Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway Part 2: Gluconeogenesis and PPP Chapter 14

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  • Slide 1
  • Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway Part 2: Gluconeogenesis and PPP Chapter 14
  • Slide 2
  • Gluconeogenesis and PPP Learning Goals. Know: 1.Entry to gluconeogenesis. 2.Glycolysis backwards: which enzymes are at Eq and those that are the drivers. 3.What makes some amino acids glucogenic. 4.Pentose Phosphate Pathway entry by glucose-6-P and transaldolases, transketolases. 5.Why the PPP is a web pathway.
  • Slide 3
  • Gluconeogenesis Forms Sugars from Other Metabolites
  • Slide 4
  • Going Forwards and Backwards
  • Slide 5
  • The Beginning of Gluconeogenesis
  • Slide 6
  • Pyruvate Carboxylase
  • Slide 7
  • PEP Carboxykinase
  • Slide 8
  • Pyruvate Actually Has Two Ways to PEP
  • Slide 9
  • The End of Gluconeogenesis
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  • Gluconeogenesis Energetics EOC Problem 21: overall energetics of Glycolysis and Gluconeogenesis. EOC Problem 22: Concept of a Futile Cycle.
  • Slide 11
  • Slide 12
  • Pentose Phosphate Pathway Beginning +aromatic amino acids + His
  • Slide 13
  • SuperOxide Dismutase NADPH and Oxygen Toxicity
  • Slide 14
  • PPP Beginning from Glucose-6-Phosphate
  • Slide 15
  • Lactonase
  • Slide 16
  • 6-Phosphogluconate DH
  • Slide 17
  • Phosphopentose Isomerase (not an Epimerase)
  • Slide 18
  • Ribose-5-Phosphate Epimerase
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  • PPP the Web like Pathway Stuck onto the Side of Glycolysis
  • Slide 20
  • PPP Transketolases transfer 2 Carbon units
  • Slide 21
  • Slide 22
  • PPP Transaldolases transfer 3 Carbon units
  • Slide 23
  • Another Transketolase
  • Slide 24
  • PPP Arranged to Oxidize Glucose (6 in and 5 out) 6 Glucose-6-P
  • Slide 25
  • Control of PPP by NADPH
  • Slide 26
  • PPP Functions: 1.Produce Ribose-5-P for Nucleotide Synthesis 2.Produce Ribose-5-P for His Synthesis 3.Produce Erythrose-4P for Trp, Tyr, Phe Synthesis WYF 4.Can Completely Oxidize Glucose 5.Source of NADPH (Biosynthesis, Oxygen Killing System) 6.Can be Rearranged to Calvin Cycle Fix CO 2 7.Other Specialized Reasons (Heterofermenters, etc. mainly in prokaryotes)
  • Slide 27
  • Things to Know and Do Before Class 1.Entry to gluconeogenesis. 2.Glycolysis backwards: which enzymes are at Eq and those that are the drivers. 3.What makes some amino acids glucogenic. 4.Pentose Phosphate Pathway entry by glucose-6-P and transaldolases, transketolases. 5.Why the PPP is a web pathway. 6.EOC Problems: 21, 22, 25 27.

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