For Accidental Overdose (such as child ingesting formula) Dial 911, 0 for operator assistance or call your nearest Poison Control Centre.

For Professional Use Only The information contained here has been accumulated from many sources.

Indications are not intended as cures, they are simply a guideline to be used at your professional discretion.

For more information please visit www.jamiesonvitamins.com or call 1-800-265-5088 to speak to a Consumer Affairs representative. 03/23/12

RESVERATROL RED WINE EXTRACT WITH GRAPESEED UPC CODE 0 646420 2611 8 EN 159899

NATURAL HEALTH PRODUCTS DIRECTORATE (NHPD) CLAIMS: NHPD Claims pending for Jamieson Resveratrol Red Wine Extract are: An antioxidant for the maintenance of good health Helps to support and maintain capillary health An antioxidant to support heart health Product Information Resveratrol Red Wine Extract from Jamieson Laboratories provides antioxidant support for cardiovascular health. Derived from French and Italian red grapes, these natural ingredients in Jamiesons Resveratrol Red Wine Extract provide all of the health benefits of approximately six glasses of red wine without the calories or alcohol content. GENERAL INFORMATION Resveratrol belongs to a group of polyphenolic compounds known as stilbenes, and it is found primarily in the skin of red grapes, red wine and purple grape juice, as well as peanuts and some berries.1 Moderate consumption of red wine has been associated with a reduction in the risk of cardiovascular disease.2 Researchers became interested in studying resveratrol when its presence was discovered in red wine, which led to the theory that resveratrol might help to explain the French Paradox. This is a concept that refers to the fact that the people of France, who regularly consume red wine, have a relatively low mortality rate from coronary heart disease, despite their high dietary intake of saturated fat and cigarette smoking.3 Resveratrol is a natural antioxidant and has anti-inflammatory, anti-viral, anti-proliferation and other anti-atherogenic effects.1,4,5,6 It is thought to exert cardioprotective effects by inhibiting the oxidation of LDL cholesterol,4 reducing platelet aggregation,5 enhancing nitric oxide (NO) production to promote vasodilation1 and blocking the effects of inflammatory enzymes.6

Jamieson Resveratrol Red Wine Extract contains a standardized extract of the oligostilbenes trans-resveratrol and e-viniferin, both extracted from grapevines (Vitis vinifera) from the Languedoc region of France. Trans-resveratrol is a stereoisomer of resveratrol, and is known to be more biologically active than the cis form of this nutrient. Viniferin is known as a dimer of resveratrol that is naturally present in the grapes. Resveravtrol has both antioxidant and anti-inflammatory properties to support cardiovascular health, which is confirmed by a number of in vitro studies.7 Jamieson Resveratrol Red Wine Extract also contains Grapeseed (Vitis vinifera) extract, which contains small molecular size polyphenols known as oligomeric procyanidins (OPCs). These are potent antioxidants well known for their ability to support capillary health, and also to protect against age-related damage caused by free radicals.6 By counteracting oxidative stress in the body, grapeseed extracts specifically protect the cardiovascular system by preventing the oxidation of low-density lipoprotein (LDL) cholesterol, a process which is associated with the development of atherosclerosis.6 Jamieson Resveratrol Red Wine Extract is formulated from natural sources and is pharmaceutically tested to guarantee full potency and absolute clinical purity. What makes Resveratrol Red Wine Extract from Jamieson Laboratories different.and why does that difference mean better? 1) Resveratrol Red Wine Extract is standardized to

contain trans-resveratrol, which is more bioavailable than the cis form of this nutrient.

2) The ingredients in this formulation are derived from a

blend of naturally antioxidant-rich French and Italian red grapes and extracts of their vines.

3) One capsule provides the equivalent Resveratrol

content of approximately six 4oz glasses of red wine. 4) Our premium formulations are manufactured using the

360 Pure process - a minimum of 360 quality tests that guarantee traceability and reliability of raw material, product safety, full potency and absolute clinical purity.

For Accidental Overdose (such as child ingesting formula) Dial 911, 0 for operator assistance or call your nearest Poison Control Centre.

For Professional Use Only The information contained here has been accumulated from many sources.

Indications are not intended as cures, they are simply a guideline to be used at your professional discretion.

For more information please visit www.jamiesonvitamins.com or call 1-800-265-5088 to speak to a Consumer Affairs representative. 03/23/12

INGREDIENT INFORMATION Available as 30 capsules. Each capsule contains: Resveravine Resveratrol (Vitis vinifera, vine)..50 mg

Providing 20% Oligostillbenes, 10% t-resveratrol and 10% Viniferin

Grape Seed (10:1) Extract (Vitus vinifera, seed)33 mg equivalent to 330 mg raw seed, standardized to 90% Oligomeric proanthocyanidins

Phosphatidylcholine (Glycine max, seed).......67 mg EXCIPIENTS Cellulose, Dicalcium Phosphate, Natural Purple Carmine Colour, Vegetable Magnesium Stearate, Silica, Calcium Silicate, Gelatin. DIRECTIONS Adults: Take 1 capsule 1-3 times daily. Consult a healthcare practitioner for use beyond 4 weeks. Store between 15C-25C, away from children. INDICATED BENEFITS Natural antioxidant to support heart health All of the health benefits of approximately six glasses

of red wine in each capsule without the calories or alcohol

Clinically proven ingredients are effective and safe Helps to support and maintain capillary health DRUG-NUTRIENT INTERACTIONS Drug Interactions This product may interact adversely when taken with anti-coagulant or anti-platelet drugs (including non-steroidal anti-inflammatory drugs [NSAIDs] and aspirin). It may also interact with drugs that are metabolized by cytochrome P450 3A4, including HMG-CoA reductase inhibitors, calcium channel antagonists, anti-arrhythmic agents, HIV protease inhibitors, immunosuppressants, anti-histamines, benzodiazepines and drugs used to treat erectile dysfunction.9

WARNINGS AND PRECAUTIONS Do not use if you are pregnant, breastfeeding or taking anticoagulant/antiplatelet drugs. TOXICITY, ADVERSE REACTIONS, AND SIDE EFFECTS None known when taken as directed. REFERENCES 1. Wallerath, T., Deckert, G., Ternes, T., Anderson, H.,

Li, H. Witte, K. & Forstermann, U. (2002). Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothial nitric oxide synthase. Circulation, 106 (13):1652-1658.

2. Klatsky, A.L. (2007). Alcohol, cardiovascular diseases

and diabetes mellitus. Pharmacol Res, Jan 25 [Epub ahead of print].

3. Criqui, M.H., Ringel, B.L. (1994). Does diet or

alcohol explain the French Paradox? Lancet, 344 (8939-8940): 1719-1723.

4. Brito, P., Almedia, L.M., Dinis, T.C. (2002). The

interaction of resveratrol with ferrylmyoglobin and peroxynitrite; protection against LDL oxidation. Free Radic Res, 36(6): 621-631.

5. Wang, Z., Huang, Y., Zou, J., Cao, K., Xu, Y., Wu, J.

M. (2002). Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro. Int J Mol Med, 9(1): 77-79.

6. Pinto, M.C., Garcia-Barrado, J.A., Macias, P. (1999).

Resveratrol is a potent inhibitor of the dioxygenase activity of lipogygenase. J Agric Food Chem, 47(12): 4842-4846.

7. Bio Serae, data on file with supplier. 8. Nuttal, S.L., Kendall, M.J., Bombardelli, E.,

Morazzoni, P. (1998). J. Clin. Pharm. Ther, 23: 385. 9. Higdon, J. (2005). Linus Pauling Institute

Micronutrient Information Center, Oregon State University.