Dr. Matt Allerson - Cases Using My PhD In Practice, Putting “Science into Practice”

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<ul><li><p>9/25/2015</p><p>1</p><p>PuttingScienceintoPracticeUsingmyPhDinpractice</p><p>MattAllerson,DVM,PhDHoldenFarms,Inc.</p><p>9/21/2015</p><p>Lifelonglearning.</p><p> B.S.:UWRF(2005) DVM&amp;MPH:UofMN(2009) PhD:UofMN(2013)</p><p> Current: HoldenFarmsInc.(Northfield,MN) Researchcoordinatorandstaffveterinarian</p></li><li><p>9/25/2015</p><p>2</p><p>WhyPhD?</p><p> UofMNVMEDgraduateprogrammission: Fosterdevelopmentofspecificskillsincluding:</p><p> Experimentalandanalyticalmethods Leadership Communication Independentandcriticalthinking Teaching Interdisciplinaryresearchincollaborativeenvironments Scientificandgrantwriting</p><p>InfluenzaAvirus</p><p> Transmissionandcontrolofinfluenzavirusinpigpopulations Weaningagepigs</p><p> Importanceforinfluenzatransmission SubpopulationforIAVsurveillance</p></li><li><p>9/25/2015</p><p>3</p><p>InfluenzaAvirusresearchapplication</p><p> Productionsystemneeds: Multisourcepigflows</p><p> ClinicalIAVpresentationacrossflows Secondaryinfections</p><p> Difficultystartingpigs</p><p> Weaningagepigs Starttofocusonthispopulationtoassessinfluenzavirusprevalenceacrossthesystem</p><p> SwineHealthMonitoringProject Influenza Currentlyapilotinitiative</p><p>InfluenzaAvirus Systemprevalence</p><p>UofMNInfluenzaSHMP,2015</p></li><li><p>9/25/2015</p><p>4</p><p>InfluenzaAvirus Surveillance</p><p>UofMNInfluenzaSHMP,2015</p><p>InfluenzaAvirus Control</p><p>UofMNInfluenzaSHMP,2015</p></li><li><p>9/25/2015</p><p>5</p><p>Influenzavirus summary</p><p> Usingweaningagepigsasoursurveillancepopulation Abilitytoinstitutecontrolmeasuresatthesowfarmlevel Weaningagepigsaveryimportantsubpopulationatthesystemlevel</p><p> Multisourceflows Movementofpigsacrossmanygeographicreasons Improvethefirstweekonfeedinthenurserystage</p><p> Goingforward Utilizingvaccinationapproachesthatarebestmatchedtooursowfarmfindings</p><p>Vaccinetrials</p><p> ProductAvs.ProductBvs.Nothing? Whataretheoptionstoanswerthesequestions?</p><p>1. Donothing2. Publishedliterature,CEmeetings,etc.3. Useofcloseoutdata4. Smallscaleresearchfacilities5. Commercialresearchfacilities6. Largescalefieldtrials</p></li><li><p>9/25/2015</p><p>6</p><p>Commitmenttoresearch</p><p>VaccinecomparisonsforPCV2 Porcinecircovirustype2(PCVAD) Ubiquitous</p><p> Difficulttoassessimpactonperformanceinthefielddirectlyacrossfinishinggroups</p><p> Indirectassessmentthroughvaccinetrials ManycofactorsknowntohaveasignificantroleinPCVAD</p><p> Theclinicalimpactisgenerallyquiteevident,subclinicalimpact?</p><p> Canweassessvaccinesinoneresearchsite?</p></li><li><p>9/25/2015</p><p>7</p><p>PCV2fieldvaccinetrials</p><p>Sowfarm</p><p> Allotmenttotreatmentwithinlitterbygender</p><p>Nursery</p><p> Treatmentsmixedwithinpen</p><p>Finisher</p><p> Treatmentsmixedwithinpen</p><p>Trial1:5cohortsTrial2:7cohorts</p><p>PCV2vaccinefieldtrialsTrial1</p><p> 1,000pigsontestpersite PCV2vaccine(severalcombinations)orcontrol Weight</p><p> Allotment(weaning) Nurseryexit Priortomarket</p><p> Mortality</p></li><li><p>9/25/2015</p><p>8</p><p>PCV2vaccinefieldtrialsTrial2</p><p> 625pigsontestpersite PCV2vaccine(severalcombinations)orcontrol Weight</p><p> Allotment(3daysofage) Nurseryexit Priortomarket</p><p> Mortality</p><p>Datacollection</p></li><li><p>9/25/2015</p><p>9</p><p>PCV2example Trial1</p><p>PCV2example Trial2</p></li><li><p>9/25/2015</p><p>10</p><p>PCV2summary</p><p> PCV2vaccination Improvedgrowthperformanceandreducedmortality(2x)</p><p> Subclinicalimpactonunvaccinatedpigshousedwithvaccinatedpigs ReducedperformancewithoutclinicalexpressionofPCVAD</p><p> Variabilityofdisease/pathogenexposure Shouldweexpectthisvariabilitywithotherpathogens?</p><p>Puttingscienceintopractice</p><p> Newandemergingpathogenswillcontinuetochallengeus: PRRSv PCV2 2009PandemicIAV PEDv SVV</p><p> Sciencebasedpracticewillcontinuetoleadourindustryintherightdirection</p></li><li><p>9/25/2015</p><p>11</p><p>Questions?</p><p>Thankyou</p></li></ul>