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Bone Graft
Cross sectional structure of bone sponge
İnternational Graft
İnternational Graft
THE SCIENCE OF NOVABONE NovaBone has been the subject of more than thirty basic science,
in vivo, and human studies. It has been favorably compared to
multiple alternative materials on the market today. NovaBone has
a 15 – year track record of safety and efficacy in a wide range of
clinical applications. Additionally, NovaBone has demonstrated
equivalent rates of bone growth when compared to autogenous
bone graft
References 1. Oonishi H, Kushitani S, Yasakawa E, et al. Particulate Bioglass Compared with Hydroxyapatite as
a Bone Graft Substitute. Clin Orthop. 1997;334:316-325.
2. Wheeler DL, Stokes KE, Hoellrich RG, Chamberland DL, McLoughlin SW. Effect of Bioactive Glass
Particle Size on Osseous Regeneration of Cancellous Defects. J Biomed Mater Res. 1998;41:527-533
3. Brice Ilharreborde, MD, Etienne Morel, MD, Franck Fitoussi, MD, Ana presedo,MD, Philippe Souched,
MD, Georges-Francois Pennecot, MD, and Keyvan Medza, MD. Bioactive Glass as a Bone Substitute
For Spinal Fusion in Adolescent İdiopathic Scoliosis. J Pediatr Orthop. 2008;28:347-351.
4. Larry L. Hench, Julia M. Polak . A Genetic Basis for Design of Biomaterials for In Situ Tissue Regeneration.
Key Engineering Materals 2008;337:151-166
5. Larry L. Hench, David M. Gaisser, The Genetic Basis for Osteogenesis Stimulation by Controlled Release
of lonic Dissolution Products. Transactions of the Orthopedic Research Society, Annual Meeting, San
Francisco, California, USA. March 2008:1697
İnternational Graft
The AlloGraft Leader
International Flexible Bone Graft
DBM Flexible Greft
BellaFuse™ yüksek miktarda allogreft kemik içeren (%50den fazla) elastik bir DBM türüdür ve insan
jelatini ile karıştırılmıştır bu nedenle kemik rejenerasyonu için mükemmel yeterliliktedir. Ayrıca rehidrasyon
yapılmadan kullanılabilir kemikli defekt bölgesine göre şekillendirilebilir ya da kesilebilir.
Endikasyonlar :
Ridge ogmentasyonu işlemlerinde onlay greftleme ile ridge genişliği oluşturması
Kemik parçaları arasındaki küçük aralıkların birleştirilmesi
Kemik oluşumu gereken defektlerin üzerinin kapatılması veya içlerinin doldurulması
Alveol rekonstrüksiyonuda kemikler veya kemik uzantılarının arasındaki boşlukların köprülenerek birleştirilmesi
Laminaktomi cerrahisinde uygun uygulama özelliği
BİRKAÇ DAKİKA 6 SAAT 20 SAAT 50 SAAT Na+ ve H+ iyon Amorf kalsiyum Biyolojik Kök hücrelerinin
Değişimi fosfatın çökmesi bileşiklerin absorbsiyonu fiksasyonu
1 SAAT 10 SAAT 24 SAAT 100 SAAT
Na+ kaybı, çözünebilen Hidroksil karbonat Makrofajların Differentiation
Silisyum dioksit (silika) apatit tabakasının faaliyeti of the stem cells
Salınmasını başlatır. kristallesşmesi
Yüzeyde silanol (Si-OH) 1-10 gün büyümesi
Gruplatı oluşur. Bunlar polimerize
Olarak zengin silikalı tabakaya dönüşür.
Product Cat.No. DBM Cortical Human
Gelatin Size
BellaFuse
DBM Flex DBF25 %50 %0 %50 25X25X2.5(mm)
BellaFuse
DBM Flex DBF50 %50 %0 %50 25X50X2.5(mm)
BellaFuse
DBM Flex DBF100 %50 %0 %50 25X100X2.5(mm)
BellaFuse
Cortical Flex CBF25 %0 %50 %50 25X25X2.5(mm)
BellaFuse
Cortical Flex CBF50 %0 %50 %50 25X50X2.5(mm)
BellaFuse
Cortical Flex CBF100 %0 %50 %50 25X100X2.5(mm)
BellaFuse
Cortical Flex CDF25 %15 %35 %50 25X25X2.5(mm)
BellaFuse
Cortical Flex CDF50 %15 %35 %50 25X50X2.5(mm)
BellaFuse
Cortical Flex CDF100 %15 %35 %50 25X100X2.5(mm)
AntartikTM Sponge
Caracteristiques • AntartikTM Sponge est un substitut osseux composé d’hydroxyapatite et de phosphate de tricalcium dispersés
dans une matrice de collagène de type I et III.
• Repousse osseuse en 3 à 4 mois
• Propriétés hémostatiques validées (testé par un laboratoire externe)
Composition:
AntartikTM Sponge
Antartik™ Sponge est utilisée pour le comblement de divers types de défauts osseux, aussi bien pour des raisons chirurgicales,
traumatiques ou pathologiques. Elle est indiquée lors de :
• prélèvement osseux (compact ou spongieux, greffe de tendon,…)
• résection d’une tumeur osseuse;
• ostéosynthèse;
• arthrodèse, spondylodèse;
• pseudarthrose;
• ostéotomie (sternotomie,…);
• autres défauts osseux.
Pour les chirurgies maxillofaciale et dentaire, Antartik™ Sponge est indiquée en cas de reconstruction osseuse.
La matrice de collagène avec une dispersion homogène du substitut osseux : propriétés hémostatiques, colonisation des cellules et ostéoconduction.
Contact entre les granulés de susbstitut osseux et la matrice de collagène
Matrice de
collagène
Substitut
osseux
Matrice de
collagène
Substitut
osseux
AntartikTM Sponge: Matrice ostéoconductrice, hémostatique et résorbable pour le comblement osseux
10% Collagen
90% HAP/TCP
60% HAP
40 % TCP
0499
FLEX GRAFT
MedicalBiomat 5 chemin du catupolan 69120 vaulx en velin- France Tel:+33(0)4 72 81 22 62- Fax: +33(0)4 72 81 22 72
Tailles
AntartikTM Sponge est présenté dans un double conditionnement et strérilisé par irradiation.
T=0
T + 3 mois
T + 1 mois
Résorption totale du collagène Absence de signe d’inflammation ou de nécrose Début de la régénération osseuse
Formation du nouvel os Début de la repousse osseux
Antartik™ Sponge : Matrice poreuse avec des granulés de substitut osseux (HAP+TCP)
AntartikTM Sponge Tailles
Granulométrie du substitut osseux
Références
12x12x12mm 80 - 200 µm SP-1XS01HT1
12x12x12mm 0,5 - 1 mm SP-1XS01HT2
12x12x24mm 80 - 200 µm SP-1S01HT1
12x12x24mm 0,5 - 1 mm SP-1S01HT2
30x30x6mm 80 - 200 µm SP-1M01HT1
30x30x6mm 0,5 - 1 mm SP-1M01HT2
35x60x6 mm 80 - 200 µm SP-1L01HT1
35x60x6 mm 0,5 - 1 mm SP-1L01HT2
70x110x6 mm 80 - 200 µm SP-1XL01HT1
70x110x6 mm 0,5-1 mm SP-1XL01HT2
Atatürk Üniversitesi Ata Teknokent Binası B Blok No.: 74 / 122 Turkey - ERZURUM Telf : +90 234 20 50 - Faks : +90 234 40 10
KOMED MEDİKAL SAĞLIK TİC. LTD. ŞTİ.
KOMED MEDİKAL SAĞLIK TİC. SAN. LTD. ŞTİ.
[G-FillinBone] Substituts osseux synthétiques
avec gentamicine
Bone substitute with
gentamicin
G-FILLINBONE est un substitut osseux synthétique
biphasé (70% HAP et 30% ß-TCP) avec antibiotique. Il
permet le comblement de cavités osseuses lors
d'opérations chirurgicales orthopédiques (hors chirurgie
contaminée), notamment dans les cas de :
• pose de prothèse articulaire,
• rachis,
• traumatologie sur fracture fermée,
• ostéotomies,
• comblement après résection d'une tumeur.
Il est particulièrement indiqué lorsque des germes
sensibles à la gentamicine constituent un risque
possible. Les substituts osseux G-FILLINBONE ont une
porosité et une surface optimisée pour permettre une
repousse osseuse rapide et une bonne ostéointégration.
La structure de notre substitut osseux combine à la fois
des macroporosités dont la totale interconnection
favorise la pénétration des cellules, et des
microporosités qui augmentent la surface de contact
avec les fluides biologiques.
La gamme G-FILLINBONE se décline en granulés
permettant de combler des cavités de forme complexe,
et en blocs qui pourront être façonnés aisément par le
chirurgien suivant
La combinaison du comblement osseux et de
l'antibioprophylaxie locale
G-FILLINBONE is a bi-phased synthetic bone substitute (70%
Hydroxyapatite and 30% ß-TCP) with antibiotic. It has been
specially designed in order to fill in bone cavities for
orthopaedic surgical operations (except contaminated
surgery), in particular in cases of:
• joint prosthesis,
• spinal,
• traumatology on closed fracture,
• osteotomies,
• filling after tumour ablation.
It is particularly indicated when germs sensitive to
gentamicin constitute a possible risk.
G-FILLINBONE Bone substitutes have an optimised porosity
and surface to allow a rapid bone ingrowth and a good
osteointegration.
The structure of our bone substitute combines at the same
time macroporosities whose total interconnection favours
the penetration of the cells, and microporosities which
increase the surface in contact with the biological fluids.
The G-FILLINBONE range includes granules designed to fill in
cavities of complex form, and blocks that can be cut easily by
the surgeon in order to adapt to any particular indication.et
de garantir ainsi une totale sécurité.
Combining bone filling and local
antibioprophylaxis
[ Caractéristiques ]
Les substituts osseux G-
FILLINBONE ont une porosité et
une surface optimisées pour
permettre une repousse osseuse
rapide et une bonne
ostéointégration.
La structure de G-FILLINBONE
combine à la fois des
macroporosités dont la totale
interconnection favorise la
pénétration des cellules et des
microporosités qui augmentent
la surface de contact avec les
fluides biologiques.
Les caractéristiques mécaniques
de l'implant permettent de
répondre à la plupart des
indications cliniques.
Les tests in vitro, les
implantations animales ainsi
que les résultats cliniques,
démontrent une parfaite
ostéointégration des substituts
FILLINBONE.
FILLINBONE bone substitutes
have optimised porosity and
surface in order to induce fast
bone ingrowth and good
osteointegration.
FILLINBONE's structure combines
two different porosities. Thanks
to their total interconnection,
macroporosities favour the cells
penetration, and the
microporosities increase the
surface in contact with the
biological fluids. The mechanical
characteristics of the implants
make them appropriate for most
clinical indications. In vitro tests,
animal implantation and clinical
results show a perfect
osteointegration of FILLINBONE
bone substitutes.
Fig.a : Implantation chez le lapin (3 mois -Ulna) bCoupe histologique 100 µm observée en microradiographieBlanc : biomatériauGris : tissu osseux minéraliséNoir : substances non minéraliséesLa minéralisation du tissu osseux qui pénètre dans lesporosités est équivalente à celle du tissu osseux qui environnel'implant.Fig.a: Implantation on rabbit (3 month - Ulna)100 µm histological section observed in microradiography.White: biomaterialGrey: mineralised bone tissueBlack: non mineralised substancesThe mineralisation of bone tissue penetratinginside theporosities is equivalent to the mineralisationof the bone tissuesurrounding the implant.
Fig.b : Implantation chez le lapin (3 mois - Ulna)Coupe histologique 50 µm coloré au May-Grünwald-GiemsaNoir : biomatériauBeige : tissu osseux minéraliséBleu : cellules et tissu non minéralisésPénétration du tissu minéralisé dans les porosités dubiomatériau et début de biodégradation du biomatériau.Fig.b: Implantation on rabbit (3 mois - Ulna)50 µm histological section coloured with May-Grünwald-GiemsaBlack: biomaterialBeige: mineralised bone tissueBlue: non mineralised cells and tissuePenetration of mineralised tissue inside theporosities of thebiomaterial and beginning of the biodegradationof thebiomaterial.
[ Présentation ]
Conditionnement en double
emballage stérile
•A conserver à une
température comprise entre
10° C et 40° C
• Produit à usage unique, ne
pas restériliser
• Date de péremption : date de
fabrication + 5 ans
• Précautions d'emploi et
contre-indications, se reporter
à la noticedu fabricant.
Packed in double sterile
packaging
•The substitutes shall be
stored at a temperature
between 10° C and 40° C.
• FILLINBONE is a single use
product, it shall not be
resterilised.
•Expiry date: manufacturing
date + 5 years
•Precautions and
contraindications: please
refer to the instructions of
the manufacturer.
GENTA FIX® 1 ve 3 steril radyopak vekendi kendine sertleşebilen çimento
• Aminosit antibiyotik olan Gentamisin içerir.
• Her ikiside artroplasti ameliyatları içindir.• İmplantların kemiğe hızlıca ve stabil şekilde
tutunmasını sağlar
İki ayrı viskozitedeki ürün tipi cerrahınihtiyaçları içindir.
GENTA FIX® 1: Manuel uygulama için standartviskozite kemik çimentosu
GENTA FIX® 3: Şırınga veya enjeksiyontabancası ile uygulama için ideal akışkanlıktakidüşük viskoziteli kemik çimentosu.
GENTA FIXANTİBİYOTİKLİ KEMİK ÇİMENTOSU
Türkiye’nin Yetkili Disbiritoru
® 1 & 3
ANTİBİYOTİKLİ AKRİLİKKEMİK ÇİMENTOSU
www.komedmedikal.com
www.komedmedikal.com
Endikasyonlar
Enfekte protezlerin revizyonları, implant �ksasyonları, kemik enfeksiyonu yüksek hastalar.
Çimentolar steril kullanıma hazır durumda ameliyathaneye teslim edilir.En fazla 25°C de temiz, karanlık ve kuru bir yerde açılmadan orjinal paketinde saklanır.Diğer bilgiler için lütfen IFU prosedürlerine bakınız.
Saklama ve Ürünler
Yeni jenerasyon kemik çimentosu avantajları• ISO 5833 Standartında mekanik özellikler
• Düşük ısı salınımı
• Diğer çimentolardan düşük monomer salınımı
• İmplant �ksasyonunda stabillik
• Radyopak etken için baryum sülfat
• Vakumlu veya spatula ile hazırlamada kolay uygulama
GENTA FIX® 1 & 3
ISO 5833 standartında mekanik özellikler:
T040140GT040340GT060404T060403T060405T060402
GENTA FIX® 1 - 40 gr toz ve 14,4 gr sıvıGENTA FIX® 3 - 40 gr toz ve 16,4 gr sıvıKase ve spatula 10 lu steril olmayan paketKase ve spatula tekli steril paketUzun borulu şırınga – steril olmayan tekli paketKısa borulu şırınga – steril olmayan tekli paket
PAKET İÇERİĞİ ÜRÜN KODU
Créa
tion
Créd
its p
hoto
s :
© Te
knim
ed •
Ale
xand
er R
aths
, ast
oria
, olly
, aur
emar
- T
F431
0403
/Ind0
- 09
/201
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C ertified
EN IS
O9001 - E N IS O
13485snch Head offices: 8, rue du Corps Franc-Pommiès 65500 VIC en BIGORRE (France) Tél (33) 5 62 96 88 38 Fax (33) 5 62 96 28 72
Administration and supply-chain offices:Z.I de la Herray65500 VIC en BIGORRE (France)Tél (33) 5 62 96 88 38Fax (33) 5 62 96 28 72
Sales and engineering departments:Z.I. de Montredon - 11, rue Apollo31240 L'UNION (France)Tél (33) 5 34 25 10 60 Fax (33) 5 34 25 27 39
Vücut içi salınım hareketi (Baz mg)
0 18 36 54 72 90 108 126 144 162
0,0
0,2
0,4
0,6
0,8
1,0
I s ı
GENTA FIX® 3GENTA FIX® 1
Basınç dayanımı (Mpa)
0
20
40
60
80
100
120
ISO
583
3
GEN
TAFI
X® 1
GEN
TAFI
X® 3
0
10
20
30
40
50
60
70
Bükülme Direnci (MPa)
ISO
583
3
GEN
TAFI
X® 1
GEN
TAFI
X® 3
0
500
1000
1500
2000
2500
3000
3500
4000
Eğilme Modülü (Mpa)
ISO
583
3
GEN
TAFI
X® 1
GEN
TAFI
X® 3
PAKETLEMESıvı: Cam ampulToz: İkili poşet
GENTA FIX® kemikçimentosu bölgesel
antibiyotik terapisi yapar.
Gentamisin aminositgrubundandır, geniş etkili vetekrarlayan enfeksiyonlar içinverilir. Bir dozdaki gentamisin
miktarı uzun süre salınımıgarantiye almak ve
enfeksiyonlarıönlemek için optimize
edilmiştir.
Classe III
Yetkili Satıcı www.komedmedikal.com
EXABONE® PASTE Bone Graft Substitute BIOMIMETIC | OSTEOSTIMULATIVE | EASY TO USE
Nano engineered biomimetic material
EXABONE PASTE is an advanced pure synthetic nano biomaterial replicating the natural mineral phase of healthy human bone.
Advanced technology leads to unique specifications
Optimised sticky viscosity allows a complete and easy filling of the defects, assuring a superior contact at the implant interface and will resist irrigation.
The EXABONE PASTE nano surface area is 50 to 100 times greater than traditional synthetic bone graft.
BIOMIMETIC
OSTEOSTIMULATIVE
EASY TO USE
Highly moldable
Optimised viscosity
Traditional bone graft
Exabone GmbH is a Swiss based biotechnology leader that develops, manufactures and distributes innovative biomaterials across the globe.Capitalising on over 30 years experience in global markets our products are innovative, easy to use and proven the world over.
EXABONE PASTE*
Sur
face
are
a
2 m2/gram
100 m2/gram
* Dried measurement
Reliability & consistent performance
The osteostimulative effects of the hydroxyapatite nano particles encourages osteogenesis.
The ultra-high molecular surface area attracts and adsorbs the natural bone growth promoters available at the implant site.
Clinical applications
Requires no mixing. Pre-loaded in convenient applicators ready for direct placement into the defect. The aqueous based composition is malleable and easily moulded by hand as needed.
EXABONE PASTE is designed for use in a broad range of non-load bearing osseous defects such as: spinal surgery (cage filling), osteotomies, bone cavity and defect filling, metaphyseal fractures, acetabulum reconstruction.
EXABONE PASTE can be mixed with autologous or synthetic bone or bone marrow aspirate.
The healing process starts by rapid colonization of the implant from the viable bone at the implant interface filling and replacing the nanostructure. The bone matures to woven bone and consolidates alongside cell mediated implant resorption.
Paste applicators
A full range ready to use
Pre-loaded in convenient applicators ready for direct placement into the defect.
EXABONE PASTE is gamma sterilized.
EXABONE® PASTE product range
PASTE 08000005 0.5cc
08000010 1cc
08000020 2cc
08000025 2.5cc
08000050 5cc
09000050 10cc (multipack 2 x 5cc units)
10000050 15cc (multipack 3 x 5cc units)
MD582166
Exabone GmbH, Route de Saint-Cergue 14CH-1260 Nyon, SwitzerlandT +41-22 362 03 94 F +41-22 362 03 93E [email protected] W www.exabone.com
EXABONE is a registered trademark of Exabone GmbH. “The Swiss Bone Architect” and the logo are trademarks of Exabone GmbH.
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