- 1. LP HC PHN: 210416401KHO: 2009-2013GVHD : TS. Nguyn Ngc
Vinh
2. DANH SCH SINH VIN THC HIN MSSV1. Nguyn Vn Hip091612812. L Th
Ngc Bch 092224313. Phan Th Ngc Hnh 092097814. Nguyn Th Kiu
Duyn091611615. Bi Duy Hng090831316. T Trn Hoi 090765817. H Long
Thin09164711 3. NI DUNG1 Phthalates v cc dng tn ti ca n2 ng dng v
tc hi ca phthalates3 Khi qut v sc k kh4 Quy trnh phn tch 4. MT S DN
CHT CA PHTHALATESTn Tn Cng thcS CAS vit tt cu toDiethyl
phthalateDEPC6H4(COOC2H5)2 84-88-2Diethylhexyl phthalate DEHP
C6H4[COOCH2CH(C2H5)(CH2)3CH3]2 117-81-7Dibutyl
phthalateDBPC6H4[COO(CH2)2CH3]284-72-2Butyl benzyl phthalate
BBPCH3(CH2)3OOCC6H4COOCH2C6H5 85-68-7Diisodecyl phthalate DINP
C6H4[COO(CH2)6CH(CH3)2]28553-54-0Di-n-octyl phthalate DNOP
C6H4[COO(CH2)7CH3)2117-84-0 5. Cc dng tn ti ca phthalates 6. NG DNG
ng dng trong cng nghip c s dng rng ri trong ngnh nha to ra tnh mm
do v bnchc cho sn phm C nhiu trong sn phm gia dng nh: chi tr em, ti
nha, giybng gi thc phm, mc, sn, keo xt tc, dng c y khoa bng nha,cht
kh mi, thuc sn mng tay, du gi u, du thm v hin dintrong tt c cc loi
bao b bng nha. Cc dn cht phthalates khc thng c dng lm cht ho do cho
ccbao b nha nh chai, can, ti, bao, gi, u nm v, bnh sa, trong chi tr
con bng cht do, nha 7. NG DNG ng dng ca Phthalates trong y hc Dn
cht phthalates l diethylphthalates (DEP) c dng lm thuc nhng ch dng
ngoi da tr bnh gh nga DEP cn c dng lm cht ho do (plasticizer) trong
bao phim bao vin thuc. 8. NG DNG ng dng ca Phthalates trong m phm
Gim gin trong nc sn mng; gip gel tc mm hn;gip da mm hn sau khi s
dng cht ty ra ng thi l chtdung mi v to mi thm. Phthalates lm gim tc
bay hi v to hng thm lu di Phthalate cng c s dng n nh mu sc v hngthm
ca mt s loi m phm 9. TC HI Phthalates c cc t chc quc t gim st cht
ch v khnng kch thch ni tit t, nh hng nghim trng n s tbin t bo, gy
qui thai v ng th. EU, M lit k phthalates lcht gy nhim. Phthalates c
trong c th ngi v ng vt, ng vai tr tngt nh estrogen, can thip vo qu
trnh ni tit, nh hngn kh nng sinh sn nam gii, c th dn n ung th
tinhhon Phthalate c th c hi cho thai nhi nam 10. TC HI DEHP_ mt
trong nhng dn cht phthalates c ghi nhn ctc dng nh mt xenoestrogen
lm xo trn h ni tit. B gi b nhim phthalates s dy th sm trc tui. Phi
nhim phthalates trc khi sinh cng lm gia tng cc vn hnh vi khi tr 3
tui (bao gm c hnh vi phn ng tnh cm, lo u,trm cm...). Phi nhim
phthalates gy nn cc hin tng d ng tr em dnti bnh hen suyn v l mt
nguyn nhn gy ra bnh ung th v. 11. TC HI 12. TC HI 13. KHI QUT V SC
K KHKhi qut Sc k kh l mt trong nhng k thut phn tch dng c rt thng
dng v mnh thng dng trong phn tch. Sc k lin quan n qu trnh tch cc
cht khc nhau trong mt mu ra khi nhau. Chnh iu ny cho php ngi phn
tch d dng nhn danh (nh tnh) v o (nh lng) tng cu t trong mu. Hp cht
c tch ch yu bi s khc nhau trong cu trc v tnh bay hi ca chng. Hn ch
cho mt s hp cht v mu khng thc hin trc tiptrn GC do tnh cht ha l ca
chng. 14. Loi hp cht ph hp phn tch bng sc k kh? Nhng hp cht d bay
hi, c nhit bc hi di 350o C n 400o C v tt c hoc mt phn ca phn t hp
cht phi trng thi kh di 350o C n 400o C. Hp cht phi chu c nhit cao v
nhanh chng c chuyn v pha hi m khng b phn hy hoc phn ng vi cc hp cht
khc. Hp cht v c khng ph hp cho phn tch GC. 15. Loi hp cht ph hp phn
tch bng sc k kh? Mt s hp cht c kim c th phn tch bng GC bi cha hmlng
hu c cao. Hu ht cc hp cht hu c ph hp phn tch bng GC nhngc mt s ngoi
tr nh mt s hp cht sinh hc v dc liu bphn hy nhit sc k kh, hp cht khc
phn ng vi cc vtliu dng trong GC v ct. 16. Nguyn l Mu thng c a vo ct
sc k di dng hi. tan ca mi cu t trong pha kh i vo ct ph thuc vo p
suthi ca chnh cu t v p sut hi ca chng li l hm nhit ct, i lc gia cu
t v pha tnh. S khc nhau v p sut hi lm cho phn t ca mi cu t phntn
gia pha tnh v pha kh ng. 17. Nguyn l Thc t khi cc phn t di chuyn
nhanh chng lin tc giahai pha, chnh s khc nhau v thi gian nh c trong
mipha m n nh hng n s phn tn. H thng sc k kh gm 6 phn chnh: ngun
cung cp khv b kim sot dng, bung tim, ct, l ct, u d, v thitb ghi o
nh trong hnh 1 18. Hnh 3 - HETP ca ct theo vn tc tuyn tnh trung bnh
cho 3 kh 19. CCH LY MU V X L MU dy chi bng nha nh hn 1 cm, ly 1 phn
mu th t phnnha i din khng vt qu 3mm. Ly t nht 5 g phn mu thvo 1 bnh
ng thch hp. dy chi bng nha ln hn 1 cm, dng mi khoan khoanvo nha
khong 1 cm. Ly t nht 5g phn mu th l cc v bothu c sau khi khoan v ng
vo trong bnh ng thch hp. 20. CCH LY MU V X L MU Cn khong 0,5 g phn
mu th, chnh xc n 1 mg, cho vol thy tinh sm mu dung tch 40ml c np vn
lt nhaPTFE. Thm 10 ml etanol v t l vo b siu m trong 15pht. Chuyn
dch tit sang mt ng nghim v c c nkhong 1 ml di lung khng kh hoc kh
nit. Lc dchchit, chuyn sang l dung tch 2 ml v y np. 21. QUY TRNH
PHN TCH Thit b, dng cThit b sc k kh phi phBung bmKiu: Khng chia dng
1 minKh mang: HeliNhit bung bm: 275 oCTh tch bm: 1lCt: Optimal
delta -316 hoc tng ng, 30 m x 0,25 mm(ID) x 0,25 m ( dy phim )Chng
trnh nhit : 100oC (1min) 7 oC/min 300oC 10 minDetector: MSDNhit dng
chuyn: 290oCKiu: SIM 22. QUY TRNH PHN TCH Cht chun Triphenyl
photphat Tri-o-cresyl photphat (tri-o-tolyl photphat) Tri-m-cresyl
photphat (tri-m-tolyl photphat) Tri-p-cresyl photphat (tri-p-tolyl
photphat) Benzyl butyl phtalat (chun ni) Thuc th Axeton, Toluen,
Etyl axetat Hn hp dung mi Hn hp cha 95% toluene v 5% etyl axetat,
theo th tch. 23. QUY TRNH PHN TCH Dung dch chun Dung dch chun gc
(120 mg/l) Cn (12 1) mg mi cht lm do, chnh xc n 0,1 mg, cho vobnh
nh mc 100ml. Thm 25ml axeton v trn u ha tan.Thm axeton n vch mc v
khuy u. Dung dch chun ni gc, 10 mg/ml, benzyl butyl phtalat
trongaxeton. Dung dch chun ni pha long , 1 mg/ml, benzyl butyl
phtalattrong axeton. 24. QUY TRNH PHN TCH Cch tin hnh Nguyn tc
chungTrng tt c cc dng c thy tinh v dng c khc c tipxc vi mu th, dung
dch chun hay dung dch hiu chun hailn bng axeton. Dung dch hiu
chunChun b mt dy cc dung dch hiu chun cht lm do,mi dung dch c cha
5mg/l chun ni, t dung dch chun gcv dung dch chun ni gc ti nng
0.3mg/l, 0,6mg/l,1,2mg/l, 1,8mg/ v 2,4mg/l cht do trong toluen. 25.
QUY TRNH PHN TCH 26. Hiu sut gii hp ph Hiu sut gii hp ph trung bnh
cho phthalates t ovs-tenax, trongkhong t 0,5 n 2,0 ln so vi nng mc
tiu l 98,4%, 99,3%,99,8%, 99,5% v 98,6% cho DMP, DEP, DBP, DEHP, v
DNOP, tngng.Gii hp ph mu vn n nh trong t nht 24hHiu sut gii hp ph
0,05, 0,1, v 0,2 ln so vi ch tiu nng (TC)DMPDEP DBPDEHPDNOP 0.05 TC
91.3 99.9101.498.399.40.1 TC91.4 98.897.6 95.592.20.2
TC95.1100.2100.199.894.9 Bng 2: Hiu sut gii hp ph 27. SC K DMP 28.
DEP 29. DBP 30. DEHP 31. KT LUNTm li, nhm cht phthalates c tc dng
lm mm cc cht plasticscng v d un cong hn nhng sn phm khc nhau, nhng
chng cnh hng nhiu n sc kho con ngi.Vic pht hin phthalates trong cc
sn phm cn c thc hinbng phng php sc k kh khi ph (GC-MS), v ly mu
theo tiuchun hin hnh nhm m bo tnh ng n v xc nh chnh xc hmlng
phthalates.Khng nn ch bin thc n qu nng trong cc t chn bng nham thay
bng vt ng bng s . Dng l chui hoc giy lm bao b thayv dng bao b nha,
plastic... Nn cho tr tr di ba tui b sa m,dng cc thc n v ung ch bin
t nhin.
