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Item Activities that the item does
Energy Source
How Energy Is Released?
Automobile
Dogs
Flashlight
Flowers
Humans
Cellular RespirationObjectives:(1) Define metabolism and give its significance to YOU(2) Identify the parts of mitochondria and give the function of each(3) Draw the complete equation of cellular respiration and its opposite reaction(4) Summarize how glucose is broken down in the first stage of cellular respiration.
Cellular RespirationObjectives:
(5)Describe how ATP is made in the stages of cellular respiration.
(6) Identify the role of and importance of fermentation in the second stage of cellular respiration.
(7) Evaluate the importance of oxygen in aerobic respiration.
is a series of reactions where fats, proteins, and carbohydrates, mostly glucose, are broken down to make CO2, water, and energy (ATP).
Cellular Respiration is a metabolic process like burning fuel
Releases much of the energy in food to make ATP
This ATP provides cells with the energy they need to carry out the activities of life.
C6H12O6+O2 6CO2 + 6H2O + ATP
8
Glucose Breakdown: Summary Reaction
Electrons are removed from substrates and received by oxygen, which combines with H+ to become water.
Glucose is oxidized and O2 is reduced
+ + energy
Reduction
Oxidation
glucoseC6H12O6 6O
2
6CO2 6H2O+
Matrix: locationof the prepreaction and thecitric acid cycle
Cristae: locationof the electrontransport chain(ETC)
cristaeIntermembrane space
Inner membrane
matrix
Outer membrane
45,000
© Dr. Donald Fawcett and Dr. Porter/Visuals Unlimited
FOOD
Carbohydrates Fats Proteins
Simple sugars Fatty acids and glycerol
Amino acids
stages of CELLULAR RESPIRATION
stages of CELLULAR RESPIRATION
Simple sugars
Fatty acids and glycerol
Amino acids
fuels
Most of the energy from cell respiration is converted into ATP
ATP is a substance that powers most cell activities.
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Cyt
op
las
mM
ito
ch
on
dri
on
Ele
ctr
on
tra
ns
po
rt c
hai
n
2net
2
glucose
2 pyruvate
2 acetyl CoA
Citric acidcycle
subtotal subtotal
glycolysis
2 CO2
4 CO2
NADH
NADH
NADH
FADH2
2
2
6
2
4 or 6
6
18
4
324
36 or 38total
6 O2 6 H2O
ATPP
ATP
ATP
ATP
ATP
ATP
ATP
ATP
ATPor 34
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
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Cellular RespirationStage One: Breakdown of Glucose
•GlycolysisGlucose is broken down to pyruvate making 2 ATP.
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FERMENTATION
•the anaerobic conversion of sugar to carbon dioxide and alcohol/acid• Alcoholic Fermentation - yeasts• Lactic Acid Fermentation - humans, fungi, and bacteria
FERMENTATIONAlcoholic Fermentation
e.g. yeastsproduce alcohol and CO2• bread, beer, wine
Lactic Acid Fermentatione.g. humans, some bacteria & fungimuscle tissue ferments lactic acid
when O2 is not delivered to cells
Lactate producing bacteria – used in the production of cheese, yogurt, sauerkraut.
other products: acetic acid, butyric acid, isopropanol etc.
Where in the cell does gylcolysis occur?
Fate of glucose in the beginning of gylcolysis?
Explain “it takes energy to make energy”?
How much net ATP is made?
What else is made? 2 types of fermentation?
Cytoplasm
Fructose (isomer) Invest 2 ATP get
4
Net= 2 ATP CO2 + NADH Lactate or
alcohol
27
Pyruvate is a pivotal metabolite in cellular respiration
If O2 is not available to the cell, fermentation, an anaerobic process, occurs in the cytoplasm. During fermentation, glucose is incompletely
metabolized to lactate, or to CO2 and alcohol (depending on the organism).
If O2 is available to the cell, pyruvate enters the mitochondria for aerobic respiration.
28
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
© The McGraw Hill Companies, Inc./Bruce M. Johnson, photographer
29
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
© The McGraw Hill Companies, Inc./Bruce M. Johnson, photographer
30
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
© The McGraw Hill Companies, Inc./Bruce M. Johnson, photographer
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Advantages Provides a quick burst of ATP energy for muscular activity.
Disadvantages Lactate and alcohol are toxic to cells. Lactate changes pH and causes muscles to fatigue.
▪ Oxygen debt Yeast die from the alcohol they produce by fermentation
Efficiency of Fermentation Two ATP produced per glucose of molecule during
fermentation is equivalent to 14.6 kcal. Complete oxidation of glucose can yield 686 kcal. Only 2 ATP per glucose are produced, compared to 36 or 38
ATP molecules per glucose produced by cellular respiration.
32
Fermentationinputs outputs
2 lactate or2 alcohol and 2 CO2
glucose
2 ADP + 2 P net gainATP2
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Pyruvate enters mitochondrion (matrix)
It is oxidized to 2 carbon acetyl groups
NADH is formedCO2 is removed (waste product)
34
Connects glycolysis to the citric acid cycle
End product of glycolysis, pyruvate, enters the mitochondrial matrix
Pyruvate is converted to a 2-carbon acetyl group
Attached to Coenzyme A to form acetyl-CoA
Electron are picked up (as hydrogen atom) by NAD+
CO2 is released and transported out of mitochondria into the cytoplasm
35
2 NAD+ 2 NADH
2 2 + 2 CoA + 2 CO2
2 pyruvate
O OHC
CH3
+ 2 CoA
CoA
CH3
pyruvatecarbondioxideacetyl CoA
C OC O
2 acetyl CoA + 2 carbondioxide
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Cellular RespirationStage Two: Production of ATP
•Krebs Cycle is a series of reactions that produce energy-storing molecules during aerobic respiration.
37
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Completes the breakdown of glucose Takes the pyruvate (3-carbons) and breaks it
down, the carbon and oxygen atoms end up in CO2 and H2O
Hydrogens and electrons are stripped and loaded onto NAD+ and FAD to produce NADH and FADH2
Production of only 2 more ATP but loads up the coenzymes with H+ and electrons which move to the 3rd stage
CO2 & H2ONADH & FADH
2 more ATP
What are the reactants?
What is produced?
What is NADH? FADH?
What is CoA and why is it important?
Pyruvate (C3)
2 ATP, CO2, NADH, FADH
Energy carriers
Escort molecule to Krebs cycle
Goal: to break down NADH and FADH2, pumping H+ into the outer compartment of the mitochondria
Where: Cristae of the mitochondria
Electron Transport Phosphorylation typically produces 32 ATP's
Electron carriers loaded with electrons and protons from the Kreb’s cycle move to this chain-like a series of steps (staircase).
As electrons drop down stairs, energy released to form a total of 32 ATP
Oxygen waits at bottom of staircase, picks up electrons and protons and in doing so becomes water
ATP is generated as H+ moves down its concentration gradient through a special enzyme called ATP synthase
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Glycolysis: 2 ATP Krebs Cycle: 2 ATP Electron Transport Phosphorylation: 32 ATP
Each NADH produced in the conversion of pyruvate to acetyl COA and Krebs Cycle is worth 3 ATP (8 x 3 = 24)
Each FADH2 is worth 2 ATP (2 x 2 = 4) 4 + 24 + 4 = 32
Net Energy Production: 36 ATP from one glucose molecule
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Net yield per glucose: From glycolysis – 2 ATP
From citric acid cycle – 2 ATP
From electron transport chain – 32 or 34 ATP
Energy content: Reactant (glucose) 686 kcal
Energy yield (36 ATP) 263 kcal
Efficiency is 39%
The rest of the energy from glucose is lost as heat
36 ATP for aerobic vs. 2 ATP for anaerobic
Glycolysis 2 ATP
Kreb’s 2 ATP
Electron Transport 32 0r 34 ATP 36 or 38 ATP
Occurs in the chlorophyll-bearing cells of plants
Needs the presence of lightWater and carbon dioxide are usedOxygen is given off as a waste
productFood is built or synthesized The weight of the plant is increasedEnergy is stored
I. Draw and label the parts of a mitochondrion. Give the function of each part.
II. Complete the table below on cellular respiration.
PHASE/PROCESS LOCATION PRODUCTS ATP
PRODUCED
___________________ matrixNADH's,
2FADH2's, acetyl coA and 2 CO2
Glycolysis________________ _______________
2
________________ _________________ Water, NADH, FADH
_____________
Preparatory reaction _________________ NADH and
releases CO2
_____________
Fermentation*Organism involve________________________________
Alcohol & CO2
_______________
_________
Net total of ATP produced/glucose molecule = __________
I. Draw and label the parts of a mitochondrion. Give the function of each part.II. Complete the table below on cellular respiration.
1. In aerobic respiration carbohydrates are ultimately broken down into:
A. acetyl-CoA B. CO2 C. H2O D. O2
2. In the process of catabolism, protein is broken into
A. sugar B. amino acids C. glucose D. fatty acids 3. Which process of aerobic respiration takes
place in the cytoplasm and NOT in the mitochondria?
A. glycolysis B. Krebs cycle C. fermentation D. ATP synthesis
4. In the presence of oxygen, all cells synthesize ATP via the process of glycolysis. Many cells also can metabolize pyruvate if oxygen is not present, via the process of:
A. fermentation B. oxidative phosphorylation C. aerobic respiration D. photophosphorylation
5. The final electron acceptor in cellular respiration is
A. ATP. D. NADPH. B. oxygen. E. carbon dioxide. C. glyceraldehyde-3-phospate (G3P)
6. Which of the following does not occur in fermentation?
A. carbon dioxide is produced B. sugar is broken down C oxygen is formed D. energy is released 7. What is the net total of ATP
produced during aerobic respiration A. 2 ATP C. 36 ATP B. 32 ATP D. 39 ATP
8. Which process of aerobic respiration takes place in the cristae of mitochondria?
A. Glycolysis B. Citric Acid Cycle cycle C. Preparatory reaction D. Electron Transport Chain
9. All of the following are common to respiration and fermentation except one
A. energy is released B. carbon dioxide is produced C. sugar molecules are broken down D. alcohol is formed