kaneshiro (summer 2003, HCI)3. Melissa Smith (summer 2003, Pharmaceutics)4. Nicole Polson (summer 2004, Pharmaceutics)5. Matt Webber (summer 2004, Pharmaceutics)6. Matt Webber (summer 2005, Pharmaceutics)7. Bryce Hill (summer 2006, Pharmaceutics)8. Thanh Nguyen (summer 2007, Pharmaceutics)9. Thanh Nguyen (summer 2008, Pharmaceutics)10. Melinda Fairman (summer 2008, Pharmaceutics)
11. Member of Advisory Committee for following graduate students
1. Scott Stayner (Bioengineering, graduated)2. Yan Wang (Chemistry, graduated)3. Travis Bridge (Chemistry)4. Gang Zuo (Chemistry, graduated)5. Hung Duong (Chemistry, graduated)6. Zhuqing Liu (Chemistry, graduated)7. Manfei Lee (Chemistry)8. Vijay Sethuraman (Pharmaceutics, graduated)9. Han Chang Kang (Pharmaceutics, graduated)10. Weiwei Zhu (Pharmaceutics, graduated)11. Jie Zhou (Chemistry)12. Venkatareddy Nadithe (Pharmaceutics, graduated)
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13. Vaikunth Cuchelkar (Bioengineering, graduated)14. Xiaoyu Xu (Chemistry, graduated)
12. Supervisor for following rotating graduate students
1. Jeff C. Chang (Fall 2002) 2. Marisa Frost (Spring 2003)3. Huifeng Gao (Spring 2004)4. Rongzuo Xu (Spring 2005)5. Clinton Jones (Fall 2006)6. Zhen Ye (Fall 2007)7. Imit Kauer (Fall 2008)
13. Supervisor for following graduate students
1. Aaron Mohs (Pharmaceutics, Ph.D., graduated in 2006, Post-Doctor in Emory University)2. Anagha Vaidya (Pharmaceutics, Ph.D., graduated in 2008, Scientist in
Abbott Laboratories)3. Yi Feng (Material Science, Ph.D., graduated in 2007, Post-Doctor in
Washington University, Nevada Cancer Center)4. Furong Ye (Pharmaceutics, Ph.D., graduated in 2009)5. Yuda Zong (Pharmaceutics, Ph.D., graduated in 2008, Scientist in Hercules
Pharmaceutics)6. Todd Kaneshiro (Pharmaceutics, Ph.D., graduated in 2008, Volunteer for
USA Government in Central Asia)7. Rongzuo Xu (Pharmaceutics, Ph.D., graduated in 2009, Post-Doctor in
J&J)8. Brandon Buckway (Pharmaceutics, Ph.D., transferred)9. Zhen Ye (Pharmaceutics, Ph.D., expected to graduate in 2011)10. Anthony Malamas (Biomedical Engineering, Ph.D. Case)11. Anthony Puntel (Biomedical Engineering, Ph.D. Case)12. Zheng Han (BME, Ph.D. Case)13. Maneesh Gujrati (BME, Ph.D. Case)
14. Supervisor for following postdoctoral fellows or visiting scientists
1. Xinghe Wang (August 2002 – July 2004, Principal Scientist in a company in San Diego, CA)
2. Tianyi Ke (January 2004 – June 2006, Senior Scientist in a company at LA, CA)
3. Xuli Wang (March 2004-June 2008, Research Assistant Professor, University of Utah)
4. Yanli Wang (January 2005 – June 2006, Manager in a company in Salt Lake
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City, Utah)
5. Xueming Wu (since May 2007-)
6. Mingqian Tan (October 2007 – November 2010, Associate Professor in Dalian Institute of Chemical Physics, Chinese Academy of Science)
7. Wanjian Jia (since January – May, 2009, post-doctor at University of Utah)
8. Shuoyu Yin (November, 09 – May, 2010, Professor in Yanji University, China)
9. China Kimmitha (March, 2010 -2011)
10. Emhonta Johnson (August, 2010 – July, 2011)
11. Chengcai Luo (August, 2010 - August, 2011, Assistant Professor in Zhejiang University )
12. Bharath Guru (March 2011 -2012)
13. Zhuxian Zhou (May, 2011 -14. Erlei Jin (June, 2011 -)
Awards received by students under my supervision
A.M. Mohs: Fox Award, Wolf Award, PhRMA Fellowship
A. Vaidya: Fox Award, 2nd place award of the best poster in the 2006 Annual Meeting of International Society of Magnetic Resonance in Medicine (ISMRM).
T. Kaneshiro: American Heart Association Graduate Student Fellowship, Top Prize of Best Students’ Poster Award of 2007 Annual meeting of the Controlled Release Society.
SERVICE ACTIVITIES
Grant reviewer for following agencies
1. The Petroleum Research Fund, 2002.2. The Italian National Research Council, 2003.3. The U.S. Civilian Research & development Foundation, 2004.4. Hong Kong Research Grants Council, 2004, 2005, 2007, 2008.5. University of Utah Seed Grant, since 2004.6. The American Heart Association Bioengineering and Biotechnology 1.
Peer Review Group, Member, 2005 -.7. Israel Science Foundation, 2006, 2007.8. NIBIB/NIH Innovation In Molecular Imaging Probes Roadmap Grant
Review Special Emphasis Panel ZEB1 OSR-C M1, Member, March 2005.
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9. NIBIB/NIH review panel for the NIBIB Quantum Program, 2006.10. Ohio Cancer Research Associates, 2007, 2008.11. National Science Foundation, 2006, 2007.12. Singapore Biomedical Research Council, 2006, 200713. Alberta Cancer Board, 200714. NIH ZRG1 F14 Special Emphasis Panel, 200815. NIH Medical Imaging Study Section, 200816. NIH Medical Imaging Study Section A, 200817. NIH Special Emphasis Panel ZRG1 F14-G, 200818. NIH Special Emphasis Panel ZRG1 F14-G, 200919. NIH Medical Imaging Study Section A, 200920. NIH Clinical Molecular Imaging and Probe Development Study Section A,
since 2009
Manuscript reviewer for following journals
Advanced Drug Delivery ReviewsAngewante Chem.European Journal of Pharmaceutics and BiopharmaceuticsInternational Journal of Pharmaceutics Journal of Pharmacy and PharmacologyJournal of the American Chemical Society Biomacromolecules Langmuir Journal of Controlled Release PDA Journal of Pharmaceutical Science and Technology Pharmaceutical Research Journal of Polymer Science Australia Journal of Chemistry Journal of Drug Targeting Polymer International Journal of Biomedical Materials Research, Part A Journal of Biomedical Materials Research, Part B Journal of Biological ChemistryBioconjugate ChemistryBiomaterialsMacromoleculesMagnetic Resonance in MedicineMacromolecular BioscienceNanomedicineJournal of Applied Polymer ScienceAdvanced Functional MaterialsJournal of Medicinal ChemistryMolecular PharmaceuticsTechnology in cancer research and treatmentJournal of Gene Medicine
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Current Opinion in Molecular TherapeuticsJournal of Cellular and Molecular MedicineTetrahedron LettersChemical CommunicationsColloids and Surfaces B: BiointerfacesMolecular ImagingCancer ResearchNature CommunicationContrast Media and Molecular Imaging
Abstract reviewer for following scientific conferences
The 30th Annual Meeting of the Controlled Release Society, 2003The 31st Annual Meeting of the Controlled Release Society, 2004The 2004 Annual Meeting of American Association of Pharmaceutical ScientistsThe 2005 Annual Meeting of American Association of Pharmaceutical ScientistsThe 2005 Annual Meeting of the International Society of Magnetic Resonance in MedicineThe 2008 Annual Meeting of the International Society of Magnetic Resonance in MedicineThe 2009 Annual Meeting of the International Society of Magnetic Resonance in MedicineThe 38th Annual Meeting of the Controlled Release Society, 2011The 39th Annual Meeting of the Controlled Release Society, 2012
Services in the Committees:
The Chair Search Committee of the Department of Pharmaceutics (Member, 2004)The Chair of Seminar Series of the Department of Pharmaceutics (spring, 2004)The College Learning and Teaching Committee (Member, 2001-2003, 2004 -)The College Research and Graduate Program Committee (Member, 2003-2004)The University Seed Grant Committee (Member, 2004 - 2007)The Department Graduate Student Admission Committee (Chair, 2004 - 2008)The program committee of the Biotechnology Section of the American Association of Pharmaceutical Scientists (Member, 2005)The Academic Senate of University of Utah (2006 - 2009)The Personnel and Selection Committee, University of Utah (2006 -2008)New Faculty Search Committees (Chair for one of the committees, CWRU, 2009)Graduate Education Committee (BME, CWRU, 2009 -)Faculty Senate of Case Western Reserve University (2011 -)
Community Service
Volunteer for Salt Lake City Figure Skating Club (2004 - 2007)
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RESEARCH AND SCHOLARLY ACTIVITIES
Current Research Grant Awards
R01 EB000498-01 (NIH/NIBIB) Lu (PI) 07/01/03 – 03/31/15Biodegradable macromolecular blood pool contrast agents. The major goal is to design and develop safe, effective MRI blood pool contrast agents based on biodegradable macromolecular gadolinium (III) complexes. The research project is focused on contrast enhanced MR cardiovascular imaging.
R01 CA097465 (NIH/NCI) Lu (PI) 03/01/04 – 04/30/12Polymer chelate conjugates for diagnostic cancer imaging. The major goal is to develop effective, safe targeted polymer-gadolinium chelate conjugates for specific MR diagnostic cancer imaging.
R24EY021126 (NIH/NEI) Lu (Co-I)10/01/10-09/30/15Pharmacological Treatment of Retinal Diseases. The major goal is to develop new drug delivery systems for sustained release of retinal therapeutics.
Completed Research Grants and Contracts
R41CA135785 (NIH/NCI) Lu (PI)07/01/09-06/30/10Multifunctional Carriers for siRNA Delivery. The major goal is to develop novel safe and effective multifunctional delivery systems for therapeutic siRNA.
R31 CA095873-01 (NIH/NCI) Lu (PI) 06/01/03 – 05/31/04Biodegradable macromolecular MRI contrast agents. The major goal is to design and develop biodegradable macromolecular gadolinium (III) complexes for cancer imaging. The research project is focused on the detection and staging of cancer in animal models.
Nitto Denko Technical Corp. Lu (PI) 07/01/02 – 06/30/04Characterization of polymeric gene carriers
University of Utah Technology Commercialization Projects, Lu (PI)07/01/05 – 06/30/07
Preclinical development of biodegradable macromolecular MRI contrast agents. The major goal is to evaluate the toxicity and pharmacokinetics of the two new biodegradable macromolecular MRI contrast agents.
University of Utah Technology Commercialization Projects, Lu (PI)07/01/08 – 06/30/09
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Multifunctional Carriers for siRNA delivery. The major goal is to develop efficient multifunctional delivery systems for siRNA.
Utah Center of Excellent Program Award, Lu (PI)07/01/08 – 06/30/09Center of Nanomedicine Applications in Cancer. The goal of the center to develop and commercialize imaging agents using drug delivery technology.
The CAO Group, Inc. 07/01/06-06/30/07
Laser ablation in animal tumor model.
R33 CA095873-01 (NIH/NCI) Lu (PI) 06/01/04 – 05/31/08Biodegradable macromolecular MRI contrast agents. The major goal is to design and develop biodegradable macromolecular gadolinium (III) complexes for cancer imaging. The research project is focused on the detection and staging of cancer in animal models.
R41CA128130 (NIH/NCI) Lu (PI)07/01/08-06/30/09Minimally-invasive image-guided therapy for cancer treatment. The major goal is to develop minimally invasive cancer therapy to treat pancreatic cancer.
Case Cancer Center CCIR Seed Grant10/01/09-09/30/10Molecular Imaging of the Prostate Tumor Microenvironment. The major goal is to develop novel imaging probes for molecular imaging of the microenvironment of prostate cancer.
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PEER REVIEWED PUBLICATIONS
1. Y. Zhou, S. Wu, Z.-R. Lu Synthesis of the derivatives of biscyclopentadienylzirconium (IV) with N,N- dialkyldithiocarbamates J. Lanzhou University (Sci. Ed.), 1987, 23(4), 152-53
2. Z.-R. Lu, Y.-Q. Yin, D.-S. Jin Novel catalysts for the epoxidation of cyclohexene with t-butyl hydroperoxide J. Mol. Catal. (China), 1989, 4, 276-283. CA 113, 39824
3. Z.-R. Lu, Y.-Q. Yin, D.-S. Jin Catalytic Epoxidation of Olefin Huaxue Jinzhan (Progress in Chem.) 1990,1,17-28
4. Z.-R. Lu, Q. Guo, Y.-Q. Yin, D.-S. Jin Epoxidation of alkene catalyzed by vanadatranes J. Mol. Catal. (China), 1991, 2, 139. CA 115, 231488
5. Z.-R. Lu, Y.-Q. Yin, D.-S. Jin Molybdenum catalysts for propylene epoxidation Chinese J. of Appl. Chem., 1991, 8(5), 49-51. CA 116, 40848
6. Z.-R. Lu, Y.-Q. Yin, D.-S. Jin Oxidation of alkene with t-butyl hydroperoxide catalyzed by copper complexes of tris(2-benzimidazolylmethyl)amine: model complexes of blue copper proteins J. Mol. Catal., 1991,70, 391-397
7. Z.-R. Lu, Q. Guo, Y.-Q. Yin, D.-S. Jin Epoxidation of cyclohexene with aqueous hydrogen peroxide catalyzed by 1,1-dioxomolybdatranic acids J. of Catal. (Cuihua Xuebao), 1992,13(3), 198-202. CA 117, 111395
8. Z.-R. Lu, Y.- Q. Yin, D.-S. Jin Synthesis and reactivity of oxoperoxomolybdenum (VI) complexes: the active species in the Halcon epoxidation process Chinese Chem. Lett., 1992, 3, 1003-6
9. Z.-R. Lu, S.-Q. Gao, Y. Zhou, S. Wu Synthesis and characterization of cyclopentadienyl(or methylcyclopentadienyl)-titanium(IV), zirconium (IV) triscarbamates Chinese J. of Appl. Chem., 1992, 9(3), 110-113. CA 117, 151099
10. Z. Wang, S. Lu, H, Guo, Z.-R. Lu, Y.-K. Zhou
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Aqueous phase synthesis of dicarboxylic derivatives of the titanocene Synth. React. Inorg. Met. Org. Chem. 1992, 22, 883-892
11. Z.-R. Lu, J. Liao, R.-X. Zhuo 2-Hydroxyethylation of L-amino acids with chlorohydrin : synthesis of L-N-2-hydroxyethyl amino acids and L-N,N-bis(2-hydroxyethyl)amino acids Chinese Chem. Lett., 1993,4, 689-692
12. R.-X. Zhuo, Z.-R. Lu, J. Liao, L.-F. Shen Synthesis and characterization of (4S)-silatrane-4 -carboxylic acids; molecular structure of (3R,4S)-1-vinyl-3-methylsilatrane-4-carboxylic acid J. Organomet. Chem., 1993, 446, 107-112
13. Z.-R. Lu, C.-Y. Tao, R.-X. Zhuo Synthesis of (4S)-ethoxysilatrane-4-carboxylic acids Chinese Chem. Lett., 1994, 5, 549-50
14. Z.-R. Lu, R.-X. Zhuo, L.-R. Shen, B.-S. Luo The synthesis and crystal structure of (4S)-(3-chloropropyl)silatrane-4-carboxylic acid monohydrate: a stable intermediate in the hydrolysis of silatrane Main Group Metal Chem., 1994, 17, 377-85
15. Z.-R. Lu, S.-Q. Gao, Y. Zhou, S. Wu Aquachemistry of titanocene dichloride and crystal structure of titanocene bissalicylate Chinese J. of Appl. Chem., 1994, 11, 28-32
16. Z.-R. Lu, Y.-Q. Yin, D.-S. Jin Oxidation of cyclohexene with sodium hypochloride or t-butyl hydroperoxide catalyzed by Fe(III),Co(II), and Ni(II) complexes of tris(2-benzimidazolylmethyl)-amine J. Mol. Catal. (China), 1994, 8, 143-46
17. Z.-R. Lu, R.-X. Zhuo, L. Shen, X. Zhang, L.-F. Shen Synthesis and characterization of (4S)-1-chloroalkylsilatrane-4-carboxylic acids, crystal structures of (3R,4S)-1-chloromethyl-3-methylsilatrane-4-carboxylic acid and (3R,4S)-1-(3-chloropropyl)-3-methylsilatrane-4-carboxylic acid J. Organomet. Chem., 1995, 489, C38-C43
18. Z.-X. Zhuo, Z.-R. Lu, J. Wen Synthesis and characterization of metal complexes of L-lysine-N,N,N',N'-tetraacetic acid and L-lysine-N,N,N',N'-tetramethylenephosphonic acid Chemical Research in Chinese Universities, 1995, 11, 276-78
19. X. Zhang, S. Mao, L. Shen, C. Ye, R.-X. Zhuo, Z.-R. Lu, G. A. Webb Conformational analysis of some substituted silatranyl carboxylic acids produced by computational study and NMR spectroscopy
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J. Mol. Struct. 1995, 372, 249-56
20. Z.-R. Lu, R.-X. Zhuo, C. Yin Synthesis and relaxivity of Gd(III) complexes with EDDS and THEC Gaodeng Xuexiao Huaxue Xuebao, 1996, 1, 24-26
21. R.-X. Zhuo, G. Fu, M. Ouyang, X. Zhao, Z.-R. Lu Modified DTPA, EDTA ligands and their paramagnetic metal complexes as contrast agents for MRI Wuhan Univ. J. Nat. Sci. 1996, 1(2), 225-29
22. C. Eaborn, Z.-R. Lu, P.B. Hitchcock, J.D. Smith _________________________________[CH2-SiMe2(SiMe3)2C-Li-C(SiMe3)SiMe2CH2] and __________________________________ [CH2-SiMe2(SiMe3)2C-Hg-C(SiMe3)SiMe2CH2] the highly crowded chelatedorganomercury compounds Organometallics, 1996, 15(6), 1651-55
23. C. Eaborn, P. Hitchcock , K. Izod, Z.-R. Lu, J.D. Smith Alkyl derivatives of Europium(+2), Ytterbium(+2), Crystal structures of Eu[C(SiMe3)3]2, and Yb[(CSiMe3)2(SiMe2CH=CH2)]I.OEt2 and Yb[C(SiMe3)2(SiMe2OMe)]I.OEt2
Organometallics, 1996, 15(22), 4783-90
24. C. Eaborn, P. Hitchcock, A. Kowalewska, Z-R. Lu, J.D. Smith, W. Stanczy Iodo(methoxydimethylsilyl)bis(trimethylsilyl)methane, A reagent for the preparation of novel organometallic compounds, crystal structures of _________________Mg{C(SiMe3)2(SiMe2OMe)}2 and Mg(OEt2)2I2
J. Organometallic Chem. 1996, 521(1-2), 113-120
25. T.-Y. Ke, R.-X. Zhuo, Z.-R. Lu, H.-Q. Feng Phosphorylating polycondensation using phosgene as a chain extender European J. Polymer, 1997, 33, 1583-86
26. Z.-R. Lu, J.-H. Yu, R.-X. Zhuo Synthesis of new ointment-like poly(ortho esters) Chinese Chem. Lett. 1997, 8(2), 114-6
27. X.-D. Zhang, S.-Z. Mao, L.-F. Shen, Z.-R. Lu, R.-X. Zhuo NMR and Molecular dynamics study on some substituted silatranes Acta Chimica Sinica, 1997, 55(3), 290-95
28. X. Zhao, R.-X. Zhuo, Z.-R. Lu, W. LiuSynthesis, characterization and relaxivity of amphiphilic chelates of DTPA
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Derivatives with GdIII, YbII and MnII
Polyhedron, 1997, 16(16), 2755-59
29. Z. Liu, Y. Qi, X. Zhou, Z.-R. Lu, G. XiaoA novel approach for gene transfer using porphyrin-dendritic macromolecular conjugatesBiotechnology Techniques, 1997, 11(8), 601-4
30. Z.-R. Lu, J.-H. Yu, R.-X. Zhuo, X.-L. Wang, F.-H. Yang Studies on the preparation and cytotoxicity of poly(L-aspartic acid) derivative-cisplatin(II) conjugatesGaodeng Xuexiao Huaxue Xuebao, 1998, 19(5), 817-820
31. X.-D. Zhang, G. Zheng, L.-F. Shen, C.-H. Ye, Z.-R. Lu, R.-X. ZhuoSolid sate NMR study of some substituted silatrane compoundsActa Chimica Sinica, 1998, 56, 986-989
32. J.-L. Liu, S.-H. Shi, R.-X. Zhuo, Z.-R. LuPreparation of dendrimers from macromolecular cores and papain immobilizationChinese Chem. Lett. 1998, 9, 263-264
33. R.-X. Zhuo, B. Du, Z.-R. LuIn vitro release of 5-fluorouracil with cyclic core dendritic polymersJ. Control. Release, 1999, 57, 249-257
34. Z.-R. Lu, P. Kopeckova, Z. Wu, J. KopecekFunctionalized semitelechelic poly[N-(2-hydroxypropyl)methacrylamide] for protein modificationBioconjugate Chem., 1998, 9(6), 793-804
35. Z.-R. Lu, P. Kopeckova, Z. Wu, J. KopecekSynthesis of semitelechelic poly[N-(2-hydroxypropyl)methacrylamide] by radical polymerization in the presence of alkyl mercaptansMacromol. Chem. Phys., 1999, 200, 2022-2230
36. Z.-R. Lu, P. Kopeckova, J. KopecekPolymerizable Fab' fragment for targeting of anticancer drugsNature Biotechnology, 1999, 17(11), 1101-1104
37. Z.-R. Lu, S.-Q. Gao, P. Kopeckova, J. KopecekSynthesis of bioadhesive lectin-HPMA copolymer-cyclosporin conjugates for treatment of colon diseasesBioconjugate Chem., 2000, 11(1), 3-7
38. J. Kopecek, P. Kopeckova, T, Minko, Z.-R. LuHPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action
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Eur. J. Pharmaceutics Biopharm., 2000, 50, 61-81
39. Jiahui Yu, Zheng-Rong Lu, Hua Zheng and Renxi Zhuo, Synthesis and characterization of new ointment–like poly(ortho esters) Eur. Polymer Journal, 2001, 38 971-975.
40. Z.-R. Lu, S.-Q. Gao, P. Kopeckova and J. KopecekModification of cyclosporin A and conjugation of its derivative to HPMA copolymersBioconjugate Chem., 2001, 12, 129-133
41. Y. Kasuya, Z.-R. Lu, P. Kopeckova, T. Minko, E. Tabibi and J. KopecekSynthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugatesJ. Control. Release, 2001, 74, 203-11.
42. Y. Kasuya, Z.-R. Lu, P. Kopeckova, and J. KopecekImproved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systemsBioorganic & Medicinal Chemistry Letters. 2001, 11, 2089-2091
43. J. Kopecek, P. Kopeckova, T. Minko, Z.-R. Lu, C.M. Peterson Water soluble polymers in tumor targeted delivery J. Control. Release, 2001, 74, 147-58.
44. L. Varticovski, Z.-R. Lu, I. de Aos, T. Kagawa, K. Mitchell, R. Christensen, and J. KopecekA water-soluble HPMA copolymer–wortmannin conjugate retains phosphoinositide 3-kinase inhibitory activity in vitro and in vivoJ. Control. Release, 2001, 74, 275-81.
45. Z.-R. Lu, J.-G. Shiah, P. Kopeckova and J. KopecekPreparation and biological evaluation of polymerizable antibody Fab' fragment targeted polymeric drug delivery systemJ. Control. Release, 2001, 74, 263-8.
46. S. Sakuma, Z.-R. Lu, P. Kopeckova and J. Kopecek. Biorecognizable HPMA copolymer-drug conjugates for colon-specific delivery of 9-aminocamptothecin J. Control. Release, 2001, 75, 365-79.
47. Z.-R. Lu, J.-G. Shiah, S. Sakuma, P. Kopeckova and J. Kopecek, Design of novel bioconjugates for targeted drug delivery J. Control. Release, 2002, 78, 165-73.
48. Y. Luo, N. Bernshaw, Z.-R. Lu, J. Kopecek and G.D. Prestwich, Hyaluronic acid containing bioconjugates: targeted delivery of anticancer drug doxorubicin to cancer cells
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Pharm. Res., 2002, 19, 396-402.
49. Y. Kasuya, Z.-R. Lu, P. Kopeckova and J. Kopecek, Improved Synthesis and Evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems Bioorg. Med. Chem. Letters. 2001, 11, 2089-91.
50. Y. Kasuya, Z.-R. Lu, P. Kopeckova, S. E. Tabibi and J. Kopecek, Influence of the structure of drug moieties on the in vitro efficacy of HPMA copolymer-geldanamycin derivative conjugates Pharm. Res. 2002, 19, 115-123.
51. S. Sakuma, Z.-R. Lu, B. Pecharova, P. Kopeckova and J. Kopecek. N-(2-Hydroxypropyl)methacrylamide copolymer-9-aminocamptothecin conjugate: colon-specific drug delivery in rats J. Bioact. Comp. Polym. 2002, 17, 305-319.
52. Z.-R. Lu, J.-G. Shiah, P. Kopeckova and J. Kopecek Polymerizable Fab' antibody fragments targeted photodynamic cancer therapy in nude mice STP Pharm. Sci. 2003, 13, 69-75.
53. Z.-R. Lu, P. Kopeckova and J. KopecekAntigen responsive hydrogels based on polymerizable antibody Fab' fragment Macrom. Biosci. 2003, 3, 296-300.
54. Z.-R. Lu, X. Wang, D.L. Parker, K.G. Goodrich, H.R. Buswell.Poly(l-glutamic acid) Gd(III)-DOTA conjugate with a degradable spacer for magnetic resonance imaging Bioconjugate Chem. 2003, 14, 715-719.
55. Z.-R. Lu, D. L. Parker, K. C. Goodrich, J. Dalle, H. R. Buswell. Extracellular biodegradable macromolecular gadolinium(III) complexes for magnetic resonance imaging Magn. Reson. Med. 2004, 51, 27-34.
56. A. M. Mohs, X. Wang, K. C. Goodrich, Y. Zong, D. L. Parker, Z.-R. LuPoly(GdDTPA-L-cystine)-g-PEG: a biodegradable macromolecular blood pool contrast agent for MR imaging Bioconjugate Chem. 2004, 15, 1424-1430.
57. Y. Zong, X. Wang, K. C. Goodrich, A. M. Mohs, D. L. Parker, Z.-R. LuContrast enhanced tumor MRI with new biodegradable macromolecular Gd(III) complexes in mice Magn. Reson. Med. 2005, 53, 835-42.
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58. X.Wang, H. Y. Feng, T. Ke, M. Schable, Z.-R. LuPharmacokinetics and long-term Gd tissue accumulation of (Gd-DTPA)-cystamine copolymers, a biodegradable macromolecular MRI contrast agent Pharm. Res. 2005, 22, 596-601.
59. A. M. Mohs, Y. Zong, J. Guo, D. L. Parker, and Z.-R. LuPEG-g-Poly(GdDTPA-co-L-cystine): effect of PEG chain length on in vivo contrast enhancement in MRIBiomacromolecules. 2005, 6, 2305-11.
60. Z.-R. Lu, A.M. Mohs, Y. Zong and Y. FengPolydisulfide Gd(III) chelates as biodegradable macromolecular magnetic resonance imaging contrast agents Intl. J. Nanomed. 2006,1, 31-40.
61. S.Q. Gao, Z.R. Lu, B. Petri, P. Kopeckova, J. Kopecek.Colon-specific 9-aminocamptothecin-HPMA copolymer conjugates containing a 1,6-elimination spacerJ. Control. Release. 2006, 110, 323-31.
62. T. Kaneshiro, T. Ke, EK Jeong, D.L. Parker and Z.-R. Lu (Gd-DTPA)-(L-cystine bisalkylamide) copolymers as novel biodegradable macromolecular contrast agents for MR blood pool imaging Pharm. Res. 2006, 23, 1285-94.
63. Y. Zong, T. Ke, A.M. Mohs, J. Guo, D.L. Parker, Z.-R. LuEffect of size and charge on in vivo MRI contrast enhancement of polydisulfide Gd(III) complexes J. Controlled Rel. 2006, 112, 350-6.
64. Y. Feng, Y. Zong, T. Ke and Z.-R. LuPharmacokinetics and blood pool contrast enhancement of Gd-DTPA Cystine Copolymers and Gd-DTPA Cystine Diethyl Ester Copolymers Pharm. Res. 2006, 23, 1736-1742.
65. T. Ke, Y. Feng, J. Guo, D. L. Parker, Z.-R. LuBiodegradable cystamine spacer facilitates the clearance of Gd(III) chelates in poly(glutamic acid) Gd-DOTA conjugates for contrast enhanced MR imaging MRI. 2006, 24, 931-40.
66. A. Vaidya, Y. Sun, T. Ke, E.K. Jeong, Z.-R. LuMRI guided photodynamic therapy for specific cancer treatment MRM, 2006, 56, 761-7.
67. Z.-R. Lu. What can you see with imaging in pharmaceutical research?
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Mol. Pharm. 2006, 3, 471.
68. T. D. Nguyen, P. Spincemaille, A. Vaidya, M. R. Prince, Z.-R. Lu, Y. Wang.Biodegradable intravascular (Gd-DTPA)-cystamine copolymer for contrast-enhanced steady-state free precession magnetic resonance angiography: comparison with MS-325 in a swine model Mol. Pharm. 2006, 3, 558-565.
69. F. Ye, T. Ke, E.-K. Jeong, M. Johnson, Z.-R. LuVisualization of size effect of poly(L-glutamic acid) in drug delivery with contrast enhanced MR imaging Mol. Pharm. 2006, 3, 507-515.
70. T. Ke, E.K. Jeong, X. Wang, Y. Feng, D.L. Parker, Z.-R. LuRGD targeted poly(L-glutamic acid)-cystamine-(Gd-DOTA) for MR imaging of angiogenesisIntl. J. Nanomed. 2007, 2, 191-9.
71. S.Q. Gao, Z.R. Lu, P. Kopeckova, J. KopecekBiodistribution and pharmacokinetics of colon-specific HPMA copolymer-9-aminocamptothecin conjugate in mice J. Controlled Rel. 2007, 117, 179-185.
72. Y. Wang, F. Ye, E.-K. Jeong, Y. Sun, D. L. Parker, Z.-R. Lu.
Noninvasive visualization of pharmacokinetics, biodistribution and tumor targeting of poly[N-(2-hydroxypropyl)methacrylamide] in mice using contrast enhanced MRI Pharm. Res. 2007, 6, 1208-16.
73. A Mohs, Z.-R. LuGadolinium(III)-Based Blood Pool Contrast Agents for Magnetic Resonance Imaging: Current Status and Clinical Potential Expert Opinion on Drug Delivery. 2007, 4, 149-164.
74. A. Mohs, T. Nguyen, E.-K. Jeong, Y. Feng, L. Emerson, Y. Zong, D.L. Parker, Z.-R. LuPegylation of Gd-DTPA Cystine Copolymers Improves Pharmacokinetics and Tissue Retention for Magnetic Resonance Angiography MRM. 2007, 58, 110-8.
75. T.L. Kaneshiro, XL Wang, Z.-R. LuSynthesis and Characterization of Globular L-Lysine Dendrimers with a Cubic Octa(3-aminopropyl)silsesquioxane CoreMol. Pharm. 2007, 4, 759-68.
76. R. Xu, Y. Wang, X. Wang, E.-K. Jeong, D.L. Parker and Z.-R. LuIn Vivo Evaluation of a PAMAM-Cystamine-(Gd-DO3A) Conjugate as a Biodegradable Macromolecular MRI Contrast Agent
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Exp. Biol. Med. 2007, 232, 1081-9.
77. Z.-R. LuApplication of biomedical imaging in drug discovery and development Pharm. Res. 2007, 6, 1170-1.
78. X.L. Wang, R. Jensen, and Z.-R. LuA novel environment-sensitive biodegradable cationic polydisulfide with protonatable pendents for nucleic acid delivery J. Control. Rel. 2007, 120, 250-8.
79. S. Sakuma, T. Matsumoto, S. Yamashita, Y. Wang, Z.-R. LuConjugation of poorly absorptive drugs with mucoadhesive polymers for the improvement of oral absorption of drugs J. Control. Rel. 2007, 123, 195-202.
80. Z.-R. Lu, F. Ye and A. Vaidya. Polymer Platform for Drug Delivery and Biomedical Imaging J. Control. Release. 2007. 122, 269-77.
81. X.-L. Wang, S. Ramusovic, T. Nguyen, Z.-R. Lu.Novel polymerizable surfactants with pH sensitive amphiphilicity and cell membrane disruption for efficient siRNA delivery Bioconjugate Chem. 2007, 18, 2169-77.
82. F. Ye and Z.-R. LuBiomedical polymers for drug delivery and biomedical imaging Pharma Focus Asia, invited paper, 2007, 5, 43-45.
83. X.-L. Wang, T. Nguyen, D. Gillespie, R. Jensen, Z.-R. LuA multifuncational and reversibly polymerizable carrier for efficient siRNA delivery Biomaterials, 2008, 29, 15-22.
84. A. Vaidya, Y. Sun, Y. Feng, L. Emerson, E.-K. Jeong, Z.-R. LuContrast-enhanced MRI-guided photodynamic cancer therapy with a pegylated bifunctional polymer-drug conjugate Pharm. Res. 2008, 25, 2002-11.
85. T. Paunesku, T. Ke, R. Dharmakumar, N. Mascheri, A. Wu, B. Lai, S. Vogt, J. Maser, K. Thurn, B. Szolc-Kowalska, A. Larson, R. C. Bergan, R. Omary, D. Li, Z.-R. Lu, G. E. Woloschak.Gadolinium-conjugated TiO2-DNA oligonucleotide nanoconjugates show prolonged intracellular retention period and T1-weighted contrast enhancement in magnetic resonance images Nanomedicine. 2008, 4, 301-7.
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86. Y. Feng, E.-K. Jeong, A. Mohs, L. Emerson, Z.-R. Lu Characterization of tumor angiogenesis with dynamic contrast enhanced magnetic resonance imaging and biodegradable macromolecular contrast agents in miceMRM. 2008, 60, 1347-52.
87. T. Kaneshiro, EK Jeong, D.L. Parker and Z.-R. LuSynthesis and Evaluation of Globular Gd-DO3A Conjugates with Precisely Controlled Nanosizes for Magnetic Resonance Angiography Biomacromolcules, 2008, 9, 2742-8.
88. F. Ye, X. Wu, EK Jeong, D.L. Parker and Z.-R. LuA Peptide Targeted Contrast Agent Specific to Fibrin-Fibronectin Complexes for Cancer Molecular Imaging with MRI Bioconjugate Chemistry, 2008, 19, 2300-3.
89. X.-L. Wang, R. Xu, Z.-R. Lu.Functionalization of a polymerizable pH-sensitive amphiphilic surfactant for efficient ligand-directed siRNA delivery. J. Controlled Release, 2009, 134, 207-13.
90. Y. Zong, X. Wang, EK Jeong, D.L. Parker and Z.-R. LuStructural effect on degradability and in vivo contrast enhancement of polydisulfide Gd(III) complexes as biodegradable macromolecular MRI contrast agents MRI, 2009, 27, 503-11.
91. X.-L. Wang, R. Xu, X. Wu, D. Gillespie, R. Jensen, Z.-R. Lu.Targeted systemic delivery of a therapeutic siRNA with a multifunctional carrier controls tumor proliferation in mice Molecular Pharmaceutics, 2009, 6, 738-46.
92. Y. Feng, X. Wu, L. Emerson, E.-K. Jeong, DL Parker, Z.-R. LuTumor differentiation based on angiogenesis with dynamic contrast enhanced magnetic resonance imaging and biodegradable macromolecular contrast agents in micePharm. Res. 2009, 26, 2202-8.
93. Y. Feng, L. Emerson, E.-K. Jeong, DL Parker, Z.-R. LuNon-invasive assessment of the efficacy of indocyanine green enhanced photothermal cancer therapy with dynamic contrast enhanced MRI using a biodegradable macromolecular contrast agent JMRI. 2009, 30, 401-6.
94. T. Kaneshiro and Z.-R. Lu, Targeted intracellular codelivery of chemotherapeutics and nucleic acid with a well-defined dendrimer-based nanoglobular carrier Biomaterials, 2009, 30, 5660-6.
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95. X, Liu, Y. Feng, Z.-R. Lu, G. Morrell, E.K. JeongRapid simultaneous acquisition of T(1) and T(2) mapping images using multishot double spin-echo EPI and automated variations of TR and TE (ms-DSEPI-T12).NMR Biomed. 2010, 23, 97-104.
96. X. Wu, L. Emerson, E.-K. Jeong, DL Parker, JM Hoffman, Z.-R. LuNoninvasive evaluation of antiangiogenic effect in a mouse tumor model by DCE-MRI with Gd-DTPA cystamine copolymers.Mol. Pharm. 2010, 7, 41-8.
97. Z.-R. LuMolecular imaging of HPMA copolymers: visualizing drug delivery in cell, mouse and man.Adv Drug Deliv Rev. 2010, 62, 246-57. .
98. Tan M, Wu X, Jeong EK, Chen Q, Lu ZR.Peptide-Targeted Nanoglobular Gd-DOTA Monoamide Conjugates for Magnetic Resonance Cancer Molecular Imaging.Biomacromolecules. 2010, 11, 754-61.
99. Xueming Wu, Yuda Zong, Zhen Ye, and Zheng-Rong LuStability and biodistribution of a biodegradable macromolecular MRI contrast agent Gd-DTPA cystamine copolymers (GDCC) in ratsPharm. Res. 2010, 27, 1390-7.
100. Mingqian Tan, Xueming Wu, Eun-Kee Jeong, Dennis L. Parker, Qianjin Chen, Zheng-Rong LuA Targeted Nanoglobular Manganese(II) Chelate Conjugate for Magnetic Resonance Molecular Imaging of Tumor StromaMol. Pharm. 2010, 7, 936.
101. R. Xu, E.-K. Jeong, D.L. Parker and Z.-R. LuSynthesis and evaluation of novel biodegradable nano-sized MR contrast agent for DCE-MR urography: nanoglobule-G4-cystamine-(Gd-DO3A).Intl. J. Nanomedicine. 2010, 5, 707.
102. Zheng-Rong Lu, Xueming Wu. Polydisulfide-based Biodegradable Macromolecular Magnetic Resonance Imaging Contrast AgentIsr. J. Chem. 2010, 50, 1-12.
103. R. Xu, Xuli Wang and Z.-R. LuNew surfactants forming pH-sensitive nanoparticles for nucleic acid deliveryLangmuir, 2010, 26, 13874.
104. R. Xu and Z.-R. Lu
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Design, synthesis and evaluation of spermine-based pH-sensitive amphiphilic gene delivery systemsScience China Chemistry, 2011, 54, 359-368. (invited)
105. M. Tan and Z.-R. LuIntegrin targeted MRI imagingTheranostics, 2011, 1 83-101.
106. Mingqian Tan, Zhen Ye, Eun-Kee Jeong, Xueming Wu, Dennis L. Parker, Zheng-Rong Lu
Synthesis and Evaluation of Nanoglobular Macrocyclic Mn(II) Chelate Conjugates As Non-Gadolinium(III) MRI Contrast AgentsBioconjugate Chem. 2011, 22, 913-7.
107. Shi X, Liu X, Wu X, Lu ZR, Li SK, Jeong EK.Ocular Pharmacokinetic Study Using T(1) Mapping and Gd-Chelate- Labeled Polymers.Pharm Res. 2011, 28, 3180-8.
108. Furong Ye, Eun-Kee Jeong, Denis Parker and Zheng-Rong LuEvaluation of CLT1-(Gd-DTPA) for Cancer MR Molecular Imaging in a Mouse Breast Cancer ModelChinese J. Magn. Reson. 2011, 2, 325-330, (invited paper).
109. Zhen Ye,1 Eun-Kee Jeong,2 Xueming Wu,3 Mingqian Tan,3 Shouyu Yin,3 and Zheng-Rong Lu3*
New Polydisulfide Manganese(II) Complexes as Biodegradable Macromolecular MRI Contrast AgentsJMRI, 2012, 35, 737-44.
110. Mingqian Tan, Susan M. Burden-Gulley, Wen Li, Xueming Wu, Daniel Lindner, Susann M. Brady-Kalnay, Vikas Gulani, and Zheng-Rong LuMR Molecular Imaging of Prostate Cancer with a Peptide-Targeted Contrast Agent in a Mouse Orthotopic Prostate Cancer Model. Pharm. Res. 2012, 29, 953-60. Reviewed by the Faculty of 1000 as top 2% research paper in biology and medicine.
111. Zheng-Rong LupH-Sensitive siRNA Delivery Systems, J Drug Del Sci Tech. 2012, 1, 55-63. (invited paper)
112. Rongzuo Xu, Xuli Wang, Zheng-Rong LuEvaluation of Novel Spermine Based Surfactant Carriers On siRNA Delivery.Chinese Science Bulletin, 2012, 57, 3979-3984 (invited paper)
113. China Malakondaiah Kummitha, Anthony S. Malamas, Zheng-Rong Lu*
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Albumin enhances intracellular uptake of multifunctional amphiphile/siRNA nanoparticles for siRNA delivery.Intl. J. Nanomedicine, 2012, 7, 5205-14.
114. Xueming Wu1, Mingqian Tan 1, Susan M. Burden-Gulley 2, Susann M. Brady-Kalnay, and Zheng-Rong Lu1
Synthesis and evaluation of a peptide targeted small molecular Gd-DOTA monoamide conjugate for MR cancer molecular imaging.Bioconjugate Chem. 2012, 23, 1548-56.
115. Susan M. Burden-Gulley, Mohammed Q. Qutaish, Kristin E. Sullivant, Mingqian Tan, Sonya E.L. Craig, James P. Basilion, Zheng-Rong Lu, David L. Wilson and Susann M. Brady-Kalnay,Molecular recognition of the dispersed cell population of glioma tumors at the single cell level using a targeted fluorescent PTPmu probeInternational J. of Cancer, 2013 Apr 1;132(7):1624-32..
116. Zhuxian Zhou, Zheng-Rong LuGadolinium-Based Contrast Agents for MR Cancer ImagingWIREs Nanomedicine & Nanobiotechnology, 2013, 5, 1-18.
117. April M. Chow, Mingqian Tan, Darwin S. Gao, Shu Juan Fan, Jerry S. Cheung, Zhongwei Qiao, Kwan Man, Zheng-Rong Lu, Ed X. WuMolecular MRI of Liver Fibrosis by a Peptide Targeted Contrast Agent in an Experimental Mouse ModelInvestigative Radiology, 2013, 48, 46-54.
118. Zhen Ye, Xueming Wu, Mingqian Tan, Jack Jesberger, Mark Griswold and Zheng-Rong LuSynthesis and evaluation of a polydisulfide with Gd-DOTA monoamide side chains as a biodegradable macromolecular contrast agent for MR blood pool imagingContrast Media and Molecular Imaging, 2013, 8, 220-8..
119. Xueming Wu, Daniel Lindner, Guan-Ping Yu, and Zheng-Rong LuCLT1 Peptide Targeted Small Molecular Contrast Agent for MR Molecular Imaging of Prostate Cancer, JoVE, accepted.
120. Mingqian Tan, Zhen Ye, Daniel Lindner, Susann M. Brady-Kalnay, Zheng-Rong Lu
Synthesis and Evaluation of a Targeted Nanoglobular Dual-Modal Imaging Agent for MR Imaging and Image-Guided Surgery of Prostate Cancer. Pharm. Res. Accepted
121. Susan M. Burden-Gulley, Zhixian Zhou, Sonya E.L. Craig, Zheng-Rong Lu, Susann M. Brady-Kalnay
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Molecular Magnetic Resonance Imaging of Tumors with a PTPmu Targeted Contrast Agent, Transl Oncol. 2013 Jun 1;6(3):329-37.
124. Anthony S. Malamas, Maneesh Gujrati, China M. Kummitha, Rongzuo Xu, and Zheng-Rong LuDesign and Evaluation of New pH-Sensitive Amphiphilic Cationic Lipids for siRNA Delivery. JCR. Accepted.
125. Zhuxian Zhou, Xueming Wu, Adam Kresak, Mark Griswold, Zheng-Rong LuTargeting Tumor Microenvironment with Small Peptide Targeted Macrocyclic Gd(III) Chelates For MR Cancer Molecular Imaging. Submitted.
Book Chapters
1. Z.-R. Lu, P. Kopeckova, J. KopecekSemitelechelic poly[N-(2-hydroxypropyl)methacrylamide] for biomedical applicationsPolymeric drugs and drug delivery systems, R.M. Ottenbrite, S.W. Kim, Eds., Technomics Publishing Co., Lancaster, PA, 1-14, 2000.
2. Z.-R. Lu. Stability of proteins and nucleic acids. Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. R. I. Mahato, Ed., CRC Press, New York, NY, 2005, 352-377.
3. Z.-R. Lu, Y. Wang, F. Ye, A. Vaidya, E.-K. Jeong. Paramagnetic polymer conjugates for non-invasive evaluation of in vivo drug delivery. Nanotechnology for Cancer Therapy. M.M. Amiji, Ed. Taylor and Francis Group, LLC, Boca Raton, FL, 2006.
4. Z.-R. Lu. In Vivo Imaging of Dosage Forms. A.T. Florence and J. Siepmann, Ed. Modern Pharmaceutics, 5th Edition. Informa Healthcare, New York, NY, 2009.
5. Z.-R. Lu, A. Vaidya. Image-Guided Photodynamic Cancer Therapy. Yi Lu and Ram I. Mahato, Ed. Pharmaceutical Perspectives of Cancer Therapeutics. Springer, New York, NY, 2009.
6. Zheng-Rong Lu.Molecular Imaging of Drug DeliveryAdvanced Drug Delivery, John Wiley & Sons, Inc.
Patents.
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Biodegradable macromolecular magnetic resonance imaging contrast agents and methods thereof. U.S. Patent No. 6,982,324.
Biodegradable macromolecular magnetic resonance imaging contrast agents and methods thereof. U.S. Patent No. 7,745,590.
Invited symposium lectures
Semitelechelic poly[N-(2-hydroxypropyl)methacrylamide]: preparation, characterization and protein modification, 3rd International Biorelated Polymer. Symposium on Polymeric Drugs and Drug Delivery Systems. ACS, Boston, MA. August 23 – 27, 1998.
Design of novel bioconjugates for targeted drug delivery. 10th International Symposium on Recent Advances in Drug Delivery System. Salt Lake City, Utah. February 19-22, 2001.
A novel biodegradable macromolecular blood pool MRI contrast agent. The XV Annual International Workshop on MRA, Dublin, Ireland, September 24-26, 2003.
Design of biodegradable macromolecular MRI contrast agents. Gordon Conference on Drug Carriers in Medicine and Biology. Big Sky, MT, September 5-10, 2004.
Recent progress on preclinical evaluation of a biodegradable macromolecular MRI contrast agent, (Gd-DTPA)-cystamine copolymers. The XVI Annual International Workshop on Magnetic Resonance Angiography (MRA). London, ON, Canada, October 5-9, 2004.
Poly(L-glutamic acid) Gd-DOTA conjugate with a disulfide spacer as novel blood pool contrast agent. The XV Annual International Workshop on MRA. Beijing, China, September 21-23, 2005.
Contrast enhanced MRA with biodegradable polydisulfide blood pool contrast agents in an animal model. The XV Annual International Workshop on MRA. Basel, Switzerland, September 13-15th, 2006.
Biodegradable macromolecular MRI contrast agents. The Nanomedicine Symposium 2006, Dallas, Texas, December 10, 2006.
Contrast enhanced MRI guided photodynamic therapy. 2006 International Conference on Bio and Pharmaceutical Science and Technology, San Diego, CA, December 18-21, 2006.
Polymer platform for drug delivery and molecular imaging. 13th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT, February 26-28, 2007.
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Biodegradable macromolecular MRI contrast agents. 2007 Annual Meeting of the Controlled Release Society. July, 7-11, 2007, Long Beach, CA.
Biodegradable macromolecular MRI contrast agents and their applications. The first Chinese Society of Magnetic Resonance in Medicine (CSMRM) Meeting, August 8-10, 2007, Dalian, China
Non-invasive visualization of in vivo drug delivery and evaluation of therapeutic response with contrast enhanced MRI. Workshop on Molecular Imaging and Drug Delivery, 2007 Annual Meeting of the Controlled Release Society. July, 7-11, 2007, Long Beach, CA.
Nanoglobular MRI contrast agents. The XVI Annual International Workshop on MRA. Istanbul, Turkey, October 3-5, 2007.
Biodegradable macromolecular MRI contrast agents. 2007 Contrast Media Research Symposium. October, 16-20th, 2007, Banff, Canada.
Macromolecules and dendrimers for targeted imaging. 16th Scientific meeting of International Society for Magnetic Resonance in Medicine. May 3-9, 2008, Toronto, Canada.
A systemic targeted siRNA delivery system for cancer therapy. The 6th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and International Symposium on Biomaterials, Sanya City, Hainan, China, November 26 -30, 2008.
Tumor Characterization with Biodegradable Macromolecular MRI Contrast Agentsand Dynamic Contrast Enhanced MRI. CMRMF & OCSMRM Joint Meeting 2008, Shenzhen, China, December 13-15, 2008.
Contrast enhanced MRI in drug development. The Controlled Release Society's 36th Annual Meeting and Exposition in Copenhagen, Denmark, 18 -22 July 2009.
Targeted MRI contrast agents. WACBE World Congress on Bioengineering 2009, Hong Kong, 26 - 29 July 2009.
Multifunctional siRNA delivery systems. ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology (NEMB2010) held Feb. 7-10, 2010 in Houston, TX.
Polymer Platforms for Magnetic Resonance Imaging, Symposium on Biomedical Polymers for Drug Delivery, Honoring Dr. Jindřich Kopeček. March 26-27, 2010, Salt Lake City, Utah
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Targeted Multifunctional siRNA delivery systems. Particles 2010: Medical/Biochemical Diagnostic, Pharmaceutical, and Drug Delivery Applications of Particle Technology, 22-25 May 2010, Regal Sun Resort, Lake Buena Vista, Florida.
Targeting Tumor Microenvironment for Cancer Molecular Imaging, Case Comprehensive Cancer Center Scientific Retreat, July 9-10, 2010, Sawmill Creek Resort, OH.
MR molecular imaging of tumor microenvironment. Third OCSMRM/CSMRM Meeting, August 13-15, 2010, Shanghai, China.
A targeted contrast agent specific to fibronectin for MR molecular imaging of atherosclerotic plaques. 22nd Annual International Conference on Magnetic Resonance Angiography. October 6 – 9th, 2010,Seoul, Korea
Magnetic Resonance Imaging of Tumor Microenvironment with Macromolecular Contrast Agents, 2010 NanoMedicine Summit, Oct. 18, 2010, Cleveland, Ohio
Multifunctional siRNA delivery systems. Wuhan International Symposium on Biomaterials, July 3, 2011, Wuhan, China
A peptide targeted MRI contrast agent for molecular imaging of of fibrin-fibronectin complex in tumor stroma. Contrast Media Research 2011. October 30 – November 1, 2011, Galveston, Texas
Biodegradable macromolecular MRI contrast agents with high kinetic stability. Polymers in Medicine. Praque, CzechRepublic, July 1-5, 2012.
Targeting tumor microenvironment for cancer detection and therapeutic efficacy evaluation. The 12th Emerging Information and Technology Conference, Toronto, Ontario, Canada, August 16-17, 2012.
Polymerizable lipid-based multifunctional siRNA delivery systems. Oligonucleotide Delivery: Biology, Engineering & Development. Hernstein, Austria, October 7-11, 2012.
pH-sensitive multifunctional lipid siRNA delivery systems. NanoDDS’12. Atlantic City, New Jersey, December 6-7, 2012.
Other invited lectures
Fall, 2003, Department of Bioengineering, University of Utah
Spring, 2004, Department of Radiology, University of Utah
January 2004, Department of Radiology, University of Pittsburg
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May 2004, Faculty of Pharmaceutical Sciences, Setsunan University, Japan
August 2005, Department of Radiology, Northwestern University
September 2005, College of Pharmacy, Shanghai Jiaotong University, China
November 2005, Department of Biomedical Engineering, Cornell University
December 2005, Department of Cardiovascular Medicine, Stanford University
September 2006, Abbott Laboratories, Chicago, IL
October 2006, Department of Chemical Engineering, University of Wyoming
January 2007, Department of Molecular Pharmaceutics, University of North Carolina
November 2007, Department of Chemistry, China Northeastern University
November 2007, Shanghai Roche Pharmaceuticals, Shanghai
January 2008, Department of Biomedical Engineering, Georgia Institute of Technology
January 2008, Department of Biomedical Engineering, Emory University
April 2008, Department of Biomedical Engineering, Case Western Reserve University
August 2008, College of Pharmacy, Rutgers University
December 2008, University of Science and Technology of China, Hefei, China
September, 2009, Lanzhou University
October, 2010, Purdue University
October, 2010, University of Pennsylvania
December, 2010, Cleveland State University
February, 2011, Michigan State University
March, 2011, Biochemistry, Case Western Reserve University
April, 2011, Ohio State University
May, 2011, CCCC seminar, Case Western Reserve UniversityJuly, 2011, Wuhan University, China.
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July, 2011, Tianjin University, China
July, 2011, Tsinghua University, China
December, 2011, Chemistry, Case Western Reserve University
December, 2011, Pharmacology, Case Western Reserve University
January, 2012, Stanford University
March, 2012, University of Illinois at Chicago
May, 2012, Curtin University, Australia
October, 2012, Hainan Medical University, Haikou, China
October, 2012, Hainan University, Haikou, China
October, 2012, Lanzhou University, Lanzhou, China
October, 2012, Tsinghua University, Beijing, China
December, 2012, Macromolecular Science, Case Western Reserve University
February, 2013, Radiology, Case Western Reserve University
Podium symposium presentations
Biorecognizable surfaces containing polymerizable antibody fragments. Surfaces in Biomaterials 2000 Symposium. Scottsdale, Arizona. August 30 – September 2, 2000
Poly(L-glutamic Acid) Gd(III)-DOTA conjugate with controlled degradation for magnetic resonance imaging. CRS Winter Symposia and 11th International Symposium & Exposition on Recent Advances in Drug Delivery Systems. Salt Lake City, UT. March 3 – 6, 2003.
Contrast Enhanced Tumor MRI with a Biodegradable Macromolecular Gd(III) Complex in Mice. 12th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine. Kyoto, Japan. May 15-21, 2004.
Antitumor efficacy of anti-VEGF SiRNA complexes with a degradable cationic polymer. 31st Annual Meeting of the Controlled Release Society. Honolulu, Hawaii. June 12-16, 2004.
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Comparison of poly(L-glutamic acid)-(Gd-DOTA) conjugates with degradable and non-degradable spacer for magnetic resonance imaging. 13th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine. Miami, FL. May 7-13, 2005
PEG-g-Poly(GdDTPA-co-L-Cystine) as Novel Biodegradable Macromolecular Contrast Agents for MRI. 32st Annual Meeting of the Controlled Release Society. Miami, Florida. June 18-22, 2005.
Bifunctional poly(L-glutamic acid)-(Gd-DO3A)-Mce6 conjugate for MRI guided photodynamic therapy. 33st Annual Meeting of the Controlled Release Society. Vienna,
Austria. July 22-26, 2006.
Characterization of Tumor Angiogenesis with Dynamic Contrast Enhanced MRI and Biodegradable Macromolecular Contrast Agents in Mice. 35th Annual Meeting & Exposition of the Controlled Release Society, New York City, NY, July 12 – 16, 2008,
Systemic targeted siRNA delivery with a multifunctional carrier. The Society For Biomaterials 2008 Translational Biomaterial Research Symposium, Atlanta, GA, September 11 - 13, 2008.
Functionalization of a polymerizable pH-sensitive amphiphilic surfactant for efficient ligand-directed siRNA delivery, the American Association of Pharmaceutical Scientists 2008 Annual Meeting and Exposition, Atlanta, GA, November 17 -21, 2008.
A Peptide Targeted Nanoglobular Contrast Agent for Cancer Molecular Imaging with MRI. World Molecular Imaging Congress, September, 23-26, 2009.
Recent abstracts
1. Z.-R. Lu, P. Kopeckova, J. KopecekPolymerizable Fab' antibody fragments The Proceedings of the 25th International Symposium on Controlled Release of Bioactive Materials. Las Vegas, Nevada. June 21-24, 1998. Proceedings, pp. 788-789
2. Z.-R. Lu, P. Kopeckova, Z. Wu, J. KopecekSemitelechelic poly[N-(2-hydroxypropyl)methacrylamide]: preparation, characterization and protein modification3rd International Biorelated Polymer Symposium on Polymeric Drugs and Drug Delivery Systems, American Chemical Society Fall 1998 Meeting. Boston, MA. August 23-27, 1998. Polymer Preprints 39 (2), 218-219
3. Z.-R. Lu, S.-Q. Gao, P. Kopeckova, J. Kopecek
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Lectin-targeted colon specific HPMA copolymer-cyclosporin conjugates14th Ann. Meeting of the Am. Assoc. of Pharmaceutical Scientists. New Orleans, Louisiana. November 14-18, 1999. AAPS PharmSci. S-441
4. Z-R. Lu, P. Kopeckova, J. Kopecek Biorecognizable surfaces containing polymerizable antibody fragments
Proceedings of Surfaces in Biomaterials 2000 Symposium. Scottsdale, Arizona. August 30 – September 2, 2000
5. Y. Kasuya, Z.-R. Lu, P. Kopeckova, T. Minko, S.E. Tabibi, J. KopecekSynthesis of HPMA copolymer-aminopropylgeldanamycin conjugateProceedings of International Symposium on Tumor Targeted Delivery Systems. Bethesda, Maryland. September 25-27, 2000
6. Z.-R. Lu, J.-G. Shiah, P. Kopeckova, J. KopecekPreparation and biological evaluation of polymerizable antibody Fab' fragment targeted polymeric drug delivery system Proceedings of International Symposium on Tumor Targeted Delivery Systems. Bethesda, Maryland. September 25-27, 2000
7. Z.-R. Lu, J.-G. Shiah, P. Kopeckova, J. KopecekA targeted polymeric drug delivery system based on polymerizable Fab' for the treatment of human ovarian carcinomaAnn. Meeting of the Am. Assoc. of Pharmaceutical Scientists. Indianapolis, Indiana. October 29-November 2, 2000. AAPS Pharm Sci. 2, 2 #668, 2000.
8. Z.-R. Lu, J.-G. Shiah, S. Sakuma, P. Kopeckova, J. KopecekDesign of novel bioconjugates for targeted drug deliveryAbstracts of 10th International Symposium on Recent Advances in Drug Delivery Systems. Salt Lake City, Utah. February 19-22, 2001.
9. S. Sakuma, Z. -R. Lu, P. Kopeckova, J. Kopecek Design of HPMA copolymer-drug conjugates for colon-specific delivery of 9-aminocamptothecin The proceedings of 28th International Symposium on Controlled Release of Bioactive Materials. San Diego, California. June 23-27, 2001
10. P. Kopeckova, T. Minko, Z.-R. Lu, J. Kopecek Bioconjugates for the treatment of cancerProceedings of 28th International Symposium on Controlled Release of Bioactive Materials. San Diego, California. June 23-27, 2001
11. Y. Kasuya, Z.-R. Lu, P. Kopeckova, S.E. Tabibi, J. KopecekInfluence of the structure of drug moieties on the efficacy of HPMA copolymer-geldanamycin derivative conjugates
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Proceedings of 28th International Symposium on Controlled Release of Bioactive Materials. San Diego, California. June 23-27, 2001
12. Z.-R. Lu, J.-G. Shiah, P. Kopeckova, J. KopecekPolymerizable Fab' antibody fragment targeted HPMA copolymer-mesochlorin e6 conjugate: biodistribution and antitumor activityProceedings of 28th International Symposium on Controlled Release of Bioactive Materials. San Diego, California. June 23-27, 2001
13. Z.-R. Lu, J.-G. Shiah, P. Kopeckova, J. KopecekAntitumor activity of polymerizable antibody Fab’ targeted mesochlorin e6 in photodynamic therapy in mice. Proceeddings of 93rd Annual Meeting of AACR. San Francisco, CA. April 6-10, 2002.
14. Z.-R.Lu, D.L. Parker, K.C.GoodrichBiodegradable macromolecular Gd(III) complexes as blood pool MRI contrast agents. Abstracts of First Annal Meeting of the Society for Molecular Imaging. Boston, MA. August 24-26, 2002.
15. Z.-R. Lu, X. Wang. Poly(L-glutamic Acid) Gd(III)-DOTA conjugate with controlled degradation for magnetic resonance imaging. Abstracts of CRS Winter Symposia and 11th International Symposium & Exposition on Recent Advances in Drug Delivery Systems. Salt Lake City, UT. March 3 – 6, 2003.
16. X. Wang and A. Vaidya, Z.-R. LuIn vivo Degradation of Gd-DTPA-cystamine Copolymers. Abstracts of Imaging in 2020. Jackson Hole, Wyoming, September 7-11, 2003.
17. Y. Zong, A. M. Mohs and Z.-R. LuSynthesis of Gd(III)-DTPA-Cystine and Gd(III)-DTPA-Cystine Ethyl Ester Copolymers for MRI. Abstracts of Imaging in 2020. Jackson Hole, Wyoming, September 7-11, 2003.
18. Z.-R. Lu, X. Wang, C. Goodrich, and D. Parker.A novel biodegradable macromolecular blood pool MRI contrast agent. Abstracts of 15th Annual Meeting of the International MR Angioclub 2003. Dublin, Ireland, September 24-26, 2003.
19. X. Wang, A. Vaidya, Z.-R. LuPharmacokinetics of Biodegradable Macromolecular Gadolinium (III)-DTPA Complexes as MRI Contrast Agents. 2003 AAPS Annual Meeting and Exposition. Salt Lake City, Utah. October 26-30,2003. AAPS PharmSci. 5 (4), M1047.
20. A. M. Mohs, X. Wang, Y. Zong, K. C. Goodrich, D. L. Parker, Z.-R. Lu
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Poly(GdDTPA-L-cystine)-g-PEG: a biodegradable macromolecular agent for blood pool MR imaging. Proceedings of 12th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine. Kyoto, Japan. May 15-21, 2004.
21. Y. Zong, X. Wang, K. C. Goodrich, A. M. Mohs, D. L. Parker, Z.-R. LuContrast Enhanced Tumor MRI with a Biodegradable Macromolecular Gd(III) Complex in Mice. Proceedings of 12th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine. Kyoto, Japan. May 15-21, 2004.
22. X. Wang, J. Zhou, Y. Zong, K. C. Goodrich, L. Yu, Z.-R. LuAntitumor efficacy of anti-VEGF SiRNA complexes with a degradable cationic polymer.Transactions of 31st Annual Meeting of the Controlled Release Society. Honolulu, Hawaii. June 12-16, 2004
23. Y. Zong, X. Wang, A.M. Mohs, C. Goodrich, Z.-R. Lu.Biodegradable cystine-(Gd-DTPA) copolymers for MR cancer imaging.Transactions of 31st Annual Meeting of the Controlled Release Society. Honolulu, Hawaii. June 12-16, 2004
24. X. Wang, S. Van, L. Yu, Z.-R. LuGene delivery to primary cells with degradable cationic polymers.Transactions of 31st Annual Meeting of the Controlled Release Society. Honolulu, Hawaii. June 12-16, 2004
25. X. Wang, Y. Zong, K. C. Goodrich, D. L. Parker, Z.-R. LuMR imaging of tumor response to the treatment with anti-VEGF siRNA. Abstracts of 3rd Annual Meeting of the Society for Molecular Imaging. September 9-12, 2004.
26. X. Wang, Y. Feng, T. Ke, M. Schabel, D.L. Parker and Z.-R. LuRecent progress on preclinical evaluation of a biodegradable macromolecular MRI contrast agent, (Gd-DTPA)-cystamine copolymers.Abstracts of The XVI Annual International Workshop on MRA. London, On, Canada, October 6-8, 2004.
27. X. Wang, F. Y. Feng, T. Ke, Z.-R. LuPharmacokinetics and excretion of biodegradable macromolecular MRI contrast agents.2004 AAPS Annual Meeting and Exposition. Baltimore, MD. October, 2004. The AAPS Journal, 6(4) W4051, 2004.
28. T. Ke, Y. Feng, F. Ye, J. Guo, D.L. Parker, Z.-R. LuComparison of poly(L-glutamic acid)-(Gd-DOTA) conjugates with degradable and non-degradable spacer for magnetic resonance imaging. Proceedings of 13th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine. Miami, FL. May 7-13, 2005.
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29. T.D. Nguyen, P. Spincemaille, A. Vaidya, Z.R. Lu, Y. WangBiodegradable intravascular Gd-DTPA cystamine copolymers for contrast enhanced magnetic resonance angiography: initial experience with steady state free precession acquisition in a swine model.Proceedings of 13th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine. Miami, FL. May 7-13, 2005.
30. Z.-R. Lu. Y. Zong, A. Mohs, Y. FengPolydisulfide based biodegradable macromoecular MRI contrast agents. Proceedings of 13th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine. Miami, FL. May 7-13, 2005.
31. A. M. Mohs, Y. Zong, Y. Feng, J. Guo, D. L. Parker, Z.-R. LuPEG-g-Poly(GdDTPA-co-L-Cystine) as Novel Biodegradable Macromolecular Contrast Agents for MRI.Transactions of 32st Annual Meeting of the Controlled Release Society. Miami, Florida. June 18-22, 2005.
32. T. K. Kaneshiro, T. Ke, Y. Feng, J. Guo, Z-R. LuSynthesis and In Vivo Study of (Gd-DTPA)-co-(L-Cystine Bisalkylamide) Copolymers As Biodegradable Mcromolecular MRI Contrast AgentsTransactions of 32st Annual Meeting of the Controlled Release Society. Miami, Florida. June 18-22, 2005.
33. A. Vaidya, T. Ke, Y. Feng, J. Guo, Z.-R. Lu Non-invasive In Vivo Imaging of A Polymeric Drug Conjugate Using Contrast Enhanced MRI Transactions of 32st Annual Meeting of the Controlled Release Society. Miami, Florida. June 18-22, 2005.
34. T. K. Kaneshiro, T. Ke, J. Guo, Z-R. LuGd-DTPA Cystine Bisamide Copolymers as Novel Biodegradable Macromolecular MRI Contrast AgentsAbstracts of 4th Annual Meeting of the Society for Molecular Imaging. Cologne, Germany, September 7-10, 2005
35. T. Ke, Y. Feng, J. Guo, D. L. Parker, Z.-R. LuPoly(L-glutamic acid) Gd-DOTA conjugate with a disulfide spacer as novel blood pool contrast agentAbstracts of The XV Annual International Workshop on MRA. Beijing, China, September 21-23, 2005.
36. A. M. Mohs, Y. Zong, D. L. Parker, Z.-R. LuPEG-g-(GDDTPA-co-cystine): Effect of the PEG chain length on in vivo contrast enhancement in MRI.
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Abstracts of The XV Annual International Workshop on MRA. Beijing, China, September 21-23, 2005
37. Y. Feng, Y. Zong, T. Ke, and Z.-R. LuIn vivo evaluation of Gd-DTPA cystine copolymers and Gd-DTPA cystine diethyl ester copolymers as biodegradable macromolecular MRI contrast agents2005 AAPS Annual Meeting and Exposition. Nashville, TN. November 6-10, 2005
38. A. Vaidya, T. Ke, Y. Sun, EK Jeong, Z.-R. Lu. Contrast enhanced MRI guided photodynamic therapy for non-invasive treatment of cancer.
14th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine. Seattle, WA. May 6-12, 2006.
39. F. Ye, T. Ke, E.-K. Jeong, X. Wang,A. Vaidya, D.L. Parker, Z.-R. Lu. Non-invasive visualization of drug delivery polymer drug conjugate. 14th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine. Seattle, WA. May 6-12, 2006.
40. T. Ke, X. Wang, E.K. Jeong, D.L. Parker, Y. Feng, Z.-R. Lu.
RGD targeted poly(L-glutamic acid)-cystamine-(Gd-DOTA) conjugate for detecting an angiogenesis biomarker v3 integrin with MR T1 mapping. 14th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine. Seattle, WA. May 6-12, 2006.
41. A. Vaidya, Y. Sun, E.K. Jeong, Z.-R. Lu. Bifunctional poly(L-glutamic acid)-(Gd-DO3A)-Mce6 conjugate for MRI guided photodynamic therapy. 33st Annual Meeting of the Controlled Release Society. Vienna, Austria. July 22-26, 2006.
42. Z.-R. Lu. Biodegradable macromolecular MRI contrast agents. The Nanomedicine Symposium 2006, Dallas, Texas, December 10, 2006.
43. Z.-R. Lu, A. Vaidya, E.K. Jeong, D.L. Parker. Contrast enhanced MRI guided photodynamic therapy. 2006 International Conference on Bio and Pharmaceutical Science and Technology, San Diego, CA, December 18-21, 2006.
44. T. Kaneshiro, X. Wang, Z.-R. Lu. Preparation and investigation of polyamidoamine octaammonium polyhedral oligosilsequixane (PAMAM OA-POSS) globular dendrimers as carriers for gene delivery. Gordon Conference on Drug Carriers in Medicine and Biology. Big Sky, MT, September, 2006.
45. Y. Wang, F. Ye, E.-K. Jeong, Z.-R. LuNon-invasive visualization of drug delivery with polymer conjugates using contrast enhanced MRI. 2006 AAPS annual meeting, San Antonio, TX. October 29 – November 2, 2006.
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46. Z.-R. Lu. Polymer platform for drug delivery and molecular imaging. 13th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT, February 26-28, 2007.
47. Y. Zong, E.-K. Jeong, D.L. Parker, Z.-R. Lu, Structure Effect of Biodegradable Macromolecular MRI Contrast Agents on Tumor MR Imaging in an Animal Tumor Model. . 15th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine. Berlin, Germany. May 19-25, 2007.
48. Y. Feng, E.-K. Jeong, A.M. Mohs, L. Emerson, Z.-R. Lu
Polydisulfide-Based Biodegradable Macromolecular Contrast Agents for Dynamic Contrast Enhanced MRI: First Experience with Human Prostate Cancer Xenograft. 15th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine. Berlin, Germany. May 19-25, 2007.
49. X. Liu, Y. Feng, Z.-R. Lu, E.-K. JeongRapid Simultaneous Data Acquisition of T1 and T2 Mapping, Using Multishot EPI and Automated Variations of TR and TE at 3T. 15th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine. Berlin, Germany. May 19-25, 2007.
49. A. Vaidya, Y. Sun, E.K. Jeong, Z.-R. Lu. A PEGylated polymer-photosensitizer conjugate containing Gd (III) for site-specific MRI-guided photodynamic therapy of cancer. 34th Annual Meeting of the Controlled Release Society. July 7-11, 2007, Long Beach, CA.
50. R. Xu, Z.-R. Lu. A PAMAM Gd-DO3A Conjugate with a Degradable Disulfide Spacer for Magnetic Resonance Imaging. 34th Annual Meeting of the Controlled Release Society. July 7-11, 2007, Long Beach, CA.
51. Z.-R. Lu. Biodegradable macromolecular MRI contrast agents. 34th Annual Meeting of the Controlled Release Society. July, 7-11, 2007, Long Beach, CA.
52. X.L. Wang, S. Ramusovic, Z.-R. Lu. A novel multifunctional and polymerizable gene carrier mediated efficient transfection. 34th Annual Meeting of the Controlled Release Society. July, 7-11, 2007, Long Beach, CA.
53. Z.-R. Lu, Y. Feng, E.-K. Jeong. Biodegradable macromolecular contrast agents and their applications. The first Chinese Society of Magnetic Resonance in Medicine (CSMRM) Meeting, August 8-10, 2007, Dalian, China
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54. F. Ye, E.-K. Jeong, D.L. Parker, Z.-R. LuTumor specific peptide-(Gd-DTPA) as targeted MRI contrast agent. Imaging in 2020. Jackson Hole, Wyoming, September 23-27, 2007.
55. T. Kaneshiro, D.L. Parker, Z.-R. LuNanoglobular Gd(III) chelates as novel MRI contrast agents. Imaging in 2020. Jackson Hole, Wyoming, September 23-27, 2007.
56. T. Kaneshiro, D.L. Parker, Z.-R. LuNanoglobular intravascular MRI contrast agents. Abstracts of The 19th Annual International Workshop on MRA. Istanbul, Turkey, October 3 – 5, 2007.
57. Z.-R. Lu, Y. Zong, Y. Feng.Biodegradable macromolecular MRI contrast agents. Contrast Media Research. October 16-20, 2007, Banff. Canada.
58. Y. Feng, E.-K. Jeong, D.L. Parker, Z.-R. LuComparison of biodegradable macromolecular MRI contrast agents with Gd-(DTPA-BMA) and albumin-(Gd-DTPA) in tumor characterization with DCE MRI, 16th Scientific meeting of International Society for Magnetic Resonance in Medicine. May 3-9, 2008, Toronto, Canada.
59. T. Kaneshiro, E.-K. Jeong, D.L. Parker, Z.-R. Lu, Nanoglobular Gd-DO3A conjugates as highly effective MRI contrast agents.16th Scientific meeting of International Society for Magnetic Resonance in Medicine. May 3-9, 2008, Toronto, Canada.
60. Y. Feng, E.-K. Jeong, Z.-R. Lu Characterization of Tumor Angiogenesis with Dynamic Contrast Enhanced MRI and Biodegradable Macromolecular Contrast Agents in Mice. 35th Annual Meeting & Exposition of the Controlled Release Society, New York City, NY, July 12 – 16, 2008.
61. Xu-Li Wang, Rongzuo Xu, Thanh Nguyen, and Zheng-Rong LuNovel Targeted siRNA Delivery Systems with the Function of pH-Sensitive Amphiphilic Endosomal Escape. 35th Annual Meeting & Exposition of the Controlled Release Society, New York City, NY, July 12 – 16, 2008.
62. Xu-Li Wang, Thanh Nguyen, and Zheng-Rong LuThe Effect of Nanoparticle Stabilization by Disulfide Linkages on DNA and siRNA Delivery with Novel Multifunctional Carriers with pH-Sensitive Amphiphilicity. 35th Annual Meeting & Exposition of the Controlled Release Society, New York City, NY, July 12 – 16, 2008.
63. Xu-Li Wang, Rongzuo Xu, and Zheng-Rong LuTargeted delivery systems for in vivo systemic siRNA delivery. Gordon Research Conference on Drug Carriers In Medicine & Biology to be held 08/24/2008 - 08/29/2008 at Big Sky Resort in Big Sky, MT.
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64. Zheng-Rong Lu, Xu-Li Wang and Randy Jensen Systemic targeted siRNA delivery with a multifunctional carrier. The Society For Biomaterials 2008 Translational Biomaterial Research Symposium, Atlanta, GA, September 11 - 13, 2008.
65. Z.-R. Lu A systemic targeted siRNA delivery system for cancer therapy. The 6th China-Japan-Korea Foresight Joint Symposium on Gene Delivery and International Symposium on Biomaterials, Sanya City, Hainan, China, November 26 -30, 2008.
66. Z.-R. LuTumor Characterization with Biodegradable Macromolecular MRI Contrast Agentsand Dynamic Contrast Enhanced MRI. CMRMF & OCSMRM Joint Meeting 2008, Shenzhen, China, December 13-15, 2008.
67. Xu-Li Wang, Rongzuo Xu, and Zheng-Rong Lu Functionalization of a polymerizable pH-sensitive amphiphilic surfactant for efficient ligand-directed siRNA delivery, the American Association of Pharmaceutical Scientists 2008 Annual Meeting and Exposition, Atlanta, GA, November 17 -21, 2008.
68. F. Ye, E.-K. Jeong, D.L. Parker, Z.-R. LuA Peptide Targeted Contrast Agent Specific to Fibrin-Fibronectin Complexes for Cancer Molecular Imaging with MRI. The World Molecular Imaging Congress; September 10-13, 2008, Nice, France.
69. Xueming Wu, Rongzuo Xu, Eun-Kee Jeong, and Zheng-Rong LuIN VIVO ASSESSMENT OF ANTIANGIOGENIC EFFECT OF AVASTIN IN A MOUSE COLON CANCER MODEL BY DCE-MRI WITH A BIODEGRADABLE MACROMOLECULAR CONTRAST AGENT GDCC. 14th International Symposium on Drug Delivery, March, 2009, Salt Lake City, UT
70. Mingqian Tan,† Xueming, Wu,† Eun-Kee Jeong,‡ Furong Ye,† Zheng-Rong LuA FIBRIN-FIBRONECTIN SPECIFIC NANOGLOBULAR CONTRAST ADENT FOR CANCER MOLECULAR IMAGING WITH MRI. 14th International Symposium on Drug Delivery, March, 2009, Salt Lake City, UT.
71. Rongzuo Xu, Xu-Li Wang, Zheng-Rong LuSpermine based multifunctional carriers for gene delivery. 14th International Symposium on Drug Delivery, March, 2009, Salt Lake City, UT.
72. Zheng-Rong Lu, Xuli Wang, Rongzuo XuIn vivo systemic and targeted delivery of a therapeutic siRNA with multifunctional delivery system. The Biology of RNA Silencing (D6). Apr. 25-30, 2009, Victoria, British Columbia, Canada
73. Mingqian Tan, Xueming Wu, Furong Ye, Eun-Kee Jeong, Zheng-Rong Lu
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A CLT1 Peptide Targeted Nanoglobular Contrast Agent for Cancer Molecular Imaging with MRI. 17th Scientific meeting of International Society for Magnetic Resonance in Medicine. April 18-24, 2009, Honolulu, HI.
74. Rongzuo Xu, Xue-Ming Wu, Eun-Kee Jeong, Zheng-Rong LuEvaluation of Toxicity of Gadolinium Based Contrast Agents on Skin Fibroblasts. 17th Scientific meeting of International Society for Magnetic Resonance in Medicine. April 18-24, 2009, Honolulu, HI.
75. Yi Feng, Eun-Kee Jeong, Lyska Emerson, Zheng-Rong LuApplication of a Biodegradable Macromolecular Contrast Agent in Dynamic Contrast Enhanced MRI to Assess the Efficacy of Indocyanine Green Enhanced Photothermal Cancer Therapy. 17th Scientific meeting of International Society for Magnetic Resonance in Medicine. April 18-24, 2009, Honolulu, HI.
76. XueMing Wu, Rongzuo Xu, Eun-Kee Jeong, James N. Lee, Zheng-Rong LuAssessment of the Antiangiogenic Therapy of Avastin in an Animal Colon Cancer Model with DCE-MRI and a Biodegradable Macromolecular Contrast Agent. 17th Scientific meeting of International Society for Magnetic Resonance in Medicine. April 18-24, 2009, Honolulu, HI.
77. Zheng-Rong Lu. Contrast Enhanced MRI in Drug Development. CRS 36th Annual Meeting & Exposition, July 18-22, 2009, Copenhagen, Denmark
78. Zheng-Rong Lu and Furong YeA Targeted Contrast Agent for MR Molecular Imaging of Cancer. WACBE World Congress on Bioengineering 2009, Hong Kong, July 26 – 29, 2009.
79. Mingqian Tan, Eun-Kee Jeong, Zheng-Rong LuA Peptide Targeted Nanoglobular Contrast Agent for Cancer Molecular Imaging with MRI. World Molecular Imaging Congress, September 23-26, 2009.
80. Zhen Ye, Eun-Kee Jeong, Dennis L. Parker, Zheng-Rong LuA Manganese Based Biodegradable Macromolecular MRI Contrast Agent for Cardiovascular Imaging. September 29th - October 1st, 2009, Lansing, MI.
81. Zheng-Rong Lu, et al., Multifunctional siRNA delivery systems. ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology (NEMB2010) held Feb. 7-10, 2010 in Houston, TX.
82. Zheng-Rong Lu, et al., Polymer Platforms for Magnetic Resonance Imaging, Symposium on Biomedical Polymers for Drug Delivery, Honoring Dr. Jindřich Kopeček. March 26-27, 2010, Salt Lake City, Utah
83. D. S. Gao, M. Tan, J. S. Cheung, A. M. Chow, S. J. Fan, K. W. Chan, K. Man, Z-R. Lu, and E. X. Wu
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MRI of Liver Fibrosis by Fibrin-Fibronectin Targeted Contrast Agent. Joint Annual Meeting ISMRM-ESMRMB 2010. 1-7 May 2010, Stockholmsmässan AB, Stockholm, Sweden
84. Mingqian Tan, Eun-Kee Jeong, Dennis Parker, Zheng-Rong LuA targeted nanoglobular Mn(II) chelate conjugate for MR cancer molecular imaging Joint Annual Meeting ISMRM-ESMRMB 2010. 1-7 May 2010, Stockholmsmässan AB, Stockholm, Sweden
85. Xueming Wu, Zhen Ye, Zheng-Rong LuComparative study of Zinc and Copper transmetallation of Gd-DTPA cystamine copolymers (GDCC), Omniscan, MultiHance and ProHance in Rats. Fourth Annual Symposium on Nephrogenic Systemic Fibrosis and Gadolinium Based Contrast Agent, May 14-15, 2010, New Heaven, CT
86. Zheng-Rong Lu, et al., Targeted Multifunctional siRNA delivery systems. Particles 2010: Medical/Biochemical Diagnostic, Pharmaceutical, and Drug Delivery Applications of Particle Technology, 22-25 May 2010, Regal Sun Resort, Lake Buena Vista, Florida.
87. Zheng-Rong Lu, et al., Targeting Tumor Microenvironment for Cancer Molecular Imaging, Case Comprehensive Cancer Center Scientific Retreat, July 9-10, 2010, Sawmill Creek Resort, OH.
88. Mei Zheng, Zheng-Rong LuDelivery of siRNA into primary macrophages with a multifunctional non-viral vector. CRS 37th Annual Meeting & Exposition, July 10-14, 2010, Portland, Oregon
89. Zheng-Rong Lu, et al., MR molecular imaging of tumor microenvironment. Third OCSMRM/CSMRM Meeting, August 13-15, 2010, Shanghai, China.
90. Xueming Wu, Zheng-Rong LuA targeted contrast agent specific to fibronectin for MR molecular imaging of atherosclerotic plaques. 22nd Annual International Conference on Magnetic Resonance Angiography. October 6 – 9th, 2010,Seoul, Korea
91. Zheng-Rong LuMagnetic Resonance Imaging of Tumor Microenvironment with Macromolecular Contrast Agents, 2010 NanoMedicine Summit, Oct. 18, 2010, Cleveland, Ohio
92. Cheung, Jerry; Chow, April; Fan, Shu; Gao, Darwin; Lu , Zheng - Rong ; Man, Kwan; Tan, Mingqian; Wu, EdMolecular MRI of Liver Fibrosis by Fibrin-Fibronectin Targeted Contrast Agent in an Experimental Mouse. Joint Annual Meeting ISMRM-ESMRMB 2011. May 7 – 13, 2011, Montreal, Canada.
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93. Tan, Mingqian and Lu , Zheng - Rong , Evaluation of a Targeted Nanoglobular Gd Chelate for MRI Molecular Imaging of Prostate Tumor in an Orthotopic Mouse Model. Joint Annual Meeting ISMRM-ESMRMB 2011. May 7 – 13, 2011, Montreal, Canada.
94. Wu, Xueming, Tan, Mingqian; Lu , Zheng - Rong . A Peptide-Targeted MRI Contrast Agent for Cancer Molecular Imaging. Joint Annual Meeting ISMRM-ESMRMB 2011. May 7 – 13, 2011, Montreal, Canada.
95. Z. Ye, X. Wu, M Tan, and Z.-R. Lu. A New Biodegradable MR Contrast Agent with High Kinetic Chelation Stability for Cancer Imaging. Joint Annual Meeting ISMRM-ESMRMB 2011. May 7 – 13, 2011, Montreal, Canada.
96 Wu, Xueming; Ye, Zhen; Tan, Mingqian; Lu, Zheng-Rong. A Peptide-Targeted smal contrast agent for MR molecular imaging. 2011 AAPS Annual Meeting and Exposition. Walter E. Washington Convention Center, Washington, DC, USA, October 23–27, 2011
97. Z.-R. Lu, X. Wu and M. Tan. A peptide targeted MRI contrast agent for molecular imaging of fibrin-fibronectin complex in tumor stroma. Contrast Media Research 2011. October 30 – November 1, 2011, Galveston, Texas
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