International Kitano Endo Seminar (IKES)The INTERNATIONAL KITANO ENDO SEMINAR (IKES) Robert D Utiger We mourns the loss of Professor Robert Utiger, who , who was recently laid to rest

International Kitano Endo Seminar (IKES)

THE 1st KITANO ENDO SEMINARTHE 1st KITANO ENDO SEMINAR Dept Diabetes & EndoDept Diabetes & Endo

The The TazukeTazuke

KofukaiKofukai Medical Research Institute KITANO HospitalMedical Research Institute KITANO Hospital

February 7th, 2004

Professor Robert D Professor Robert D UtigerUtiger Clinical Professor, Harvard Medical SchoolClinical Professor, Harvard Medical School Brigham & WomenBrigham & Women’’s Hospitals Hospital

This special project is partly supported by

AventisAventis PhramaPhrama Co.,Co., NovoNordiskNovoNordisk Japan CoJapan Co, SANKYO Co.,SANKYO Co.,匠里・都市研究所匠里・都市研究所, MINAMIKAWA CLINIC (Kadoma City,

Osaka)

The INTERNATIONAL KITANO ENDO SEMINAR (IKES) The INTERNATIONAL KITANO ENDO SEMINAR (IKES)

Robert D Robert D UtigerUtiger

We mourns the loss of Professor Robert We mourns the loss of Professor Robert UtigerUtiger, who , who was recently laid to rest on June 29 at age 76.••He was a mentor of He was a mentor of KoshiyamaKoshiyama at Endocrine Round at at Endocrine Round at Brigham & WomenBrigham & Women’’s Hospital.s Hospital.••He kindly accepted our invitation to make a lecture on He kindly accepted our invitation to make a lecture on February 7, 2004, which became the First IKES....February 7, 2004, which became the First IKES....

The 2nd International The 2nd International KITANO ENDO SEMINARKITANO ENDO SEMINAR

Center for Diabetes & EndoCenter for Diabetes & Endo The The TazukeTazuke KofukaiKofukai Medical Research Institute KITANO Hospital Medical Research Institute KITANO Hospital

November 20th, 2004November 20th, 2004

ArmenArmen H H TashjianTashjian Jr.Jr. Emeritus Professor, Harvard Medical SchoolEmeritus Professor, Harvard Medical School

& Harvard School of Public Health& Harvard School of Public Health


ArmenArmen H H TashjianTashjian JrJr

Professor Professor ArmenArmen H H TashjanTashjan JtJt was recently laid to rest on July 3 at age 77.••He was a mentor of He was a mentor of KoshiyamaKoshiyama in Harvard.in Harvard.••It was a great pleasure to work under It was a great pleasure to work under ArmenArmen, who always gave us smiling, , who always gave us smiling, excellent advice, and free environment.excellent advice, and free environment.••All colleagues and students all over the world mourns the great All colleagues and students all over the world mourns the great loss.loss.••He always He kindly gave a lecture on He always He kindly gave a lecture on November 20th, 2004November 20th, 2004, on the 2, on the 2ndnd IKES.IKES.

The 3The 3rdrd INTERNATIONALINTERNATIONALKITANO ENDO SEMINARKITANO ENDO SEMINAR

We will here have The 3rd INTERNATIONAL KITANO ENDO SEMINAR, as described below.This time, we will have a guest, Dr Anderson (Medical Director, Eli Lilly Co, USA), who has been

involved in the development of insulin analog (Humalog) and its mixture (HumalogMix 75/25 etc ). Inthis seminar, he will give us a talk about ŅRecent Progress of Insulin TherapyÓ.

Special Lecture　 James H Anderson Jr, MDMedical Director, Diabetes, Eli Lilly Co. USAAssociate Professor, Division of Endocrinology & MetabolismIndiana University Medical School, USA

Title ŅRecent Progress in Insulin Therapy for Diabetes Mellitus with Special

Reference to Insulin Analog MixtureÓChair 　　 Yoshiyuki Hamamoto, MDPhD Deputy Director, Center for Diabetes & Endocrinology, Medical Institute KITANO HospitalTIME & DATE: 6:30-7:30 pm, March 2nd (Wed), 2005,PLACE: 7th Conference Room, 5th Floor, Medical Institute KITANO Hospital, Osaka City, Japan: PHONE+81-6-6312-8824 , FAX+81-6-6312-8867

　　　　　　Hosted by: Center for Diabetes & Endocrinology, The TAZUKE Kofukai Foundation Medical Institute KITANO Hospital & Eli Lilly Japan, Co.

Hosted by

Center for Diabetes & EndocrinologyMedical Institute KITANO Hospital &

Pfizer

Japan

Inc

TIME & PLACE 15:00-17:0 0 September 17th (Saturday), 2005; ; KITANO Hall, Medical Institute KITANO Hospital, Osaka, Japan.

Opening RemarksOpening Remarks: Y Yamaoka, MD (President, KITANO Hospital & Emeritus Professor Kyoto University)

Case SeminarCase Seminar: Chair: Y Hamamoto (Deputy Director, Center for Diabetes & Endo, KITANO Hospital)

1.T Abe, O Kikuchi, K Sasaki, K Nakagawa (Interns, KITANO Hospital)

2. Y NakamuraY Nakamura (Director, Division of Diabetes & Endocrinology, Department

of Internal Medicine, Hyogo Prefectural Amagasaki Hospital)

Special CommentsSpecial Comments: T NishikawaT Nishikawa (Vice President, Yokohama Rosai Hospital)

Special LectureSpecial Lecture Chair: R Nohara(Vice President, KITANO Hospital & Clinical Professor, Graduate School of Medicine, Kyoto University)

Title (TBA) GH Williams, GH Williams, JrJrProfessor, Harvard Medical School & Brigham& WomenProfessor, Harvard Medical School & Brigham& Women’’s Hospitals Hospital

Special CommentsSpecial Comments: I TanakaI Tanaka ( President, Kei-Han-Na Hospital)

Y IwasakiY Iwasaki (Associate Prof, Dept Med, Kochi Univ)

Closing RemarksClosing Remarks : Y Y ShishibaShishiba (Executive, The Japan Endocrine Society)

Acknowledgements: H Koshiyama(Director , KITANO Hospital & Clinical Professor, Graduate School of Medicine, Kyoto University)

The 4The 4thth INTERNATIONAL KITANO ENDO SEMINARINTERNATIONAL KITANO ENDO SEMINAR Half a Century of Aldosterone~From the Old History to the Update

Horizon~

ARBThe 5th INTERNATIONAL KITANO ENDO SEMINAR (IKES)The 5th INTERNATIONAL KITANO ENDO SEMINAR (IKES)

““PPAR and ARB in Metabolic SyndromePPAR and ARB in Metabolic Syndrome””Program Moderator

Hiroyuki Hiroyuki KoshiyamaKoshiyama, MD, MD

Special GuestsYoshihiro Ogawa, MDYoshihiro Ogawa, MD

Professor, Tokyo Medical & Dental UniversityProfessor, Tokyo Medical & Dental University

&&Theodore W Kurtz, MDTheodore W Kurtz, MD

Professor & Vice Chair, Department of Laboratory Medicine,Professor & Vice Chair, Department of Laboratory Medicine,University of California, San FranciscoUniversity of California, San Francisco

March 23, 2006March 23, 2006KITANO Hall, TAZUKE KOFUKAI Medical Research Institute KITANO HoKITANO Hall, TAZUKE KOFUKAI Medical Research Institute KITANO Hospitalspital

Cardiovascular SystemPPAR

Co-sponsored byAstellas

Co., Nippon Boehringer

Ingelheim

Co., &Center for Diabetes & Endocrinology

Medical Research Institute KITANO Hospital.

----------------------------------------------------------------------------------------------------------------------------------THEMETHEME ““StatinStatin --state of the art in US and Japanstate of the art in US and Japan--””TIME & PLACE September 23TIME & PLACE September 23rdrd (Saturday), 2006; 0(Saturday), 2006; 0--1pm 1pm

The 1st conf The 1st conf RmRm, 5th , 5th Floor,KITANOFloor,KITANO HospitalHospital,, Osaka, Japan.Osaka, Japan.------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Program Moderator Program Moderator KoshiyamaKoshiyama, , MDPhDMDPhD

(Director , KITANO Hospital & Clinical Professor, Graduate Schoo(Director , KITANO Hospital & Clinical Professor, Graduate School of Medicine, Kyoto University)l of Medicine, Kyoto University)

Chair: Chair: Ryuji Ryuji NoharaNohara, , MDPhDMDPhD(Vice President , KITANO Hospital & Clinical Professor, Graduate(Vice President , KITANO Hospital & Clinical Professor, Graduate School of Medicine, Kyoto University)School of Medicine, Kyoto University)

# 1# 1 Hiroyuki Hiroyuki KoshiyamaKoshiyama, , MDPhDMDPhD““Concern about Concern about StatinStatin in Japan: fact or fiction?in Japan: fact or fiction? ””#2 Special Lecture#2 Special Lecture

““Update on Recent LDLUpdate on Recent LDL--Cholesterol Lowering TrialsCholesterol Lowering Trials””

David D Waters, MDDavid D Waters, MDChief, Division of Cardiology, San Francisco General HospitalChief, Division of Cardiology, San Francisco General Hospital

Professor, University of California, San FranciscoProfessor, University of California, San FranciscoHosted by

Center for Diabetes & EndocrinologyMedical Research Institute

KITANO HospitalAstellas

Co. & Pfizer JapanCo..

It is our great pleasure to invite you to the 6th IKES with Professor Walters form UCSFas a special guest, who is involved in clinical megatrials

such as TNT and MIRACLE. He will give us a special talk about

diabetes mellitus & CVD. Registration Free Language: English only

The 6The 6thth INTERNATIONAL KITANO ENDO SEMINAR (IKES)INTERNATIONAL KITANO ENDO SEMINAR (IKES)

The 7The 7thth INTERNATIONAL KITANO ENDO SEMINAR (IKES)INTERNATIONAL KITANO ENDO SEMINAR (IKES)It is our great pleasure to invite you to the 6th IKES with Professor Scernthaner as a special guest, who is a former president of

EASD. He will give us a specialtalk about diabetes mellitus & CVD. Registration Free Language: English only

----------------------------------------------------------------------------------------------------------------------------------THEMETHEME ““Diabetes Mellitus & Cardiovascular DiseaseDiabetes Mellitus & Cardiovascular Disease””TIME & PLACE October 11TIME & PLACE October 11thth (Wednesday), 2006;5(Wednesday), 2006;5--8pm 8pm KITANO HALL, 5th KITANO HALL, 5th Floor,MedicalFloor,Medical Research Research Institute KITANO Hospital, Osaka, Japan.Institute KITANO Hospital, Osaka, Japan.

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Opening Remarks Opening Remarks : Yoshio Yamaoka, : Yoshio Yamaoka, MDPhDMDPhD

(President , KITANO Hospital & Emeritus Professor, Graduate Scho(President , KITANO Hospital & Emeritus Professor, Graduate School of Medicine, Kyoto University)ol of Medicine, Kyoto University)

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SESSION 1SESSION 1

Chair: H Chair: H KoshiyamaKoshiyama, , MDPhDMDPhD (Director , Center for Diabetes & Endo, Medical Research Institu(Director , Center for Diabetes & Endo, Medical Research Institute KITANO te KITANO Hospital & Clinical Professor, Graduate School of Medicine, KyotHospital & Clinical Professor, Graduate School of Medicine, Kyoto University)o University)1. Case Discussion (DM) 1. Case Discussion (DM) Y. Arai, MD, Y. Arai, MD, T.MiyoshiT.Miyoshi, MD & S. Takada, MD , MD & S. Takada, MD (Junior Residents, KITANO Hospital, (Junior Residents, KITANO Hospital, PGY1) PGY1)

2. Short Lecture 2. Short Lecture ““Clock Gene and Glucose MetabolismClock Gene and Glucose Metabolism””H. Ikeda, MD H. Ikeda, MD (Deputy Director, Center for Diabetes & Endo, Medical Research I(Deputy Director, Center for Diabetes & Endo, Medical Research Institute KITANO Hospital)nstitute KITANO Hospital)

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SESSION 2SESSION 2Special LectureSpecial Lecture

Chair: Ryuji Chair: Ryuji NoharaNohara, , MDPhDMDPhD (Vice President , KITANO Hospital & Clinical Professor, Graduate(Vice President , KITANO Hospital & Clinical Professor, Graduate School of School of Medicine, Kyoto University)Medicine, Kyoto University)

“New Management of Type 2 Diabetes to Prevent Cardiovascular Disease”

GuntramGuntram SchernthanerSchernthaner, MD, MDProfessor, University of Vienna, Professor, University of Vienna,

H d f th D t t f M di i IHead of the Department of Medicine I R d lf tifRudolfstifung H it l ViHospital Vienna

Hosted byCenter for Diabetes & Endocrinology Medical Research Institute

KITANO Hospital&

Takeda Co..

Hosted byCenter for Diabetes & Endocrinology

Medical Institute KITANO Hospital & Eli Lilly Japan Inc.

TIME & PLACE November 16November 16thth (Thursday), 2006;7(Thursday), 2006;7--9 pm 9 pm KITANO HALL, 5th Floor,Medical Research Institute KITANO Hospital, Osaka, Japan.

Opening RemarksOpening Remarks: H Koshiyama, MDPhD(Director , KITANO Hospital & Clinical Professor, Graduate School of Medicine, Kyoto University)

Case SeminarCase Seminar: Chair: Takehisa Yamamoto , MDPhD (Director, Department of Pediatrics, Mino City Hospital)1. Primary hyperparathyroidism presenting with hypercalcemic crisis K Nomura, MDPhD2. Early cases with Primary hyperparathyroidism : how to treat?

H Hamamoto, MDPhD(Visiting Scientist , KITANO Hospital & Assistant Professor, Graduate School of Medicine, Kyoto University)

#Special LectureSpecial LectureChair: Kiyoshi Tanaka, Kiyoshi Tanaka, MDPhDMDPhD( Professor, Kyoto Women’s University)

“Update on Osteoporosis Treatment”Daniel Daniel ThiebaudThiebaud, MD, MD

Global Medical Fellow II, Eli Lilly and CompanyGlobal Medical Fellow II, Eli Lilly and Company

The 8The 8thth INTERNATIONAL KITANO ENDO SEMINAR(IKES)INTERNATIONAL KITANO ENDO SEMINAR(IKES)““New Era of Osteoporosis TreatmentNew Era of Osteoporosis Treatment””

AgendaAgenda

The 9The 9thth

INTERNATIONAL INTERNATIONAL KITANO ENDO KITANO ENDO

SEMINAR (IKES)SEMINAR (IKES) January 15th, 2007January 15th, 2007

Co-sponsored by: SANKYO Co. &

Center for Diabetes & Endocrinology,Medic

al

Research Institute KITANO Hospital

Opening RemarksOpening Remarks: H. Koshiyama, MDPhDSESSION 1 SESSION 1 18:0018:00--19:00 19:00 Chair: S. FujimotoS. Fujimoto

, MDPhD

Lecturer, Graduate School of

Medicine, Kyoto University1. K. Nabe, MD Deputy Director, , KITANO Hospital2. Y. Hamamoto, MDPhD

Visiting Scientist , KITANO Visiting Scientist , KITANO

Hospital & Assistant Professor, Graduate School of Hospital & Assistant Professor, Graduate School of Medicine, Kyoto UniversityMedicine, Kyoto University

SESSION 2 SESSION 2 19:0019:00--20:00 20:00 Special LectureSpecial LectureChair: Susumu SeinoSusumu Seino, MDPhD

Professor, Kobe University Professor, Kobe University

Graduate School of Medicine & Visiting Professor, Kyoto Graduate School of Medicine & Visiting Professor, Kyoto UniversityUniversityErik Erik RenstromRenstrom, , MDPhDMDPhDAssociate Professor, Associate Professor, Department of Experimental Medical

Science,Lund University, Lund, Sweden.

Free

Discussion

&

Wine

PartyFree

Discussion

&

Wine

Party

20:0020:00

AdjournmentAdjournment


Medical Institute KITANO Hospital, Astellas

Co, Nippon Boehringer

Ingelheim Co.p

TIME & PLACETIME & PLACE 19:0019:00--21: 00 June 25th (Monday), 2007;21: 00 June 25th (Monday), 2007;KITANO Hall, Medical Institute KITANO Hospital, KITANO Hall, Medical Institute KITANO Hospital, OsakaOsaka

Opening Remarks: Opening Remarks: EriEri MusoMuso, , MDPhDMDPhD, Deputy Chairman, Research Institute, KITANO Hospital & Clinic, Deputy Chairman, Research Institute, KITANO Hospital & Clinical al Professor, Graduate School of Medicine, Kyoto UniversityProfessor, Graduate School of Medicine, Kyoto University

Session 1: Session 1: Chair: Chair: Takeshi Kurose, Takeshi Kurose, MDPhDMDPhD

Director, Kansai Electronic Hospital & Clinical Professor, GradDirector, Kansai Electronic Hospital & Clinical Professor, Graduate School of Medicine, Kyoto Universityuate School of Medicine, Kyoto University

““Beneficial effect of antiBeneficial effect of anti--hypertensive drug on hypertensive drug on glycemicglycemic control in type 2 diabetes control in type 2 diabetes

〜〜Be able to cure two diseases with one drug ? Be able to cure two diseases with one drug ? ““

Yoshiyuki Yoshiyuki HamamotoHamamoto, , MDPhDMDPhD Visiting Scientist, KITANO Hospital & Assistant Professor, GVisiting Scientist, KITANO Hospital & Assistant Professor, Graduate raduate School of Medicine, Kyoto University School of Medicine, Kyoto University

Session 2 :Session 2 :Chair: Chair: Hiroyuki Hiroyuki KoshiyamaKoshiyama, MD , MD PhDPhDDirector, KITANO Hospital & Clinical Professor, Graduate School of Medicine, Kyoto University

““New Opportunities for Preventing Diabetes and Cardiovascular DisNew Opportunities for Preventing Diabetes and Cardiovascular Disease in Patients with Hypertensionease in Patients with Hypertension““

Theodore W KurtzTheodore W Kurtz

Professor, Department of Laboratory Medicine,Professor, Department of Laboratory Medicine,

University of California, San FranciscoUniversity of California, San Francisco

Closing Remarks: Closing Remarks: EriEri MusoMuso, , MDPhDMDPhD



Hosted by Center for Diabetes & EndocrinologyMedical Institute KITANO Hospital, Astellas

Co, Nippon Boehringer

Ingelheim

Co.

‘‘PPAR in Type 2 Diabetes as Vascular Disease 2007PPAR in Type 2 Diabetes as Vascular Disease 2007’’TIME & PLACE September 1st (Saturday), 2007;2-4pm; KITANO HallOpening Remarks: Eri Muso, MDPhD, Vice President, Research Institute,

KITANO Hospital & Visiting Professor, Graduate School of Medicine, Kyoto University

Session 1Session 1: Chair: Yoshiyuki Hamamoto, MDPhD, Assistant Professor, Department of Medicine, Kyoto University

Tetsuya Matsushita, MDPhD,Department of Circulatory Medicine & Nephrology, Saga Univeristy

Session 2Session 2 :Chair: Shunichi Miyazaki, Shunichi Miyazaki, MDPhDMDPhD, Professor, Department of Circulatory Medicine, Kinki University1. Toshimasa Yamauchi, MDPhD,

Associate Professor, Department of Medicine, The University of Tokyo

2. 2. Jorge Jorge PlutzkyPlutzky, MD, MD“PPARs as Therapeutic Targets: Promises, Pitfalls and Ongoing Progress”

Director, The Vascular Disease Prevention Program, Cardiovascular Division, Brigham and Women‘s Hospital, Harvard Medical School, USA.

Closing Remarks: Ryuji Nohara, MDPhDVice President, Research Institute, KITANO Hospital & Clinical Professor,

Graduate School of Medicine, Kyoto University

Hosted by

Center for Diabetes & EndocrinologyMedical Institute KITANO Hospital &

Pfizer

Japan

Inc

We will hold the 12th

International KITANO ENDO Seminar (IKES). We will invite Professor Gordon H Williams of Harvard Medical School, again as a special guest of IKES. Professor Gordon Williams is an author of Textbook of Harrison’s Principles of Internal Medicine and Williams Textbook of Endocrinology. He will give us a special talk

about aldosterone

and a new aldosterone

antagonist. He will also join the ‘Endocrine Case Seminar’

session. We hope that med students, interns, residents, and clinicians or researchers of various fields will come together to this valuable

chance.

TIME & PLACE

14:00-16:00 May 10th

(Saturday), 2008; ; The 1st Conference Room, 5F, Medical Institute KITANO Hospital, Osaka.

SESSION 1: Endocrine Case SeminarSESSION 1: Endocrine Case Seminar:

Chair: Hiroyuki Koshiyama

(Program Moderator; Director , KITANO Hospital & Clinical Professor, Graduate School of Medicine, Kyoto University)1. Masatoshi Nakata, MD (Junior Resident, KITANO Hospital)2. Yoshihiro Iwasaki, MD (Junior Resident, KITANO Hospital)

SESSION 2: Special LectureSESSION 2: Special Lecture

Chair: Ryuji Nohara(Vice President, KITANO Hospital & Clinical Professor, Graduate

School of Medicine, Kyoto University)

““AldosteroneAldosterone: Evolution of Cardiovascular Risk Hormone: Evolution of Cardiovascular Risk Hormone””

Gordon H Williams, Gordon H Williams, JrJrProfessor of Medicine, Harvard Medical School, Professor of Medicine, Harvard Medical School,

Director, Center for Clinical Investigation, Brigham & WomenDirector, Center for Clinical Investigation, Brigham & Women’’s Hospitals Hospital

The 12The 12thth INTERNATIONAL KITANO ENDO SEMINARINTERNATIONAL KITANO ENDO SEMINAR

23


Hosted by Center for Diabetes & EndocrinologyMedical Institute KITANO & Daiichi-Sankyo Co.

TIME & PLACE November 17th (Monday), 2008;7-9pm; KITANO Hall

Special Lecture: ChairChair: Yutaka Seino, Yutaka Seino, MDPhDMDPhDPresident, Kansi Electric Power Hospital,

& Emeritus Professor, Graduate School of Medicine,

Kyoto UniversityVivian Fonseca, MDVivian Fonseca, MD

““Recent Diabetes Treatment Strategy in U.S.A.Recent Diabetes Treatment Strategy in U.S.A.””Professor, Tulane University

PROGRAM MODERATOR Hiroyuki Hiroyuki KoshiyamaKoshiyama, , MDPhDMDPhDMedical Research Institute, KITANO Hospital

& Clinical Professor, Graduate School of Medicine, Kyoto University

2

The 14The 14thth INTERNATIONAL KITANO ENDO SEMINAR INTERNATIONAL KITANO ENDO SEMINAR (IKES)(IKES)

Hosted by Center for Diabetes & EndocrinologyMedical Institute KITANO Hospital &Sanofi -Aventis Co.

AARHUSUNIVERSITY

TIME & PLACE : April 17 th

(Friday), 2009, 7‐9pm KITANO HallTHEME : “Diabetes Mellitus & Bone”Opening

Remarks: Eri

Muso, MD, PhDLecture 1

Chair : Tatsuo Tsukamoto, MD, PhDHiroyuki Koshiyama, MD, PhD

“Bone mineral density in Japanese patients with type 2 diabetes ”Lecture 2

Chair : Tatsuo Tsukamoto, MD, PhDMasaaki Inaba, MD, PhD

“Sorbitol

pathway to develop osteoblast

dysfunction in diabetic osteopathy”

Associate Professor of Internal Medicine Metabolism,Endocrinology

and Molecular Medicine

Osaka City University Graduate School of MedicineSpecial Lecture

Chair :

Takehisa

Yamamoto, MD, PhDPeter Vestergaard, MD, PhD,DrMedSc

“Recent knowledge from ADA/EASD consensus”～Thiazolidinedione

treatment and the risk of fractures～Assistant Professor of Calcium Metabolic Disorders

The Osteoporosis Clinic Aarhus

Amtssygehus, Denmark•

Closing Remarks: Eri

Muso, MD, PhD

PROGRAM MODERATOR

:

Hiroyuki Koshiyama, MD,PhD

TIME & PLACE : April 17 TIME & PLACE : April 17 thth

(Friday), 2009, 7(Friday), 2009, 7‐‐9pm KITANO Hall9pm KITANO HallTHEME : THEME : ““Diabetes Mellitus & Diabetes Mellitus & BoneBone””OpeningOpening

Remarks: Remarks: EriEri

MusoMuso, MD, PhD, MD, PhDLecture 1Lecture 1

Chair : Tatsuo Tsukamoto, MD, PhDChair : Tatsuo Tsukamoto, MD, PhDHiroyuki Hiroyuki KoshiyamaKoshiyama, MD, PhD, MD, PhD

““Bone mineral density in Japanese patients with type 2 diabetes Bone mineral density in Japanese patients with type 2 diabetes ””Lecture 2Lecture 2

Chair : Tatsuo Tsukamoto, MD, PhDChair : Tatsuo Tsukamoto, MD, PhDMasaaki Masaaki InabaInaba, MD, PhD, MD, PhD

““SorbitolSorbitol

pathway to develop pathway to develop osteoblastosteoblast

dysfunction dysfunction in in diabetic osteopathydiabetic osteopathy””

Associate Professor of Internal Medicine Associate Professor of Internal Medicine Metabolism,EndocrinologyMetabolism,Endocrinology

and and Molecular Medicine Molecular Medicine

Osaka City University Graduate School of MedicineOsaka City University Graduate School of MedicineSpecial LectureSpecial Lecture

Chair :Chair :

TakehisaTakehisa

Yamamoto, MD, PhDYamamoto, MD, PhDPeter Peter VestergaardVestergaard, MD, , MD, PhD,DrMedScPhD,DrMedSc

““Recent knowledge from ADA/EASD consensusRecent knowledge from ADA/EASD consensus””～～ThiazolidinedioneThiazolidinedione

treatment and the risk of fracturestreatment and the risk of fractures～～Assistant Professor of Calcium Metabolic Disorders Assistant Professor of Calcium Metabolic Disorders

The Osteoporosis Clinic The Osteoporosis Clinic AarhusAarhus

AmtssygehusAmtssygehus, Denmark, Denmark••

Closing Remarks: Closing Remarks: EriEri

MusoMuso, MD, PhD, MD, PhDPROGRAM MODERATORPROGRAM MODERATOR

::

Hiroyuki Hiroyuki KoshiyamaKoshiyama, , MD,PhDMD,PhD

28


DOWNDOWN UNDER!!!UNDER!!!

TIME & PLACE : 18:00-20:00 May 14th

(Thursday), 2009

; KITANO HallTHEME : ““AldosteorneAldosteorne & Cardiovascular Diseases& Cardiovascular Diseases””

•• Opening RemarksOpening Remarks: Hiroyuki Hiroyuki KoshiyamaKoshiyama, MD, PhD, MD, PhD: PROGRAM MODERATORSESSION 1SESSION 1::

ChairChair: R: Ryuji Nohara, MDPhD

Case report Yorihiro

Iwasaki, MD: Senior Resident, KITANO Hospital“Difficult cases with primary aldosteronism”

Special Lecture Special Lecture Takashi Takashi AkasakaAkasaka, MD, MDProfessor, Division of Cardiovascular Medicine, Wakayama Medical

University““Coronary Lesion Assessment by OCTCoronary Lesion Assessment by OCT””

SESSION 2SESSION 2: Special Lecture : Special Lecture Chair: Takashi Akasaka, MD““EplerenoneEplerenone, , AldosteroneAldosterone and and MineralocorticoidMineralocorticoid Receptor Receptor

BlockadeBlockade””

John W John W FunderFunder, MD, MDProfessor, Professor, Prince HenryPrince Henry’’s Institute of Medical Researchs Institute of Medical Research

Closing Remarks: EriEri MusoMuso, MD, PhD, MD, PhDMelbourneMelbourne

30

TIME & PLACE : 18:00-19:00 July 29th (Wednesday), 2009The 7th

CONF Room, KITANO HospitalCLOSED TO MEMBERS OF DM & ENDO CTR Only

THEME : ““IncretinIncretin & Insulin now& Insulin now””Special Special SpecialSpecial LectureLecture Chair: Hiroyuki Koshiyama, MDPhD

Alan Moses, M.DAlan Moses, M.DGlobal Chief Medical Officer, Novo Nordisk Inc, USA

Closing Remarks: Hiroyuki Hiroyuki Koshiyama,MDKoshiyama,MD, PhD, PhDPROGRAM MODERATOR



Medical Institute KITANO Hospital & Novo Norsik

Inc.


Medical Institute KITANO Hospital &

Novo Norsik

Inc.

TIME: 19:00-20:00, Fri., Feb 5th, 2010VENUE: 1st Conference Room, KITANO Hospital

Special Lecture:Special Lecture:““The Kidney in DiabetesThe Kidney in Diabetes””

-- Dynamic pathways of injury and repair Dynamic pathways of injury and repair --

Paola Paola FiorettoFioretto, MD, , MD, Ph.DPh.DUniversity of Padova Medical School

Chairperson: （未定）

Closing Remarks: Hiroyuki Hiroyuki Koshiyama,MDKoshiyama,MD, PhD, PhDPROGRAM MODERATOR

This lecture is open to members of DM & ENDO CTRs only

The 17The 17thth

INTERNATIONAL KITANO ENDO SEMINARINTERNATIONAL KITANO ENDO SEMINAR

Dear Colleagues,You are kindly invited to meet our special guest speaker, Dr. Paola Fioretto, Professor of Endocrinology, Department ofMedical and Surgical Sciences, University of Padova Medical School, Padova, Italy, at the coming KITANOENDO Seminar.Prof. Fioletto is the leading researcher and the pioneer in the area of diabetic nephropathy, whose contribution has been tremendous in this particular therapeutic area. She will be discussing the recent development in diabeticnephropathy and promises for its prevention and therapy.

Presented by IKESand

KOWA Pharm. Co.

The 19The 19thth IKESIKES (International Kitano ENDO Seminar)(International Kitano ENDO Seminar)

TIME & PLACE :TIME & PLACE : 19:0019:00--

March 29March 29thth

(Mon)(Mon), 2010; , 2010; The 1The 1stst conference roomconference room

Opening Opening RemarksRemarks::HiroyukiHiroyuki KoshiyamaKoshiyama, MD, PhD, MD, PhDSESSION 1: SESSION 1: Chair:YoshiyukiChair:Yoshiyuki Hamamoto,MD,PhDHamamoto,MD,PhD

Hiroyuki Hiroyuki KoshiyamaKoshiyama, MD, PhD, MD, PhD ::

Director , KITANO Hospital &Clinical Professor,

Graduate School of Medicine, Kyoto University ““KISHIMEN STUDYKISHIMEN STUDY ””

SESSION 2 SESSION 2 ：：

Special Lecture Special Lecture Chair: Chair: Ryuji Ryuji NoharaNohara, MD, PhD, MD, PhD

““HyperlipidemiaHyperlipidemia

and Type 2 Diabetes Mellitusand Type 2 Diabetes Mellitus

““John John BetterridgeBetterridge , , MD,PhDMD,PhD

Professor of Endocrinology and Metabolism University College MedProfessor of Endocrinology and Metabolism University College Medical School, London UK ical School, London UK Associate Dean Royal Society of Medicine London, UKAssociate Dean Royal Society of Medicine London, UK

Closing Remarks: Closing Remarks: Ryuji Ryuji NoharaNohara, MD, PhD, MD, PhD

IKES

Case Presentation by ResidentsDiscussion by Participants

Dr Erik Renstrom , MDPhD

Lund Lund University,SweUniversity,Swe denden

Professor Bob Professor Bob UtigerUtigerHarvard Medical SchoolHarvard Medical School

Professor Gordon H Williams Professor Gordon H Williams JrJrHarvard Medical SchoolHarvard Medical SchoolBrigham & WomenBrigham & Women’’s Hospitals Hospital

Professor Professor ArmenArmen H H TashjianTashjianHarvard School of Public Health Harvard School of Public Health

& Harvard Medical School& Harvard Medical School

Professor Professor SchernthanerSchernthanerVienna, AustriaVienna, Austria

Professor David Waters UCSF, San Francisco General HospitalUCSF, San Francisco General Hospital

Dr Dr YoshimasaYoshimasa ShishibaShishiba((JpnJpn Endocrine Society)Endocrine Society)

Professor T Kurtz UCSFUCSF

IKESJorge Jorge PlutzkyPlutzky, MD, MDHarvard Medical SchoolHarvard Medical SchoolBrigham & WomenBrigham & Women’’s Hospitals Hospital

The 22nd INTERNATIONAL KITANO ENDO SEMINAR (IKES)The 22The 22ndnd INTERNATIONAL KITANO ENDO SEMINAR (IKES)INTERNATIONAL KITANO ENDO SEMINAR (IKES)

DOWNDOWN--UNDER!!!UNDER!!! MelbourneMelbourne

TIME & PLACE : 18:00-20:00 May 13th (Friday), 2011 ; The 1st Conference Room, 5th Floor, KITANO Hospital

THEME : “Primary Aldosteornism & Cardiovascular Diseases”• Opening Remarks: Tomomi Fujisawa, MD, PhD SESSION 1:“Cases with Primary Aldosteronism”

Chair: Hiroyuki Koshiyama, MD, PhD• R. Yamaguchi MD (PGY2)• Y. Tabuchi, MD (PGY2)• H. Tatsuoka, MDSESSION 2: Chair: Issei Tanaka, MD. PhD“Syndrome of Inappropriate Aldosterone Secretion (SIALD)：

a possible new

concept for understanding subclinical primary aldosteronism” Yasumasa Iwasaki, MD, PhD

SESSION 3: Special Lecture Chair: Yasumasa Iwasaki, MD. PhD“Aldosterone, Mineralocorticoid Receptors, Evolution;

Questions We Never Thought to Ask ”John W Funder, MD

Professor, Prince Henry’s Institute of Medical ResearchClosing Remarks: Masaaki Inaba, MD, PhD

TIME & PLACE : 18:00-20:00 May 13th (Friday), 2011 ; The 1st Conference Room, 5th Floor, KITANO Hospital

THEME : “Primary Aldosteornism & Cardiovascular Diseases”• Opening Remarks: Tomomi Fujisawa, MD, PhDSESSION 1:“Cases with Primary Aldosteronism”

Chair: Hiroyuki Koshiyama, MD, PhD• R. Yamaguchi MD (PGY2)• Y. Tabuchi, MD (PGY2)• H. Tatsuoka, MDSESSION 2: Chair: Issei Tanaka, MD. PhD“Syndrome of Inappropriate Aldosterone Secretion (SIALD)：

a possible new

concept for understanding subclinical primary aldosteronism”Yasumasa Iwasaki, MD, PhD

SESSION 3: Special Lecture Chair: Yasumasa Iwasaki, MD. PhD“Aldosterone, Mineralocorticoid Receptors, Evolution;

Questions We Never Thought to Ask ”John W Funder, MD

Professor, Prince Henry’s Institute of Medical ResearchClosing Remarks: Masaaki Inaba, MD, PhD

45

The 23rd INTERNATIONAL KITANO ENDO SEMINAR The 23rd INTERNATIONAL KITANO ENDO SEMINAR (IKES)(IKES)

Hosted by Center for Diabetes & Endocrinology

Medical Research Institute KITANO Hospital &Sanofi –Aventis K. K.

Opening Remarks: Hiroyuki Opening Remarks: Hiroyuki KoshiyamaKoshiyama, , MD,PhDMD,PhDSpecial LectureSpecial LectureChair : Tomomi Fujisawa, Chair : Tomomi Fujisawa, MD,PhDMD,PhD

DirectorDirector

DiabetesDiabetes

,,

DepartmentDepartment

ofof

NephrologyNephrology

andand

MetabolismMetabolism

,,

Sakai Municipal HospitalSakai Municipal Hospital

David Raymond OWENS, CBE, MD, FRCPDavid Raymond OWENS, CBE, MD, FRCPProfessor, Centre for Endocrine & Diabetes Sciences, Cardiff UniProfessor, Centre for Endocrine & Diabetes Sciences, Cardiff University, UKversity, UK

““

The 90th anniversary year; the Evolution of The 90th anniversary year; the Evolution of Insulin therapy for type 2 diabetes Insulin therapy for type 2 diabetes ””

Closing Remarks: Hiroyuki Closing Remarks: Hiroyuki KoshiyamaKoshiyama, , MD,PhDMD,PhDPROGRAM MODERATOR : Hiroyuki PROGRAM MODERATOR : Hiroyuki KoshiyamaKoshiyama, , MD,PhDMD,PhD

TIME & PLACE : October 1st (Saturday), 2011, 11:00-12:30; KITANO Hall, Medical Institute KITANO Hospital, Osaka

http://upload.wikimedia.org/wikipedia/ja/e/e9/Kitano_Hospital_%28Osaka%29.jpg

http://www.cardiff.ac.uk/index.html

http://en.wikipedia.org/wiki/File:Cardiff_University_main_building.jpg

The 24The 24thth INTERNATIONAL KITANO INTERNATIONAL KITANO ENDO SEMINAR (IKES)ENDO SEMINAR (IKES)

TIME & PLACE : July 1st (Sunday), 2012, 12:00-13:50 Hilton Osaka Hotel 10F 『Kyoto』

Opening Remarks:Hiroyuki Koshiyama,MD,PhD

Lecture Chair:Kunihiko Hashimoto,MD,PhDChief,Diabetes Education and Support Center Division ofDiabetes and Endocrinology,NTT WEST OSAKA Hospital

Yoshiyuki Hamamoto,MD,PhDDeputy Director,Center for Diabetes＆Endocrinology The TAZUKE KOFUKAI Foundation Medical Research Institute KITANO Hospital

「Incretin Therapy in Our Institute」~The Anti-inflammatory Effect of DPP4 inhibitors

and Combination Therapy with Insulin~

Special LectureChair:Masaaki Inaba,MD,PhDProfessor,Department of Metabolism,Endocrinology and Molecular Medicine,Osaka City University

Jean-Francois Yale,MD,FRCPCProfessor,McGill Nutrition and Food Science Centre,Canada

「New Dimension of DM Treatment~Learning from ORIGIN Study~」

Closing Remarks:Hiroyuki Koshiyama,MD,PhD

1Hosted by Center for Diabetes & EndocrinologyMedical Research Institute KITANO Hospital & Sanofi

–Aventis

co.,

5

The 25The 25thth INTERNATIONAL KITANO INTERNATIONAL KITANO

ENDO SEMINAR (IKES)ENDO SEMINAR (IKES)

1Hosted by

Center for Diabetes & Endocrinology

Medical Research Institute KITANO Hospital

& Mitsubishi Tanabe Pharma co.,

& DAIICHI SANKYO co.,

TIME & PLACE : October 15th (Monday), 2012, 19:30-21:00

The Rits-Carlton Osaka 4F 『『『『The Terrace Room』』』』

Opening Remarks: Shizuka Kaneko, MD, PhDDirector Of Division Diabetes/endocrinology/lifestyle-related Disease

Takatsuki Red Cross Hospital

Special LectureChair: Hiroyuki Koshiyama, MD, PhDDirector,Center for Diabetes＆Endocrinology The TAZUKE KOFUKAI

Foundation Medical Research Institute KITANO Hospital

Ele Ferrannini, MDProfessor of Internal Medicine, University of Pisa School of Medicine, Italy

「「「「 The diabetic cure; now and the future 」」」」

Hosted by

Center for Diabetes & Endocrinology

Medical Institute KITANO Hospital &

Novo Norsik Inc.

TIME & PLACE : 17:00-19:30 Jan 28th (Monday), 2013

The 2nd building of

Department of Preventive Medicine Ⅱ 2F conference room,

KITANO HOSPITAL

CLOSED TO MEDICAL Staffs of

KITANO HOSPITAL Only

＊Please contact with following person for the registration of meeting. Mr. Hideki Goda, Novo Nordisk Japan, mailto:[email protected]

THEME : “New ultra long acting basal insulin,

Tresiba®”

Short Lecture

Chair: Hiroyuki Koshiyama, MD,PhD

Alan Moses, M.D Global Chief Medical Officer, Novo Nordisk Inc, USA

(ex. Professor, Harvard Medical School & Joslin Clinic)

CLINICAL CASE CONFERENCE

The 26th INTERNATIONAL KITANO ENDO SEMINAR （IKES）


1st: Robert D Robert D UtigerUtiger (Clinical Professor, Harvard Medical School, Ex Deputy Editor, New Engl J Med) 2/7/042nd: ArmenArmen H H TashjianTashjian, , JrJr (Emeritus Professor, Harvard

Medical School & Harvard School of Public Health) 11/20/04

3rd: James H Anderson, James H Anderson, JrJr (Medical Director, Eli Lilly Co, USA) 3/3/05

4th: Gordon H WilliamsGordon H Williams (Professor, Harvard Medical School)

9/17/055th: Theodore W KurtzTheodore W Kurtz (Professor, Department of

Laboratory Medicine University of California San Francisco) 3/23/06

IKESIKESIKES


6th: 6th: David WatersDavid Waters (Chief, Division of Cardiology, San (Chief, Division of Cardiology, San Francisco Francisco

General Hospital; Professor, University of California, San General Hospital; Professor, University of California, San Francisco) Francisco)

9/23/069/23/06• •7th: 7th: GuntramGuntram SchernthanerSchernthaner (Emeritus Professor, University (Emeritus Professor, University of of

Vienna, Head of the Department of Medicine I, Vienna, Head of the Department of Medicine I, RudolfstiftungRudolfstiftung Hospital, Hospital,

Vienna, Austria) 10/11/06Vienna, Austria) 10/11/06••8th:8th: Daniel Daniel ThiebaudThiebaud (Global Medical Fellow II, Eli Lilly and Company) 11/16/06

9th: 9th: Erik Erik RenstromRenstrom (Associate Professor, (Associate Professor, Department of Experimental Medical Science, Lund University, Sweden) 1/15/07

10th:10th: Theodore W KurtzTheodore W Kurtz (Professor, Department of (Professor, Department of Laboratory Laboratory Medicine,UniversityMedicine,University of California, San Francisco)of California, San Francisco)

6/25/076/25/07 IKESIKESIKES

11th: Jorge Plutzky

(Director, Brigham and Women’s Hospital, and Harvard Medical School, Boston) 9/1/0712th: Gordon H Williams (Professor, Harvard Medical School) 5/10/08

•

13th: Vivian Fonseca (Professor, Tulane Univerisity) 9/1708•

14th: Peter Vestergaard, MD, PhD, DrMedSc(Associate

Professor, Calcium Metabolic

Disorders, Aarhus

University, Denmark)4/17/09 •

15th

: John Funder, MD ( Professor, Prince Henry’s Institute of Medical Research) 5/14/09

•

16th

:Alan Moses, MD (ex Professor, Harvard Medical School;Corporate

Vice President, Novo Nordisk) 6/14/09

•

17th:Paola Fioretto

, MD, PhD((University

of Padova

Medical School)2/5/10•

18th: Paul Yen, MD(Duke-NUS Graduate Medical School, Singapore, Duke Medical School)3/27/10

•

19th:John Betterridge,MD,PhD(Professor

of Endocrinology and Metabolism University College Medical School, London)3/29/10

••

2020thth

: : Steve Steve HaffnerHaffner, MD (, MD (ProfessorProfessorofof

Internal Medicine, Internal Medicine, University of Texas Health Science University of Texas Health Science CenterCenter10/23/10

The INTERNATIONAL KITANO ENDO SEMINAR (IKES) The INTERNATIONAL KITANO ENDO SEMINAR (IKES) IKESIKESIKES

21st: Susan Bonner-Wier, PhD and Gordon Wier, MD (Professors, Section on Islet Transplantation and Cell Biology Joslin Diabetes Center, Harvard Medical School 3/3/1122nd: John Funder, MD (Professor, Prince Henry’s Institute of Medical Research) 5/13/1123th: David R Owens, M.D, CBE (Professor and Consultant Diabetologist, Cardiff University,Wales, UK) 10/1/1124th: Jean-Francois Yale,MD,FRCPC (Professor,McGill Nutrition and Food Science Centre,Canada )7/1/1225th : Ele Ferrannini(Professor, the University of Pisa )10/15/12

The INTERNATIONAL KITANO ENDO SEMINAR (IKES)

12年9月16日日曜日


IKESIKESIKES

Documents

International Kitano Endo Seminar (IKES)The INTERNATIONAL KITANO ENDO SEMINAR (IKES) Robert D Utiger We mourns the loss of Professor Robert Utiger, who , who was recently laid to rest