Glycolysis Slides

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2 ATP

2

T

1.

2. 2 3C

3. ATP

1

2 . 3

:

: ,

8 -

8 -

P-

Glu 165 1 H+ His 95

3-P

His 176

Cys 149

3-P

ATP 1,3-P

ATP

: NAD+ (1 2) ( ) () . (3).

2

3

1

NAD+

NAD+

()

-

:

. ,

Km hexokinase Km

ATP . (, , ) . : ( sec) (, sec) ( )

4

AMP

() . ATP/AMP () (.. ) .

2,6-P

2,6-P

2

, 2 (PFK2) , 2 (FBP 2)

2,6-P

6-P F-2,6-BP,

. , , . (HIF-1), . ,

HIF-1 , (VEGF),