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#11 Anemii Yanev DM 2013
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. . , , ,
- *
- ,
**
1
(7 - 8 ; 5.1012/L). , ( ). ~ 120 .
5.2 0.3.1012/L 4.7 0.3.1012/L - 160 20 g/L 140 20 g/L 0,40 0,54 0,36 0,47
- , / , .
(, -) (. 12)
.
- - - - ()- - - -
( )
( )
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Hb , Ers , Hct
, - ( ) , B12 Fe
*(, , , ) .
-
: Adisson Biermer ( ) ( )
HLA-A3, HLA-B7 : 12
- Addison-Biermer
( ) (, , )
, , , . , , () Ers ( ) -
Er (M. Minkowski-Chauffard)
Ers-6- - - - -
Icterus gravis Rh Rh- Rh+ 1 2
Rh -
- (-thalassemia mayor) - (-thalassemia minor) - -
Thalassemia mayor (M. Cooley) HbF HbA2 - - - Ers
OXY-DEOXY- - , S
I
II
. : , ()
, . .
:
:
. 3 :
( VIII) B ( IX) C ( XI)
X , , .
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Thrs ( 150-450109/L) Thrs 150109/L.
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,, ( )
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Thrs ()
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* O2 CO2.RBC contain a large quantity of carbonic anhydrase: a large amount of CO2 is transported from the tissues to the lungs under the form of bicarbonate.
*Deoxygenation of SS erythrocytes leads to intracellular hemoglobin polymerization, loss of deformability and changes in cell morphology.