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Lecture 5 the respiratory system
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Copyright 2010, John Wiley & Sons, Inc.
Chapter 18
The Respiratory System
Copyright 2010, John Wiley & Sons, Inc.
Respiration: Three Major Steps1. Pulmonary ventilation
Moving air in and out of lungs
2. External respiration Gas exchange between alveoli and blood
3. Internal respiration Gas exchange between blood and cells
Copyright 2010, John Wiley & Sons, Inc.
Organs of the Respiratory System Upper respiratory system
Nose and pharynx Lower respiratory system
Trachea, larynx, bronchi, bronchioles, and lungs “Conducting zone” consists of
All airways that carry air to lungs: Nose, pharynx, trachea, larynx, bronchi, bronchioles,
and terminal bronchioles
“Respiratory zone” Sites within lungs where gas exchange occurs
Respiratory bronchioles, alveolar ducts, alveolar sacs, and alveoli
Copyright 2010, John Wiley & Sons, Inc.
Organs of the Respiratory System
Copyright 2010, John Wiley & Sons, Inc.
Upper Respiratory System: Nose Structure
External nares nasal cavity internal nares Nasal septum divides nose into two sides Nasal conchae covered by mucous membrane
Functions Warm, humidify, filter/trap dust and microbes
Mucus and cilia of epithelial cells lining nose Detect olfactory stimuli Modify vocal sounds
Copyright 2010, John Wiley & Sons, Inc.
Upper Respiratory System: Pharynx Known as the “throat” Structure
Funnel-shaped tube from internal nares to larynx 3 parts
Three regions (with tonsils in the upper two) Upper: nasopharynx; posterior to nose
Adenoids and openings of auditory (Eustachian) tubes Middle: oropharynx; posterior to mouth
Palatine and lingual tonsils are here Lower: laryngeal pharynx
Connects with both esophagus and larynx: food and air
Copyright 2010, John Wiley & Sons, Inc.
Respiratory System: Head and Neck
Copyright 2010, John Wiley & Sons, Inc.
Lower Respiratory System: Larynx “Voice box” Made largely of cartilage
Thyroid cartilage: V-shaped “Adam's apple”: projects more anteriorly in males Vocal cords “strung” here (and to arytenoids)
Epiglottis: leaf-shaped piece; covers airway During swallowing, larynx moves up so epiglottis covers
opening into trachea Cricoid cartilage: inferior most portion Arytenoids (paired, small) superior to cricoid
Copyright 2010, John Wiley & Sons, Inc.
Lower Respiratory System: Larynx
Copyright 2010, John Wiley & Sons, Inc.
Voice Production Mucous membrane of larynx forms two pairs
of folds Upper = false vocal cords Lower = true vocal cords
Contain elastic ligaments When muscles pull elastic ligaments tight, vocal
cords vibrate sounds in upper airways Pitch adjusted by tension of true vocal cords
Lower pitch of male voice Vocal cords longer and thicker; vibrate more
slowly
Copyright 2010, John Wiley & Sons, Inc.
Lower Respiratory System: Trachea “Windpipe” Location
Anterior to esophagus and thoracic vertebrae Extends from end of larynx to primary bronchi
Structure Lined with pseudostratified ciliated mucous
membrane: traps and moves dust upward C-shaped rings of cartilage support trachea, keep
lumen open during exhalation Tracheostomy: opening in trachea for tube
Copyright 2010, John Wiley & Sons, Inc.
Lower Respiratory System: Bronchi, Bronchioles Structure of bronchial tree
Bronchi contain cartilage rings Primary bronchi enter the lungs medially In lungs, branching secondary bronchi
One for each lobe of lung: 3 in right, 2 in left Tertiary bronchi terminal bronchioles
These smaller airways Have less cartilage, more smooth muscle. In
asthma, these airways can close. Can be bronchodilated by sympathetic nerves,
epinephrine, or related medications.
Copyright 2010, John Wiley & Sons, Inc.
Lower Respiratory System: Lungs Two lungs: left and right
Right lung has 3 lobes Left lung has 2 lobes and cardiac notch
Lungs surrounded by pleural membrane Parietal pleura attached to diaphragm and lining
thoracic wall Visceral pleura attached to lungs Pleural cavity with little fluid between pleurae Broad bottom of lungs = base; pointy top = apex
Copyright 2010, John Wiley & Sons, Inc.
Lung Lobes Divided into lobules fed by tertiary bronchi Further divisions terminal bronchioles Respiratory bronchioles
Lined with nonciliated epithelium Alveolar ducts Alveolar sacs Surrounded by alveoli
Copyright 2010, John Wiley & Sons, Inc.
Lung Lobes
Copyright 2010, John Wiley & Sons, Inc.
Lower Respiratory System: Alveoli Cup-shaped outpouchings of alveolar sacs
Alveoli: composed of three types of cells Lined with thin alveolar cells (simple squamous);
sites of gas exchange Scattered surfactant-secreting cells. Surfactant:
Lowers surface tension (keeps alveoli from collapsing) Humidifies (keeps alveoli from drying out)
Alveolar macrophages: “cleaners” Respiratory membrane: alveoli + capillary
Gases diffuse across these thin epithelial layers: air blood
Copyright 2010, John Wiley & Sons, Inc.
Lobule of the Lung
Copyright 2010, John Wiley & Sons, Inc.
Lobule of the Lung
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Structure of an Alveolus
Copyright 2010, John Wiley & Sons, Inc.
Respiration Step: 1. Pulmonary Ventilation Air flows: atmosphere lungs due to
difference in pressure related to lung volume Lung volume changes due to respiratory muscles
Inhalation: diaphragm + external intercostals Diaphragm contracts (moves downward) lung
volume Cohesion between parietal-visceral pleura
lung volume as thorax volume .
Copyright 2010, John Wiley & Sons, Inc.
Exhalation Exhalation is normally passive process due
to muscle relaxation Diaphragm relaxes and rises lung volume External intercostals relax lung volume
Active exhalation: exhale forcefully Example: playing wind instrument Uses additional muscles: internal intercostals,
abdominal muscles
Copyright 2010, John Wiley & Sons, Inc.
Muscles of Inhalation and Exhalation
Copyright 2010, John Wiley & Sons, Inc.
Muscles of Inhalation and Exhalation
Copyright 2010, John Wiley & Sons, Inc.
Volume-Pressure Changes in Lungs Volume and pressure are inversely related
As lung volume alveolar pressure As lung volume alveolar pressure
Contraction of diaphragm lowers diaphragm lung volume alveolar pressure so it is < atmospheric pressure air enters lungs = inhalation
Relaxation of diaphragm raises diaphragm lung volume alveolar pressure so it is > atmospheric pressure air leaves lungs = exhalation
Copyright 2010, John Wiley & Sons, Inc.
Volume-Pressure Changes in Lungs
Copyright 2010, John Wiley & Sons, Inc.
Air Flow Terms Frequency = breaths/min; normal: 12 Tidal volume (TV) = volume moved in one
breath. Normal ~ 500 ml About 70% of TV reaches alveoli (350 ml) Only this amount is involved in gas exchange 30% in airways = anatomic dead space
Minute ventilation (MV) = f x TV = 6000 mL/min
Copyright 2010, John Wiley & Sons, Inc.
Lung Volumes Measured by spirometer
Inspiratory reserve volume (ERV) = volume of air that can be inhaled beyond tidal volume (TV)
Expiratory reserve volume (IRV) = volume of air that can be exhaled beyond TV
Air remaining in lungs after a maximum expiration = residual volume (RV)
Copyright 2010, John Wiley & Sons, Inc.
Lung Capacities Inspiratory capacity = TV + IRV Functional residual capacity (FRC) =
RV + ERV Vital capacity (VC) = IRV + TV + ERV Total lung capacity (TLC) = VC + RV
Copyright 2010, John Wiley & Sons, Inc.
Lung Capacities
Copyright 2010, John Wiley & Sons, Inc.
Breathing Patterns Eupnea = normal breathing
Highly variable in pattern Costal breathing: shallow with rib movements Diaphragmatic breathing: deep breathing
Special modifications for speech and emotional responses
Also variations for coughing and sneezing to clear airways See Table 18.1
Copyright 2010, John Wiley & Sons, Inc.
Nature of Air Mixture of gases (N2, O2,, CO2, H2O, and
others) Each gas has own partial pressure, such as
PO2 or PN2
Sum of all partial pressures = atmospheric pressure
Each gas diffuses down its partial pressure gradient
Copyright 2010, John Wiley & Sons, Inc.
Respiration Step 2: Pulmonary Gas Exchange: External Respiration Diffusion across alveolar-capillary membrane
O2 diffuses from air (PO2 ~105 mm Hg) to pulmonary artery (“blue”) blood (PO2 ~40 mm Hg). (Partial pressure gradient = 65 mm Hg)
Continues until equilibrium (PO2 ~100-105 mm Hg)
Meanwhile “blue” blood (PCO2 ~45) diffuses to alveolar air (PCO2 ~40) (Partial pressure gradient = 5 mm Hg)
Copyright 2010, John Wiley & Sons, Inc.
Respiration Step 3: Systemic Gas Exchange: Internal Respiration Occurs throughout body O2 diffuses from blood to cells: down partial
pressure gradient PO2 lower in cells than in blood because O2
used in cellular metabolism Meanwhile CO2 diffuses in opposite direction:
cells blood
Copyright 2010, John Wiley & Sons, Inc.
Internal and External Respiration
Copyright 2010, John Wiley & Sons, Inc.
Transport of Oxygen within Blood 98.5% of O2 is transported bound to
hemoglobin in RBCs Binding depends on PO2
High PO2 in lung and lower in tissues O2 dissolves poorly in plasma so only 1.5% is
transported in plasma Tissue release of O2 to cells is increased by
factors present during exercise: High CO2 (from active muscles) Acidity (lactic acid from active muscles) Higher temperatures (during exercise)
Copyright 2010, John Wiley & Sons, Inc.
Transport of Carbon Dioxide CO2 diffuses from tissues into blood
CO2 carried in blood: Some dissolved in plasma (7%) Bound to proteins including hemoglobin (23%) Mostly as part of bicarbonate ions (70%)
CO2 + H2O H+ + HCO3-
Process reverses in lungs as CO2 diffuses from blood into alveolar air exhaled
Copyright 2010, John Wiley & Sons, Inc.
Transport of Oxygen and Carbon Dioxide
Copyright 2010, John Wiley & Sons, Inc.
Control of Respiration Medullary rhythmicity area in medulla
Contains both inspiratory and expiratory areas Quiet breathing
Inspiratory area nerve signals to inspiratory muscles for ~2 sec
Inspiration Inspiration ends and muscles relax Expiration Expiratory center active only during forceful
breathing Two areas in pons adjust length of inspiratory
stimulation
Copyright 2010, John Wiley & Sons, Inc.
Control of Respiration
Copyright 2010, John Wiley & Sons, Inc.
Control of Respiration
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Regulation of Respiratory Center Cortical input: voluntary adjustment of
patterns For talking or cessation of breathing while
swimming Chemoreceptor input will override breath-holding
Copyright 2010, John Wiley & Sons, Inc.
Regulation of Respiratory Center Chemoreceptor input to increase
ventilation Central receptors in medulla: sensitive to H+ or
PCO2 in CSF
Peripheral receptors in arch of aorta + common carotids: respond to PO2 as well as H+ or PCO2 in blood
Blood and brain pH can be maintained by these negative feedback mechanisms
Copyright 2010, John Wiley & Sons, Inc.
Regulation of Respiratory Center
Copyright 2010, John Wiley & Sons, Inc.
Other Regulatory Factors of Respiration Respiration can be stimulated by
Limbic system: anticipation of activity, emotion Proprioception as activity is started Increase of body temperature
Sudden pain can apnea: stop breathing Prolonged somatic pain can increase rate
Airway irritation cough or sneeze Inflation reflex
Bronchi wall stretch receptors inhibit inspiration Prevents overinflation
Copyright 2010, John Wiley & Sons, Inc.
Aging and the Respiratory System Lungs lose elasticity/ability to recoil more
rigid; leads to Decrease in vital capacity Decreased blood PO2 level Decreased exercise capacity
Decreased macrophage activity and ciliary action Increased susceptibility to pneumonia, bronchitis
and other disorders
Copyright 2010, John Wiley & Sons, Inc.
End of Chapter 18
Copyright 2010 John Wiley & Sons, Inc.All rights reserved. Reproduction or translation of this work beyond that permitted in section 117 of the 1976 United States Copyright Act without express permission of the copyright owner is unlawful. Request for further information should be addressed to the Permission Department, John Wiley & Sons, Inc. The purchaser may make back-up copies for his/her own use only and not for distribution or resale. The Publishers assumes no responsibility for errors, omissions, or damages caused by the use of theses programs or from the use of the information herein.