Blood Disorders

Blood Disorders

Sickle cell anemia

( ) . . 30% .

() ()

1. . .2. . .3. . .4. . .

. .

1. : .2. : . .3. : .

() .

. .

:1. .2. .3. : -6- -6- ( G6PD ) 1956 400 . favism . .

favism , , -6- .

G6PD 23 . 23 X and Y ( ) . . G6PD .

G6PD , . G6PD . G6PD , . . , G6PD G6PD . 400 G6PD . G6PD . , . , " " Mediterranean variant , Japan variant . (%) (%) G6PD ( ) (100%) (50%) (50%) ( 50%) (%) (50%) ( 50%) ( ) . ( ) 1925 . . " " . . . .

. ( ) . 25% .

:

1. . 2. .3.

Iron deficiency anemia in children (1/2 1 ) (4.5 5 ) . (1- 1.5 ) (10 15 ) / .

proximal duodenum jejunum .

:1. .2. .3. ( c ) . :1. .2. .3. .4. . :1. hemoglobin :2. (1 3) ( ) (1 3) ( 1 ) .3. stores :4. :1. serum ferritin: ( 35 ng/ml ) .2. hemosiderin: .5. serum iron : 6. ( 50 120 / = 100 ) ( 70 160 / = 100 ) .7. enzymes :8. :9. ( catalase , pyroxidase , mono amin oxidase , cytochrome) :

:1. : .2. : ( ).3. ( ) . :

. :1. : . .2. 3. 4. 5. ( 10 15 % )6. : ( ). :

: 1. : Hemosidrene serum ferritin ( 10 / ) =35 ng/ml) n).2. hematological changes serum iron ( 30 / )(50- 120 microgram/dl ). (total iron binding capacity (tibc (350 / )( 350 mcg/dl 250 ). transferrin saturation (15 % ) ( = 33 % ). ... microcytic hypochromic ( MCV MCH MCHC .3. ENZYM DEPLETION : anorexia irritability neurological changes ferrous . : ( ferrous sulphate , f.gluconate , f. fumarate) ( 6 / / ) ( ). ( 4- 6 ) . ( ) ( 12 24 ) .

( 36 ) ( ) . retcs .

( 1 3 ) .

: : ( ) = ( 3 ) . Iron-deficiency Anemia ( Anemia) . .

().

. ( ) .

sprue ( ) .

. :1. .2. .3. .4. .5. .6. .

: . : :: .... . : ( ) . cheilosis. . . () . 4 /100 14 /100 .

Blood film . . .

( ) . .

. . :1. .2. .3. . ( infection).