Glycolysis, Gluconeogenesis, Pentose Phosphate

Pathway

Highlights from Nelson and Cox’s Lehninger’s Biochemistry

Know all of the reactions for Glycolysis Know all structures, names, enzymes, cofactors and Standard Free Energy Change Also, Know if the reaction is reversible under cellular conditions.

Glycolysis vs. Gluconeogenesis •  Glycolysis occurs mainly in the muscle and brain •  Gluconeogenesis occurs mainly in the liver

Age-Related Rise in Blood Sugar Linked to Memory Decline New York (Jul 16, 2009)

Randy S. Levinson, Nature Medicine C. Ron Kahn, Joslin Diabetes Center, Harvard Medical School Domenico Accili, Naomi Berrie Diabetes Center and Department of Medicine, Columbia University

The Cory Cycle

Pentose Phosphate Pathway

•  The main goals are to produce NADPH for anabolic reactions and ribose 5-phosphate for nucleotides

NADPH Regulates Partitioning into Glycolysis vs. Pentose

Phosphate Pathway

•  NADPH inhibits glucose-6-phosphate dehydrogenase